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A Toolkit of CRISPR-Based Genome Editing Systems in Drosophila

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Journal of Genetics and Genomics 2015年第4期42卷 141-149页

作者： Jiang Xu Xingjie Ren Jin Sun Xia Wang huan-huan qiao Bo-Wen Xu Lu-Ping Liu Jian-Quan Ni Gene Regulatory Lab School of MedicineTsinghua University Tsinghua Fly Center Tsinghua University School of Basic Medical Sciences Wuhan University College of Bioengineering Hubei University of Technology

The last couple of years have witnessed an explosion in development of CRISPR-based genome editing technologies in cell lines as well as in model organisms. In this review, we focus on the applications of this popular system in Drosophila. We discuss the effectiveness of the CRISPR/Cas9 systems in terms of delivery, mutagenesis detection, parameters affecting efficiency, and off-target issues, with an emphasis on how to apply this powerful tool to characterize gene functions.

关键词： CRISPR Genome editing Drosophila Cas9 sgRNA Off-target

Condition monitoring and fault diagnosis of industrial robots: A review

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Science China Technological Sciences 2025年第1期 121-145页

作者： Yaguo LEI huan LIU Naipeng LI Junyi CAO Yuting qiao Hongbo WANG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi'an Jiaotong University

Health management of industrial robots is paramount for maintaining effective operations, ensuring consistent performance, minimizing downtime, and ultimately enhancing the safety and productivity of robotic systems. Since the invention of industrial robots, significant efforts have been dedicated to their health management. In recent years, thanks to advances in condition monitoring and fault diagnosis technologies of industrial robots, robot health management has shifted from scheduled maintenance to condition-based maintenance. This paper aims to comprehensively review the evolution of condition monitoring and fault diagnosis technologies that are critical for implementing condition-based maintenance of industrial robots. A brief introduction to robotic systems is given first to analyze the robot failure modes and their corresponding root causes. Next, the data acquisition strategies and commonly used sensors of industrial robots are ***, the development of robot condition monitoring and fault diagnosis technologies are reviewed, with an emphasis on the remarkable achievements and challenges in model-based and data-driven methods. Finally, the paper summarizes the challenges facing this research field and provides potential avenues for future advancements.

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First measurement of strong interaction between antiprotons

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National Science Review 2016年第2期3卷 154-155页

作者： huan-qiao Zhang China Institute of Atomic Energy

Our world is made of matter,but matter has a counterpart called antimatter,in which the subatomic particles(protons and electrons)of antimatter have charges opposite to those of ordinary *** an ordinary matter,the protons are positively charged,and the electrons carry negative *** antimatter,the antiprotons are negatively charged,while the antielectrons(called positrons)are positively *** antimatter and matter ever meet,they annihilate in a flash of light.

关键词： First measurement of strong interaction between antiprotons

Influence of Deformation on the Microstructure and Low-temperature Refining Behavior of Al-3.5P Master Alloy

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Journal of Materials Science & Technology 2015年第4期31卷 391-396页

作者： huan qiao Xiangzhen Zhu Tong Gao Yuying Wu Xiangfa Liu Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong University

In this paper,the influence of deformation on the microstructure and low-temperature refining behavior of Al-3.5P master alloy was *** results show that the average size of AIP particles can be reduced obviously from 15.3 μm to about 2.1 μm by ***,it exhibits entirely opposite influence on refining performance when A1-3.5P master alloy was deformed at room temperature and high temperature,*** when Al-3.5P master alloy was subjected to thermal deformation,can an improvement of low-temperature refining performance be *** this condition,primary Si in A390 alloy can be refined from 137 to 21 μm,making it a potential candidate for die casting production.A mechanism associated with the transformation of particle-matrix interface during deformation has been proposed and further experiment has been designed to validate it.

关键词： Al-Si alloy A-P master alloy Deformation Grain ref

Surface effects on cylindrical indentation of a soft layer on a rigid substrate

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Acta Mechanica Sinica 2020年第2期36卷 422-429页

作者： Min Li huan-Xin Zhang Zi-Long Zhao Xi-qiao Feng Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China

In this paper,theoretical and numerical methods are combined to investigate the two-dimensional,cylindrical indentation of an elastic soft layer bonded on a rigid *** incorporating the Gurtin-Murdoch’s theory of surface elasticity into the Kerr model,we account for surface effects on the indentation behavior of a soft *** governing differential relation between the surface pressure and displacement of the film-substrate system is *** an incompressible thin layer,the explicit solutions are derived,which are simple and *** element simulations are performed using an explicit restart algorithm to study the indentation properties of the layer-substrate system and to examine the validity and accuracy of the theoretical *** work holds promise for applications in mechanical characterization of soft materials,such as biological tissues and cells.

关键词： Soft materials Indentation Surface effect Contact Kerr model

A Fuzzy Hierarchical Strategy for Improving Frequency Regulation of Battery Energy Storage System

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Journal of Modern Power Systems and Clean Energy 2021年第4期9卷 689-698页

作者： Kaifeng Wang Ying qiao Lirong Xie Jiaming Li Zongxiang Lu huan Yang School of Electrical Engineering Xinjiang UniversityUrumqiChina State Key Laboratory of Control and Simulation of Power Systems Generation Equipments of Electrical Engineering Tsinghua UniversityBeijingChina

Battery energy storage systems(BESSs)can provide instantaneous support for frequency regulation(FR)because of their fast response ***,purely pursuing a better FR effect calls for continually rapid cycles of BESSs,which shortens their lifetime and deteriorates the operational *** coordinate the lifespan savings and the FR effect,this paper presents a control strategy for the FR of BESSs based on fuzzy logic and hierarchical *** fuzzy logic controller improves the effect of FR by adjusting the charging/discharging power of the BESS with a higher response speed and precision based on the area control error(ACE)signal and the change rate of ACE in a non-linear *** controllers effectively reduce the life loss by optimizing the depth of discharge,which ensures that the state of charge(SOC)of BESS is always in the optimal operating range,and the total FR cost is the lowest at this *** proposed method can achieve the optimal balance between ACE reduction and operational economy of *** effectiveness of the proposed strategy is verified in a two-area power system.

关键词： Battery energy storage system(BESS) frequency regulation(FR) coordinated control strategy optimal depth of discharge charging/discharging threshold

One-step synthesis of CoSn(OH)_6 nanocubes for high-performance all solid-state flexible supercapacitors

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Rare Metals 2017年第5期36卷 457-464页

作者： Bing Li Guang-Xun Zhang Ke-Sheng huang Li-Fan qiao huan Pang College of Chemistry and Chemical Engineering Yangzhou University College of Chemistry and Chemical Engineering Anyang Normal University

CoSn（OH）6 nanocubes were synthesized by a facile one-step co-precipitate method. Their supercapacitor performances were investigated via a traditional threeelectrode system and all solid-state flexible asymmetric supercapacitor. The electrode shows a maximum specific capacitance up to 695 F·g^-1. The flexible all solid-state asymmetric supercapacitor was fabricated based on CoSn（OH）6 nanocubes and active carbon as positive and negative electrode. The assembled asymmetric supercapacitor exhibits a specific capacitance（97.3 mF·cm^-2）, good rate/mechanical stability and a long cycling stability（5000 cycles）, demonstrating great promise for applications in all solid-state flexible supercapacitors.

关键词： One-step Cobalt tin hydroxides All-solid Flexible Asymmetric supercapacitor

Judd-Ofelt Analysis on Trifluoroacetate Europium Complexes for Liquid Laser Media

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Chemical Research in Chinese Universities 2013年第1期29卷 166-170页

作者： SHE Jiang-bo LI Dong-dong GAO Fei qiao Ze-bang LIU huan-huan WEI Wei PENG Bo State Key Laboratory of Transient Optics and Photonics Xi 'an Institute of Optics and Precision Mechanics Chinese Academy of Science Xi 'an 710119 P. R. China School of Electronic Engineering Xi' an University of Posts and Telecommunications Xi 'an 710121 P. R. China Institute of Advanced Materials Nanjing University of Posts and Telecommunications Nanjing 210003 P. R. China

Four europium trifiuoroacetate complexes, Eu（CF3COO）3＂bpy（bpy=2,2＇-bipyridine）（l）, Eu（CF3COO）3＂ phen（phen=l,10-phenanthroline）（2）, Eu（CF3COO）3.2bp（bp=benzophenone）（3） and Eu（CF3COO）3-2tppo（tppo=triphenyl- phosphine oxide）（4） were synthesized and characterized by elemental analysis, Fourier transform infrared（FTIR） spectroscopy, photoluminescence（PL） spectroscopy and thermogravimetric analysis（TGA）. The PL spectra of the complexes at room temperature show the strong typical Eu3＋ ion red emission, due to the efficient energy ＂antenna absorption＂ of ligands and transitions of Eu3＋ ion between 5Do----7Fj（j-0-4）. The long lifetime and high quantum yield reflect that the multiphonon relaxations by coupling to O--H and C--H vibrations were reduced. According to the photoluminescent spectra, the Judd-Ofelt parameters f22 and 04 of the complexes were calculated and the radiative properties were also presented. The 5D0 radiative lifetime, quantum yield and the stimulated emission cross-section of the complexes are excellent, which prove that they have promising optical properties for liquid laser. The thermal analyses indicate that they are quite stable to heat.

关键词： Europium complex Luminescent property Judd-Ofelt theory

Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older

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World Journal of Diabetes 2022年第3期13卷 251-259页

作者： Xiao-Fang Bai huan Wang qiao-Ling Zhao Department of Ultrasound Medicine The First Affiliated HospitalXi'an Jiaotong UniversityXi'an 710061Shannxi ProvinceChina Department of Pain Medicine The First Affiliated HospitalXi'an Jiao tong UniversityXi'an 710061Shannxi ProvinceChina

BACKGROUND Protein glycosylated hemoglobin,hemoglobin A1c(HbA1c)binds hemoglobin(Hb)in red blood cells to blood ***,the relationship between Hb and HbA1c remains *** To elucidate their relationship in a nondiabetic population aged≥16 years in the United States,using data from the 1999-2018 National Health and Nutrition Examination *** This study was based on data from 44560 adults aged≥16 years,excluding those with *** relationship was estimated using a multivariate *** also used piecewise linear regression for subgroup analysis based on age and sex stratification and analysis of the threshold effects of Hb on *** Hb and HbA1c levels were negatively correlated in the unadjusted model(β=-0.01;95%CI:-0.01,-0.01).The correlation was significantly negative when the regression model was minimally regulated and stratified by age and sex,and remained negative when the model was further regulated(more than 10%)to identify covariates with the HbA1c level influence *** subgroup analyses based on age and sex stratification,the association remained negative when the covariates were controlled.A nonlinear relationship was observed between them when the Hb levels reached the tipping point(13.2 g/dL)(adjusted odds ratio,-0.04;95%CI:-0.05,-0.03)and when the Hb levels exceeded 13.2 g/dL(adjusted odds ratio,-0.10;95%CI:-0.10,-0.09).CONCLUSION Our study shows that normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged≥16 years.

关键词： Haemoglobin Glycosylated haemoglobin Diabetes National Health and Nutrition Examination Survey