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Mapping the fallowed area of paddy fields on Sanjiang Plain of Northeast China to assist water security assessments

Journal of Integrative Agriculture 2020年第7期19卷 1885-1896页

作者： LUO chong LIU huan-jun FU Qiang GUAN Hai-xiang YE Qiang ZHANG Xin-le KONG Fan-chang School of Economics and Management Northeast Agricultural UniversityHarbin 150030P.R.China School of Pubilc Adminstration and Law Northeast Agricultural UniversityHarbin 150030P.R.China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102P.R.China

Rice growth requires a large amount of water,and planting rice will increase the contradiction between supply and demand of water *** field fllowing is important for the sustainable development of an agricultural region,but it remains a great challenge to accurately and quickly monitor the extent and area of fallowed paddy *** fields have unique physical features associated with paddy rice during the flooding and transplanting *** comparing the differences in phenology before and after paddy field fllowing,we proposed a phenology-based fallowed paddy field mapping *** used the Google Earth Engine(GEE)cloud computing platform and Landsat 8 images to extract the fllowed paddy field area on Sanjiang Plain of China in *** results indicated that the Landsat8,GEE,and phenology-based fllowed paddy field mapping algorithm can effectively support the mapping of fallowed paddy fields on Sanjiang Plain of *** on remote sensing monitoring,the total fallowed paddy field area of Sanjiang Plain is 91543 *** resultant fallowed paddy field map is of high accuracy,with a producer(user)accuracy of 83%(81%),based on validation using ground-truth *** Landsat-based map also exhibits high consistency with the agricultural statistical *** estimated that paddy field fallowing reduced irigation water by 384-521 million cubic meters on Sanjiang Plain in *** research results can support subsidization grants for fallowed paddy fields,the evaluation of fallowed paddy field effects and improvement in subsequent fallowed paddy field policy in the future.

关键词： fllowed paddy fields Landsat 8 Sanjiang Plain Google Earth Engine water security

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基于效标法与分布法的消化性溃疡生命质量测定量表的最小临床重要性差值制定与评估

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现代预防医学 2024年第16期51卷 2898-2902页

作者：欧金清雷平光刘欢婷于磊何均辉余洁梅万崇华深圳市宝安区松岗人民医院消化内科广东医科大学生命质量与应用心理研究中心/生命质量与心理测评干预重点实验室南方医科大学附属花都医院

目的探讨慢性病患者生命质量测量体系之消化性溃疡量表QLICD-PU(V2.0)得分的最小临床重要性差值(MCID)。方法采用方便抽样，于2013年3月至2014年8月使用QLICD-PU(V2.0)量表进行问卷调查，采用效标法和分布法制定MCID,分析比较取平均... 详细信息

目的探讨慢性病患者生命质量测量体系之消化性溃疡量表QLICD-PU(V2.0)得分的最小临床重要性差值(MCID)。方法采用方便抽样，于2013年3月至2014年8月使用QLICD-PU(V2.0)量表进行问卷调查，采用效标法和分布法制定MCID,分析比较取平均值法、取小值法和取大值法制定的MCID。结果取平均值法得到的生理功能(8.53)、心理功能(8.45)、社会功能(7.61)、共性模块(7.05)、特异模块(8.82)和量表总分(7.53);取小值法得到的MCID分别为5.25、5.78、6.16、4.19、7.18、4.09;取大值法得到的MCID分别为11.99、12.05、10.09、9.48、10.99、11.04。结论本文采用多种方法和标准制定了MCID,使用者可根据情况选用。MCID可用于评估消化性溃疡患者的临床疗效，为生命质量的应用提供参考。在后续研究中，制定的MCID值可通过临床实践进一步验证。

关键词：消化性溃疡慢性病生命质量最小临床重要性差值

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Phase transformations and mechanical properties of a Ti36Nb5Zr alloy subjected to thermomechanical treatments

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Rare Metals 2022年第1期41卷 209-217页

作者： Qing-Kun Meng Jia-Dong Xu huan Li chong-Hang Zhao Ji-Qiu Qi Fu-Xiang Wei Yan-Wei Sui Wen Ma School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China Department of Materials Science and Chemical Engineering Stony Brook UniversityStony BrookNY 11794USA Grinm Group Co. LtdBeijing 100088China

Various solid state phase transformations exist in metastable β-type Ti alloys,which can be employed to optimize the mechanical *** this paper,synchrotron X-ray diffraction(SXRD)experiments were carried out to study the phase transformations of a Ti36Nb5Zr alloy subjected to different thermomechanical ***,the correlation between the phase constitutions and the mechanical properties was *** a" texture formed,and high-density defects were introduced after cold rolling of the solution treated specimen,leading to the decrease in Young’s modulus and the increase in *** cold-rolled specimens were then annealed at temperatures from 423 to 773 K for 30 *** the Young’s modulus and strength increased with annealing temperatures increasing up to 673 K,which resulted from the precipitation of the ω and/or α *** further increase in annealing temperatures to 773 K,the β→α precipitation replaced the β→ω_(iso) phase transformation,and the density of defects decreased,leading to the decrease in both the Young’s modulus and *** results provide theoretical basis for the design biomedical Ti alloys with both low Young’s modulus and high strength.

关键词： β-type Ti alloys Phase transformations Mechanical properties Thermomechanical treatments Synchrotron X-ray diffraction

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Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation:PAH risk score

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Frontiers of Medicine 2022年第6期16卷 957-968页

作者： Shan chong Yun He Yejun Wu Peng Zhao Xiaolu Zhu Fengrong wang Yuanyuan Zhang Xiaodong Mo Wei Han Jingzhi wang Yu wang huan Chen Yuhong Chen Xiangyu Zhao Yingjun Chang Lanping Xu Kaiyan Liu Xiaojun huang Xiaohui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing100044China National Clinical Research Center for Hematologic Disease Beijing100044China

Skin and soft tissue infections(SSTIs)refer to infections involving the skin,subcutaneous tissue,fascia,and *** transplant populations with hematological malignancies,an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs ***,to date,the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation(HSCT)patients remain *** study included 228 patients(3.67%)who developed SSTIs within 180 days after allogeneic HSCT from January 2004 to December 2019 in Peking University People’s *** overall annual survival rate was 71.5%.We compared the differences between survivors and non-survivors a year after transplant and found that primary platelet graft failure(PPGF),comorbidities of acute kidney injury(AKI),and hospital-acquired pneumonia(HAP)were independent risk factors for death in the study population.A PPGF-AKI-HAP risk stratification system was established with a mortality risk score of 1×PPGF+1×AKI+1×*** areas under the curves of internal and external validation were 0.833(95%CI 0.760–0.906)and 0.826(95%CI 0.715–0.937),*** calibration plot revealed the high consistency of the estimated risks,and decision curve analysis showed considerable net benefits for patients.

关键词： skin and soft tissue infections hematopoietic stem cell transplantation risk stratification system mortality

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The natural course of bacillus Calmette-Guerin induced bladder lesions:A long-term follow-up study and systematic review

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Asian Journal of Urology 2023年第3期10卷 356-363页

作者： chong Ma Shuxiong Zeng Lihe Dai huan Han Ruixiang Song Jinshan Xu Xing Ai Chuanliang Xu Department of Urology The Third Medical Center of PLA General HospitalBeijingChina Department of Urology Changhai HospitalNaval Medical UniversityShanghaiChina Department of Urology The 943 Hospital of Joint Logistics Support Force of Chinese PLAGansuChina Department of Pathology Changhai HospitalNaval Medical UniversityShanghaiChina

Objective:Bacillus Calmette-Gue´rin(BCG)instillation is the standard adjuvant treatment for intermediate-and high-risk non-muscle-invasive bladder cancer after transurethral ***,its toxicity often causes bladder *** follow-up cystoscopy,post-BCG bladder lesions can be pathologically benign,urothelial carcinoma recurrence,or other types of bladder *** a small number of case reports have been published on post-BCG bladder *** clinical features,natural course,and management remain ***:We retrospectively studied cystoscopic videos and medical records of BCG-treated bladder cancer patients at our *** a long-term follow-up,we took biopsies on tumor-like lesions and described their *** addition,we summarized previous studies on post-BCG bladder lesions by systematic literature searching and ***:We described a series of three cases with post-BCG bladder lesions mimicking tumor recurrence from a total of 38 cases with follow-up data for more than 5 *** lesions could last,grow,or disappear spontaneously,and remain pathological benign for *** systematic review,we identified and analyzed a total of 15 cases with post-BCG bladder lesions with detailed clinical *** of the 15 were benign and have a good prognosis with nephrogenic adenoma being the most common pathological ***:Based on previous studies and our experience,benign lesions after BCG instillation cannot distinguish with cancer recurrence by cystoscopy alone,even under narrow band imaging ***,given most of them have a good prognosis,random biopsy or transurethral resection might be spared in the patients with long-term negative biopsy and urine cytology.

关键词： Bacillus Calmette-Guerin Bladder cancer Side effects Cystoscopy Follow-up

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采用光纤光栅级联结构实现光纤延迟线

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光谱学与光谱分析 2022年第7期42卷 2241-2246页

作者：王翀杜欢王静王菁王景华西安邮电大学电子工程学院陕西西安710121

在使用光纤光栅实现皮秒级别时延的基础上,提出一种光纤光栅与单模光纤相结合的微秒级别级联结构,该结构可以实现中心波长1550~1553 nm范围内,间距为1 nm的窄波长反射型时延线,共1,1.5,2和2.5μs四种不同的时延。将单波长反射的啁啾布... 详细信息

在使用光纤光栅实现皮秒级别时延的基础上,提出一种光纤光栅与单模光纤相结合的微秒级别级联结构,该结构可以实现中心波长1550~1553 nm范围内,间距为1 nm的窄波长反射型时延线,共1,1.5,2和2.5μs四种不同的时延。将单波长反射的啁啾布拉格光纤光栅与103 m单模光纤连接构成延迟单元,再利用光环形器将4个延迟单元级联并使用内半径为3 cm的光纤绕线盘,将四种延时单元的传输光纤进行整合。借助光纤光栅的反射镜作用,控制不同波长光信号通过不同的传输距离,从而达到时延目的。本文通过对啁啾布拉格光纤光栅的反射谱进行仿真分析,发现相邻反射谱的旁瓣会出现交叠现象,因此使用六个切趾函数对旁瓣滤除。结果显示:不同切趾函数的滤除效果也不同,能够完全滤除旁瓣并且对反射谱包络影响最小的是柯西切趾函数,经柯西切趾后能使不同波长光信号在对应中心波长1 nm范围内反射率达到1,而其他位置均为0。由于使用光纤绕线盘整合延迟单元传输光纤会产生一定损耗,因此对弯曲损耗进行仿真分析,结果表明:弯曲半径相同时,损耗与工作波长成正比;工作波长相同时,弯曲损耗与弯曲半径成反比。当弯曲半径大于2.9 cm时,弯曲损耗曲线变化平缓并趋于0,因此当光纤绕线盘内半径为3 cm时保证了在减小延迟模块体积的同时又不会有过大的损耗。通过TDS784D型示波器对频率为2000 Hz的信号经不同传输距离后的波形进行测试,结果显示经3 m和5 km传输线后信号的各项参数基本保持不变,经过长距离传输后,依然能保持原信号特性,因此使用103 m传输线可达到延迟目的。使用W-GGL型光功率计对不同频率下的输出功率进行测量,与直光纤的输出功率相比,当弯曲半径为2~3 cm时偏差较大,等于3 cm时偏差为0.18 dBm,大于3 cm时则无限趋近,因此设置绕线盘内半径为3 cm符合光纤延迟线的损耗范围。

关键词：光纤延迟线光纤光栅级联结构反射谱切趾函数弯曲损耗

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A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers

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Journal of Pharmaceutical Analysis 2022年第6期12卷 879-888页

作者： Yuqing Meng Jiayun Chen Yanqing Liu Yongping Zhu Yin-Kwan Wong Haining Lyu Qiaoli Shi Fei Xia Liwei Gu Xinwei Zhang Peng Gao huan Tang Qiuyan Guo chong Qiu Chengchao Xu Xiao He Junzhe Zhang Jigang wang Artemisinin Research Center and Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China Department of Biological Sciences National University of Singapore117543Singapore Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

The composition of serum is extremely complex,which complicates the discovery of new pharmacodynamic biomarkers via serum proteome for disease prediction and ***,nanoparticles have been reported to efficiently reduce the proportion of high-abundance proteins and enrich lowabundance proteins in ***,we synthesized a silica-coated iron oxide nanoparticle and developed a highly efficient and reproducible protein corona(PC)-based proteomic analysis strategy to improve the range of serum proteomic *** identified 1,070 proteins with a median coefficient of variation of 12.56%using PC-based proteomic analysis,which was twice the number of proteins identified by direct *** were also more biological processes enriched with these *** applied this strategy to identify more pharmacodynamic biomarkers on collagen-induced arthritis(CIA)rat model treated with methotrexate(MTX).The bioinformatic results indicated that 485 differentially expressed proteins(DEPs)were found in CIA rats,of which 323 DEPs recovered to near normal levels after treatment with *** strategy can not only help enhance our understanding of the mechanisms of disease and drug action through serum proteomics studies,but also provide more pharmacodynamic biomarkers for disease prediction,diagnosis,and treatment.

关键词： Protein corona Nanoparticles Mass spectrometry Proteomic analysis Pharmacodynamic biomarkers

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Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling

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Journal of Molecular Cell Biology 2020年第9期12卷 723-737页

作者： Li Liu Yudong Wu Cheng Zhang chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang wang Long Zhang Shuo Tu huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang UniversityNanchang 330006China Department of Breast Surgery Jiangxi Provincial Cancer HospitalNanchang 330029China School of Pharmacy Nanchang UniversityNanchang 330006China School of Basic Medical Sciences Nanchang UniversityNanchang 330006China Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang UniversityHangzhou 310058China Department of Pathology The Fourth Affiliated Hospital of Nanchang UniversityNanchang 330003China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China The State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Institute of Biomedical Sciences Nanchang University Medical CollegeNanchang 330031China Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology Nanchang University Medical CollegeNanchang 330006China

Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain *** isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in *** CAAs exhibited significantly different gene expression profiles as assessed by transcriptome *** of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating ***,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer *** pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC ***,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer ***,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF.

关键词： cancer-associated adipocyte G-CSF triple-negative breast cancer(TNBC) epithelial-mesenchymal transition(EMT) migration and invasion

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Ore-forming environment of Pb−Zn mineralization related to granite porphyry at huangshaping skarn deposit,Nanling Range,South China

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Transactions of Nonferrous Metals Society of China 2022年第9期32卷 3015-3035页

作者： Da-peng ZHU huan LI Wei-cheng JIANG chong wang Xiao-Jun HU Hua KONG Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Department of Earth and Environmental Sciences Macquarie UniversityNSW2109Australia

Multiple metallogenic types(skarn-type and vein-type)related to hypabyssal granites are found at the huangshaping polymetallic deposit in the Nanling Range,South *** constrain the crystallization and mineralization processes of skarn formation,three generations of magnetite and pyrrhotite from the hydrous silicate stage,oxide stage,early quartz–sulfide stage,and late quartz–sulfide stage were *** geochemical compositions of magnetite and pyrrhotite were obtained by electron probe microanalyzer(EPMA)and in-situ ablation-inductively coupled plasma-mass spectrometry(LA‒ICP‒MS).The results show that there may be silicate inclusions in magnetite and interaction of wall rock occurred in the mineralization *** geochemical trends recorded in pyrrhotite show the influence of limestone during the crystallization of *** re-equilibration temperatures of Po I,Po II,and Po III are 420.46,380.45,and 341.81°C,respectively,which suggests a continuous evolution following the high-temperature W–Sn mineralized *** content change of Ni and V reflects a gradual decrease of oxygen fugacity from Mag I to Mag III,while the sulfur fugacity calculated from pyrrhotite gradually *** continuous skarn mineralization evolution process helps us to better understand the change of metallogenic environment in the retrograde stage of the huangshaping deposit.

关键词： trace elements magnetite pyrrhotite geochemistry

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Association of baseline hemoglobin A1c levels with bleeding in patients with non-ST-segment elevation acute coronary syndrome underwent percutaneous coronary intervention:insights of a multicenter cohort study from China

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Journal of Geriatric Cardiology 2022年第7期19卷 487-497页

作者： Hua-Lin FAN Li-huan ZENG Peng-Yuan CHEN Yuan-Hui LIU chong-Yang DUAN Wen-Fei HE Ning TAN Ji-Yan CHEN Peng-Cheng HE Department of Cardiology School of MedicineSouth China University of TechnologyGuangzhouChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Cardiology the Second People’s Hospital of Nanhai DistrictGuangdong Provincial People’s Hospital’s Nanhai HospitalFoshanChina De-partment of Biostatistics School of Public HealthSouthern Medical UniversityGuangzhouChina Department of Cardiology Heyuan People’s HospitalHeyuanChina

OBJECTIVE To investigate the association between baseline hemoglobin A1c(HbA1c)levels and bleeding in patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS)who underwent percutaneous coronary intervention(PCI).METHODS This observational cohort study enrolled 6283 consecutive NSTE-ACS patients undergoing PCI from January 1,2010 to December 31,*** on baseline HbA1c levels,the patients were divided into the group with HbA1c<7%(n=4740)and the group with HbA1c≥7%(n=1543).The primary outcomes are major bleeding(BARC grades 3-5)and all-cause death during *** Of patients enrolled,4705(74.9%)were male,and 2143(34.1%)had a history of diabetes mellitus,with a mean(SD)age of 64.13(10.32)*** median follow-up duration was 3.21 *** with the patients with HbA1c<7%,the risk of major bleeding events during follow-up was higher in patients with HbA1c≥7%(adjusted hazard ratio[HR]=1.57;95%con-fidence interval[CI]:1.01-2.44;P=0.044),while the risk of all-cause death during follow-up was not associated with the higher HbA1c levels(adjusted HR=0.88;95%CI:0.66-1.18;P=0.398).CONCLUSIONS Compared with the lower baseline HbA1c levels,the higher baseline HbA1c levels were associated with an increase in long-term bleeding risk in NSTE-ACS patients undergoing PCI,though higher baseline HbA1c levels were not associ-ated with the higher risk in all-cause death.

关键词： patients bleeding coronary

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