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中国药理学与毒理学杂志 2018年第4期32卷 317-318页

作者： huan-li xu Ru YUAN Xiao LI Cong LI Gan QIAO Xiu-kun LIN Department of Pharmacology School of Basic Medical Sciences Capital Medical University Beijing 100069 China

OBJECTIVE Zn-doped CuO nanocomposites(nZn-CuO NPs) are novel nanoparticles synthesized by sonochemical *** study aimed to further investigate the antitumor effects and mechanism of nZn-CuO NPs,as well as the exact mechanism of reactive oxygen species(ROS) on nZn-CuO NPs-induced death using N-acetylcysteine(NAC).METHODS The antitumor effects of nZn-CuO NPs were evaluated by MTS assay and orthotopic transplantation tumor model in nude *** effects of nZn-CuO NPs with or without NAC on ROS production,DNA damage,apoptosis,mitochondrial damage,autophagy,lysosome impairment,and ER and Golgi stress were ***,western blot was used to detect apoptosis and autophagy related proteins,as well as NF-κB pathway related *** nZn-CuO NPs significantly inhibit tumor growth both in vitro and in ***-CuO NPs were able to cause cytotoxicity,ROS production,DAN damage mitochondrial damage,apoptosis,and autophagy,and NAC can attenuate *** studies showed that nZn-CuO NPs induced changes of apoptosis,autophagy and NF-κB pathway related proteins,and NAC can restore *** Overall,our data demonstrated that nZn-CuO NPs could inhibit tumor growth both in vitro and in vivo by ROS-dependent regulation of apoptosis and autophagy,which might be cross-linked by NF-κB pathways.

关键词：超声化学方法抗肿瘤临床分析治疗方法

Multiomics analyses unveil the involvement of microRNAs in pear fruit senescence under high-or low-temperature conditions

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Horticulture Research 2020年第1期7卷 153-164页

作者： Chao Gu huan-Yu xu Yu-Hang Zhou Jia-Long Yao Zhi-Hua Xie Yang-Yang Chen Shao-Ling Zhang Centre of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095China New Zealand Institute of Plant&Food Research Ltd. Private Bag 92169Auckland 1142New Zealand

Senescence leads to declines in fruit quality and shortening of shelf *** is known that low temperatures(LTs)efficiently delay fruit senescence and that high temperatures(HTs)accelerate ***,the molecular mechanism by which temperature affects senescence is ***,through multiomics analyses of fruits subjected to postharvest HT,LT,and room temperature treatments,a total of 56 metabolic compounds and 700 mRNAs were identified to be associated with fruit senescence under HT or LT *** compounds could be divided into antisenescent(I→III)and prosenescent(IV→VI)*** affected the expression of 202 mRNAs to enhance the biosynthesis of prosenescent compounds of types V and VI and to inhibit the accumulation of antisenescent compounds of types II and *** affected the expression of 530 mRNAs to promote the accumulation of antisenescent compounds of types I and II and to impede the biosynthesis of prosenescent compounds of types IV and ***,16 microRNAs were isolated in response to HT or LT conditions and interacted with the mRNAs associated with fruit senescence under HT or LT *** transformation of pear fruit showed that one of these microRNAs,Novel_188,can mediate fruit senescence by interacting with its target ***,both HT and LT conditions can affect fruit senescence by affecting microRNA–mRNA interactions,but the molecular networks are different in pear fruit.

关键词： involvement senescence conditions

Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomeraseⅠ and topoisomeraseⅡ

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中国药理学与毒理学杂志 2017年第10期31卷 1005-1006页

作者： huan-li xu Qun-ying CHEN Hong WANG Ping-xiang xu Ru YUAN Xiao-rong LI Lu BAI Ming xuE Department of Pharmacology School of Basic Medical SciencesCapital Medical University

OBJECTIVE Lapachol is a natural naphthoquinone compound that possesses extensive biological *** aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vivo,as well as the potential *** The antitumor effect of lapachol was firstly evaluated in the C6 glioma model in Wistar *** effects of lapachol on C6 cell proliferation,apoptosis and DNA damage were detected by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium(MTS)/phenazinemethosulfate(PMS)assay,hoechst 33358 staining,annexinⅤ-FITC/PI staining,and comet *** of lapachol on topoisomerase I(TOP I)and topoisomeraseⅡ(TOPⅡ)activities were detected by TOPⅠand TOPⅡmediated supercoiled p BR322DNA relaxation assays and molecular ***Ⅰand TOPⅡexpression levels in C6 cells were also *** High dose lapachol showed significant inhibitory effect on the C6 glioma in Wistar rats(P<0.05).It was showed that lapachol could inhibit proliferation,induce apoptosis and DNA damage of C6 cel s in dose dependent *** could inhibit the activities of both TOPⅠ and Ⅱ.Lapachol-TOPⅠshowed relatively stronger interaction than that of lapachol-TOPⅡin molecular docking ***,lapachol could inhibit TOPⅡexpression levels,but not TOPⅠexpression *** These results showed that lapachol could significantly inhibit C6 glioma both in vivo and in vitro,which might be related with inhibiting TOPⅠ and TOPⅡ activities,as wel as TOPⅡ expression.

关键词： lapachol C6 glioma topoisomeraseⅠ topoisomeraseⅡ

Genome-wide association study and metabolic pathway prediction of barrenness in maize as a response to high planting density

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Journal of Integrative Agriculture 2022年第12期21卷 3514-3523页

作者： ZHANG xu-huan LIU Hao MA xu-hui ZHOU Gu-yi RUAN Hong-qiang CUI Hong-wei PANG Jun-ling KHAN Ullah Siffat ZONG Na WANG Ren-zhong LENG Peng-fei ZHAO Jun Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093P.R.China

Increasing the planting density is one way to enhance grain production in ***,high planting density brings about growth and developmental defects such as barrenness,which is the major factor limiting grain *** this study,the barrenness was characterized in an association panel comprising 280 inbred lines under normal(67500 plants ha–1,ND)and high(120000 plants ha–1,HD)planting densities in 2017 and *** population was genotyped using 776254 single nucleotide polymorphism(SNP)markers with criteria of minor allele frequency>5%and<20%missing data.A genome-wide association study(GWAS)was conducted for barrenness under ND and HD,as well as the barrenness ratio(HD/ND),by applying a Mixed Linear Model that controls both population structure and relative kinship(Q+K).In total,20 SNPs located in nine genes were significantly(P<6.44×10–8)associated with barrenness under the different planting *** them,seven SNPs for barrenness at ND and HD were located in two genes,four of which were common under both ND and *** addition,13 SNPs for the barrenness ratio were located in seven genes.A complementary pathway analysis indicated that the metabolic pathways of amino acids,such as glutamate and arginine,and the mitogen-activated protein kinase(MAPK)signaling pathway might play important roles in tolerance to high planting *** results provide insights into the genetic basis of high planting density tolerance and will facilitate high yield maize breeding.

关键词： Zea mays L high planting density barrenness genome-wide association study MAPK pathway

Spatio-temporal analysis of the incidence of colorectal cancer in Guangzhou,2010-2014

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Chinese Journal of Cancer 2017年第10期36卷 516-523页

作者： Ke Li Guo-Zhen Lin Yan Li Hang Dong huan xu Shao-Fang Song Ying-Ru Liang Hua-Zhang Liu Department of Biostatistics and Cancer Registration Guangzhou Center for Disease Control and PreventionGuangzhou 510440GuangdongP.R.China

Introduction: Colorectal cancer(CRC) is a common type of neoplasm. This study examined the spatio?temporal distribution of the CRC incidence in Guangzhou during 2010–***: Colorectal cancer incidence data were obtained from the Guangzhou Cancer Registry System. Spatial autocorrelation analysis and a retrospective spatio?temporal scan were used to assess the spatio?temporal cluster distribution of CRC ***: A total of 14,618 CRC cases were registered in Guangzhou during 2010–2014, with a crude incidence of 35.56/100,000 and an age?standardized rate of incidence by the world standard population(ASRIW) of 23.58/100,000. The crude incidence increased by 19.70% from 2010(32.88/100,000) to 2014(39.36/100,000) with an average annual percentage change(AAPC) of 4.33%. The AAPC of ASRIW was not statistically significant. The spatial autocorrelation analysis revealed a CRC incidence hot spot in central urban areas in Guangzhou City, which included 25 streets in southwestern Baiyun District, northwestern Haizhu District, and the border region between Liwan and Yuexiu Dis?tricts. Three high? and five low?incidence clusters were identified according to spatio?temporal scan of CRC incidence clusters. The high?incidence clusters were located in central urban areas including the border regions between Bai?yun, Haizhu, Liwan, and Yuexiu ***: This study revealed the spatio?temporal cluster pattern of the incidence of CRC in Guangzhou. This information can inform allocation of health resources for CRC screening.

关键词： Colorectal cancer Spatial analysis Spatial autocorrelation Spatio-temporal clustering

Integrated printed BDNF/collagen/chitosan scaffolds with low temperature extrusion 3D printer accelerated neural regeneration after spinal cord injury

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Regenerative Biomaterials 2021年第6期8卷 26-45页

作者： Xiao-Yin Liu Chong Chen Hai-huan xu Yu-sheng Zhang Lin Zhong Nan Hu Xiao-Li Jia You-Wei Wang Kun-Hong Zhong Chang Liu xu Zhu Dong Ming Xiao-Hong Li Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of PAPFTianjin 300162China National Engineering Research Center in Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064SichuanChina Department of Neurosurgery West China Medical SchoolWest China HospitalSichuan UniversityChengdu 610041SichuanChina and 5Department of Hematology The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500SichuanChina

Recent studies have shown that 3D printed scaffolds integrated with growth factors can guide the growth of neurites and promote axon regeneration at the injury ***,heat,organic solvents or cross-linking agents used in conventional 3D printing reduce the biological activity of growth *** temperature 3D printing can incorporate growth factors into the scaffold and maintain their biological *** this study,we developed a collagen/chitosan scaffold integrated with brain-derived neurotrophic factor(3D-CC-BDNF)by low temperature extrusion 3D printing as a new type of artificial controlled release system,which could prolong the release of BDNF for the treatment of spinal cord injury(SCI).Eight weeks after the implantation of scaffolds in the transected lesion of T10 of the spinal cord,3D-CC-BDNF significantly ameliorate locomotor function of the *** with the recovery of locomotor function,3D-CC-BDNF treatment could fill the gap,facilitate nerve fiber regeneration,accelerate the establishment of synaptic connections and enhance remyelination at the injury site.

关键词： low temperature extrusion 3D printing brain-derived neurotrophic factor collagen chitosan diffusion tensor imaging spinal cord injury

SO（3） classifier of Lie group machine learning

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通讯和计算机（中英文版） 2007年第3期4卷 76-80页

作者： LI Fan-zhang xu huan Computer Science ＆ Technology School Soochow University Suzhou 215006 China

Algorithms of Dynkin diagrams in Lie group machine learning

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通讯和计算机（中英文版） 2007年第3期4卷 13-17页

作者： xu huan LI Fan-zhang School of Computer Science and Technology Soochow University Suzhou 215006 China

不同制剂肺表面活性物质对早产儿呼吸窘迫综合征的疗效分析

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中华危重病急救医学 2021年第2期33卷 174-179页

作者：胥焕许平聊城市人民医院NICU 山东聊城252000 聊城市人民医院中西医结合儿科重点实验室山东聊城252000

目的探讨早产儿呼吸窘迫综合征(RDS)的高危因素,对比分析牛肺表面活性剂联合布地奈德混悬液与猪肺磷脂注射液两种肺表面活性物质(PS)的疗效。方法回顾性分析2016年7月至2020年7月在聊城市人民医院产科出生并于24 h内收住新生儿科重症监... 详细信息

目的探讨早产儿呼吸窘迫综合征(RDS)的高危因素,对比分析牛肺表面活性剂联合布地奈德混悬液与猪肺磷脂注射液两种肺表面活性物质(PS)的疗效。方法回顾性分析2016年7月至2020年7月在聊城市人民医院产科出生并于24 h内收住新生儿科重症监护病房(NICU)的早产儿临床资料,包括围生期情况、一般资料、PS治疗效果及预后等。根据新生儿呼吸窘迫综合征(NRDS)诊断标准将早产儿分为NRDS组和非NRDS组,首先比较两组患儿的临床资料并分析NRDS的相关因素,再通过二元多因素Logistic回归分析确认。此外,根据PS替代治疗方案将患儿分为牛肺表面活性剂联合布地奈德混悬液组和猪肺磷脂注射液组,对比两种PS制剂的疗效。结果①共1690例早产儿纳入研究,其中NRDS患儿297例,NRDS发病率为17.6%。NRDS组与非NRDS组比较性别、胎龄、胎次、出生体重、新生儿窒息、剖宫产、胎膜早破、胎膜早剥、母亲妊娠期糖尿病和父亲烟瘾(母孕期烟雾暴露)差异均有统计学意义(男性:71.0%比59.0%;胎龄:0.05)。二元多因素Logistic回归分析显示,胎龄、性别、剖宫产、胎膜早破、妊娠期糖尿病、父亲烟瘾和新生儿窒息为早产儿RDS的高危因素〔优势比(OR)和95%可信区间(95%CI)分别为0.621(0.557~0.693)、2.043(1.478~2.825)、1.365(1.036~1.797)、0.697(0.506~0.961)、3.223(1.906~5.449)、1.836(1.261~2.673)、3.596(2.622~4.933),均P<0.05〕。②共有160例Ⅲ/Ⅳ级NRDS患儿纳入PS替代治疗疗效分析,其中42例使用牛肺表面活性剂联合布地奈德混悬液,118例使用猪肺磷脂注射液。与猪肺磷脂注射液组比较,牛肺表面活性剂联合布地奈德混悬液组总用氧时间缩短〔d:9.0(5.0,19.0)比13.0(6.0,26.0)〕,住院费用降低〔万元:3.46(2.88,5.18)比4.58(3.08,6.06)〕,支气管肺发育不良(BPD)发生率降低(11.9%比28.8%),差异均有统计学意义(均P<0.05)。结论除胎龄、性别、剖宫产、胎膜早破、妊娠期糖尿病、新生儿窒息外,父亲烟瘾(母孕期烟雾暴露)是导致早产儿RDS的一项重要高危因素;产前应用DEX预防早产儿RDS的疗效受胎儿期烟雾暴露、用药时机、多胎等多种因素的影响;牛肺表面活性剂联合布地奈德混悬液在降低BPD发生率方面优于猪肺磷脂注射液。

关键词：早产儿新生儿呼吸窘迫综合征肺表面活性物质烟雾暴露

Comparative studies on Fenton-like reactions catalyzed by Fe_(3)O_(4) loaded inside and outside halloysite nanotubes for the removal of organic pollutants

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Frontiers of Materials Science 2024年第1期18卷 15-28页

作者： Yang Li Jia-Qi Zhou huan-Yan xu Li-Min Dong Mao-Chang Cao Lian-Wei Shan Li-Guo Jin Xiu-Lan He Shu-Yan Qi Heilongjiang Provincial Key Laboratory of CO_(2) Resource Utilization and Energy Catalytic Materials School of Materials Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040China

In this work,Fe_(3)O_(4) nanoparticles(NPs)loaded inside and outside halloysite nanotubes(HNTs)were prepared and developed as the heterogeneous Fenton-like catalysts for the removal of representative organic *** results indicated that the samples with Fe_(3)O_(4) NPs loaded outside the HNTs lumen(Fe_(3)O_(4)/HNTs)and inside the HNTs lumen(Fe_(3)O_(4)@HNTs)were successfully *** samples had typical magnetic hysteresis loops,while Fe_(3)O_(4)@HNTs exhibited higher magnetization *** comparative experiments showed that Fe_(3)O_(4)@HNTs had better Fenton-like catalytic ability than that of Fe_(3)O_(4)/HNTs in the degradation of various organic *** Rhodamine B(RhB)as an example,the adsorption thermodynamics and kinetics of RhB onto Fe_(3)O_(4)/HNTs and Fe_(3)O_(4)@HNTs were also *** comparative results demonstrated that the adsorption ability of Fe_(3)O_(4)/HNTs was better than that of Fe_(3)O_(4)@***,the dissolved concentration of Fe^(2+)and production amount of hydroxyl radical(·OH)in the Fe_(3)O_(4)@HNTs-H_(2)O_(2) system were significantly higher than those in the Fe_(3)O_(4)/HNTs-H_(2)O_(2) *** on aforementioned comparison,the nano-confinement effect in the Fe_(3)O_(4)@HNTs-H_(2)O_(2) system was *** work provides meaningful guidance for the cheap and convenient design of nanoreactors for Fenton-like applications.

关键词： Fe_(3)O_(4) halloysite nanotube adsorption Fenton-like reaction mechanism