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The essential functions of mitochondrial dynamics in immune cells

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Cellular & Molecular Immunology 2020年第7期17卷 712-721页

作者： Jia-huan xie Yi-Yuan Li Jin Jin MOE Laboratory of Biosystem Homeostasis and Protection and Life Sciences Institute Zhejiang UniversityHangzhou 310058China Key Laboratory for Developmental Genes and Human Disease Ministry of EducationInstitute of Life SciencesJiangsu Province High-Tech Key Laboratory for Biomedical ResearchSoutheast UniversityNanjing 210096China Sir Run Run Shaw Hospital College of Medicine Zhejiang UniversityHangzhou 310016China

Mitochondria are highly mobile organelles due to fission,fusion,transport,and mitophagy,and these processes are known as mitochondrial *** dynamics play an important role in energy production,cell division,cell differentiation,and cell *** the past decade,numerous studies have revealed the importance of mitochondrial metabolism in immunity,and mitochondrial dynamics are essential for immune responses mediated by various cell *** this review,we mainly discuss the role of mitochondrial dynamics in activation,differentiation,cytokine production,and the activity of related pathways in immune cells,particularly T cells,B cells,and other cells involved in the innate immune response.

关键词： Mitochondrial dynamics Metabolism T cell B cell Innate immune cell

Recent advances in Cu-based nanocomposite photocatalysts for CO_2 conversion to solar fuels

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Journal of Energy Chemistry 2017年第6期26卷 1039-1049页

作者： huan xie Jingyun Wang Kemakorn Ithisuphalap Gang Wu Qing Li State Key Laboratory of Material Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Department of Chemical and Biological Engineering University at Buffalo The State University of New York

COconversion via photocatalysis is a potential solution to address global warming and energy *** can directly utilize the inexhaustible sunlight as an energy source to catalyze the reduction of COto useful solar fuels such as CO, CH, CHOH, and CHOH. Among studied formulations, Cubased photocatalysts are the most attractive for COconversion because the Cu-based photocatalysts are low-cost and abundance comparing noble metal-based catalysts. In this literature review, a comprehensive summary of recent progress on Cu-based photocatalysts for COconversion, which includes metallic copper, copper alloy nanoparticles（NPs）, copper oxides, and copper sulfides photocatalysts, can be found. This review also included a detailed discussion on the correlations of morphology, structure, and performance for each type of Cu-based catalysts. The reaction mechanisms and possible pathways for productions of various solar fuels were analyzed, which provide insight into the nature of potential active sites for the catalysts. Finally, the current challenges and perspective future research directions were outlined, holding promise to advance Cu-based photocatalysts for COconversion with much-enhanced energy conversion efficiency and production rates.

关键词： Cu-based photocatalyst CO_2 conversion Solar light Solar fuels Quantum efficiency

Adaptive mechanisms of Ardisia crenata *** along an elevational gradient on Gaoligong Mountain,Southwest China

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Journal of Mountain Science 2023年第3期20卷 765-778页

作者： AI Xing-mei LI Yu xie huan ZHAO Cai-bao College of Landscape Architecture and Horticulture Sciences Southwest Forestry UniversityKunming 650224China Southwest Research Center for Engineering Technology of Landscape Architecture(State Forestry and Grasslan Administration) Southwest Forestry UniversityKunming 650224China

Plants overcome environmental stress by generating metabolic ***,it is crucial to understand the physiological mechanisms of plant responses to changing *** crenata *** has an important ornamental and medicinal *** reveal the impact of elevational gradient on the habitat soil and plant physiological attributes of this species,we collected root topsoil(0–20 cm)and subsoil(20–40 cm)samples and upper leaves at the initial blooming phase,in a survey of six elevations at 1,257 m,1,538 m,1,744 m,1,970 m,2,135 m,and 2,376 m,with 18 block plots,and 5sampling points at each *** decreases with an increase in elevation,and soil variables,and enzymatic activities fluctuated in both the topsoil and subsoil,with all of them increasing with elevation and decreasing with soil *** analysis was conducted to explore the correlation between the distribution of *** *** along the elevational gradient and soil nutrients and enzyme activities,the soil properties were mainly affected by p H at low elevations,and governed by total phosphorus(TP)and available nitrogen(AN)at high *** levels of chlorophyll,carbohydrates,and enzymatic activity except for anthocyanin in this species showed significant variation depending on physiological attributes evaluated at the different collection *** decline in chlorophyll a and b may be associated with the adaptive response to avoid environmental stress,while its higher soluble sugar and protein contents play important roles in escaping adverse climatic conditions,and the increases in activities of antioxidant enzymes except peroxidase(POD)reflect this species’higher capacity for reactive oxygen scavenging(ROS)at high *** study provides supporting evidence that elevation significantly affects the physiological attributes of *** *** on Gaoligong Mountain,which is helpful for understanding plant adaptation strategies and the plastic

关键词： Ardisia crenata var.bicolor Adaptive distribution Elevation Gaoligong Mountain Plant physiological trait Soil physicochemical properties

ADSCs通过PI3K/Akt和NF-κB途径调控神经元存活及炎症反应

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脑与神经疾病杂志 2025年第1期33卷 1-7页

作者：李伟宽周治来谢欢张辉南方医科大学第二临床医学院广东省第二人民医院脊柱骨科广州暨南大学第一临床学院

目的探究体外脂肪间充质干细胞(ADSCs)对神经元的保护作用及机制。方法培养并鉴定原代ADSCs,并建立谷氨酸诱导的HT22神经元细胞系损伤模型。细胞免疫荧光检测损伤模型中HT22细胞分支数目及分支长度的变化。构建ADSCs与HT22共培养,检测... 详细信息

目的探究体外脂肪间充质干细胞(ADSCs)对神经元的保护作用及机制。方法培养并鉴定原代ADSCs,并建立谷氨酸诱导的HT22神经元细胞系损伤模型。细胞免疫荧光检测损伤模型中HT22细胞分支数目及分支长度的变化。构建ADSCs与HT22共培养,检测ADSCs对HT22细胞凋亡的调节作用。采用ELISA研究ADSCs对HT22损伤细胞中炎症因子(TNF-α、IL-1β、IL-6、IL-10)的影响。通过Western blot检测PI3K/Akt及NF-κB的磷酸化变化,探讨ADSC对损伤HT22的机制。结果细胞免疫荧光验证酶解法培养的ADSCs高表达CD44。相较于对照组,细胞毒性试验表明随着谷氨酸增高,HT22细胞存活率下降,且20mM为半数抑制浓度,该浓度下HT22支数目及分支长度显著减少。相较于谷氨酸组,ADSCs共培养有效降低了谷氨酸诱导的HT22细胞系突起的分细胞凋亡,减少了Cleaved caspase3的表达。ELISA结果显示ADSCs共培养显著降低损伤HT22细胞中促炎因子的表达,同时提高抗炎因子IL-10的水平。ADSCs通过促进PI3K/Akt的磷酸化和抑制NF-κB的磷酸化,调节神经元存活及炎症反应。结论 ADSCs具有显著的神经保护作用,通过调节关键信号途径促进受损神经元的存活和功能恢复。这为脊髓损伤的治疗提供了新的研究方向和希望。

关键词：脊髓损伤脂肪间充质干细胞 HT22 谷氨酸

Effects of Strain Rate and Plastic Work on Martensitic Transformation Kinetics of Austenitic Stainless Steel 304

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Journal of Iron and Steel Research International 2015年第10期22卷 931-936页

作者： Fang PENG Xiang-huai DONG Kai LIU huan-yang xie School of Materials Science and Engineering Shanghai Jiao Tong University

The martensitic transformation behavior and mechanical properties of austenitic stainless steel 304 were studied by both experiments and numerical simulation. Room temperature tensile tests were carried out at various strain rates to investigate the effect on volume fraction of martensite, temperature increase and flow stress. The results show that with increasing strain rate, the local temperature increases, which suppresses the transformation of martensite. To take into account the dependence on strain level, strain rate sensitivity and thermal effects, a kinetic model of martensitic transformation was proposed and constitutive modeling on stress-strain response was conducted. The validity of the proposed model has been proved by comparisons between simulation results and experimental ones.

关键词： stainless steel 304 martensitic transformation kinetics constitutive model strain rate sensitivity

Achieving highly selective electrochemical CO_(2) reduction to C_(2)H_(4) on Cu nanosheets

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Journal of Energy Chemistry 2023年第4期79卷 312-320页

作者： huan xie Ruikuan xie Zhiyuan Zhang Yongyu Pang Yuting Luo Jiong Li Bilu Liu Maria-Magdalena Titirici Guoliang Chai State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037JiangsuChina Shenzhen Geim Graphene Center(SGC) Tsinghua-Berkeley Shenzhen Institute(TBSI)and Tsinghua Shenzhen International Graduate School(TSIGS)Tsinghua UniversityShenzhen 518055GuangdongChina School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Department of Chemical Engineering Imperial College LondonSW72AZUK

The conversion of CO_(2)into value-added chemicals coupled with the storage of intermittent renewable electricity is *** nanosheets with an average size and thickness of~30 and~20 nm have been developed,which are in situ reduced into Cu nanosheets during electrochemical CO_(2)reduction reaction(ECO_(2)RR).The derived Cu nanosheets demonstrate much higher selectivity for C2H4production than commercial CuO derived Cu powder,with an optimum Faradaic efficiency of 56.2%and a partial current density of C_(2)H_(4)as large as 171.0 mA cm^(-2)in a gas diffusion flow *** operando attenuated total reflectance-Fourier transform infrared spectra measurements and density functional theory simulations illustrate that the high activity and selectivity of Cu nanosheets originate from the edge sites on Cu nanosheets with a coordinate number around 5(4–6),which facilitates the formation of^(*)CHO rather than^(*)COH intermediate,meanwhile boosting the C-C coupling reaction of^(*)CO and^(*)CHO intermediates,which are the critical steps for C_(2)H_(4)formation.

关键词： Electrochemical CO_(2)reduction Cu nanosheets C_(2)H_(4) High selectivity Coordination number

Denoising for satellite laser altimetry full-waveform data based on EMD-Hurst analysis

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International Journal of Digital Earth 2020年第11期13卷 1212-1229页

作者： Zhijie Zhang huan xie Xiaohua Tong Hanwei Zhang Yang Liu Binbin Li School of Surveying and Land Information Engineering Henan Polytechnic UniversityJiaozuoPeople’s Republic of China College of Surveying and Geo-Informatics and State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghaiPeople’s Republic of China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghaiPeople’s Republic of China College of Marine Science Shanghai Ocean UniversityShanghaiPeople’s Republic of China

Full-waveform decomposition is crucial for obtaining accurate satelliteground distance,the accuracy of which is severely affected by ***,the traditional filters all depend on filtering *** paper presents a new and adaptive method for denoising based on empirical mode decomposition(EMD)and Hurst analysis(EMD-Hurst).The noisy full-waveforms are first decomposed into their intrinsic mode functions(IMFs),and the Hurst exponent of each IMF is established by the detrended fluctuation *** IMF is regarded as the highfrequency noise and is deleted if its Hurst exponent is≤*** simulated and real full-waveforms were conducted to validate and evaluate the method by comparing with six other IMF selection methods via metrics like waveform decomposition consistency ratio(CR),average error of decomposition parameters,and ICESat/GLAS waveformparameter product *** comparisons show that:(1)under different SNR conditions,EMD-Hurst performs robustly and obtains a higher CR than other EMD based methods;(2)obtains the highest average CR and a relatively lower average error for the echo parameters;and(3)peak numbers and fitting accuracy for GLAH01 are more reasonable and precise than those of GLAH05,which could offer a good reference for the processing on future space-borne full-waveform data.

关键词： EMD-Hurst satellite laser altimetry full-waveform denoising IMF selection

Damage evolution and fragmentation behavior of pyramid cut blasting under uniaxial compression

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Journal of Mountain Science 2022年第5期19卷 1475-1486页

作者： CHEN Si-yu YANG Li-yun YANG Ai-yun huanG Chen xie huan-zhen School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China Oulu Mining School University of OuluOulu 90014Finland

Pyramid cut blasting is an essential form of inclined hole cut blasting,but the in-situ stress effect of pyramid cut blasting is rarely *** on the research background of pyramid cut blasting in a deep rock mass,the size,volume,and fragment size distribution of the blasting cavity before and after uniaxial compression were analysed by a model ***,the damage and effective stress of the pyramid cut blasting were analysed with LS-DYNA numerical *** results show that the damage and fragmentation of pyramid cut blasting are not only affected by blasting stress wave and blasting gas,but also affected by uniaxial *** the influence of uniaxial compression,the blasting stress wave and blasting gas are more likely to damage the rock mass parallel to the uniaxial compression direction near the connecting line of blasting hole,and make the volume of cavity larger and the fragment rate ***,uniaxial compression has a prominent influence during the middle and late stages of blasting.

关键词： Model test Pyramid cut blasting Blasting cavity sizes Uniaxial compression Fragment size

Robust template feature matching method using motion-constrained DCF designed for visual navigation in asteroid landing

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Astrodynamics 2023年第1期7卷 83-99页

作者： Yaqiong Wang Xiongfeng Yan Zhen Ye huan xie Shijie Liu Xiong Xu Xiaohua Tong College of Surveying and Geo-Informatics and Shanghai Key Laboratory of Space Mapping and Remote Sensing for Planetary EaplorationTongji UniversityShanghai 200092China Shanghai Institute of Intelligent Science and Technology Shanghai 200092China

A robust and eficient feature matching method is necessary for visual navigation in asteroid-landing *** on the visual navigation framework and motion characteristics of asteroids,a robust and efficient template feature matching method is proposed to adapt to feature distortion and scale change cases for visual navigation of *** proposed method is primarily based on a motion-constrained discriminative correlation filter(DCF).The prior information provided by the motion constraints between sequence images is used to provide a predicted search region for template feature ***,some specific template feature samples are generated using the motion constraints for correlation filter learning,which is beneficial for training a scale and feature distortion adaptive correlation filter for accurate feature ***,average peak-to-correlation energy(APCE)and jointly consistent measurements(JCMs)were used to eliminate false *** captured by the Touch And Go Camera System(TAGCAMS)of the Bennu asteroid were used to evaluate the performance of the proposed *** particular,both the robustness and accuracy of region matching and template center matching are *** qualitative and quantitative results illustrate the advancement of the proposed method in adapting to feature distortions and large-scale changes during spacecraft landing.

关键词： discriminative correlation filter(DCF) motion constraints feature distortion adaptive scale changes adaptive template feature matching