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多西他赛白蛋白纳米粒的制备及处方工艺优化

中国药剂学杂志（网络版） 2024年第2期22卷 40-50页

作者：陈东健肖健阳罗美岭田柳乔明曦张晓君沈阳药科大学药学院辽宁沈阳110016 石药集团中奇制药技术(石家庄)有限公司河北石家庄050011 北京抗创联生物制药技术研究有限公司北京102600

目的优化多西他赛白蛋白纳米粒(DTX-HSANps)的处方和制备工艺,并对其进行初步的质量评价。方法采用NabTM技术制备DTX-HSANps,通过Plackett-Burman实验设计,对DTX在油相中的浓度、人血白蛋白(Humanserumalbumin,HSA)在水相中的浓度、水... 详细信息

目的优化多西他赛白蛋白纳米粒(DTX-HSANps)的处方和制备工艺,并对其进行初步的质量评价。方法采用NabTM技术制备DTX-HSANps,通过Plackett-Burman实验设计,对DTX在油相中的浓度、人血白蛋白(Humanserumalbumin,HSA)在水相中的浓度、水相溶液的pH、油水相体积比、乳化器的转速和均质压力共6个因素进行考察,以粒径、稳定性及过药量作为指标,筛选影响产品质量的关键因素。采用Box-Behnken效应面法筛选最优的处方工艺,对样品的粒径、包封率、载药量、微观形态进行表征。结果确定HSA在水相中的浓度、水相溶液的pH和均质压力为影响产品质量的关键因素。根据最佳处方工艺制备三批样品,冻干复溶后,DTX-HSA Nps的粒径为(107.3±1.3)nm,PDI为(0.123±0.012),载药量为(3.9±0.2)%,包封率为(92.0±0.6)%。结论所制备的DTX-HSANps粒径分布均匀,理化性质稳定,具有较高的产品开发价值以及较好的临床应用潜力。

关键词：药剂学白蛋白纳米粒 NabTM 多西他赛 Plackett-Burman Box-Behnken

Cobalt disulfide/carbon nanofibers with mesoporous heterostructure and excellent hydrophilicity for high energy density asymmetric supercapacitor

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Nano Research 2023年第7期16卷 10401-10411页

作者： Wenjie Liu Fen qiao Jing Yang Jiaren Yuan Yi Xie Tao Wang Jinzhi Hu Jihua Zheng Rui Ren Xiaomin Kang Yan Zhao Jiangwei zhang School of Energy&Power Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China School of Physics and Materials Science Nanchang UniversityNanchang 330031China State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Key Laboratory of Power Station Energy Transfer Conversion and System Ministry of EducationNorth China Electric Power UniversityBeijing 102206China

Herein,a unique mesoporous heterostructure(average pore size:15 nm)cobalt disulfide/carbon nanofibers(CoS_(2)/PCNFs)composite with excellent hydrophilicity(contact angle:23.5°)is prepared using polyethylene glycol(PEG)as a pore-forming *** CoS_(2)/PCNF electrode exhibits excellent cycle stability(95.2%of initial specific capacitance at 10 A·g^(-1)after 8000 cycles),good rate performance(46.5%at 10 A·g^(-1)),and high specific capacity(86.1 mAh·g^(-1)at 1 A·g^(-1),about 688.8 F·g^(-1)at 1 A·g^(-1)).Density functional theory(DFT)simulation elucidates that CoS_(2)tends to transfer substantial charges to *** the center of positive charge,CoS_(2)is more likely to capture negative ions in the electrolyte,thus accelerating the ion diffusion *** excellent properties of the electrode material can not only accelerate the electrochemical reaction kinetics,but also provide abundant redox-active sites and a high Faradaic capacity for the entire electrode due to the synergistic contributions of CoS_(2)nanoparticles,mesoporous heterostructure of PCNF,and admirable hydrophilicity of the composite material.A CoS_(2)/PCNF-0.25//AC(AC:activated carbon)asymmetric supercapacitor is assembled using CoS_(2)/PCNF-0.25 as the positive electrode and AC as the negative electrode,which possesses a high energy density(35.5 Wh·kg^(-1)at a power density of 824 W·kg^(-1))and superior cycling stability(maintaining over 98%of initial capacitance after 2000 cycles).In addition,the unique CoS_(2)/PCNF electrode is expected to be widely used in other electrochemical energy storage devices,such as lithium-ion batteries,sodium-ion batteries,lithium-sulfur batteries,etc.

关键词： supercapacitor cobalt disulfide carbon nanofibers porosity electrostatic spinning density functional theory(DFT)simulation

Characterization of wavy root 1,an agravitropism allele,reveals the functions of OsPIN2 in fine regulation of auxin transport and distribution and in ABA biosynthesis and response in rice(Oryza sativa L.)

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The Crop Journal 2022年第4期10卷 980-992页

作者： Wenqiang Li Minjuan zhang Lei qiao Yunbo Chen Dapeng zhang Xiuqing Jing Pengfei Gan Yangbin huang Junru Gao Wenting Liu Chunhai Shi Hongchang Cui Haifeng Li Kunming Chen State Key Laboratory of Crop Stress Biology in Arid Areas College of Life SciencesNorthwest A&F UniversityYangling 712100ShaanxiChina The Sericultural and Silk Research Institute College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100ShaanxiChina College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina Department of Agronomy College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058ZhejiangChina Department of Biological Science Florida State UniversityTallahasseeFL 32306USA Coconut Research Institute of Chinese Academy of Tropical Agricultural Sciences Wenchang 571339HainanChina

Root system architecture is influenced by *** the root senses gravity and directs its orientation,so-called gravitropism,is not only a fundamental question in plant biology but also theoretically important for genetic improvement of crop root ***,the mechanism has not been elucidated in most *** characterized a rice agravitropism allele,wavy root 1(war1),a loss-of-function allele in OsPIN2,which encodes an auxin efflux *** loss of OsPIN2 function,war1 leads to altered root system architecture including wavy root,larger root distribution angle,and shallower root system due to the loss of gravitropic perception in root *** the war1 mutant,polar auxin transport was disrupted in the root tip,leading to abnormal auxin levels and disturbed auxin transport and distribution in columella *** sedimentation,an important process in gravitropic sensing,was also decreased in root tip columella *** results indicated that OsPIN2 controls gravitropism by finely regulating auxin transport,distribution and levels,and amyloplast sedimentation in root *** identified a novel role of OsPIN2 in regulating ABA biosynthesis and response *** of OsPIN2 function in the war1 resulted in increased sensitivity to ABA in seed germination,increased ABA level,changes in ABA-associated genes in roots,and decreased drought tolerance in the *** results suggest that the auxin transporter OsPIN2 not only modulates auxin transport to control root gravitropism,but also functions in ABA signaling to affect seed germination and root development,probably by mediating crosstalk between auxin and ABA pathways.

关键词： Auxin transporter Root development Wavy root Gravitropism Abscisic acid(ABA) Drought tolerance

Formation process of extension knee joint contracture following external immobilization in rats

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世界骨科杂志:英文版 2023年第9期14卷 669-681页

作者： Chen-Xu Zhou Feng Wang Yun Zhou qiao-Zhou Fang Quan-Bing zhang Department of Rehabilitation Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina The Second Clinical Medicine College Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Current research lacks a model of knee extension contracture in *** To elucidate the formation process of knee extension *** We developed a rat model using an aluminum external *** male Sprague-Dawley rats with mature bones were divided into the control group(n=6)and groups that had the left knee immobilized with an aluminum external fixator for 1,2,and 3 d,and 1,2,3,4,6,and 8 wk(n=6 in each group).The passive extension range of motion,histology,and expression of fibrosis-related proteins were compared between the control group and the immobilization *** Myogenic contracture progressed very quickly during the initial 2 wk of *** 2 wk,the contracture gradually changed from myogenic to *** arthrogenic contracture progressed slowly during the 1^(st) week,rapidly progressed until the 3^(rd) week,and then showed a steady progression until the 4^(rd) *** analyses confirmed that the anterior joint capsule of the extended fixed knee became increasingly thicker over ***,the level of transforming growth factor beta 1(TGF-β1)and phosphorylated mothers against decapentaplegic homolog 2(p-Smad2)in the anterior joint capsule also increased with the immobilization *** time,the cross-sectional area of muscle fibers gradually decreased,while the amount of intermuscular collagen and TGF-β1,p-Smad2,and p-Smad3 was ***,the amount of intermuscular collagen and TGF-β1,p-Smad2,and p-Smad3 was decreased during the late stage of immobilization(6-8 wk).The myogenic contracture was stabilized after 2 wk of immobilization,whereas the arthrogenic contracture was stabilized after 3 wk of immobilization and completely stable in 4 *** This rat model may be a useful tool to study the etiology of joint contracture and establish therapeutic approaches.

关键词： Knee joint Immobilization Contracture External fixator Rats

Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury

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Bioactive Materials 2023年第5期23卷 369-382页

作者： Dongjian Han Fuhang Wang Zhentao qiao Bo Wang Yi zhang Qingjiao Jiang Miaomiao Liu Yuansong Zhuang Quanxu An Yan Bai Jiahong Shangguan Jinying zhang Gaofeng Liang Deliang Shen Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Key Laboratory of Cardiac Injury and Repair of Henan Province ZhengzhouChina Department of Vascular and Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China School of Basic Medical Sciences Henan University of Science and TechnologyLuoyang471023HenanChina

Acute myocardial infarction(AMI)induces a sterile inflammatory response,leading to cardiomyocyte damage and adverse cardiac ***-5(IL-5)plays an essential role in developing eosinophils(EOS),which are beneficial for the resolution of ***,the proangiogenic properties of IL-5 also contribute to tissue healing following ***,targeted delivery of IL-5 is an innovative therapeutic approach for treating *** has been shown that conventional IL-5 delivery can result in undesirable adverse effects and potential drug *** this study,we successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging the IL-5 nanoparticle in a neutrophilic *** administration of neutrophil membrane-camouflaged nanoparticles(NM-NPIL-5)in the in vivo model showed that these nanoparticles promoted EOS accumulation and angiogenesis in the infarcted myocardium,thereby limiting adverse cardiac remodeling after *** results also demonstrated that the NM-NPIL-5 could serve as neutrophil“decoys”to adsorb and neutralize the elevated neutrophil-related cytokines in the injured heart by inheriting multiple receptors from their“parent”***,the targeted delivery of NM-NPIL-5 protected the cardiomyocytes from excessive inflammatory-induced apoptosis and maintained cardiac *** findings provided a promising cardiac detoxification agent for acute cardiac injury.

关键词： Biomimetic nanoparticles Interleukin-5 Eosinophils Angiogenesis Myocardial infarction

Friction Stir Processing of Magnesium Alloys:A Review

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 43-57页

作者： Wen Wang Peng Han Pai Peng Ting zhang Qiang Liu Sheng-Nan Yuan Li-Ying huang Hai-Liang Yu Ke qiao Kuai-She Wang School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China National and Local Joint Engineering Research Center for Functional Materials Processing Xi’an 710055China Experimental Teaching Demonstration Center for Materials Processing Xi’an University of Architecture and TechnologyXi’an 710055China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China

Magnesium(Mg)alloys have been extensively used in various fields,such as aerospace,automobile,electronics,and biomedical industries,due to their high specific strength and stiff ness,excellent vibration absorption,electromagnetic shielding eff ect,good machinability,and *** stir processing(FSP)is a severe plastic deformation technique,based on the principle of friction stir *** addition to introducing the basic principle and advantages of FSP,this paper reviews the studies of FSP in the modification of the cast structure,superplastic deformation behavior,preparation of finegrained Mg alloys and Mg-based surface composites,and additive *** not only refines,homogenizes,and densifies the microstructure,but also eliminates the cast microstructure defects,breaks up the brittle and network-like phases,and prepares fine-grained,ultrafine-,and nano-grained Mg ***,FSP significantly improves the comprehensive mechanical properties of the alloys and achieves low-temperature and/or high strain rate ***,FSP can produce particle-and fiber-reinforced Mg-based surface *** a promising additive manufacturing technique of light metals,FSP enables the additive manufacturing of Mg ***,we prospect the future research direction and application with friction stir processed Mg alloys.

关键词： Friction stir processing Magnesium alloy Superplasticity Grain refinement Mg-based surface composites Additive manufacturing

The role of a drug-loaded poly(lactic co-glycolic acid)(PLGA) copolymer stent in the treatment of ovarian cancer

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Cancer Biology & Medicine 2020年第1期17卷 237-250页

作者： Yanqing Wang Xiaoyin qiao Xiao Yang Mengqin Yuan Shu Xian Li zhang Dongyong Yang Shiyi Liu Fangfang Dai Zhikai Tan Yanxiang Cheng Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China College of Biology Hunan UniversityChangsha 410082China Department of Obstetrics and Gynecology Renmin Hospital of Peking UniversityBeijing 100044China Department of Obstetrics and Gynecology Taihe HospitalHubei University of MedicineShiyan 442000China

Objectives:Cisplatin(CDDP)is a widely used and effective basic chemotherapeutic drug for the treatment of a variety of tumors,including ovarian ***,adverse side effects and acquired drug resistance are observed in the clinical application of *** a mode of administration that can alleviate side effects and reduce drug resistance has become a promising strategy to solve this ***:In this study,3 D printing technology was used to prepare a CDDP-poly(lactic-co-glycolic acid)(CDDP-PLGA)polymer compound stent,and its physicochemical properties and cytotoxicity were evaluated both in vitro and in ***:The CDDP-PLGA stent had a significant effect on cell proliferation and apoptosis and clearly decreased the size of subcutaneous tumors in nude mice,whereas the systemic side effects were mild compared with those of intraperitoneal CDDP *** with the control group,CDDP-PLGA significantly increased the mRNA and protein levels of p-glycoprotein(P<0.01;P<0.01)and decreased vascular endothelial growth factor mRNA(P<0.05)and protein levels(P<0.01),however,CDDP-PLGA significantly decreased the mR NA and protein levels of p-glycoprotein(P<0.01;P<0.01)and vascular endothelial growth factor(P<0.01;P<0.01),which are associated with chemoresistance,in subcutaneous tumor *** assay results revealed that,in the CDDP-PLGA group,the staining of the proliferation-related genes Ki67 and PCNA were lightly,and the apoptosis-related gene caspase-3 stained ***:PLGA biomaterials loaded with CDDP,as compared with the same amount of free CDDP,showed good efficacy in terms of cytotoxicity,as evidenced by changes in *** local CDDP release can decrease the systemic side effects of this drug and the occurrence of drug resistance and angiogenesis,and improve the therapeutic *** new approach may be an effective strategy for the local treatment of epithelial ovarian cancer.

关键词： 3D printing drug-loaded stent local treatment cisplatin ovarian cancer

线性逆问题中惩罚优化方法信号重建误差界研究

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电子与信息学报 2019年第12期41卷 2939-2944页

作者：张欢雷宏中国科学院电子学研究所北京100190 中国科学院大学北京100049

惩罚优化问题常常用于在有噪声的条件下用较少的观测个数来求解线性逆问题。目前,对惩罚优化问题恢复误差的研究主要存在以下两点不足:一是对权重参数往往有要求;二是噪声的方向对误差的影响未知。针对这两个问题,该文研究了当存在有界... 详细信息

惩罚优化问题常常用于在有噪声的条件下用较少的观测个数来求解线性逆问题。目前,对惩罚优化问题恢复误差的研究主要存在以下两点不足:一是对权重参数往往有要求;二是噪声的方向对误差的影响未知。针对这两个问题,该文研究了当存在有界噪声时,惩罚优化问题恢复的误差界。首先,该文从问题的几何出发,给定了一个几何条件。当这一条件满足时,就能够推导出惩罚优化问题恢复的一个明确的误差界。这个误差界保证了恢复的解是稳定的,也就是说,恢复误差不会超过观测误差的常数倍。同时,这一误差界对于任意的正权重参数都成立,并且揭示了恢复误差以及最优的权重选择与观测噪声的方向之间的联系。进一步地,当观测矩阵是一个高斯矩阵时,依据这一几何条件可以得到高概率稳定恢复所需的观测次数。仿真实验证明了理论结果的正确性。

关键词：线性逆问题压缩感知稳定恢复惩罚优化问题权重选择

论意图主义反私有语言谬误的阐释效力——以列文森、卡罗尔和戴维森三种进路为例

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文艺理论研究 2018年第5期38卷 58-68页

作者：张巧广东外语外贸大学外国文学文化研究中心

反意图主义认为任何对意图概念的承诺都会陷入私有语言谬误,如果意图主义要继续享有阐释效力,则必须提供能够摆脱私有语言谬误的可替代性的意图概念。当前分析美学中列文森、卡罗尔和戴维森的三种意图主义进路均有其反私有语言谬误的阐... 详细信息

反意图主义认为任何对意图概念的承诺都会陷入私有语言谬误,如果意图主义要继续享有阐释效力,则必须提供能够摆脱私有语言谬误的可替代性的意图概念。当前分析美学中列文森、卡罗尔和戴维森的三种意图主义进路均有其反私有语言谬误的阐释效力。前两种版本的意图主义仍然对反意图主义做出了让步,因为他们和反意图主义共享了这样的观点:语言约定才是阐释语言交流的决定因素,意图概念只是衍生性的;而戴维森将意图置入诠释学视域下,认为语言交流的本质是诠释者对说话者意图的识别,语言约定并非语言交流的必要条件。戴维森的意图论彻底地摆脱了语言约定的担保,将意图作为考察文本诠释的关键因素,比起前两者,它能在与反意图主义的争论中显示出更强的阐释力。

关键词：意图主义复兴私有语言谬误阐释效力列文森卡罗尔戴维森