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Deep learning quantified mucus-tumor ratio predicting survival of patients with colorectal cancer using whole-slide images

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Precision Clinical Medicine 2021年第1期4卷 17-24页

作者： Ke Zhao lin Wu Yanqi huang Su Yao Zeyan Xu huan lin Huihui Wang Yanting Liang Yao Xu Xin Chen Minning Zhao Jiaming Peng Yuli huang Changhong Liang Zhenhui Li Yong Li Zaiyi Liu Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510006China Department of Pathology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Department of Pathology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Shantou University Medical College Shantou 515041China School of Bioengineering Chongqing UniversityChongqing 400044China Department of Radiology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China School of Life Science and Technology Xidian UniversityXi’an 710071China Department of Radiology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Background:In colorectal cancer(CRC),mucinous adenocarcinoma differs from other adenocarcinomas in gene-phenotype,morphology,and ***,mucinous components are present in a large number of adenocarcinomas,and the prognostic value of mucus proportion has not been *** intelligence provides a way to quantify mucus proportion on whole-slide images(WSIs)*** aimed to quantify mucus proportion by deep learning and further investigate its prognostic value in two CRC patient ***:Deep learning was used to segment WSIs stained with hematoxylin and ***-tumor ratio(MTR)was defined as the proportion of mucinous component in the tumor area.A training cohort(N=419)and a validation cohort(N=315)were used to evaluate the prognostic value of *** analysis was performed using the Cox proportional hazard ***:Patients were stratified tomucus-low andmucus-high groups,with 24.1%as the *** the training cohort,patients with mucus-high had unfavorable outcomes(hazard ratio for high *** 1.88,95%confidence interval 1.18–2.99,P=0.008),with 5-year overall survival rates of 54.8%and 73.7%in mucus-high and mucus-lowgroups,*** resultswere confirmed in the validation cohort(2.09,1.21–3.60,0.008;62.8%vs.79.8%).The prognostic value of MTR was maintained in multivariate analysis for both ***:The deep learning quantified MTR was an independent prognostic factor in *** the advantages of advanced efficiency and high consistency,our method is suitable for clinical application and promotes precision medicine development.

关键词： deep learning whole-slide images mucus-tumor ratio colorectal cancer digital pathology

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Major risk-stratification models fail to predict outcomes in patients with multivessel coronary artery disease undergoing simultaneous hybrid procedure

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Chinese Medical Journal 2013年第3期126卷 450-456页

作者： WANG Hao-ran ZHENG Zhe XIONG Hui XU Bo LI Li-huan GAO Run-lin HU Sheng-shou Research Center for Cardiac Regenerative Medicine of the Ministry of Health Cardiovascular Institute & Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background The hybrid procedure for coronary heart disease combines minimally invasive coronary artery bypass grafting （CABG） and percutaneous coronary intervention （PCI） and is an alternative to revascularization treatment. We sought to assess the predictive value of four risk-stratification models for risk assessment of major adverse cardiac and cerebrovascular events （MACCE） in patients with multivessel disease undergoing hybrid coronary revascularization. Methods The data of 120 patients were retrospectively collected and the SYNTAX score, EuroSCORE, SinoSCORE and the Global Risk Classification （GRC） calculated for each patient. The outcomes of interest were 2.7-year incidences of MACCE, including death, myocardial infarction, stroke, and any-vessel revascularization. Results During a mean of 2.7-year follow-up, actuarial survival was 99.17%, and no myocardial infarctions occurred. The discriminatory power （area under curve （AUC）） of the SYNTAX score, EuroSCORE, SinoSCORE and GRC for 2.7-year MACCE was 0.60 （95% confidence interval 0.42-0.77）, 0.65 （0.47-0.82）, 0.57 （0.39-0.75） and 0.65 （0.46-0.83）, respectively. The calibration characteristics of the SYNTAX score, EuroSCORE, SinoSCORE and GRC were 3.92 （P=0.86）, 5.39 （P=0.37）, 13.81 （P=0.32） and 0.02 （P=0.89）, respectively. Conclusions In patients with multivessel disease undergoing a hybrid procedure, the SYNTAX score, EuroSCORE, SinoSCORE and GRC were inaccurate in predicting MACCE. Modifying risk-stratification models to improve the predictive value for a hybrid procedure is needed.

关键词： hybrid coronary revascularization risk stratification model multivessel coronary artery disease

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Image enhancement of color fundus photographs for age-related macular degeneration:the Shanghai Changfeng Study

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 268-275页

作者： Jing-Jing Shen Rui Wang Li-Long Wang Chuan-Feng Lyu Shuo Liu Guo-Tong Xie Hai-Luan Zeng ling-Yan Chen Min-Qian Shen Xin Gao huan-Dong lin Yuan-Zhi Yuan Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200032China Center for Evidence-based Medicine Fudan UniversityShanghai 200032China Pingan Technology(Shenzhen)Co. Ltd.Shenzhen 518029Guangdong ProvinceChina Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghai 200032China Fudan Institute for Metabolic Diseases Shanghai 200032China

AIM:To develop and evaluate a new fundus image optimization software based on red,green,blue channels(RGB) for the evaluation of age-related macular degeneration(AMD) in the Chinese ***:Fundus images that were diagnosed as AMD from the Shanghai Changfeng Study database were analyzed to develop a standardized optimization *** brightness,contrast,and color balance were *** between central lesion area and normal retinal area under different image brightness,contrast,and color balance were *** optimal optimization parameters were determined based on the visual system to avoid image distortion.A paired-sample diagnostic test was used to evaluate the enhancement *** optical coherence tomography(OCT) was used as the gold *** performances were compared between original images and optimized images using Mc Nemar’s ***:A fundus image optimization procedure was developed using 86 fundus images of 74 subjects diagnosed with *** observing gray-scale images,choroid can be best displayed in red channel and retina in green channel was *** was limited information in blue *** 104 participants were included in the paired sample diagnostic test to assess the performance of the optimization *** the image enhancement,sensitivity increased from 74% to 88%(P=0.008),specificity decreased slightly from 88% to 84%(P=0.500),and Youden index increased by ***:The standardized image optimization software increases diagnostic sensitivity and may help ophthalmologists in AMD diagnosis and screening.

关键词： age-related macular degeneration image enhancement image optimization retina

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Study of circumferential resection margin in patients with middle and lower rectal carcinoma

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World Journal of Gastroenterology 2007年第24期13卷 3380-3383页

作者： Ze-Yu Wu Jin Wan Jing-Hua Li Gang Zhao lin Peng Yuan Yao Jia-lin Du Quan-Fang Liu Zhi-Du Wang Zhi-Ming huang Hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Zhong Shan Medical-College Sun Yat-sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM: To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma. The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carcinoma was also evaluated. METHODS: Cancer specimens from 56 patients with middle and lower rectal carcinoma who received total mesorectal excision at the Department of General Surgery of Guangdong Provincial People's Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. RESULTS: Local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma. Distant recurrence occurred in 25% (14 of 56 cases) of patients with middle and lower rectal carcinoma. Twelve patients (21.4%) had positive circumferential resection margin. Local recurrence rate of patients with positive circumferential resection margin was 33.3% (4/12), whereas it was 6.8% (3/44) in those with negative circumferential resection margin (P = 0.014). Distant recurrence was observed in 50% (6/12) of patients with positive circumferential resection margin; conversely, it was 18.2% (8/44) in those with negative circumferential resection margin (P = 0.024). Kaplan-Meier survival analysis showed significant improvements in median survival (32.2 ± 4.1 mo, 95% CI: 24.1-40.4mo vs 23.0 ± 3.5 mo, 95% CI: 16.2-29.8 mo) for circumferential resection margin-negative patients over circumferential resection margin-positive patients (log-rank, P < 0.05). 37% T3 tumors examined were positive for circumferential resection margin, while only 0% T1 tumors and 8.7% T2 tumors were examined as circumferential resection margin. The difference between these three groups was statistically significant (P = 0.021). In 18 cancer specimens with tumor diameter ≥ 5 cm 7 (38.9%) were detected as positive c

关键词： Middle and lower rectal carcinoma Circumferential resection margin Prognosis

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Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

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World Journal of Gastroenterology 2007年第45期13卷 6048-6052页

作者： Ze-Yu Wu Jin Wan Jing-Hua Li Gang Zhao Yuan Yao Jia-lin Du Quan-Fang Liu lin Peng Zhi-Du Wang Zhi-Ming huang Hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Department of Clinical Laboratory The First Affiliated Hospital Huangpu Division Sun Yat-Sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To evaluate the risk factors for lateral lymph node metastasis in patients with advanced low rectal cancer, in order to make the effective selection of patients who could benefit from lateral lymph node dissection, as well as the relationship of lateral lymph node metastasis with local recurrence and survival of patients with advanced low rectal cancer. METHODS： A total of 96 consecutive patients who underwent curative surgery with lateral pelvic lymphadenectomy for advanced lower rectal cancer were retrospectively analyzed. The relation of lateral lymph node metastasis with clinicopathologic characteristics, local recurrence and survival of patients was identified. RESULTS： Lateral lymph node metastasis was observed in 14.6% （14/96） of patients with advanced low rectal cancer. Lateral lymph node metastasis was detected in 10 （25.0%） of 40 patients with tumor diameter ≥ 5 cm and in 4 （7.1%） of 56 patients with tumor diameter 〈 5 cm. The difference between the significant （X^2 = 5.973, P = two groups was statistically 0.015）. Lateral lymph node metastasis was more frequent in patients with 4/4 diameter of tumor infiltration （7 of 10 cases, 70.0%）, compared with patients with 3/4, 2/4 and 1/4 diameter of tumor infiltration （3 of 25 cases, 12.0%; 3 of 45 cases, 6.7%; 1 of 16 cases, 6.3%）（X^2 = 27.944, P = 0.0001）. The lateral lymph node metastasis rate was 30.0% （9 of 30 cases）, 9.1% （4 of 44 cases） and 4.5% （1 of 22cases） for poorly, moderately and well-differentiated carcinoma, respectively. The difference between the three groups was statistically significant （X^2 = 8.569, P = 0.014）. Local recurrence was 18.8% （18 of 96 cases）, 64.3% （9 of 14 cases）, and 11.0% （9 of 82 cases） in patients with advanced low rectal cancer, in those with and without lateral lymph node metastasis, respectively. The difference between the two groups was statistically significant （X^2 = 22.308, P = 0.0001）. Kaplan-Meier survival analysis showed significant improvements in median sur

关键词： Low rectal cancer Lateral lymph nodemetastasis Local recurrence Prognosis

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教育自觉与高校传统文化的传承与发展

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广西民族大学学报（哲学社会科学版） 2017年第3期39卷 193-196页

作者：黄宦霖广西经济管理干部学院

基于对高校大学生学习传统文化的现状和存在问题,提出推进高校传统文化教育长效发展的路径与措施。在反思中创生传统文化在当代中国社会的实践价值,从根本上提升当代大学生对传统文化的教育自觉。认为高校要适应民族复兴对传统文化教育... 详细信息

基于对高校大学生学习传统文化的现状和存在问题,提出推进高校传统文化教育长效发展的路径与措施。在反思中创生传统文化在当代中国社会的实践价值,从根本上提升当代大学生对传统文化的教育自觉。认为高校要适应民族复兴对传统文化教育的新要求,充分发挥传统文化在人才培养和推进文明进程的作用。

关键词：传统文化民族复兴教育自觉

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冠状病毒Spike蛋白及其针对性治疗研究进展

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南京医科大学学报（自然科学版） 2021年第7期41卷 1095-1103页

作者：林欢冯旰珠南京医科大学第二附属医院呼吸与危重症医学科江苏南京210011

冠状病毒(coronavirus,CoV)是可以感染人类及动物的正链RNA病毒,其包含的最大RNA基因组长度为32 kb,可分为4类:α、β、γ和δ。冠状病毒颗粒包含4个标准结构蛋白:包膜蛋白(E)、膜蛋白(M)、核衣壳蛋白(N)和刺突蛋白(S)。S蛋白既包含受... 详细信息

冠状病毒(coronavirus,CoV)是可以感染人类及动物的正链RNA病毒,其包含的最大RNA基因组长度为32 kb,可分为4类:α、β、γ和δ。冠状病毒颗粒包含4个标准结构蛋白:包膜蛋白(E)、膜蛋白(M)、核衣壳蛋白(N)和刺突蛋白(S)。S蛋白既包含受体结合域(receptor-binding domain,RBD),又包含融合相关结构域,使其成为CoV进入过程中的关键蛋白。本文主要阐述S蛋白的主要结构、结构域以及该蛋白在病毒入侵宿主细胞过程中的自身水解切割、构象变化等相关特点,并就该蛋白的相关中和抗体以及CoV尤其是新型冠状病毒(SARS-CoV-2)灭活疫苗、亚单位疫苗RNA疫苗等研究现状进行介绍。

关键词：冠状病毒 Spike蛋白受体结合域膜融合中和抗体

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多级能量异构传感器网络能量有效的路由算法

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计算机应用 2011年第A01期31卷 4-7页

作者：邓亚平蔺换换重庆邮电大学计算机科学与技术学院重庆400065

能量异构在无线传感器网络中普遍存在,由于多级能量异构无线传感器网络节点的初始能量在一定范围内随机分布,为了能有效地利用节点能量的异构性降低网络能耗、延长网络稳定周期,提出一种适用于能量异构环境的多级能量异构传感器网络能... 详细信息

能量异构在无线传感器网络中普遍存在,由于多级能量异构无线传感器网络节点的初始能量在一定范围内随机分布,为了能有效地利用节点能量的异构性降低网络能耗、延长网络稳定周期,提出一种适用于能量异构环境的多级能量异构传感器网络能量有效的路由算法。节点根据其当前剩余能量与网络平均能量的比值决定其成为簇首的概率,通过调整节点的阈值,并基于此决定是否成为簇首,且在簇间采用多跳路由协议。仿真结果表明多级能量异构传感器网络能量有效的路由算法可以有效地均衡网络能量消耗,延长网络稳定周期。

关键词：多级能量路由算法能量有效异构传感器网络

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碳纳米管海绵导热性能的实验研究

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中国材料进展 2021年第9期40卷 722-728页

作者：刘心颖林欢董华青岛理工大学环境与市政工程学院山东青岛266033

为了实现资源可持续性发展,保温材料的使用成为当代社会生产节能的重要手段。基于碳纳米管的三维宏观体——碳纳米管海绵,其立体空心网状塔接结构使得碳纳米管海绵具有良好的保温性能和热稳定性。显然,碳纳米管海绵的导热性能实验研究... 详细信息

为了实现资源可持续性发展,保温材料的使用成为当代社会生产节能的重要手段。基于碳纳米管的三维宏观体——碳纳米管海绵,其立体空心网状塔接结构使得碳纳米管海绵具有良好的保温性能和热稳定性。显然,碳纳米管海绵的导热性能实验研究可以为该新型材料的应用提供相应的数据支持,并且对满足社会生产需求意义重大。通过实验室针对一维材料热扩散系数的表征方法——瞬态电热(TET)测量技术,对碳纳米管海绵材料进行室温下热扩散系数的测量,借助Schuetz多孔介质导热模型得到样品的骨架导热率为45~51 W·m^(-1)·K^(-1),而真实导热率达到了0.15 W·m^(-1)·K^(-1)。最后,从微尺度传热的角度解释了碳纳米管海绵的热运输机理,并通过SEM照片证实了碳纳米管海绵结构缺陷会使得样品表面声子散落和接触电阻增大,从而导致了碳纳米管海绵的低导热性能。

关键词：瞬态电热测量技术热运输碳纳米管海绵保温材料导热率

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Estimation of Parameters of Japanese eel Anguilla japonica in Kao-Ping River by Mark-Recapture method

Estimation of Parameters of Japanese eel Anguilla japonica i...

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中国海洋湖沼动物学会鱼类学分会第七届会员代表大会暨朱元鼎教授诞辰110周年庆学术研讨会

作者： Su-Lean Chang Shih-huan lin Tzyy-Ing Chen Wann-Nian Tzeng Division of Biotechnology Fisheries Research InstitutePingtung 928Taiwan Institute of Fisheries Science College of Life ScienceNTUTaipei10617Taiwan

The Japanese eel(Anguilla japonica)is an economically important aquaculture species in Taiwan,and fish farmers mostly still depend on juvenile eels(elvers)collected in the estuaries. Recently,populations of temperate eels,including the Japanese eel,have declined world-wide,which raises concerns about eel resource management and *** increase elver recruitment, hormone-injected adult eels have been released every year since 1976 by the Taiwan Fishery Research *** to date few studies on the population dynamics of eels in Taiwan have been documented. Thus we attempted to estimate the vital parameters,such as population size,fishing and natural mortality of Japanese eel in the downstream region of the Kao-Ping River in southwest Taiwan by the mark-recapture method.A total of 867 cultured and wild yellow eels were tagged on September 28, 2005,including 561 individuals marked with electronic chips and 306 individuals marked by clipping their pectoral *** recaptures were reported by *** to February 2006,a total of 23 marked eels had been returned among the 866 eels caught in the *** abundance in the recapture area was estimated as 3,380(95% CI:1,670～6,842)eels by the Chapman method,which was much smaller than an estimate made in 2001 in the same area(7,364 eels).This indicates that the eel population in the study area has ***,a recovery plan,including controls of fishing, restocking and habitat restoration,is urgently needed.

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