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国外医药(抗生素分册) 2025年第1期46卷 39-44页

作者：马兴换微山县第三人民医院

依拉环素是一种新型、全合成、广谱和含氟四环素类抗菌药物，用于治疗常见的革兰阴性菌和革兰阳性菌感染在内的多重耐药菌感染。本文主要对依拉环素构效关系、作用机制、抗菌谱、药效/药代动力学和不良反应进行概述，旨在为依拉环素的... 详细信息

依拉环素是一种新型、全合成、广谱和含氟四环素类抗菌药物，用于治疗常见的革兰阴性菌和革兰阳性菌感染在内的多重耐药菌感染。本文主要对依拉环素构效关系、作用机制、抗菌谱、药效/药代动力学和不良反应进行概述，旨在为依拉环素的临床应用提供参考。

关键词：依拉环素四环素耐药性核糖体构效关系药效药代动力学

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裂纹联轴器—碰摩转子系统的振动特性分析

内燃机 2025年第1期41卷 23-30页

作者：邢欢刘子良沈阳理工大学机械工程学院辽宁沈阳110159

对同时具有联轴器裂纹故障和碰摩故障的转子系统的振动特性进行研究。使用Solid Works绘制了系统的三维模型,利用Workbench平台,结合有限元方法对系统的振动响应进行仿真分析,在联轴器中添加椭圆形裂纹,模拟裂纹故障,并分析其对转子振... 详细信息

对同时具有联轴器裂纹故障和碰摩故障的转子系统的振动特性进行研究。使用Solid Works绘制了系统的三维模型,利用Workbench平台,结合有限元方法对系统的振动响应进行仿真分析,在联轴器中添加椭圆形裂纹,模拟裂纹故障,并分析其对转子振动特性的影响。研究发现:当转子系统出现联轴器裂纹故障后,系统振幅增大;频谱图中出现了高倍频成分,其中2×倍频振幅较大;轴心轨迹随着裂纹加重,嵌套现象愈加明显。出现裂纹联轴器-碰摩耦合故障后,时域波形出现削顶现象;轴心轨迹图中内凹和多环嵌套现象逐渐加剧;联轴器存在本文设定尺寸裂纹时,频谱图中的成分变化与仅发生碰摩故障时相差不大;联轴器裂纹扩展到更大的一定尺寸时,频谱图中出现2×至5×倍频,各阶次成分振幅均有增大。

关键词：裂纹联轴器碰摩转子振动特性

黄芪-葛根配伍对T2DM胰岛素抵抗大鼠铁死亡的影响及机制研究

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中国药房 2025年第1期36卷 57-63页

作者：魏爽郝峰章文春赵张旸李冀韩东卫邢欢江西中医药大学中医学院南昌330004 江西中医药大学临床医学院南昌330004 黑龙江中医药大学基础医学院哈尔滨150040

目的探讨黄芪-葛根配伍对2型糖尿病(T2DM)胰岛素抵抗(IR)大鼠肝细胞铁死亡的影响及潜在机制。方法将雄性SD大鼠60只分为对照组(12只)与造模组(48只),造模组大鼠以高脂饲料连续喂养4周后按25 mg/kg的剂量一次性尾静脉注射1%链脲佐菌素溶... 详细信息

目的探讨黄芪-葛根配伍对2型糖尿病(T2DM)胰岛素抵抗(IR)大鼠肝细胞铁死亡的影响及潜在机制。方法将雄性SD大鼠60只分为对照组(12只)与造模组(48只),造模组大鼠以高脂饲料连续喂养4周后按25 mg/kg的剂量一次性尾静脉注射1%链脲佐菌素溶液以复制T2DM IR大鼠模型。将造模成功的大鼠随机分为模型组、黄芪-葛根配伍组[QG组,4.05 g/(kg·d)灌胃]、铁死亡抑制剂ferrostatin-1组(Fer-1组,5 mg/kg隔日1次腹腔注射)、黄芪-葛根配伍+铁死亡诱导剂erastin组[QG+erastin组,4.05 g/(kg·d)灌胃+erastin 10 mg/(kg·d)腹腔注射]。干预4周后,检测各组大鼠血清空腹血糖(FBG)、空腹胰岛素(FINS)水平,并计算稳态模型胰岛素抵抗指数(HOMA-IR)和胰岛素敏感指数的自然对数(IAI);检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)水平,血清Fe^(2+)及Fe水平,肝脏组织中谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平以及烟酰胺腺嘌呤二核苷酸磷酸(NADP+)/还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)和活性氧(ROS)水平;观察其肝脏组织病理形态,检测肝脏组织谷胱甘肽过氧化物酶4(GPX4)、铁蛋白重链1(FTH1)、长链脂酰辅酶A合成酶3(ACSL3)、ACSL4、线粒体铁蛋白(FTMT)、胱氨酸/谷氨酸反向转运蛋白(xCT)的蛋白表达情况。结果与对照组比较,模型组大鼠肝脏组织内肝细胞排列紊乱、肿胀,细胞核染色加深,可见较多炎症细胞浸润,大量肝细胞空泡及脂肪变性;FBG(给药后)、TC、TG、LDL-C、AST、ALT、FINS、MDA、ROS、Fe^(2+)、Fe水平及HOMA-IR,NADP+/NADPH和ACSL4蛋白的表达均显著升高或上调(P<0.01);HDL-C、GSH、SOD水平,IAI及GPX4、FTH1、ACSL3、FTMT、xCT蛋白的表达均显著降低或下调(P<0.01)。与模型组比较,QG组和Fer-1组大鼠肝脏组织病理损伤及上述指标水平均有不同程度改善,且大部分指标的变化差异有统计学意义(P<0.01或P<0.05)。与QG组比较,QG+erastin组大鼠上述指标水平的改善均被显著逆转(P<0.01)。结论黄芪-葛根配伍水煎液可降低T2DM IR大鼠FBG水平,减轻其IR程度和肝脏组织铁负荷,缓解其肝脏组织病理损伤,上述作用与其抑制铁死亡有关。

关键词：黄芪葛根配伍铁死亡 2型糖尿病胰岛素抵抗

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QoS multicast routing scheme using QGA in IP/DWDM networks

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 95-100页

作者： xing huan-lai BAI Lin JI Yue-feng Key Laboratory of Optical Communications and Lightwave Techno ogies Beijing University of Posts and Telecommunications Beijing 100876 China

This article studies multi-constraints least-cost multicast routing problem in internet protocol over dense wavelength division multiplexing （IP/DWDM） networks. To address this problem, an individual-difference-based quantum genetic algorithm （IDQGA） is proposed. This algorithm considers individual differences among chromosomes by introducing an adaptive rotation angle step determination scheme and a grouping-based quantum mutation operation. Simulations are conducted over network topologies. The results indicate that compared with other heuristic algorithms, IDQGA has better optimal performance on solving quality of service （QoS） multicast routing problem in IP/DWDM networks and is characterized by strong robustness, high success ratio and excellent capability on global searching.

关键词： IP-over-DWDM multicast QoS quantum genetic algorithm

The effects of caudal fin deformation on the hydrodynamics of thunniform swimming under self-propulsion

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Journal of Hydrodynamics 2020年第6期32卷 1122-1137页

作者： Yi-kun Feng Yu-min Su huan-xing Liu Yuan-yuan Su College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China Beijing Institute of Specialized Machinery Beijing100081China Science College Harbin Engineering UniversityHarbin150001China

To investigate the effects of the caudal fin deformation on the hydrodynamic performance of the self-propelled thunniform swimming,we perform fluid-body interaction simulations for a tuna-like swimmer with thunniform *** 3-D vortices are visualized to reveal the role of the leading-edge vortex(LEV)in the thrust *** comparing the swimming velocity of the swimmer with different caudal fin flexure amplitudes fa,it is shown that the acceleration in the starting stage of the swimmer increases with the increase of fa,but its cruising velocity *** results indicate that the caudal fin deformation is beneficial to the fast start but not to the fast cruising of the *** the entire swimming process,the undulation amplitudes of the lateral velocity and the yawing angular velocity decrease as fa *** is found that the formation of an attached LEV on the caudal fin is responsible for generating the low-pressure region on the surface of the caudal fin,which contributes to the ***,the caudal fin deformation can delay the LEV shedding from the caudal fin,extending the duration of the low pressure on the caudal fin,which will cause the caudal fin to generate a drag-type force over a time period in one swimming cycle and reduce the cruising speed of the swimmer.

关键词： Computational fluid dynamics(CFD)numerical simulation self-propulsion caudal fin deformation

The ultrasonic harmonic scalpel for circumcision： experimental evaluation using dogs

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Asian Journal of Andrology 2013年第1期15卷 93-96页

作者： Mou Peng Zhe Meng Zhong-Hua Yang xing-huan Wang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China

Male circumcision is one of the most commonly performed operations worldwide, and many novel techniques have been developed for better postoperative outcomes. The purpose of this study was to explore the feasibility of applying the ultracision harmonic scalpel （UHS） for circumcision by using dogs. Sixteen adult male dogs were divided into two groups： the UHS group and the control group. The dogs were circumcised with either the UHS or a conventional scalpel. The UHS circumcision procedure and the effects were imaged 1 week after surgery. The two groups were compared with respect to the operative time and volume of blood loss. Postoperative complications, including oedema, infection, bleeding of the incision and wound dehiscence, were recorded for both groups. The mean operative time for the UHS group was only 5.1 min compared with the 35.5 min of the conventional group. The mean blood loss was less than 2 ml for the UHS group and 15 ml for the conventional group. There was only one case of mild oedema in the UHS group, but the postoperative complications in the conventional group included two cases of mild oedema, one infection of the incision and one Case of bleeding of the incision. In conclusion, circumcision using UHS is a novel technique to treat patients with phimosis and excessive foreskin, and this method has a short operative time, less blood loss and fewer complications than the conventional scalpel method. This small animal study orovides a basis for embarking on a larger-scale clinical trial of the UHS.

关键词： conventional circumcision dog electrocautery technique Plastibell device ultracision harmonic scalpel

Systematic review and meta-analysis on phosphodiesterase 5 inhibitors and α-adrenoceptor antagonists used alone or combined for treatment of LUTS due to BPH

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Asian Journal of Andrology 2015年第6期17卷 1022-1032,I0012页

作者： xing-huan Wang Xiao Wang Ming-Jun Shi Sheng Li Tao Liu Xin-Hua Zhang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China.

The aim of this systematic review is to determine the comparative effectiveness and safety of phosphodiesterase 5 inhibitors （PDE5-1s） and （x-blockers used alone or combined for the treatment of lower urinary tract symptoms （LUTS） due to benign prostatic hyperplasia （BPH）. An electronic search of PubMed, Cochrane Library and Embase up to January 2014 was performed to identify randomized controlled trials comparing the efficacy and safety of PDE5-Is and （x-blockers for treatment of lower urinary tract symptoms due to benign prostatic hyperplasia, which assessed IPSS score, maximum flow rate, postvoided residual urine, quality of life and Erectile Function （IIEF） score as outcomes. Data were analyzed by fixed or random effect models using Cochrane Collaboration review manager software. A total of 12 studies were included, Our novel data demonstrated that there was a trend that （x-blockers were more efficacious than PDE5-Is on decreasing IPSS score and increasing maximum flow rate. （x-blockers were significantly more effective than PDE5-Is on reduction of postvoided residual urine with a mean difference of 3.67 （95% CI 1.56 to 5.77, P = 0.0006） and PDE5-Is showed greater effect than （x-blockers on increasing IIEF score with a mean difference of 9.82 （95% CI 3.80 to 15.85, P = 0.001）. In conclusion, our novel data demonstrated that PDE5-Is plus ABs ranked the highest on the improvement of LUTS/BPH. PDE5-Is monotherapy was also effective in this kind of disorder except less reduction of PVR than ABs, In addition, both combined- or mono-therapy were safe.

关键词： benign prostatic hyperplasia lower urinary tract symptoms meta-analysis phosphodiesterase 5 inhibitors -adrenoceptorantagonists

Cavernous nerve reconstruction with autologous vein graft and platelet-derived growth factors

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Asian Journal of Andrology 2017年第3期19卷 298-302页

作者： Xie-Gang Ding Shi-Wen Li Xin-Min Zheng xing-huan Wang Yi Luo Department of Urology Zhongnan Hospital Wuhan University Wuhan 430071 China.

In this study, we investigated the feasibility of using autologous vein graft and platelet-derived growth factors to bridge transected cavernous nerve in a rat model. A short defect in the bilateral cavernous nerve was created and repaired with vein graft from the right jugular vein or vein graft plus platelet-derived growth factors. The 32 rats were divided into four groups, namely Group 1 - no repair as a negative control, Group 2 - vein graft alone, Group 3 - vein graft plus platelet-derived growth factors, and Group 4 - sham operation as a positive control. We evaluated nerve regeneration and functional recovery using retrograde tracing study with FluoroGold, Toluidine blue staining of cavernous nerve, and the intracavernous pressure at 3 months. Three months after surgery, rich FluoroGold-positive cells were observed in the sham and vein graft plus platelet-derived growth factors group, but very few were found in the no repair group. The number of myelinated axons of regenerated cavernous nerve and intracavernous pressure were increased obviously in the two vein graft groups, especially in the vein graft plus platelet-derived growth factors group. These findings confirm the feasibility of using autologous vein as guides for cavernous nerve regeneration, and the regeneration can be further enhanced when the vein is filled with Dlatelet-derived growth factors.

关键词： cavernous nerve nerve regeneration platetet-rich plasma vein graft

A novel rat model of seminal vesiculitis

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Asian Journal of Andrology 2019年第4期21卷 360-364页

作者： Peng Zhang Xiao-Long Wang Zhong-Hua Yang Xin-Jun Su xing-huan Wang Department of Urology Zhongnan Hospital Wuhan University Wuhan 430071 China Department of Urology Research Lab/LIFE-Zentrum University of Munich (LMU) Munchen 81377 Germany

We aimed to establish a novel rat model of seminal vesiculitis that would provide an effective approach to investigate the pathogenesis of this disease in the future. Eight male rats received the same operation, during which the root of one of the two seminal vesicles was partly ligatured with sutures and the other vesicle was left in tact. The samples of seminal vesicles were harvested on the 8th day followi ng the operation. Hematoxylin and eosi n and Mass on's trichrome stains were used to observe the histopathology and the presenee of fibrous tissue in seminal vesicles, respectively. Immunoblotting and immunohistochemistry were applied to determine the tumor n ecrosis factor-alpha and cyclooxygenase-2 levels in semi nal vesicle tissues. Real-time fluoresce nee qua ntitative polymerase chain reaction was performed to measure the gene expression levels of proinflammatory cytokines. H2O2 levels in the seminal plasma from the seminal vesicle were also measured. Hematoxylin and eosin staining suggested that there was inflammatory cell in filtration into the semi nal vesicles treated by partial root ligati on. The tumor n ecrosis factor-alpha and cyclooxygenase-2 proteins were significantly upregulated in the treated seminal vesicles. The tumor necrosis factor-alpha, cyclooxygenase, interleukin 6, and inducible nitric oxide synthase mRNA expression levels were also upregulated in the treated seminal vesicles. The H2O2 levels in the seminal plasma from seminal vesicles with partial root ligation were significantly elevated compared with those from vesicle left intact. In conclusion, partially ligating the root of the seminal vesicle via sutures in rats is an effective method to establish a seminal vesiculitis rat model.

关键词： cyclooxygenase-2 rat model seminal vesiculitis tumor necrosis factor

Effects of ammonia exposure on carcass traits and fatty acid composition of broiler meat

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Animal Nutrition 2016年第4期2卷 282-287页

作者： huan xing Sujun Luan Yongbo Sun Renna Sa Hongfu Zhang State Key Laboratory of Animal Nutrition Institute of Animal Science Chinese Academy of Agricultural Science

We aimed to study the effects of ammonia on carcass traits, organ indices and fatty acid composition of broilers. Four hundred 21-d-old male Arbor Acres broilers with initial weight 563.52 ± 2.82 g were randomly allotted to 1 of 4 groups treated with ammonia at <3 mg/kg(control),25 ± 3. 50 ± 3, and75 ± 3 mg/kg concentrations. Each group consisted of 4 replicates of 25 birds. Broilers from 21 to 42 d were reared on the net floor in the respiration-metabolism chambers where similar environmental conditions were maintained. At 32 and 42 d of age, carcass traits and organ indices were determined for4 birds per pen. At 42 d of age, fatty acid composition in the breast and thigh muscle of broilers was measured. Results showed as follows: 1) At 32 d, the dressing percentage of broilers exposed to 25 and75 mg/kg ammonia were lower than those in the control group(P < 0.05); eviscerated yield percentage of broilers in the 25 mg/kg ammonia group was also lower(P < 0.05). At 42 d, the dressing percentage of broilers in the ammonia treatments and the thigh muscle percentage of broilers in the 50 and 75 mg/kg ammonia groups were lower(P < 0.05) than those in the control. Breast muscle percentage of broilers exposed to 25 and 50 mg/kg ammonia and eviscerated yield percentage exposed to 50 mg/kg ammonia were lower than those in the control(P < 0.05). 2) The kidney index of broilers(d 32) exposed to ammonia was greater(P < 0.05) than that of the control. At 42 d, hepatic index of broilers exposed to ammonia was increased(P < 0.05), and spleen index was decreased(P < 0.05). 3) At 42 d, stearic(C18:0)and saturated fatty acids(SFA) in the thigh muscle of broilers were higher, while the unsaturated fatty acid:saturated fatty acid(U:F) ratio and unsaturated fatty acid(UFA) were lower in the 50 mg/kg ammonia treatment than in the control group(P < 0.05). In conclusion, ammonia over 25 mg/kg could decline carcass traits and immune organ indices and increase the kidney and hepatic indices.

关键词： Ammonia Broiler Carcass traits Fatty acid Organ indices