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Dual modulation of homogeneous nanomaterialization and electrochemical activation enhancing zinc ion storage

Science China Chemistry 2025年第01期 385-393页

作者： Jianwei wang huan wang Kangning wang Wenhui wang Wenlin Zhang Yanzhong Zhen School of Chemistry & Chemical Engineering Yan'an University

Vanadium-based electrode materials are widely investigated,but the low specific capacity and slow electrochemical kinetics in aqueous zinc-ion batteries still limit their commercial ***,the VS2/Ca V4O9material with the morphology of nanoflower was synthesized by a one-step hydrothermal *** to the blocky structure of pure VS2material,the VS2/Ca V4O9material is composed of thinner homogeneous *** open structures could provide abundant electrochemical active sites and ion transport channels,and then promote the electrochemical reaction *** addition,they can also buffer the bulk strain during the reaction *** improve the utilization of vanadium elements,an in-situ electrochemical activation strategy is used to explore the storage performance of the VS2/Ca V4O9material,the different activation voltage range of 0.4–1.6 and 0.4–1.4 V are selected,*** with the longer activation plateau of activated-VS2,the VS2/Ca V4O9cathode could quickly reach the activation state in the range of 1.4–1.6 V and cause the release of additional Zn storage sites *** VS2/Ca V4O9cathode delivers a higher power density of 37,000 W kg-1and a significant energy density of 423 Wh *** the high current density of 15 A g-1,the VS2/Ca V4O9cathode still has a discharge capacity of 183.9m Ah g-1after 5,000 cycles,and the capacity decay rate per cycle is only 0.0042%.Continuous cyclic voltammetry （CV） curves,electrochemical impedance spectroscopy （EIS） measurements,density functional theory （DFT） calculation and galvanostatic intermittent titration technique （GITT） measurements demonstrate that the VS2/Ca V4O9cathode has a faster ion diffusion/charge transfer ***,the assembled flexible device has an excellent mechanical stability.

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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu huan wang Xin Xie Wei huang B O Liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Background:Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and CO-IP experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate PPI.Results:By developing three PPI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related PPIs. Our network analysis revealed the central role of Beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. Subsequently, investigations showed that overexpressing Beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Autophagy Beclin 2 Protein-protein interactions (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1

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几种海洋硬骨鱼类快、慢肌的化学组分差异分析

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渔业科学进展 2025年第1期46卷 59-70页

作者：王焕柳淑芳海水养殖生物育种与可持续产出全国重点实验室中国水产科学研究院黄海水产研究所山东青岛266071 青岛海洋科技中心海洋渔业科学与食物产出过程功能实验室山东青岛266237

硬骨鱼类的骨骼肌根据收缩特征主要分为快肌和慢肌,分别支撑爆发性和持续性游泳。为认识这2种骨骼肌的化学组分特征,解析快、慢肌功能差异的物质基础,本研究整合3类不同游泳习性鱼类:黄带拟鲹(Pseudocaranx dentex)、梭鱼(Liza haematoc... 详细信息

硬骨鱼类的骨骼肌根据收缩特征主要分为快肌和慢肌,分别支撑爆发性和持续性游泳。为认识这2种骨骼肌的化学组分特征,解析快、慢肌功能差异的物质基础,本研究整合3类不同游泳习性鱼类:黄带拟鲹(Pseudocaranx dentex)、梭鱼(Liza haematocheila)和金枪鱼类,通过自测结合文献资料,比较了快、慢肌在蛋白质、氨基酸、脂肪、脂肪酸及矿物元素等化学组分特征方面的差异。结果显示,快肌的粗蛋白及12种氨基酸含量更为丰富,其中尤以组氨酸含量差异最大(快肌为慢肌的1.22~3.83倍);快、慢肌的主要氨基酸组成相似,必需氨基酸含量均占氨基酸总量的40%左右,谷氨酸和天冬氨酸是含量最丰富的2种氨基酸类型,赖氨酸和亮氨酸是含量最高的2种必需氨基酸;慢肌的粗脂肪及每种脂肪酸的含量均显著高于快肌;在脂肪酸组成方面,慢肌中饱和脂肪酸(saturated fatty acid,SFA)的比例较快肌高,而快肌中的多不饱和脂肪酸(polyunsaturated fatty acid,PUFA)比例则比慢肌高;慢肌含有更为丰富的微量元素铁(Fe)和锌(Zn)。结果表明,海洋硬骨鱼类的快肌和慢肌在蛋白质、氨基酸、脂肪、脂肪酸及矿物元素组成方面存在较大的差异,这些差异为其分别支撑爆发性游泳运动和持续性游泳运动提供了一定的物质基础。

关键词：海洋硬骨鱼类快肌慢肌化学成分特征

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Corrosion Behavior of a Low-Carbon Steel in Simulated Marine Splash Zone

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Acta Metallurgica Sinica(English Letters) 2017年第6期30卷 585-593页

作者： huan-huan wang Min Du Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationCollege of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

Experiments were designed to simulate the corrosion of a low-carbon steel exposed to a marine splash zone. The composition and morphology of the rust were investigated using Raman spectroscopy, X-ray photoelectron spectroscopy, energy-dispersive spectrometry and scanning electron microscopy. Corrosion resistance of the rust films was demonstrated by the electrochemical impedance spectroscopy. The wettability of the steel surface was calculated from the data conceruing the wetting degree and the conductivity. The results showed that, in the initial stage, the products of the outer rust layer were mainly made up of Fe（Ⅲ） oxyhydroxide, while the main component of the inner rust layer was magnetite. With an increase in the corrosion time, the inner rust layer continuously turned into the outer rust layer. In addition, both rust layers became dense, thus playing a protective role with respect to matrix. The existence of the rust layer significantly prolonged the residence time of the seawater on the sample surface, a result that tends to improve the cathodic protection effect for steel structures exposed to marine splash zones.

关键词： Marine splash zone Low-carbon steel Corrosion behavior Electrochemical impedance spectroscopy (EIS) Wetting degree

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Graphdiyne-supported metal electrocatalysts:From nanoparticles and cluster to single atoms

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Nano Research 2022年第11期15卷 9764-9778页

作者： Tiantian Lu huan wang Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

The supported-metal catalysts are of great importance to the energy-related electrocatalysis,which is regarded as a green and sustainable technology to address energy and environmental *** metal size and metal–support interaction can significantly affect the electrocatalytic activity and *** a novel two-dimensional(2D)carbon allotrope comprising sp-and sp2-hybridized carbon atoms,graphdiyne(GDY)possesses uniformly distributed pores,naturally created anchoring sites,high electrical conductivity,and good stability,making it as an attractive matrix for supporting metal ***,this review will present a systematical summary on the synthesis of size-controlled metal catalysts from nanoparticles to single atoms anchored on GDY and their applications in energy related electrocatalysis,in which the size effect and confinement effect on electrocatalytic performance will be *** first briefly introduce the emerging synthetic methods for GDY,laying a foundation for the subsequent fabrication of nano-scale GDY-supported metal *** the corresponding electrocatalytic applications including hydrogen evolution reaction(HER),oxygen reduction reaction(ORR),oxygen evolution reaction(OER),nitrogen reduction reaction(NRR),and CO_(2)reduction reaction(CO_(2)RR)are elaborately *** review will be helpful for understanding the effect of support-metal interaction on electrocatalytic performance and thereby designing ideal supportedmetal catalysts on atomic scale.

关键词： graphdiyne metal electrocatalyst nanoparticle cluster single atom electrocatalysis

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The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(H)

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： huan wang Qin wang Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(H) Coarse geometry K-Theory

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Peripheral nerve injury induced changes in the spinal cord and strategies to counteract/enhance the changes to promote nerve regeneration

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Neural Regeneration Research 2020年第2期15卷 189-198页

作者： Yan Liu huan wang Department of Hand Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Neurologic Surgery Mayo ClinicRochesterMNUSA

Peripheral nerve injury leads to morphological, molecular and gene expression changes in the spinal cord and dorsal root ganglia, some of which have positive impact on the survival of neurons and nerve regeneration, while the effect of others is the opposite. It is crucial to take prompt measures to capitalize on the positive effects of these reactions and counteract the negative impact after peripheral nerve injury at the level of spinal cord, especially for peripheral nerve injuries that are severe, located close to the cell body, involve long distance for axons to regrow and happen in immature individuals. Early nerve repair, exogenous supply of neurotrophic factors and Schwann cells can sustain the regeneration inductive environment and enhance the positive changes in neurons. Administration of neurotrophic factors, acetyl-L-carnitine, N-acetyl-cysteine, and N-methyl-D-aspartate receptor antagonist MK-801 can help counteract axotomy-induced neuronal loss and promote regeneration, which are all time-dependent. Sustaining and reactivation of Schwann cells after denervation provides another effective strategy. FK506 can be used to accelerate axonal regeneration of neurons, especially after chronic axotomy. Exploring the axotomy-induced changes after peripheral nerve injury and applying protective and promotional measures in the spinal cord which help to retain a positive functional status for neuron cell bodies will inevitably benefit regeneration of the peripheral nerve and improve functional outcomes.

关键词： axotomy dorsal root ganglion neural regeneration neurotrophic factors outcomes peripheral nerve injury repair spinal cord

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Synthesis and luminescence properties of Ca_2SiO_4-based red phosphors with Sm^(3+) doping for white LEDs

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 663-667页

作者： Jin-jun Cai huan-huan Pan Yi wang School of Applied Physics and Materials Wuyi University Jiangmen 529020 China

Sm3＋-activated Ca2SiO4 red phosphors were prepared by the conventional high-temperature solid-state reaction method, and the effects of sodium （Na＋） and samarium （Sm3＋） ions doping concentrations on their crystal structure and luminescent properties were investigated by X-ray diffraction （XRD） and fluorescent spectrofluorometer. XRD patterns demonstrate that a well-crystalline structure forms in the phosphors when they are treated by calcination at 1200~C for 4 h, and the excitation spectra exhibit good absorption in the range between 350 and 420 nm. Under the irradiation of 405 nm near-ultraviolet （NUV） light, the spectra of the phosphors show a main emission peak at 601 nm attributed to the 4G5/2→6H7/2 transition of Sm3＋ ions, and its intensity is greatly influenced by the concentrations of Sm3＋ and Na2CO3. When the concentrations of Sm3＋ ions and Na2CO3 are 2mol% and 6mol%, respectively, the optimal emission intensity can be obtained. From strong absorption in the near ultraviolet zone, the Na0.06Sm0.02Ca1.92SiO4 phosphor is a promising red-emitting phosphor for white light emitting diodes （W-LEDs）.

关键词： light emitting diodes phosphors photoluminescence doping samarium calcium silicate

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Through-thickness heterogeneity in creep properties of friction stir welding 7B50-T7451 aluminum alloy thick plate joint:Experiments and modeling

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Chinese Journal of Aeronautics 2023年第6期36卷 378-389页

作者： huan wang Weifeng XU Hongjian LU Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical UniversityXi'an 710072China

Through-thickness heterogeneity in creep properties of 7B50-T7451 aluminum alloy Friction Stir Welding(FSW)joints was *** tests for three slices of the FSW joint were conducted at the temperature of 150-200℃ and applied stress of 60-225 *** theta projection method was used to predict creep curves and minimum creep *** results show that the minimum creep rate increases and creep rupture life decreases with the increase of creep temperature and applied *** properties of the FSW joint deteriorate along the thickness direction from the top to the *** threshold stress of all three slices of the FSW joint decreases with the increase of creep temperature and even disappears at 200℃ for the bottom *** activation energy approaches the activation energy of the lattice self-diffusion of *** value of true stress exponent for different slices is approximately equal to *** predominant creep mechanism of the FSW joint is dislocation viscous glide by lattice *** is more,a constitutive model is established based on the theta method to accurately describe creep behavior ofdifferent slices of the FSW joint.

关键词： 7B50 high strength aluminum alloy Creep mechanism Creep modeling Friction stir welding Theta projection method Through-thickness heterogeneity

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Local cohomology for Gorenstein homologically smooth DG algebras

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Science China Mathematics 2023年第6期66卷 1161-1176页

作者： Xuefeng Mao huan wang Department of Mathematics Shanghai UniversityShanghai 200444China

In this paper,we introduce the theory of local cohomology and local duality to Notherian connected cochain DG *** show that the notion of the local cohomology functor can be used to detect the Gorensteinness of a homologically smooth DG *** any Gorenstein homologically smooth locally finite DG algebra A,we define a group homomorphism Hdet:Aut_(dg)(A)→k^(×),called the homological *** applications,we present a sufficient condition for the invariant DG subalgebra A^(G)to be Gorenstein,where A is a homologically smooth DG algebra such that H(A)is a Noetherian AS-Gorenstein graded algebra and G is a finite subgroup of Aut_(dg)(A).Especially,we can apply this result to DG down-up algebras and non-trivial DG free algebras generated in two degree-one elements.

关键词： Gorenstein DG algebra homologically smooth DG algebra local cohomology homological determinant

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