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The Crop Journal 2020年第6期8卷 929-942页

作者： huan si Hongling Liu Yiwen Sun Zhongping Xu sijia Liang Bo Li Xiao Ding Jianying Li Qiongqiong Wang Lin Sun Xianlong Zhang Shuangxia Jin National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina

Cotton(Gossypium hirsutum)is an important fiber crop *** attack causes cotton yield and quality ***,little is known about the mechanism of cotton response to insect *** simulated insect feeding by applying insect oral secretions(OS)to wounds,and combined transcriptome and metabolome analysis to investigate how OS from two major pest species(Helicoverpa armigera and Spodoptera litura)affect cotton defense *** found that respectively 12,668 and 13,379 genes were differentially expressed in comparison with wounding *** addition of OS,the jasmonic acid signaling pathway was rapidly and strongly induced,whereas genes involved in salicylic acid biosynthesis were *** constructing a coexpression gene network,we identified a hub gene encoding a leucine-rich repeat receptor kinase that may play an important role in early signal recognition and *** from the two insect species altered the abundance of flavonoid-related compounds in different *** remained in lower concentration after OS application than after wounding alone,suggesting a suppressive effect of OS on cotton defense *** study illustrated transcriptional and metabolic changes of cotton in responding to OS from two chewing insect species,identified potential key response genes,and revealed evidence for OS inhibition of wounding-induced cotton defense response.

关键词： Oral secretions Helicoverpa armigera Spodoptera litura Cotton Host plant defense

Identification of transition factors in myotube formation from proteome and transcriptome analyses

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Journal of Integrative Agriculture 2023年第10期22卷 3135-3147页

作者： ZHENG Qi HU Rong-cui ZHU Cui-yun JING Jing LOU Meng-yu ZHANG si-huan LI Shuang CAO Hong-guo ZHANG Xiao-rong LING Ying-hui College of Animal Science and Technology Anhui Agricultural UniversityHefei 230036P.R.China Key Laboratory of Embryo Development and Reproductive Regulation of Anhui Province Fuyang Normal UniversityFuyang 236041P.R.China Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-Breeding Anhui Agricultural UniversityHefei 230036P.R.China

Muscle fibers are the main component of skeletal muscle and undergo maturation through the formation of *** early development,a population of skeletal muscle satellite cells(SSCs)proliferate into *** myoblasts then undergo further differentiation and fusion events,leading to the development of ***,the mechanisms involved in the transition from SSCs to myotube formation remain *** this study,we characterized changes in the proteomic and transcriptomic expression profiles of SSCs,myoblasts(differentiation for 2 d)and myotubes(differentiation for 10 d).Proteomic analysis identified SLMAP and STOM as potentially associated with myotube *** addition,some different changes in MyoD,MyoG,Myosin7 and Desmin occurred after silencing SLMAP and STOM,suggesting that they may affect changes in the myogenic *** analysis indicated that the differentiation and migration factors SVIL,ENSCHIG00000026624(AQP1)and SERPINE1 enhanced the transition from SSCs to myoblasts,accompanied by changes in the apoptotic *** the myoblast *** group,candidates related to cell adhesion and signal transduction were highly expressed in the ***,CCN2,TGFB1,MYL2 and MYL4 were identified as hub-candidates in this *** data enhance our existing understanding of myotube formation during early development and repair.

关键词： proteome transcriptome skeletal muscle satellite cells myoblast myotube

A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the huanglongbing pathogen

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Plant Communications 2023年第6期4卷 216-220页

作者： Zhongping Xu Guanying Wang Qiongqiong Wang Xiaoting Li Guangyu Zhang Ali Qurban Can Zhang Yi Zhou huan si Lisong Hu Fuqiu Wang Ying Wang Zhitao Tian Wei Chen Shuangxia Jin Fang Ding Hubei Key Laboratory of Plant Pathology College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanHubeiChina National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubeiChina Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdaoShandongChina Spice and Beverage Research Institute Chinese Academy of Tropical Agricultural SciencesWanningHainanChina National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubeiChina Key Laboratory of Horticultural Plant Biology of MOE(Ministry of Education) Huazhong Agricultural UniversityWuhanHubeiChina

Dear Editor,Catharanthus roseus,an important medicinal plant native to Madagascar,is the sole source of the two important anticancer drugs vinblastine and vincristine,which are synthesized by the monoterpene-derived indole alkaloid(MIA)pathway(Das et al.,2020).It is also an important model plant for the study of huanglongbing(HLB),a devastating citrus disease that causes severe economic losses worldwide(Ma et al.,2022).Vincristine is an FDA-approved drug that has been used for acute lymphocytic leukemia,lymphoid blast crisis of chronic myeloid leukemia,and Hodgkin’s/non-Hodgkin’s lymphoma(Below and M Das,2021).

关键词： drugs lymphocytic

Current status and prospects of studies on human genetic alleles associated with hepatitis B virus infection

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World Journal of Gastroenterology 2003年第4期9卷 641-644页

作者： Fu-Sheng Wang Division of Biological Engineering,Beijing Institute of Infectious Diseases,100 Xi si-huan-Zhong Road,Beijing 100039,China Division of Bioengineering Beijing Institute of Infectious Diseases 100 Xi Si-Huan-Zhong Road Beijing 100039 China. fswang@***

Chronic hepatitis B virus (HBV) infection can cause a broad spectrum diseases, including from asymptomatic HBV carriers or cryptic hepatitis, to acute hepatitis, chronic hepatitis, Liver cirrhosis and primary hepatocellular carcinoma. The variable pattern and clinical outcome of the infection were mainly determined by virological itself factors, host immunological factors and genetic factors as well as the experimental factors. Among the human genetic factors, major candidate or identified genes involved in the process of HBV infection fall into the following categories: (1) genes that mediate the processes of viral entry into hepatocytes, induding genes involved in viral binding, fusion with cellular membrane and transportation in target cells; (2) genes that modulate or control the immune response to HBV infection; (3) genes that participate in the pathological alterations in liver tissue;(4) genes involved in the development of liver cirrhosis and hepatocellular carcinoma associated with chronic HBV infection, including genes related to mother-to-infant transmission of HBV infection; and (5) those that contribute to resistance to antiviral therapies. Most of the reports of human genes associated with HBV infection have currently focused on HLA associations. For example, some investigators reported the association of the HLA class Ⅱ alleles such as DRB1*1302 or HLA-DR13 or DQA1*0501-DQB1*0301-DQB1*1102 haplotypes with acute and/or chronic hepatitis B virus infection, respectively. Several pro-inflammatory cytokines such as Th1 cytokines (including IL-2 and IFN-γ)and TNF-α have been identified to participate the process of viral clearance and host immune response to HBV. In contrast, the Th2 cytokine IL-10 serves as a potent inhibitor of Th1 effector cells in HBV diseases. The MBP polymorphisms in its encoding region were found to be involved in chronic infection. Thus, reports from various laboratories have shown some inconsistencies with regard to the effects of

关键词：乙型肝炎病毒慢性乙型肝炎遗传学等位基因基因多态性病毒携带者

Plasmacytoid Dendritic Cells Act as the Most Competent Cell Type in Linking Antiviral Innate and Adaptive Immune Responses

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Cellular & Molecular Immunology 2005年第6期2卷 411-417页

作者： Zheng Zhang~1 Fu-Sheng Wang~(1,2) ~1Research Center of Biological Therapy,Beijing 302 Hospital,Beijing 100039,China ~2Research Centre of Biological Therapy,Beijing Institute of Infectious Diseases,Beijing 302 Hospital,100 Xi si huan Middle Road,Beijing 100039,China. Research Center of Biological Therapy Beijing 302 Hospital Beijing 100039 China.

Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamentalrequirement for defense against viral *** this process,a pivotal event that influences the outcome ofviral infection is the production of high levels of type I interferon by *** particular,recent research findingsshowed that pDCs not only shape the nature of innate resistance,but are also responsible for the successfultransition from innate to adaptive immunity for viral *** addition,pDCs can differentiate into antigenpresenting cells that may regulate tolerance to a given ***,in a series of recent clinical studies,pDCs appeared to be defective in number and function in conditions of chronic viral diseases such as infected withHIV-1,HBV or ***-associated clinical antiviral therapy is also *** review describes researchfindings examining the functional and antiviral properties of in vivo pDC *** & MolecularImmunology.2005;2(6):411-417.

关键词： virus plasmacytoid dendritic cell innate immunity adaptive immunity

我国1978-2004年生态足迹需求与供给动态分析

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武汉大学学报（信息科学版） 2006年第11期31卷 1022-1026页

作者：钟晓青赵永亮钟山司寰中山大学生命科学学院中山大学岭南学院广州市新港西路135号510275

基于生态足迹理论,用实证方法进行了我国可持续发展的定量测算与分析。在静点测算基础上,对我国20多年来的生态足迹供给与需求进行了动态测算与分析。通过Eviews软件分析了生态足迹与GDP、POP(人口)的线性关系。利用分析结果和变量之间... 详细信息

基于生态足迹理论,用实证方法进行了我国可持续发展的定量测算与分析。在静点测算基础上,对我国20多年来的生态足迹供给与需求进行了动态测算与分析。通过Eviews软件分析了生态足迹与GDP、POP(人口)的线性关系。利用分析结果和变量之间的估计方程可以判断我国可持续发展状况,并预测未来走势。

关键词：环境与生态经济生态足迹生态承载力生态生产性土地动态分析

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融合机器学习的加权Slope One算法

小型微型计算机系统 2016年第8期37卷 1712-1716页

作者：张玉连郇思思梁顺攀燕山大学信息科学与工程学院河北秦皇岛066004 燕山大学信息科学与工程学院计算机教学实验中心河北秦皇岛066004 河北省计算机虚拟技术与系统集成重点实验室河北秦皇岛066004

Slope One算法是一种基于内存的协同过滤推荐算法,在计算时,内存消耗过大,尤其当数据集稀疏时,预测结果的准确度不高.基于此,将一种基于模型的算法融合到基于内存的Slope One算法中,提出一种使用机器学习中最小二乘法改进的加权Slope On... 详细信息

Slope One算法是一种基于内存的协同过滤推荐算法,在计算时,内存消耗过大,尤其当数据集稀疏时,预测结果的准确度不高.基于此,将一种基于模型的算法融合到基于内存的Slope One算法中,提出一种使用机器学习中最小二乘法改进的加权Slope One算法,该算法简单直观且计算高效,可以克服传统基于内存推荐算法的诸多缺点.最后,在Filmtrust和Movielens数据集上的对比实验结果表明,融合偏差因子的加权Slope One算法在这两个稀疏度不同的数据集下,均能获得较高的推荐准确度.

关键词：协同过滤机器学习最小二乘法加权Slope One算法

融合用户相似度与项目相似度的加权Slope One算法

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小型微型计算机系统 2016年第6期37卷 1174-1178页

个性化推荐技术为人们处理信息过载问题提供了一种有效的解决方式.协同过滤是推荐技术常用的算法之一,本文研究的Slope One算法就是一种基于项目的协同过滤推荐算法,但是,它并未考虑到用户相似度及项目相似度的问题.因此,本文提出5种新... 详细信息

个性化推荐技术为人们处理信息过载问题提供了一种有效的解决方式.协同过滤是推荐技术常用的算法之一,本文研究的Slope One算法就是一种基于项目的协同过滤推荐算法,但是,它并未考虑到用户相似度及项目相似度的问题.因此,本文提出5种新的融合用户相似度与项目相似度的加权Slope One算法,即分别使用信任因子和Jaccard方法找出具有影响力的用户,使用Pearson方法找出当前项目的相似项目.最后,在Epinions和Movielens数据集上的对比实验结果表明,融合Jaccard和Pearson的混合算法在数据集稀疏以及邻居数目较少的情况下,仍能获得较高的推荐准确度.

关键词：个性化推荐协同过滤用户相似度项目相似度 Slope One算法

HYBRID COMPUTATIONS UsiNG PARTICLES AND CONTINUUM DYNAMICS FOR MICRO-FLUIDICS

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HYBRID COMPUTATIONS USING PARTICLES AND CONTINUUM DYNAMICS F...

微波消解/电感耦合等离子体质谱法测定注射用奈达铂中微量金属元素

中国力学学会学术大会'2005

作者： Cui Jia He Guowei (LNM, Institute of Mechanics, Chinese Academy of Sciences, 15, Bei si huan Xi Lu, Beijing, 100080 China )

A hybrid numerical scheme is developed for micro-fluidics. It describes fluid as amount of particles in one domain that is solved by molecular dynamics (MD), and as continuum hydrodynamics in another domain that is solved by Navier-Stokes (NS) equations plus boundary conditions (BC). These two solutions are coupled in the overlap domain where the fluid is described by both ways, in order to ensure that the physical quantities (density,

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中国医院药学杂志 2018年第14期38卷 1492-1495,1499页

作者：还传静王思寰李悦中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室上海200040

目的:建立了微波消解结合电感耦合等离子体(ICP-MS)方法,采用内标法定量测定注射用奈达铂中的20种微量元素。方法:试样经逆王水-氢氟酸消解体系进行消解,并使用ICP-MS进行测定。选取4种同位素作为内标,选取丰度高和干扰因素少的同位素... 详细信息

目的:建立了微波消解结合电感耦合等离子体(ICP-MS)方法,采用内标法定量测定注射用奈达铂中的20种微量元素。方法:试样经逆王水-氢氟酸消解体系进行消解,并使用ICP-MS进行测定。选取4种同位素作为内标,选取丰度高和干扰因素少的同位素进行测定,一定程度上避免了基体效应,并使测定结果更准确。结果:实验结果表明该方法所有元素的线性关系良好,相关系数r为0.995 4~1.0000;检出限为0.001 0~0.819 7 ng·mL^(-1);重复性和精密度的相对标准偏差(RSD)均小于4%;加样回收率为80%~117%。试样中各元素的含量均符合ICH Q3D与USP通则〈232〉的规定。结论:该方法灵敏度高,专属性与重复性好,分析速度快,为注射用奈达铂的质量控制提供了参考依据。

关键词：奈达铂电感耦合等离子体质谱元素分析