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非核糖体多肽合成酶研究进展

生物化学与生物物理进展 2002年第5期29卷 667-669页

作者：明镇寰潘建伟朱睦元浙江大学生命科学学院杭州310012

细菌和真菌采用非核糖体系统合成一些重要的多肽类物质 .近年来的研究表明 ,在该系统中发挥关键作用的是一类分子巨大的非核糖体多肽合成酶 .它们由顺序排列的组件构成 ,酶分子结构本身即蕴涵着多肽合成的信息 .对非核糖体多肽合成酶结... 详细信息

细菌和真菌采用非核糖体系统合成一些重要的多肽类物质 .近年来的研究表明 ,在该系统中发挥关键作用的是一类分子巨大的非核糖体多肽合成酶 .它们由顺序排列的组件构成 ,酶分子结构本身即蕴涵着多肽合成的信息 .对非核糖体多肽合成酶结构和功能的了解。

关键词：非核糖体多肽合成酶研究进展结构功能细菌真菌

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视错觉现象在户外广告中的运用

郑州轻工业学院学报（社会科学版） 2010年第6期11卷 24-27页

作者：潘欢欢周口师范学院美术系河南周口466001

进行户外广告创意设计,可借助视错觉原理,结合户外广告画面、户外广告媒介载体及其周围空间环境,因地制宜地创造出新颖独特的视错觉效果,吸引消费者的注意力,提高户外广告信息的到达率。在户外广告的创意设计中,创意形态要符合商品定位... 详细信息

进行户外广告创意设计,可借助视错觉原理,结合户外广告画面、户外广告媒介载体及其周围空间环境,因地制宜地创造出新颖独特的视错觉效果,吸引消费者的注意力,提高户外广告信息的到达率。在户外广告的创意设计中,创意形态要符合商品定位,并在充分考虑媒介载体特性的基础上,结合其空间环境进行设计。

关键词：户外广告视错觉空间环境

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基于抵押品扩展与替代机制的林业金融创新

北京林业大学学报（社会科学版） 2009年第4期8卷 124-128页

作者：田治威秦涛潘焕学北京林业大学经济管理学院

随着我国农村金融体制和林权制度改革,林业金融环境也得以改善。但是,现有的金融体系、金融机构对林农和中小企业所需要的金融零售服务仍难以满足。借助于林权制度改革及相关的配套改革成果,应该进一步完善林业金融服务功能,加大林业金... 详细信息

随着我国农村金融体制和林权制度改革,林业金融环境也得以改善。但是,现有的金融体系、金融机构对林农和中小企业所需要的金融零售服务仍难以满足。借助于林权制度改革及相关的配套改革成果,应该进一步完善林业金融服务功能,加大林业金融创新力度,缓解林农和林业中小企业的融资困境。本文从金融需求角度出发,基于信贷供给理论分析导致林业信贷约束的原因和影响因素,提出通过抵押品扩展和替代机制,寻求林业金融服务创新的方向和模式。

关键词：林业信贷约束抵押机制金融创新

A Bayesian network for estimating hypertension risk due to occupational aluminum exposure

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Chronic Diseases and Translational Medicine 2024年第2期10卷 130-139页

作者： Le Zhao Jinzhu Yin Jiaping huan Xiao Han Dan Zhao Jing Song Linping Wang Huifang Zhang Baolong pan Qiao Niu Xiaoting Lu Department of Occupational Health School of Public HealthShanxi Key Laboratory of Environmental Health Impairment and PreventionMOE Key Laboratory of Coal Environmental Pathogenicity and PreventionShanxi Medical UniversityTaiyuanShanxiChina Sinopharm Tongmei General Hospital Shanxi Health Commission Key Laboratory of Nervous System Disease Prevention and TreatmentDatongShanxiChina Sixth Hospital of Shanxi Medical University(General Hospital of Tisco) TaiyuanShanxiChina

Background The correlation between metals and hypertension,such as sodium,zinc,potassium,and magnesium,has been confirmed,while the relationship between aluminum and hypertension is not very *** study aimed to evaluate the correlation between plasma aluminum and hypertension in electrolytic aluminum workers by the Bayesian networks(BN).Methods In 2019,476 male workers in an aluminum factory were *** plasma aluminum concentration of workers was measured by inductively coupled plasma mass *** influencing factors on the prevalence of hypertension were analyzed by the *** The prevalence of hypertension was 23.9%in 476 male *** risk of hypertension from plasma aluminum in the Q2,Q3,and Q4 groups was 5.20(1.90–14.25),6.92(2.51–19.08),and 7.33(2.69–20.01),respectively,compared with that in the Q1 *** risk of hypertension from the duration of exposure to aluminum of>10 years was 2.23(1.09–4.57),compared without aluminum *** under the curve was 0.80 of plasma aluminum and the duration of exposure to aluminum was based on covariates,indicating that aluminum exposure had important predictive value in the prevalence of hypertension in the occupational *** results of the study using the BN model showed that if the plasma aluminum of all participants was higher than Q4(≥47.86µg/L)and the participants were drinking,smoking,diabetes,central obesity,dyslipidemia,and aged>50 years,the proportion of hypertension was 71.2%.Conclusions The prevalence of hypertension increased significantly with the increase of plasma aluminum level.

关键词： Bayesian networks hypertension occupational aluminum exposure

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基于改进量子粒子群算法的配电网络优化重构

电测与仪表 2018年第18期55卷 31-36,49页

作者：潘欢杨丽胡钢墩宁夏大学物理与电子电气工程学院宁夏沙漠信息智能感知重点实验室银川750021

为了更好地利用分布式电源(DG),需要调整配电网开关状态优化网络结构。基于此,旨在利用一种智能算法对含DG的配电网进行优化重构。以网损最小为目标函数,建立配电网重构模型,并给出重构需要满足的约束条件;按照DG接入配电网的接口类型... 详细信息

为了更好地利用分布式电源(DG),需要调整配电网开关状态优化网络结构。基于此,旨在利用一种智能算法对含DG的配电网进行优化重构。以网损最小为目标函数,建立配电网重构模型,并给出重构需要满足的约束条件;按照DG接入配电网的接口类型将其分为PQ型、PV型、PI型和PQ(V)型四种类型,选择前推回代法对含DG的配电网进行潮流计算;通过分析二进制粒子群算法(BPSO)与量子粒子群算法(QPSO),提出了一种改进的量子粒子群算法—加权的二进制量子粒子群算法(WBQPSO)。以IEEE33节点配电系统为例,采用二进制编码方式,通过仿真结果可以发现WBQPSO通过对粒子的平均最好位置加权处理,改善种群多样性,提高收敛速度,可以得到更好的网络重构的优化结果。

关键词：配电网重构分布式电源粒子群算法量子粒子群算法二进制

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水冷壁清扫检测爬壁机器人

机器人 1999年第5期21卷 375-378页

作者：沈为民潘涣涣潘沛霖王炎赵言正张稳哈尔滨工业大学机器人研究所 150001 天力机器人公司

本文简要介绍了一种适用于火力发电站的大型排管锅炉中的水冷壁清扫、检测用爬壁机器人，该机器人具有工作效率高，安全可靠，并能极大地降低作业费用，提高检测精度等优点，是爬壁机器人技术在电站锅炉领域中的新应用。

关键词：水冷壁爬壁机器人无损检测锅炉火力发电站

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我国在用医疗器械安全监管法律主体研究

中南林业科技大学学报（社会科学版） 2014年第2期8卷 109-112页

作者：潘寰湘潭大学法学院湖南湘潭411105

随着医疗技术的进步和科技水平的提升,在用医疗器械安全已成为影响人的生命健康的重要因素之一。站在行政法的角度,从法律体系、监管职权、社会监管等方面分析发现当前我国在用医疗器械安全监管主体存在的问题。建立以政府食品药品监管... 详细信息

随着医疗技术的进步和科技水平的提升,在用医疗器械安全已成为影响人的生命健康的重要因素之一。站在行政法的角度,从法律体系、监管职权、社会监管等方面分析发现当前我国在用医疗器械安全监管主体存在的问题。建立以政府食品药品监管部门为主导、社会组织和机构为补充的在用医疗器械安全监管主体模式能够完善我国在用医疗器械监管体系,确保人民群众"用械"安全。

关键词：在用医疗器械行政监管监管主体

2×3 kW bidirectional output fiber oscillator employing spindle-shaped ytterbium-doped fiber

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Chinese Optics Letters 2024年第7期22卷 42-46页

作者： Lingfa Zeng Baolai Yang Penglin Zhong huan Yang Peng Wang Zhiping Yan Xiaoming Xi Liangjin huang Hanwei Zhang Xiaolin Wang Zhiyong pan Kai Han Zefeng Wang College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China

A 2×3 kW-level bidirectional output fiber oscillator is realized by combining the specially designed spindle-shaped ytterbium-doped fiber,non-wavelength-stabilized 976-nm LDs,and grating bandwidth optimization to balance transverse mode instability and stimulated Raman *** maximum output powers at both ends are 3265 and 2840 W,respectively,with a total efficiency of 73.2%.The M^(2) factors of the lasers at both ends are about 1.98 and 2.38,*** beam profile at both ends shows that a bidirectional output annular beam fiber oscillator has been realized,which has great potential in practical applications.

关键词： fiber laser bidirectional output fiber oscillator spindle-shaped ytterbium-doped fiber.D0I:10.3788/COL202422.071401

Recent advances in chemical protein synthesis:method developments and biological applications

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Science China Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong Ji-Shen Zheng Yiming Li huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man pan Shan Tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Health Sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and *** protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image *** review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic ***,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse *** applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further ***,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs