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Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution

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Science China(life Sciences) 2022年第9期65卷 1811-1823页

作者： ling Zhong Xiao Yang Yu Zhou Jialing Xiao huan li Jiang Tao Qian Xi Chen Chu Chenglong li Xi Yang Chen Yang Yi Zhang Ping Shuai Yuping liu Man Yu Yi Shi Jiang Hu Wei Zhang Bo Gong Zhenglin Yang Department of Health Management Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610075China The Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengdu 610072China Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610072China Department of Orthopaedics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of hematology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Cancer Biology Dana-Farber Cancer Institute and Department of GeneticsBlavatnik InstituteHarvard Medical SchoolBostonMA 02115USA

The Revised International Staging System(R-ISS)is a simple and powerful prognostic tool for multiple myeloma(MM).However,heterogeneity in R-ISS stage is still poorly characterised,hampering improvement of treatments.We used single-cell RNA-seq to examine novel cellular heterogeneity and regular networks in nine MM patients stratified by R-ISS.Plasma cells were clustered into nine groups(P1–P9)based on gene expression,where P1–P5 were almost enriched in stage III.PDIA6 was significantly upregulated in P3 and LETM1was enriched in P1,and they were validated to be upregulated in the MM cell line and in 22 other patients’myeloma cells.Furthermore,in progression,PDIA6 was newly found and verified to be activated by UQCRB through oxidative phosphorylation,while LETM1 was activated by STAT1 via the C-type lectin receptor-signalling pathway.Finally,a subcluster of monocytes was exclusively found in stage III specifically expressed chemokines modulated by ATF3.A few ligand-receptor pairs(CCL3/CCL5/CCL3L1-CCR1)were obviously active in monocyte-plasma communications in stage III.Herein,this study identified novel molecules,networks and crosstalk pairs in different R-ISS stages of MM,providing significant insight for its prognosis and treatment.

关键词： multiple myeloma the revised international staging system single-cell RNA-seq

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Lasiodiplodia pseudotheobromae causes stem canker of Chinese hackberry in China

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Journal of Forestry Research 2020年第6期31卷 2571-2580页

作者： Lu liang huan li lifeng Zhou Fengmao Chen Co-Innovation Center for Sustainable Forestry in Southern China College of ForestryNanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China

Chinese hackberry(Celtis sinensis Pers.)is an adaptable species widely growing in southern China.The symptoms of canker on stems of seedlings were discovered mid-July 2017 in Shuyang,Jiangsu Province.The diseased portions of the stems were dark brown due to discoloured xylem.Some seedlings showed symptoms of wilting,leaf fall,twig dieback,and tissue discolouration.The outbreak period was concentrated in July and August,suggesting that the disease spread during summer months.Possible fungal causal agents were isolated from naturally infected canker tissue and discoloured xylem.The isolate from xylem tissue with a high frequency(>50%)was named Ls7 type.Pathogenicity tests were carried out on 4-yearold seedlings.The symptoms of canker began to develop 20 days after inoculation with Ls7 isolate and by day 35,there were dark,enlarged longitudinal lesions.A phylogenetic tree of the isolate was developed using the internal transcribed spacer,elongation factor-1α(tef1-α),β-tubulin gene(TUB)and RNA polymerase II subunit primer genes(RPB2).Based on morphological features and phylogenetic information,the pathogen was identifi ed as Lasiodiplodia pseudotheobromae.This is the fi rst report of L.pseudotheobromae causing canker on Chinese hackberry stems in China.

关键词： Botryosphaeriaceae Plant pathogen Tree disease

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Lane departure warning systems and lane line detection methods based on image processing and semantic segmentation:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 748-774页

作者： Weiwei Chen Weixing Wang Kevin Wang Zhaoying li huan li Sheng liu School of Information Engineering Chang’an UniversityXi'an 710064China Xi’an Aeronautical Polytechnic Institute Xi'an 710089China Royal Institute of Technology Stockholm 10044Sweden Audible Inc. NewarkNJ 07102USA School of Computer Science and Engineering Xi’an University of TechnologyXi'an 710048China

Recently,the development and application of lane line departure warning systems have been in the market.For any of the systems,the key part of lane line tracking,lane line identification,or lane line departure warning is whether it can accurately and quickly detect lane lines.Since 1990 s,they have been studied and implemented for the situations defined by the good viewing conditions and the clear lane markings on road.After then,the accuracy for particular situations,the robustness for a wide range of scenarios,time efficiency and integration into higher-order tasks define visual lane line detection and tracking as a continuing research subject.At present,these kinds of lane marking line detection methods based on machine vision and image processing can be divided into two categories:the traditional image processing and semantic segmentation(includes deep learning)methods.The former mainly involves feature-based and model-based steps,and which can be classified into similarity-and discontinuity-based ones;and the model-based step includes different parametric straight line,curve or pattern models.The semantic segmentation includes different machine learning,neural network and deep learning methods,which is the new trend for the research and application of lane line departure warning systems.This paper describes and analyzes the lane line departure warning systems,image processing algorithms and semantic segmentation methods for lane line detection.

关键词： Traffic engineering Lane departure warning Lane line detection Image processing Image analysis Semantic segmentation

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吩嗪-芘共聚物电极新材料的制备及储能性能研究

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现代化工 2024年第3期44卷 118-123,129页

作者：费强徐立环苏畅沈阳化工大学辽宁沈阳110142

以5,10-二氢吩嗪和1,6-二溴芘为原料,通过Buchwald-Hartwig芳胺化反应合成出新型聚合物聚(吩嗪-芘)(p-PyPZ),将其作为有机锂电池正极材料,研究其电化学和电池性能。通过FT-IR及XPS对新型聚合物材料的结构形貌进行表征,并通过电化学循环... 详细信息

以5,10-二氢吩嗪和1,6-二溴芘为原料,通过Buchwald-Hartwig芳胺化反应合成出新型聚合物聚(吩嗪-芘)(p-PyPZ),将其作为有机锂电池正极材料,研究其电化学和电池性能。通过FT-IR及XPS对新型聚合物材料的结构形貌进行表征,并通过电化学循环伏安(CV)法对其性能进行测试。结果表明,聚合物p-PyPZ具有多重氧化还原特征,在3.590/3.447 V处出现芘结构单元对应的氧化还原特征峰,表明新型共聚物中芘结构单元即作为链接单元,同时参与氧化还原过程,使制备的电极材料具有多电子储能特性。作为锂离子电池正极材料,聚合物p-PyPZ表现出优良的循环稳定性。在电流密度为20 mA/g的条件下,其稳定放电比容量达到112.1 mAh/g,经过50圈充放电循环后仍能保持在113 mAh/g。在20、50、100、200 mA/g和500 mA/g的电流密度下的放电比容量分别稳定在114.7、109.6、103、96.6 mAh/g和92.1 mAh/g。

关键词：有机材料正极 π共轭吩嗪芘

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新中国成立初期学校劳动教育的历程回溯、主要特征及现实启示

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井冈山大学学报（社会科学版） 2024年第3期45卷 102-110页

作者：李欢四川大学马克思主义学院四川成都610065

中国共产党一贯重视劳动的重要作用,通过学校劳动教育培育劳动情感、涵养劳动精神,培养全面发展的劳动者。新中国成立初期,我国学校劳动教育经历了发轫、拓展、强化、调整的发展历程。在十七年的教育实践中,劳动教育呈现出教育主体综合... 详细信息

中国共产党一贯重视劳动的重要作用,通过学校劳动教育培育劳动情感、涵养劳动精神,培养全面发展的劳动者。新中国成立初期,我国学校劳动教育经历了发轫、拓展、强化、调整的发展历程。在十七年的教育实践中,劳动教育呈现出教育主体综合化、内容多样化以及方法多元化的主要特征。在新的历史条件下,学校劳动教育应深入总结历史经验,坚持守正与创新的辩证统一。以多元主体参与为牵引,构建主体协同的劳动育人新格局;以全面发展为导向,坚持价值观教育与技能教育相统一;以回应现实为着力点,统筹推进劳动教育理论化与实践化。通过推动学校劳动教育持续发展,促进人的自由全面发展,使劳动教育更好地服务于社会主义现代化建设的需要,服务于国家战略发展的需要,为中华民族伟大复兴提供精神动力与人才支撑。

关键词：新中国成立初期学校劳动教育历程回溯主要特征现实启示

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In-situ growth of nanowire WO_(2.72) on carbon cloth as a binder-free electrode for flexible asymmetric supercapacitors with high performance

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Journal of Energy Chemistry 2019年第2期28卷 58-64页

作者： Xiao huang Zhiguo Zhang huan li Hongxia Wang Tingli Ma Department of life Science and System Engineering Kyushu Institute of Technology School of Chemistry Physics and Mechanical EngineeringQueensland University of Technology School of Petroleum and Chemical Engineering Dalian University of Technology

For the first time,WO_(2.72) nanowires were in-situ grown on carbon cloth by a simple solvothermal reaction.The nanowire WO_(2.72)/carbon cloth(NW WO_(2.72)/CC) electrode showed good electrochemical performance with specific capacitance(C_s) reaching up to 398 F g^(-1) at a current density of 2 A g^(-1).The capacitance of 240 F g^(-1) was retained at a high current density of 16 A g^(-1).To further evaluate the energy storage performance,flexible asymmetric supercapacitors(FASC_s) were fabricated using the activated carbon/carbon cloth(AC/CC) as negative electrode and NW WO_(2.72)/CC as positive electrode,respectively.The FASC_s delivered a high energy density of 28 Wh kg^(-1) at a power density of 745 W kg^(-1) and 13 Wh kg^(-1) even at a high power density of 22.5 k W kg^(-1).More impressively,81% of the specific capacitance of the FASC_s was retained after 10,000 cycles,indicating excellent cycle stability.This work indicates the NW WO_(2.72)/CC holds a great potential for application in energy storage devices.

关键词： Solvothermal reaction Asymmetric supercapacitors High energy density Flexibility

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工业互联网在石化行业环保领域的应用与展望

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石油石化绿色低碳 2024年第1期9卷 78-84页

作者：李焕中国石化安全工程研究院有限公司化学品安全全国重点实验室山东青岛266100

该文从工业互联网技术进展入手,从现有基础、数据、模型和应用4个层面介绍了工业互联网在石化行业环保领域的现状、问题和发展趋势。参考相关领域的成熟技术或可行性研究,从完善工业互联网架构、水气污染物在线监测提升、分级控制、固... 详细信息

该文从工业互联网技术进展入手,从现有基础、数据、模型和应用4个层面介绍了工业互联网在石化行业环保领域的现状、问题和发展趋势。参考相关领域的成熟技术或可行性研究,从完善工业互联网架构、水气污染物在线监测提升、分级控制、固体废物风险管控、场地污染风险管控、环保绿色低碳管理和生态风险防控等7个方面提出推进“工业互联网+环保”在石化行业落地的对策建议,并对未来进行了适度展望。

关键词：工业互联网环保石化

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Ce(Ⅲ)-modulation over non-enzymatic Pt/CeO_(2)/GO biosensor with outstanding sensitivity and stability for lactic acid detection

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稀土学报:英文版 2023年第9期41卷 1437-1447,I0006页

作者： Luyao Zhang Fuli Tian huan li Jiangman Meng Qi liu Xiaoqian Guo Yun Qiu Jun Zhang Changyan li College of Chemistry and Chemical Engineering.Inner Mongolia University Hohhot 010021China Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province Hainan Vocational University of Science and TechnologyHaikou 571126China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

A series of non-enzymatic graphene functionalized biosensors was developed via deposition precipitation method for lactic acid(LA) detection,which we re characterized by transmission electron micro scopy(TEM),Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),gas chromatography-mass spectrometry,liquid chromatography-mass spectro metry,and proton nuclear magnetic re sonance(~1H NMR).The electrochemical performances of the non-enzymatic biosensors were measured by means of the electrochemical impedance spectroscopy(EIS) and cyclic voltammetry(CV) method.The comprehensive analysis of structures shows that Pt,CeO_(2),and GO components interact with each other.During the storing and releasing oxygen,the valence ratio of Ce^(3+)/Ce^(4+) and the number of oxygen vacancies in CeO_(2) change accordingly,which can be conducive to increasing electronic transmission capacity and finally leads to the improvement of electrocatalytic performance.Among them,the Pt/CeO_(2)/GO biosensor containing 0.47 at% platinum exhibits an excellent electrochemical detection performance with high sensitivity of 12.3 μA·L/(mmol·cm^(2)) and a low limit of detection(LOD) of 5.12 μmol/L in a wide linear range from 10 to 900 μmol/L.In addition,the proposed biosensor possesses a promising anti-interference capability,as well as high stability and good reproducibility,which was assessed by testing the cyclic voltammogram in 0.1 mol/L lactic acid one year later.The underlying mechanism was proposed for electrochemical oxidation of LA to carbon dioxide and acetic acid with the synergistic effect among Pt,CeO_(2),and GO.Furthermore,the results of the standard addition method in real samples(human serum and urine samples) reveal that the lactic acid detection of the non-enzymatic Pt/CeO_(2)/GO biosensor is accompanied by high reliability.Thus,it will be a valuable biosensor for in vitro detection of lactic acid level in clinical samples.

关键词： Non-enzymatic biosensor Lactic acid Graphene functionalized Pt/CeO_(2) Oxygen vacancy Synergistic effect Rare earths

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An improved SOI trench LDMOST with double vertical high-k insulator pillars

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Journal of Semiconductors 2018年第9期39卷 61-66页

作者： huan li Haimeng huang Xingbi Chen State Key Laboratory of Electronic Thin Films and Integrated Devices of China University of Electronic Science and Technology of China

An SOI trench LDMOST（TLDMOST）with ultra-low specific on-resistanceis proposed.It features double vertical high-k insulator pillars（Hk1 and Hk2）in the oxide trench,which are connected to the source electrode and drain electrode,respectively.Firstly,under reverse bias voltage,most electric displacement lines produced by the charges of the depleted drift region in the source side go through the Hk1,and thus the average electric field strength under the source can be enhanced.Secondly,two additional electric field peaks are induced by the Hk_1,which further modulate the electric field in the drift region under the source.Thirdly,most electric displacement lines produced by the charges of the depleted drift region in the drain side enter into the Hk2.This not only introduces one more electric field peak at the corner of the oxide trench around the Hk2,but also forms the enhanced vertical reduced surface field effect,which modulates the electric field in the drift region under the drain.With the effects of the two Hk insulator pillars,the breakdown voltage（BV）and the drift region doping concentration are significantly improved.The simulation results indicate that compared with the oxide trench LDMOST（previous TLDMOST）with the same geometry,the proposed double Hk TLDMOST enhances the BV by 86%and reduces theby 88%.

关键词： breakdown voltage high-k specific on-resistance trench LDMOST

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大宗工业固体废弃物煤矸石的综合利用研究进展

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湖南师范大学自然科学学报 2024年第1期47卷 1-9页

作者：李欢杨春明湖南师范大学化学化工学院中国长沙410081

煤矸石是煤炭开采及加工过程中产生的一种大宗工业固体废弃物,长期露天堆积不仅占用宝贵的土地资源,还会造成严重的环境问题从而危害人类健康。随着生态文明建设的深入推进及环保要求的不断提高,煤矸石的减量化、无害化处理及资源化利... 详细信息

煤矸石是煤炭开采及加工过程中产生的一种大宗工业固体废弃物,长期露天堆积不仅占用宝贵的土地资源,还会造成严重的环境问题从而危害人类健康。随着生态文明建设的深入推进及环保要求的不断提高,煤矸石的减量化、无害化处理及资源化利用已成为煤炭行业的迫切需求。本文从煤矸石的资源化综合利用等方面综述了煤矸石处理和利用的研究进展,总结了煤矸石处理的现状和存在的问题,探讨了煤矸石处理和利用的高质量发展趋势,最后提出了煤矸石全元素精细化及高值化利用等建议。

关键词：煤矸石处理利用环保高质量发展

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