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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan Li wei Dong yu-Qi liu yang Wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi Hua Jing-yu He Jun Li Bai Du ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen yang-Gan wang Hai-rong wang Qin yu Jing He Yi-Lin Mao xiao-Fang Bin yue Deng yu-Dan Tian qing-Hua Han Da-Jin liu Li-Qin Duan Ming-Jun Zhao Cui-Ying zhang Hai-Ying Dai Ze-Hua Li Ying xiao You-Zhi Hu xiao-yu huang Kun xing xin Jiang Chao-Feng liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying yang yao-rong Dong Lei zhang Guang Fu Ying Li Shu-wei huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li yun Xia Jun liu Fan liu Wen-Jin He Ying Li Jian-Cong Tan yang Lin ya-Bin Zhou Jian-Fei yang Guo-qing Ma Hui-Jun Chen He-Ping liu Zong-Wu liu Jian-xiong liu xiao-Jia Luo xiao-Hong Bin ya-Nan yu Hai-Xia Dang Bing Li Fei Teng wang-Min Qiao xiao-Long Zhu Bing-wei Chen Qi-Guang Chen Chun-Ti Shen Yong-yan wang yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng huang wei-Zhu yang Guo-Wen Yin Bin-yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua huang wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-wei Wen yan-Ming Lei yu-Sheng Song Chun-wang yuan wei-Dong wang Ming huang wei Zhao Jian-Bing Wu Song wang Xu Zhu Jian-Jun Han wei-xin Ren Zai-Ming Lu Wen-Ge xing Yong Fan Hai-Lan Lin Zi-Shu zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-ya Zhao Zhu-ting Fang Qi wang Jin-wei Zhao Ai-Bing Xu Jian Xu qing-Hua Wu huan-zhang Niu Jian wang Feng Dai Dui-Ping Feng qing-Dong Li rong-Shu Shi Jia-Rui Li Guang yang Hai-Bin Shi Jian-Song Ji yu-E liu Zheng Cai Po yang yang Zhao xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Guidelines for Diagnosis and Treatment of Atopic Dermatitis in China(2020)#

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International Journal of Dermatology and Venereology 2021年第1期4卷 1-9页

作者： Xu yao Zhi-Qiang Song wei Li yun-Sheng Liang yan Zhao Hua Cao Tao Chen Xue Chen Ai-Ping Feng Song-Mei Geng Heng Gu Shu-Ping Guo yan-Ling He Ye-Hong Kuang Chun-Ying Li xiao-Hong Li Zheng-xiao Li Jun-Qin Liang Hong-Ye liu Ling-Ling liu yu-Mei liu Zhi liu Hai Long Qian-Jin Lu yan Lu xiao-qun Luo xiao-yan Lv Lin Ma Zhu Shen xin Shi Zhong-Xiang Shi Xiang-yang Su qing Sun Jian-Ping Tang Ao-Xue wang Hui-Ping wang Jian-Qin wang Ming-yue wang Zai-xing wang yu-Min Xia ting xiao Zhi-Qiang Xie huan xing Ying xiong Zi-Gang Xu Bin yang Zhi-rong yao Jian-Bin yu Nan yu Kang Zeng Jian-Zhong zhang Jun-Ling zhang Hua Zhao Zuo-Tao Zhao wei Zhu Ying-Hua Zhu Ying Zou Atopic Dermatitis Working Group,Immunology Group,Chinese Society of Dermatology Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical SciencesNanjingJiangsu 210042China Southwest Hospital of Military Medical University Chongqing 400038China Huashan Hospital Affiliated with Fudan UniversityShanghai 200040China Dermatology Hospital of Southern Medical University GuangzhouGuangdong 510091China Peking University People’s Hospital Beijing 100044China Ruijin Hospital Affiliated with Shanghai Jiaotong UniversityShanghai 310000China Chengdu Second People’s Hospital ChengduSichuan 610017China Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology WuhanHubei 430022China The Second Affiliated Hospital of Xi’an Jiaotong University Xi’anShaanxi 710004China First Hospital of Shanxi Medical University TaiyuanShanxi 030012China Beijing Chao-yang Hospital Capital Medical UniversityBeijing 100027China Xiangya Hospital Central South UniversityChangshaHunan 410008China Xijing Hospital Fourth Military Medical UniversityXi’anShaanxi 710032China The First Affiliated Hospital of Zhengzhou University ZhengzhouHenan 450052China People’s Hospital of xinjiang Uygur Autonomous Region WulumuqiXinjiang 830001China Peking University First Hospital Beijing 100034China Guangzhou Institute of Dermatology GuangzhouGuangdong 510095China The Affiliated Hospital of Guizhou Medical University GuiyangGuizhou 550004China The Second Xiangya Hospital of Central South University ChangshaHunan 410011China The First Affiliated Hospital of Nanjing Medical University NanjingJiangsu 210029China West China Hospital Sichuan UniversityChengduSichuan 610041China Beijing Children’s Hospital Capital Medical UniversityBeijing 100045China Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital ChengduSichuan 610072China The Second Affiliated Hospital of Soochow University SuzhouJiangsu 215004China Shandong Provincial Dermatology Hospital JinanShandong 250022China The Third Affiliated Hospital of Sun yat-sen U

Atopic dermatitis(AD)is a common disease clinically characterized by chronic recurrent eczematous lesions,dry skin,and *** can negatively impact patients’quality of *** prevalence of AD in China has been increasing during the past few *** on the most recent advances in the treatment of AD,we updated the 2014 version of the Guidelines for Diagnosis and Treatment of Atopic Dermatitis in China regarding the definition,epidemiology,pathogenesis,clinical classification,diagnosis,prevention,and treatment of AD.

关键词： atopic dermatitis diagnosis therapy guideline

MyD88依赖途径在膝骨关节炎进程中的基因表达相关性研究

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中国骨伤 2018年第10期31卷 933-936页

作者：王欢王庆甫史榕荇张美丽杨帆刘思婷樊小燕郭玉茹丁海涛唐学章中日友好医院北京100029 北京中医药大学第三附属医院北京100029 北京中医药大学北京100039

目的 :探讨MyD88依赖途径的相关基因TLR4、NF-κB与MyD88在膝骨关节炎(osteoarthritis,OA)不同病程下大鼠滑膜组织的表达特点及相关性。方法:将60只Wistar大鼠随机分为6组:空白组(N)、假手术组(F)和模型组[2周组(2W)、4周组(4W)、8周组(... 详细信息

目的 :探讨MyD88依赖途径的相关基因TLR4、NF-κB与MyD88在膝骨关节炎(osteoarthritis,OA)不同病程下大鼠滑膜组织的表达特点及相关性。方法:将60只Wistar大鼠随机分为6组:空白组(N)、假手术组(F)和模型组[2周组(2W)、4周组(4W)、8周组(8W)、12周组(12W)],每组各10只。各模型组以Hulth法建立大鼠膝OA动物模型,空白组不予手术,假手术组仅打开关节腔。按上述设计时间收集样本,经总RNA的提取及反转录后,用Realtime PCR法对各组滑膜组织中TLR4、NF-κB及MyD88的相对表达量进行检测,分析其相关性。结果 :假手术组各基因的mRNA表达与空白组相比差异均无统计学意义((P>0.05);而各模型组较空白组各基因表达增强(P<0.05)。相关性分析显示:MyD88与TLR4及NF-κB的mRNA相关性系数分别为0.91和0.86,差异有统计学意义(P<0.05)。结论:MyD88与TLR4、NF-κB的表达均呈显著的正相关性,在通路上起重要的枢纽作用,可通过其表达预测通路上其他基因的表达情况,进一步明确膝OA病理机制。

关键词：膝骨关节炎 MyD88依赖途径固有免疫滑膜炎症

2017年中国ICU患者营养治疗实施状况横断面调查

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解放军医学杂志 2019年第5期44卷 388-393页

作者：邢娟章仲恒柯路周晶秦秉玉梁宏开陈晓梅刘文明刘忠民艾宇航王迪芬王秋卉周青山张福森钱克俭蒋东坡臧彬黎毅敏黄晓波曲彦谢颖光许东琳邹志强郑祥德刘建波郭丰梁亚风孙强高红梅刘阳常平程爱斌杨荣利么改琦孙昀王晓蓉张怡熊旭明于健孙荣青李志伟袁世荧宋云林高培阳刘海燕张朝辉吴允孚马标郭强山峰杨明施李海玲李圆菲鲁卫华王磊钱传云王智勇林建东张汝敏万鹏彭志勇龚裕强黄林喜伍国宝孙洁邓义军师东武周立新周发春石秦东郭晓东刘雪燕武卫东孟祥忠李连弟陈炜炜李树生万献尧曹志新张安古利明陈炜吴京兰周丽华张震环翁以炳封永顺杨春丽冯永健赵素民佟飞郝东韩辉付宝才巩传勇李志平胡琨琳寇秋野张晗刘洁樊楚明周新陈秀梅孙俊丽周学军宋斌孙诚赵丽芸董兴鲁张琳琳佟大为潘志国蔡常洁王东浩董英俊龚园其吴志松孟新科王平李维勤南京医科大学金陵临床医学院南京210002 无锡人民医院江苏无锡214001 北京市密云区医院北京101500 洛阳市中心医院河南洛阳471009 北京市怀柔区第一医院北京101400 陆军总医院北京100700 广东省人民医院广州510080 广东省第二中医院广州510095 北京中医医院北京100010 安徽省立医院西院区合肥230001 沈阳市第一人民医院沈阳110041 南部战区总医院广州510050 湖北省人民医院武汉430060 中山大学附属第一医院广州510080 天津市肿瘤医院天津300060 山西省肿瘤医院太原030000 南昌大学第二附属医院南昌330006 北京中医药大学东方医院北京100029 深圳第二人民医院广东深圳100730 成都市第五人民医院成都611130 泰安市中心医院山东泰安271000 南昌大学第一附属医院南昌330006 陆军军医大学大坪医院重庆400042 中国医科大学附属第二医院沈阳110004 广州医科大学附属第一医院广州510120 四川省人民医院成都610072 青岛市立医院青岛266071 济宁市第一人民医院山东济宁272000 浙江大学医学院附属邵逸夫医院杭州310016 广州市第一人民医院广州510000 福建医科大学附属协和医院福州350001 达州市中心医院四川达州635000 内蒙古自治区人民医院呼和浩特010017 烟台毓璜顶医院山东烟台264000 天津市人民医院天津300000 天津市第一中心医院天津300192 唐山市工人医院河北唐山063000 南方医科大学珠江医院广州510515 华北理工大学附属医院河北唐山063210 河南省人民医院郑州450003 大连市中心医院辽宁大连116033 北京大学第三医院北京100083 安徽医科大学第二附属医院合肥230601 温州医科大学附属第一医院浙江温州325000 陕西省人民医院西安710068 广州医科大学附属第二医院广州510120 大连医科大学附属第二医院辽宁大连116011 郑州大学第一附属医院郑州450052 昆明市第一人民医院昆明650011 华中科技大学同济医学院附属协和医院武汉430030 中山市人民医院广东中山528403 新疆医科大学第一附属医院乌鲁木齐830054 成都中医药大学附属医院成都610075 安徽医科大学第一附属医院合肥230032 宜昌市中心人民医院湖北宜昌443003 苏州市立医院东区江苏苏州215008 济宁医学院附属医院山东济宁272000 苏州大学附属第一人民医院江苏苏州215006 青岛大学医学院附属医院东院区山东青岛266071 中南大学湘雅三医院长沙410013 海军第971医院山东青岛266073 山东大学齐鲁医院济南250012 长沙市中心医院长沙410000 皖南医学院弋矶山医院安徽芜湖241002 山西医科大学第一医院太原030001 昆明医科大学第一附属医院昆明650032 河北医科大学第三医院石家庄050017 福建医科大学附属第一医院福州350004 淄博市中心医院山东淄博100085 宜昌市第一人民医院湖北宜昌443003 武汉大学中南医院武汉430071 温州医科大学附属第二医院浙江温州325035 常州市第二人民医院江苏常州213003 汕头大学医学院第一附属医院广东汕头515041 中南大学湘雅二医院长沙410013 云南省第二人民医院昆明650021 盐城市第一人民医院江苏盐城224006 山西省人民医院太原030012 佛山市第一人民医院广东佛山528000 重庆医科大学附属第一医院重庆400016 西安交通大学第一附属医院西安710061 解放军总医院第三医学中心北京100039 深圳市人民医院广东深圳518001 吉林大学第一医院长春130031 山西医学科学院山西大医院太原030032 解放军第254医院天津300142 青岛大学附属医院山东青岛266003 临海市第一人民医院浙江台州317000 华中科技大学同济医学院附属同济医院武汉430030 大连医科大学附属第一医院辽宁大连116011 北京朝阳医院京西院区北京100043 重庆医科大学附属第二医院重庆400016 玉溪市人民医院云南玉溪653405 首都医科大学世纪坛医院北京100036 中南大学湘雅医院长沙410013 深圳市南山人民医院广东深圳518067 内蒙古医科大学附属医院呼和浩特010050 南京明基医院南京210019 首都医科大学附属北京潞河医院北京101149 京煤集团总医院北京102300 江西省人民医院南昌330006 暨南大学附属第一医院广

目的了解国内ICU收治患者的营养治疗实施状况。方法对国内116家医院的118个ICU内的患者进行营养治疗实施状况的横断面调查。以2017年4月26日0时所有在ICU内治疗的患者为调查对象,收集患者基本信息、2017年4月25日(即调查日)的营养实施... 详细信息

目的了解国内ICU收治患者的营养治疗实施状况。方法对国内116家医院的118个ICU内的患者进行营养治疗实施状况的横断面调查。以2017年4月26日0时所有在ICU内治疗的患者为调查对象,收集患者基本信息、2017年4月25日(即调查日)的营养实施和胃肠道耐受情况,以及患者的28 d临床转归情况。结果调查共收集病例1953例,女631例(32.4%),男1306例(66.9%),缺失16例(0.7%);年龄(64.1±19.3)岁(1950例)。患者GCS、SOFA和APACHEⅡ评分分别为(10.76±4.35)分(1749例)、(5.65±3.52)分(1783例)、(17.14±7.31)分(1792例)。28 d临床转归存活1483例(75.9%),死亡312例(16.0%),失访+缺失158例(8.1%)。除身高和体重(P=0.000)外,男性与女性患者在年龄、病情严重程度及28 d临床转归等方面差异均无统计学意义。1953例患者中,胃肠功能评估为正常或轻度损害占73.7%(1440例),中-重度损害占10.8%(210例),衰竭占1.7%(33例),13.2%(258例)的患者未做评估。截至调查日,69.4%(1356例)的患者已启动肠内营养(EN),36.4%(711例)的患者已启动肠外营养(PN)。调查日有营养摄入的患者1720例(88.1%)。1953例患者中明确有恶心、呕吐反流、误吸、腹痛、腹胀、腹泻(大便次数≥3次/d且量≥500 ml/d)等胃肠道不耐受表现的分别占总人数的4.8%(93例)、5.4%(105例)、0.9%(17例)、8.7%(170例)、27.5%(538例)和4.3%(84例)。在1270例使用EN的病例中,明确存在恶心、呕吐反流、误吸、腹痛、腹胀、腹泻等不耐受症状的分别占3.2%(40例)、4.3%(54例)、0.8%(10例)、4.4%(56例)、26.9%(341例)和5.4%(69例)。入ICU后24 h内开始EN治疗的患者占22.4%(437/1953),48 h内开始的占38.6%(754/1953),72 h内开始的占46.6%(911/1953)。患者入ICU后3 d总热卡(EN+PN非蛋白热卡)达标率为12.9%(78/607),7 d总热卡达标率为18.7%(189/1010),14 d总热卡的达标率为23.0%(305/1325)。入ICU后3、7、14 dEN达标率分别为9.9%(60/607)、15.0%(151/1010)和18.6%(246/1325)。结论目前我国ICU内的绝大多数患者均接受了营养治疗,其中EN的使用率明显高于PN;但EN的开始时间和达标情况仍不理想,且实施营养治疗时未能体现个体化差异,营养治疗的细节仍需要提高。

关键词：横断面研究肠内营养重症监护病房胃肠道耐受性营养达标率

2018 Chinese Guidelines for Prevention and Treatment of Hypertension——A report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension

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Journal of Geriatric Cardiology 2019年第3期16卷 182-241页

作者： Joint Committee for Guideline Revision Chinese Hypertension League Chinese Society of Cardiology Hypertension Committee of the Chinese Medical Doctor Association Hypertension Branch of the China Association for the Promotion of International Exchanges of Health Care Hypertension Branch of the Chinese Geriatrics Society Li–Sheng liu Chinese Hypertension LeagueChinese Society of CardiologyHypertension Committee of the Chinese Medical Doctor AssociationHypertension Branch of the China Association for the Promotion of International Exchanges of Health CareHypertension Branch of the Chinese Geriatrics SocietyRevision Committee MembersChair: Li-Sheng liu[*]Deputy Chairs: Zhao-Su WU Ji-Guang WANG Wen WANGMembers (Listed in alphabetic order by last name in Chinese Pinyin)Yu-Jing BAO Jun CAI Lu-Yuan CHEN Wei-Wei CHEN Shao-Li CHU Ying-Qing FENG Ping-Jin GAO Ting-Rui GUAN Zi-Hong GUO Qi HUA Jun HUANG Yong HUO Wei-Ping JIA Xiong-Jing JIANG Yi-Nong JIANG Li LI Li-Huan LI Nan-Fang LI Wei LI Xiao-Ying LI Xue-Wang LI Yan LI Yong LI Jin-Xiu LIN Li-Sheng LIU Xin-Zheng LU Ji-Xiang MA Jie MI Jian-Jun MU Chang-Yu PAN Gang SUN Ning-Ling SUN Ying-Xian SUN Jun TAO Hao WANG Ji-Guang WANG Wen WANG Wen-Zhi WANG Yong-Jun WANG Yu WANG Zeng-Wu WANG Hai-Ying WU Zhao-Su WU Liang-Di XIE Zhang-Rong XU Xiao-Wei YAN Yan-Min YANG Chong-Hua YAO Zheng-Pei ZENG Jian ZHANG Wei-Zhong ZHANG Xin-Hua ZHANG Xin-Jun ZHANG Yu-Qing ZHANG Ding-Liang ZHU Jun ZHU Zhi-Ming ZHUScientific Committee MembersXiang-Mei CHEN Hong CHEN Jun-Shi CHEN Xiao-Ping CHEN Yun-Dai CHEN Zhao-Qiang CUI Xue-Ping DU Li FAN Run-Lin GAO Jun-Bo GE Luo-Bu GE-SANG Dong-Feng GU Jing-Xuan GUO Yi-Fang GUO Qing-Hua HAN Ya-Ling HAN Zhao-Guang HONG Da-Yi HU Jian-Ping LI Guang-Wei LI Guang-Ping LI Xin-Li LI Yu-Ming LI Xiao-Feng LIANG Yi-Shi LI Yu-Hua LIAO Shu-Guang LIN Mei-Lin LIU Jing LIU Wei LIU Fang-Hong LU Shu-Ping MA Qian-Hui SHANG Yi-Pu CHEN Hai-Qin Tang Xin-Hua TANG Gang TIAN Ke-An WANG Xing-Yu WANG Dao-Wen WANG Shou-Ling WU Cheng-Bin XU Shou-Chun XU Xin-Juan XU Xin-Hua YIN Bo YU Guo-Ying YU Jing YU Wei YU Meng-Sun YU Hong YUAN Ru-Yu YUAN Chun-Yu ZENG Zhe-Chun ZENG Lin ZHANG Hui-Min ZHANG Dong ZHAO Luo-Sha ZHAO Lian-You ZHAO Xiao-Fang ZHOU Man-Lu ZHU*Correspondence to:moc.621@lhcsll (LIU LS)

Table of Contents Preamble 1 Prevalence of hypertension in Chinese population 1.1 Prevalence,incidence and epidemic trend of hypertension in Chinese population 1.2 Awareness,treatment and control of Hypertension in China 1.3 Important risk factors for hypertension in Chinese population 2 Hypertension and cardiovascular risk 2.1 Relationship between blood pressure and cardiovascular risk 2.2 Cardiovascular risk characteristics of hypertension population in China 3 Diagnostic evaluation 3.1 Medical history 3.2 Physical examination 3.3 Laboratory examinations 3.4 Genetic analysis 3.5 BP measurement 3.6 Evaluation of target organ damage.

关键词： 2018 Chinese Guidelines Contents Preamble Prevention and Treatment