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Evaluation of neuromuscular activity in patients with obstructive sleep apnea using chin surface electromyography of polysomnography

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Chinese Medical Journal 2013年第1期126卷 16-21页

作者： YIN Guo-ping YE Jing-ying HAN De-rain WANG Xiao-yi ZHANG yu-huan LI yan-ru Department of Otolaryngology Head and Neck Surgery AffiliatedBeijing Tongren Hospital Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University) Ministry of Education Beijing 100730 China

Background It is believed that defects in upper airway neuromuscular control play a role in sleep apnea pathogenesis. Currently, there is no simple and non-invasive method for evaluating neuromuscular activity for the purpose of screening in patients with obstructive sleep apnea. This study was designed to assess the validity of chin surface electromyography of routine polysomnography in evaluating the neuromuscular activity of obstructive sleep apnea subjects and probe the neuromuscular contribution in the pathogenesis of the condition. Methods The chin surface electromyography of routine polysomnography during normal breathing and obstructive apnea were quantified in 36 male patients with obstructive sleep apnea. The change of chin surface electromyography from normal breathing to obstructive apnea was expressed as the percent compensated electromyography value, where the percent compensated electromyography value = （normal breath surface electromyography - apnea surface electromyography）/normal breath surface electromyography, and the percent compensated electromyography values among subjects were compared. The relationship between sleep apnea related parameters and the percent compensated electromyography value was examined. Results The percent compensated electromyography value of the subjects varied from 1% to 90% and had a significant positive correlation with apnea hypopnea index （R2=0.382, P 〈0.001）. Conclusions Recording and analyzing chin surface electromyography by routine polysomnography is a valid way of screening the neuromuscular activity in patients with obstructive sleep apnea. The neuromuscular contribution is different among subjects with obstructive sleep apnea.

关键词： chin surface electromyography neuromuscular activity sleep apnea, obstructive upper airway dilator muscles

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Data analysis guidelines for single‑cell RNA‑seq in biomedical studies and clinical applications

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Military Medical Research 2023年第4期10卷 529-553页

作者： Min Su Tao Pan Qiu‑Zhen Chen Wei‑Wei Zhou Yi Gong Gang Xu huan‑yu yan Si Li Qiao‑Zhen Shi Ya Zhang Xiao He Chun‑Jie Jiang Shi‑Cai Fan Xia Li Murray J.Cairns Xi Wang Yong‑Sheng Li State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China College of Biomedical Information and Engineering the First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 571199HainanChina College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081HeilongjiangChina Department of Immunology Nanjing Medical UniversityNanjing 211166China Department of Laboratory Medicine Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401174China Baylor College of Medicine HoustonTX 77030USA Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110GuangdongChina School of Biomedical Sciences and Pharmacy Faculty of Health and Medicinethe University of NewcastleUniversity DriveCallaghanNSW 2308Australia Precision Medicine Research Program Hunter Medical Research InstituteNew Lambton HeightsNSW 2305Australia

The application of single-cell RNA sequencing(scRNA-seq)in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic *** the expansion of capacity for high-throughput scRNA-seq,including clinical samples,the analysis of these huge volumes of data has become a daunting prospect for researchers entering this ***,we review the workflow for typical scRNA-seq data analysis,covering raw data processing and quality control,basic data analysis applicable for almost all scRNA-seq data sets,and advanced data analysis that should be tailored to specific scientific *** summarizing the current methods for each analysis step,we also provide an online repository of software and wrapped-up scripts to support the *** and caveats are pointed out for some specific analysis tasks and *** hope this resource will be helpful to researchers engaging with scRNA-seq,in particular for emerging clinical applications.

关键词： Single-cell RNA-sequencing(scRNA-seq) Data analysis Biomedical research Clinical applications

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复式晶格声子晶体的多带隙实验研究

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振动与冲击 2017年第11期36卷 129-133页

作者：赵寰宇严珠妹盖晓玲刘兵飞北京交通大学工程力学研究所北京100044 北京市劳动保护科学研究所环境噪声与振动北京市重点实验室北京100054 中国民航大学机场学院天津300300

由于人工声子晶体具有天然材料所不具备的异常物理性质,它能够调控弹性波或声波的传输。考虑复式晶格可以降低晶体结构的对称性,容易打开完全带隙,进而抑制波的传播。设计了单胞含6个"原子"的(3.***.6.4)晶格钢/水声子晶体,结合超声浸水... 详细信息

由于人工声子晶体具有天然材料所不具备的异常物理性质,它能够调控弹性波或声波的传输。考虑复式晶格可以降低晶体结构的对称性,容易打开完全带隙,进而抑制波的传播。设计了单胞含6个"原子"的(3.***.6.4)晶格钢/水声子晶体,结合超声浸水透射技术,测试了第一布里渊区Γ-K和Γ-M方向带隙性质。结果表明:实验得到的宽频段8个完全带隙频率范围和有限元法计算值可以很好地吻合。还详细分析了完全带隙边界频率点本征模态和声波局域效应,这对于设计多带隙隔声材料具有重要参考意义。

关键词：声子晶体复式晶格多带隙实验研究

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超子同位旋相互作用对中子星性质的影响

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四川大学学报（自然科学版） 2004年第5期41卷 1007-1011页

作者：贾焕玉徐延冰西南交通大学现代物理研究所成都610031 四川大学物理科学与技术学院成都610016

作者从相对论平均场理论出发,考虑到核子、超子和介子的自由度,研究了不同Σ超子同位旋相互作用对中子星性质的影响.经计算发现,大的Σ超子与ρ介子耦合常数对中子星中Σ-超子的出现有抑制作用,当该耦合常数超过1.4时,不会有Σ-出现,同... 详细信息

作者从相对论平均场理论出发,考虑到核子、超子和介子的自由度,研究了不同Σ超子同位旋相互作用对中子星性质的影响.经计算发现,大的Σ超子与ρ介子耦合常数对中子星中Σ-超子的出现有抑制作用,当该耦合常数超过1.4时,不会有Σ-出现,同时其它超子(比如Λ,Ξ-等)则在更小的密度下生成.该同位旋耦合常数亦对中子星物质的状态方程有影响,耦合常数越大,状态方程越硬,得到的中子星的最大质量越大.由计算结果得中子星的最大质量为1.3～1.4M⊙(M⊙为太阳质量),与观测结果基本相符.

关键词：中子星超子相对论平均场超子同位旋相互作用

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Prediction of Listed Company Innovation Ability Based on Attention Mechanism

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Journal of the Operations Research Society of China 2023年第1期11卷 177-187页

作者： huan-yu Ma yan Xu yu-Long Liu Department of Information and Computer Science University of Science and Technology BeijingBeijing100083China No.15 Research Institute China Electronics Technology Group CorporationBeijing100083China

Innovation is the center of the enterprise development, which is the main driving force of enterprises’ competitiveness. To evaluate the enterprises’ innovation ability, we firstly establish an index system which aims at analyzing the enterprise innovation ability. We also retrieve the data of the listed companies in Wind database from 2015 to 2019 and label them using factor analysis method. Then, a new deep learning classificational framework with attention mechanism and LSTM is established. The results show that when attention mechanism and LSTM are added into the convolutional neural network(CNN), the model’s prediction performance is better improved, and the accuracy, recall, precision and F-score are 0.914, 0.914, 0.916 and 0.915, respectively. This indicates the strong generalization ability of our new model. Finally, we also find that patents and R &D expenditures are the most important factor affecting the corporate innovation ability through SHapley Additive exPlanations(SHAP). Companies with more patents and R &D expenditures are generally considered to be more innovative.

关键词： Corporate innovation ability convolutional neural network Attention mechanism long short-term memory

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Facile synthesis of porous germanium-iron bimetal oxide nanowires as anode materials for lithium-ion batteries

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Nano Research 2018年第7期11卷 3702-3709页

作者： Xiongwu Zhong Huijuan huan Xiaowu Liu yan yu Key Laboratory of Materials for Energy Conversion Chinese Academy of Sciences (CAS) Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Tianjin 300071 China State Key Laboratory of Fire Science University of Science and Technology of China Hefei 230026 China

Germanium-based oxide has been found to be a promising high-capacity anode material for lithium-ion batteries （LIBs）. However, it exhibits poor electrochemical performance because of the drastic volume change during cycling. Herein, we designed porous Ge-Fe bimetal oxide nanowires （Ge-Fe-Ox-700 NWs） by a large-scale and facile solvothermal reaction. When used as the anode material for LIBs, these Ge-Fe-Ox-700 NWs exhibited superior electrochemical performance （- 1,120 mAh·g^-1 at a current density of 100 mA·g^-1） and good cycling performance （- 750 mAh·g^-1 after 50 cycles at a current density of 100 mA·g^-1）. The improved performance is due to the small NW diameter, which allows for better accommodation of the drastic volume changes and zero-dimensional nanoparticles, which shorten the diffusion length of ions and electrons.

关键词： lithium-ion batteries anode materials germanium oxide iron oxide nanowires

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反对称矩阵空间上保持行列式的函数

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哈尔滨商业大学学报（自然科学版） 2016年第6期32卷 703-705页

作者：樊玉环马艳芬魏喆修涛黑龙江工程学院数学系哈尔滨150001

刻画了反对称矩阵空间上的保持行列式的函数的形式,受反对称矩阵空间上行列式性质的影响,分别研究了奇数阶反对称矩阵空间及偶数阶反对称矩阵空间上保行列式的函数的形式.

关键词：保持行列式反对称矩阵函数

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Early acceleration of electrons and protons at the nonrelativistic quasiparallel shocks with different obliquity angles

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Research in Astronomy and Astrophysics 2019年第12期19卷 298-304页

作者： Jun Fang Chun-yan Lu Jing-Wen yan huan yu Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China Department of Physical Science and Technology Kunming UniversityKunming 650214China

The early acceleration of protons and electrons in the nonrelativistic collisionless shocks with three obliquities are investigated through 1D particle-in-cell simulations. In the simulations, the charged particles possessing a velocity of 0.2c flow towards a reflecting boundary, and the shocks with a sonic Mach number of 13.4 and an Alfven Mach number of 16.5 in the downstream shock frame are *** these quasi-parallel shocks with the obliquity angles θ = 15°, 30° and 45°, some of the protons and the electrons can be injected into the acceleration processes, and their downstream spectra in the momentum space show a power law tail at a time of 1.89 × 10^5ω^-1pe, where ωpe is the electron plasma ***, the charged particles reflected at the shock excite magnetic waves upstream of the shock. The shock drift acceleration is more prominent with a larger obliquity angle for the shocks, but the accelerated particles diffuse parallel to the shock propagation direction more easily to participate in the diffusive shock acceleration. In the early acceleration stage, more energetic protons and electrons appear in the downstream of the shock for θ = 15° compared with the other two obliquities. Moreover, in the upstream region, the spectrum of the accelerated electrons is the hardest for θnB = 45° among the three obliquities, whereas the proton spectra for θnB = 15° and 45° are similar as a result of the competition of the effectiveness of the shock drift acceleration and the diffusive shock acceleration.

关键词： acceleration of particles methods:numerical shock waves

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Preparation of Core-Shell Structured Cobalt Coated Tungsten Carbide Composite Powders by Intermittent Electrodeposition

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Journal of Materials Science & Technology 2016年第11期32卷 1171-1178页

作者： huan Zhong yuejun Ouyang Gang yu Bonian Hu Dalong yan State Key Laboratory of Chemo/Biosensing and Chemometrics. College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Huaihua Key Laboratory of Functional Inorganic & Polymeric Materials Huaihua University Huaihua 418000 China Department of Materials and Chemical Engineering Hunan Institute of Technology Hengyang 421008 China

Core-shell structured cobalt coated tungsten carbide（WC/Co） composite powders were prepared by intermittent electrodeposition. The influence of process parameters such as current density, single deposition pulse, p H value and surfactants on the formation of WC/Co was investigated and characterized by scanning electron microscopy（SEM）, electrochemical station, acidometer and X-ray diffraction（XRD） *** composite powders with 54% cobalt content were fabricated at a current density of 16 A dm-2, with a load of 10 g dm-3WC powders and a stirring speed of 600 r min-1at an operation temperature of 40 ± 2 °C,and 90% current efficiency was obtained with a single deposition pulse of 1.5 min and single stirring pulse of 2 min during 12 min efficient electrodeposition time. The uniformly distributed WC/Co powders could be obtained in the cobalt electrolyte containing 300 mg dm-3PEG-2000. The spherical cobalt grains coated WC particles were prepared in the p H 4-5 electrolyte at the Co deposition rate of 0.58 g min-1. A practical process for high efficient production of WC/Co powders by electrodeposition was developed in the present work.

关键词： Composite powder Electrodeposition Dispersion Crystal structure

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Oxygen defects boost polysulfides immobilization and catalytic conversion:First-principles computational characterization and experimental design

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Nano Research 2020年第8期13卷 2299-2307页

作者： Qiu He Bin yu huan Wang Masud Rana Xiaobin Liao yan Zhao State Key Laboratory of Silicate Materials for Architectures International School of Materials Science and EngineeringWuhan University of TechnologyWuhan430070China Materials Engineering School of Mechanical and Mining EngineeringThe University of QueenslandSt LuciaQLD4072Australia The Institute of Technological Sciences Wuhan UniversityWuhan430072China

Although some experiments have shown that point defects in a cathode host material may enhance its performance for lithium-sulfur battery(LSB),the enhancement mechanism needs to be well investigated for the design of desired sulfur ***,the first principle density functional theory(DFT)is adopted to investigate a high-performance sulfur host material based on oxygen-defective TiO2(D-TiO2).The adsorption energy comparisons and Gibbs free energy analyses verify that D-TiO2 has relatively better performances than defect-free TiO2 in terms of anchoring effect and catalytic conversion of ***,D-TiO2 is capable of absorbing the most soluble and diffusive long-chain *** newly designed D-TiO2 composited with three-dimensional graphene aerogel(D-TiO2@Gr)has been shown to be an excellent sulfur host,maintaining a specific discharge capacity of 1,049.3 mAhg^−1 after 100 cycles at 1C with a sulfur loading of 3.2 mgcm^−*** with the sulfur mass loading increasing to 13.7 mgcm^−2,an impressive stable cycling is obtained with an initial areal capacity of 14.6 mAhcm^−2,confirming the effective enhancement of electrochemical performance by the oxygen *** DFT calculations shed lights on the enhancement mechanism of the oxygen defects and provide some guidance for designing advanced sulfur host materials.

关键词： oxygen defects catalytic conversion lithium-sulfur battery density functional theory

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