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左氧氟沙星杂质N的全合成工艺

高校化学工程学报 2024年第3期38卷 468-474页

作者：王洁利王凯罗艳娟商甜波陈彩萍章潮军沈华良沈润溥虞国棋绍兴文理学院脂溶性维生素浙江省工程研究中心浙江绍兴312000 绍兴文理学院药物制剂研究所浙江绍兴312000 浙江医药股份有限公司浙江绍兴312000

化合物((S)-(-)-2,3-二氢-3-甲基-9,10-双(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-de][1,4]苯并噁嗪-6-羧酸)是抗菌药左氧氟沙星的杂质N,可作为左氧氟沙星生产过程中的杂质对照品。针对其合成难度大的问题,设计了左氧氟沙星杂质N(6)... 详细信息

化合物((S)-(-)-2,3-二氢-3-甲基-9,10-双(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-de][1,4]苯并噁嗪-6-羧酸)是抗菌药左氧氟沙星的杂质N,可作为左氧氟沙星生产过程中的杂质对照品。针对其合成难度大的问题,设计了左氧氟沙星杂质N(6)的合成工艺。以左氧氟沙星中间体环合酯((S)-(-)-2,3-二氢-3-甲基-9,10-二氟-7-氧代-7H-吡啶并[1,2,3-de][1,4]苯并噁嗪-6-羧酸乙酯)(1)为原料,先在8位引入硝基,经N-甲基哌嗪的亲核取代反应得到化合物(3),再在氢氧化钠作用下水解、铁粉/氯化铵体系还原、重氮化脱除8-氨基得到目标化合物。该工艺原料易得,反应条件温和,总收率约为35.8%,解决了缺少左氧氟沙星相关研究中杂质N对照品的难题。

关键词：左氧氟沙星全合成左氧氟沙星杂质N 重氮化反应

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Answer for questions of repeated measurements of variance analysis and distribution test of data—Authors’reply

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Frontiers of Medicine 2022年第4期16卷 661-665页

作者： Dao Wen Wang Li Ni hualiang Jiang Division of Cardiology Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Thank the journal for sending us the Correspondence of *** Wei for our article“Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial”published in Frontiers of Medicine[1].We appreciate *** Wei for agreeing with most of the conclusions in our paper and we address *** Wei’s comments carefully as below.

关键词： journal comment carefully

免疫失衡在腹泻型肠易激综合征发病中的机制及中药干预研究进展

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中国全科医学 2024年第35期27卷 4462-4467页

作者：梅笑潘海迪吴晓睿贺昌辉窦鑫邓华亮王伟山东中医药大学第一临床医学院山东省济南市250014 山东中医药大学中医学院山东省济南市250014 山东中医药大学附属医院消化内二科山东省济南市250014

腹泻型肠易激综合征(IBS-D)是一种临床常见的功能性胃肠病,免疫失衡在其发病中起重要作用。相关免疫细胞包括固有免疫细胞和适应性免疫细胞,免疫细胞因子包括免疫球蛋白、干扰素、白介素、肿瘤坏死因子等。中药单体/化合物或复方可通过... 详细信息

腹泻型肠易激综合征(IBS-D)是一种临床常见的功能性胃肠病,免疫失衡在其发病中起重要作用。相关免疫细胞包括固有免疫细胞和适应性免疫细胞,免疫细胞因子包括免疫球蛋白、干扰素、白介素、肿瘤坏死因子等。中药单体/化合物或复方可通过多通路、多靶点调节免疫治疗IBS-D。本文从免疫失衡与肠道感染、菌群失调、脑肠轴紊乱、内分泌紊乱的关系等方面,对中药单体/化合物和复方靶向免疫治疗IBS-D的相关文献进行了系统回顾与梳理,并同时印证了“脾为之卫”与免疫相通之处,以期为中医药通过免疫介导途径治疗IBS-D及相关疾病提供思路。

关键词：腹泻型肠易激综合征免疫失衡中药复方中药单体/化合物研究进展

压缩空气储能系统膨胀机末级叶片特殊边界处理与失效分析

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动力工程学报 2024年第3期44卷 355-360页

作者：刘畅朱阳历张华良陶海亮李俊左志涛陈海生中科南京未来能源系统研究院南京211135 中国科学院工程热物理研究所北京100190 中国科学院大学北京100049

以压缩空气储能(CAES)系统中膨胀机末级叶片为研究对象,针对末级叶片的离心力工况,提出了一种高效的等效叶冠约束模型,并对比了循环对称约束模型和多叶片模型的仿真结果。同时,还开发了一种能够模拟弹塑性和失效行为的本构程序。结果表... 详细信息

以压缩空气储能(CAES)系统中膨胀机末级叶片为研究对象,针对末级叶片的离心力工况,提出了一种高效的等效叶冠约束模型,并对比了循环对称约束模型和多叶片模型的仿真结果。同时,还开发了一种能够模拟弹塑性和失效行为的本构程序。结果表明:与其他模型相比,等效叶冠约束模型的仿真结果与全尺寸模型结果最接近,兼具精度和效率优势;所编写的本构子程序可有效模拟17-4ph钢的应力-应变响应曲线;针对所研究的叶片构型,当失效发生在叶片径向约1/4位置处时,失效区域快速扩大。

关键词：末级叶片离心力工况失效行为

Silicon-coated fibrous network of carbon nanotube/iron towards stable and wideband electromagnetic wave absorption

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Journal of Materials Science & Technology 2022年第26期121卷 199-206页

作者： Xiaodi Zhou He Han Yuchao Wang Cheng Zhang hualiang Lv Zhichao Lou Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Willian G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA School of Science Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China

Materials that can absorb electromagnetic(EM)wave have garnered increased attention in recent years due to their potential to mitigate the ever increasing environmental pollution by EM *** to recent advances in micro/nanofabrication,a variety of magnetic metal-based EM absorbers have been *** design and synthesis of EM absorbers that exhibit efficient and wide-band absorption at small thicknesses,however,remains *** we report the design of fibrous nanostructures consisting of magnetic iron(Fe)nanoparticles and carbon nanotubes(CNTs),which exhibits a wide-band EM absorption(3.8 GHz)while maintain the thickness at 1.2 *** our work,we created a novel core-shell structure by immersing the highly fibrous CNT-Fe structure into solid-state silicon(SiO)***,the SiO-coated CNT-Fe structures exhibit good stability against air-induced oxidation and acid corrosion while maintaining high EM ***,the results reported in this study present new avenues to absorb EM from ambient *** believe that our work elevates the utility of EM absorbers to real-world applications such as anti-acid and oxidation ability.

关键词： Fibrous network Silicon-coated nanostructure Electromagnetic pollution Magnetic-dielectric loss

Professor hualiang Jiang:A tribute to an esteemed visionary chemist and pharmacist

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Chinese Chemical Letters 2023年第2期34卷 F0003-F0003页

作者： Jiang, hualiang Editorial Board of Chinese Chemical Letters

Professor hualiang Jiang,a leading chemist and pharmacist in China,Academician of Chinese Academy of Sciences,former Director General of Shanghai Institute of Materia Medica(SIMM),Chinese Academy of Sciences,and the founding Dean of School of Pharmacy,East China University of Science and Technology(ECUST),passed away on 23 December 2022 in Shanghai at the age of *** was well-known for his brilliance and strategic vision as a scientist his kindness and generosity as a friend,and his dedication as a teacherand a *** untimelydemise of Professor hualiang Jiang is a significant loss to us and to the field of chemical and pharmaceutical research.

关键词： Academician founding Director

离子液体在非光气法合成异氰酸酯过程中的应用

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石油化工 2024年第3期53卷 402-409页

作者：马旭彤王桂荣赵茜赵新强安华良王延吉河北工业大学化工学院绿色化工与高效节能河北省重点实验室天津300130

综述了以离子液体为催化剂、助催化剂、溶剂和热载体,在采用氨基甲酸酯催化热分解路线制备异氰酸酯反应过程中的应用研究进展,阐述了离子液体阴阳离子种类及取代基等对其应用效果的影响规律,总结了离子液体在该路线各步骤中作为不同角... 详细信息

综述了以离子液体为催化剂、助催化剂、溶剂和热载体,在采用氨基甲酸酯催化热分解路线制备异氰酸酯反应过程中的应用研究进展,阐述了离子液体阴阳离子种类及取代基等对其应用效果的影响规律,总结了离子液体在该路线各步骤中作为不同角色发挥作用的效果与机理,以期为异氰酸酯合成过程的绿色化研究提供参考。

关键词：离子液体非光气法氨基甲酸酯异氰酸酯羰基化热裂解

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High catalytic performance of CuCe/Ti for CO oxidation and the role of TiO_(2)

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Chinese Journal of Chemical Engineering 2023年第10期62卷 1-10页

作者： Tingting Chang Ziyan Wang Zhimiao Wang hualiang An Fang Li Wei Xue Yanji Wang Hebei Provincial Key Laboratory of Green Chemical Technology and High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China Purification Equipment Research Institute of CSIC Handan 056027China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Hebei Industrial Technology Research Institute of Green Chemical Industry Huanghua 061100China

CuCe/Ti-A and CuCe/Ti-R catalysts were prepared using anatase TiO_(2)(TiO_(2)-A)and rutile TiO_(2)(TiO_(2)-R)as supports using the incipient wetness impregnation method for the carbon monoxide(CO)oxidation reaction and were compared with a CuCe-C catalyst prepared using the co-precipitation *** CuCe/Ti-A catalyst exhibited the highest activity,with complete CO conversion at 90℃,when the gas hourly space velocity was 24000 ml.g^(-1).h^(-1) and the CO concentration was approximately 1%(vol).A series of characterizations of the catalysts revealed that the CuCe/Ti-A catalyst has a larger specific surface area,more Cu+species and oxygen vacancies,and the Cu species of CuCe/Ti-A catalyst is more readily *** situ FT-IR results indicate that the bicarbonate species generated on the CuCe/Ti-A catalyst have lower thermal stability than the carbonate species on CuCe/Ti-R,and will decompose more readily to form CO_(2).Therefore,CuCe/Ti-A has excellent catalytic activity for CO oxidation.

关键词： CO oxidation TiO_(2)crystal phase CuCe/Ti Reaction mechanism

工具变量法在环境流行病学因果推断中的应用与进展

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环境与职业医学 2024年第2期41卷 219-225页

作者：石慧郑古峥玥赵星黄守瑞艾宝卓吴佳隆林华亮中山大学公共卫生学院流行病学系广东广州510080 四川大学华西公共卫生学院四川成都610041

环境流行病学研究中环境暴露广泛而非随机、混杂偏倚较为复杂,对其因果推断带来了巨大的挑战。近年来,随着因果推断方法引入观察性研究中,其为环境流行病学因果推断研究提供了更多统计方法的选择。工具变量法(Ⅳ)作为一种能够很好控制... 详细信息

环境流行病学研究中环境暴露广泛而非随机、混杂偏倚较为复杂,对其因果推断带来了巨大的挑战。近年来,随着因果推断方法引入观察性研究中,其为环境流行病学因果推断研究提供了更多统计方法的选择。工具变量法(Ⅳ)作为一种能够很好控制未测量混杂因素的因果推断方法,逐渐应用在环境流行病学研究领域中。本研究介绍了Ⅳ的基本原理,归纳了目前应用Ⅳ进行环境流行病学因果推断的研究进展与局限性。当前环境流行病领域应用Ⅳ方法进行因果推断研究尚处于初级阶段,合理使用Ⅳ并与其他因果推断方法的有效整合将成为环境流行病学因果推断的发展重点。本研究旨在为我国环境暴露的人群健康效应的因果推断研究提供方法学上的参考和依据。

关键词：工具变量法因果推断环境流行病学环境暴露健康效应应用