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人体生物样本中有机磷类农药前处理以及检测方法的研究进展

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理化检验（化学分册） 2024年第4期60卷 440-448页

作者：陈玉婕刘华良张昊卢宇剑南京医科大学公共卫生学院南京211100 江苏省疾病预防与控制中心理化检验所南京210009

有机磷类农药是目前应用最广泛的农药类别之一,可经呼吸道、消化道、皮肤和黏膜等多途径进入人体,长期暴露会对人体的心血管系统、生殖系统、神经系统造成损伤,甚至会导致癌症。人体生物监测是评估人体环境污染物暴露水平的“金标准”,... 详细信息

有机磷类农药是目前应用最广泛的农药类别之一,可经呼吸道、消化道、皮肤和黏膜等多途径进入人体,长期暴露会对人体的心血管系统、生殖系统、神经系统造成损伤,甚至会导致癌症。人体生物监测是评估人体环境污染物暴露水平的“金标准”,通过对人体组织和体液内(血、尿、母乳等)环境化学物质及其代谢产物的分析,可以精确测量通过不同暴露途径进入人体内的环境化合物总量。为了更好地了解和评估有机磷类农药的人群暴露剂量及其对健康的影响,主要综述了人体生物样本中有机磷类农药的常用前处理方法(液液萃取法、固相萃取法、QuEChERS以及其他方法)及检测方法(气相色谱法、气相色谱-质谱法、气相色谱-串联质谱法和液相色谱-串联质谱法)(引用文献68篇)。

关键词：有机磷类农药人体生物监测前处理方法检测方法

液相色谱-串联质谱法检测人体尿液中12种农药代谢物

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环境与职业医学 2024年第8期41卷 919-924+953页

作者：陈玉婕邓淑铃周永林张昊刘华良南京医科大学公共卫生学院江苏省疾病预防与控制中心理化检验所

[背景]有机磷和拟除虫菊酯等农药应用广泛，环境介质和食品摄入等多途径暴露所导致的人体健康危害不容忽视，有必要基于农药暴露生物标记进行人体内暴露研究，以客观评估人体农药暴露情况。[目的]建立快速、准确测定尿液中12种农药代谢... 详细信息

[背景]有机磷和拟除虫菊酯等农药应用广泛，环境介质和食品摄入等多途径暴露所导致的人体健康危害不容忽视，有必要基于农药暴露生物标记进行人体内暴露研究，以客观评估人体农药暴露情况。[目的]建立快速、准确测定尿液中12种农药代谢物（5种有机磷农药代谢物、4种拟除虫菊酯农药代谢物、2种苯氧乙酸除草剂和1种杀虫剂）的液相色谱-串联质谱法检测方法。[方法]将尿液样品酶解过夜后，经Oasis HLB 96孔固相萃取提取净化，液相色谱-串联质谱法检测，同位素内标法定量。应用建立的方法检测143份普通人群的尿液样品，考察方法的适用性和了解农药的暴露情况。[结果] 12种目标物均具有良好的线性范围，校准曲线相关系数均大于0.999；方法检出限为0.02～0.19μg·L-1，方法定量限为0.06～0.27μg·L-1。在低、中、高3个浓度加标水平下，方法的回收率在84%～112%之间，日内精密度为0.43%～9.6%，日间精密度为1.6%～9.7%。基于本方法，测定了143份江苏地区的尿液样品，除N,N-二乙基甲苯胺（DEET）外的其他11种农药均有检出。[结论]本研究建立的固相萃取-液相色谱-串联质谱法，具有检出限低、重复性好、通量高的特点，适用于大批量人体尿液样品中12种农药暴露的定量检测，可为农药的内暴露监测和健康风险评估提供技术支撑。

关键词：农药代谢物液相色谱-串联质谱法尿液人体生物监测内暴露

Insight into Urban Faults by Wavelet Multi-Scale Analysis and Modeling of Gravity Data in Shenzhen,China

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Journal of Earth Science 2018年第6期29卷 1340-1348页

作者： Chuang Xu Haihong Wang Zhicai Luo hualiang liu Xiangdong liu MOE Key Laboratory of Fundamental Physical Quantities Measurement School of PhysicsHuazhong University of Science and Technology School of Geodesy and Geomatics Wuhan University Key Laboratory of Geospace Environment and Geodesy Ministry of EducationWuhan University China Water Resources Beifang Investigation Design and Research Co.Ltd.

Urban faults in Shenzhen are potential threats to city security and sustainable development. In consideration of the importance of the Shenzhen fault zone, the author provide a detailed interpretation on gravity data model. Bouguer gravity covering the whole Shenzhen City was calculated with a 1-km resolution. Wavelet multi-scale analysis（MSA） was applied to the Bouguer gravity data to obtain the multilayer residual anomalies corresponding to different depths. In addition, 2D gravity models were constructed along three profiles. The Bouguer gravity anomaly shows an NE-striking high-low-high pattern from northwest to southeast, strongly related to the main faults. According to the results of MSA, the correlation between gravity anomaly and faults is particularly significant from 4 to 12 km depth. The residual gravity with small amplitude in each layer indicates weak tectonic activity in the crust. In the upper layers, positive anomalies along most of faults reveal the upwelling of high-density materials during the past tectonic movements. The multilayer residual anomalies also yield important information about the faults, such as the vertical extension and the dip direction. The maximum depth of the faults is about 20 km. In general, NE-striking faults extend deeper than NW-striking faults and have a larger dip angle.

关键词： urban faults Bouguer gravity anomaly wavelet multi-scale analysis gravity modeling Shenzhen

小麦叶锈菌2个候选效应因子的克隆及其qRT-PCR分析

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现代农业研究 2024年第2期30卷 99-102页

作者：李建嫄李林刘华梁杜军霞郭丽邢台学院生物科学与工程学院河北邢台054001

小麦叶锈病是由隐匿柄锈菌(Puccinia triticina,Pt)侵染的一种气传性真菌病害,对小麦造成严重的产量损失。Pt产生的吸器是产生效应因子的主要场所,而效应因子是Pt致病的关键。本研究基于早期构建的小麦叶锈菌单胞菌系13-5-28-1(JHKT)在... 详细信息

小麦叶锈病是由隐匿柄锈菌(Puccinia triticina,Pt)侵染的一种气传性真菌病害,对小麦造成严重的产量损失。Pt产生的吸器是产生效应因子的主要场所,而效应因子是Pt致病的关键。本研究基于早期构建的小麦叶锈菌单胞菌系13-5-28-1(JHKT)在休眠孢子、萌发夏孢子和侵染6 d的转录组文库,在系统筛选候选效应因子的基础上,选取两个候选效应因子Pt12448和Pt34354进行克隆,利用qRT-PCR分析候选效应因子的表达模式,结果发现其中Pt12448基因表现为后期诱导上调,Pt34354基因则为前期诱导上调。研究结果将推进对小麦叶锈菌致病机制的研究进程。

关键词：小麦叶锈菌效应因子 qRT-PCR

基于头颈CTA的牙周炎与动脉粥样硬化相关性研究

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中国病案 2024年第7期25卷 104-107页

作者：刘华亮张苗单艺梁萌赵国华徐冰北京市顺义区医院放射科北京市101300 首都医科大学宣武医院放射与核医学科磁共振成像脑信息学北京市重点实验室北京市100053

目的基于头颈CTA检查探讨牙周炎严重程度与头颈动脉粥样硬化的关系,对脑血管病预防提供参考。方法收集某医院2022年1月1日-2023年7月31日行头颈CTA检查、并于一周内在口腔科做牙周检查的87例患者,根据牙周炎诊断标准分为四组:无牙周炎组... 详细信息

目的基于头颈CTA检查探讨牙周炎严重程度与头颈动脉粥样硬化的关系,对脑血管病预防提供参考。方法收集某医院2022年1月1日-2023年7月31日行头颈CTA检查、并于一周内在口腔科做牙周检查的87例患者,根据牙周炎诊断标准分为四组:无牙周炎组(19例),轻度牙周炎组(24例),中度牙周炎组(23例),重度牙周炎组(21例)。详细记录并比较四组病例性别、年龄、头颈动脉不同程度狭窄、狭窄血管段数及斑块类型有无差别。结果四组病例的性别、年龄没有统计学差异(P>0.05)。有牙周炎组血管狭窄占比(95.8%~100%)明显高于无牙周炎组(42.1%);牙周炎程度越重,血管狭窄占比越高,狭窄程度越重(P0.05);斑块总数有统计学差异(49~226枚),牙周炎程度越重,斑块数量越多(P<0.05)。结论牙周炎和头颈动脉粥样硬化密切相关,积极治疗牙周炎对预防脑血管病有重要临床意义。

关键词：牙周炎计算机体层成像血管造影术头颈动脉动脉粥样硬化斑块

Geochemistry, zircon U–Pb geochronology, and Hf isotopes of S-type granite in the Baoshan block, constraints on the age and evolution of the Proto-Tethys

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Acta Geochimica 2024年第1期43卷 40-58页

作者： Jianjun Zhang Chuanlong Mou Chendong liu Yong Zhang Ting Chen hualiang Li Institute of Geological Survey East China University of TechnologyNanchang 330013China School of Earth Sciences East China University of TechnologyNanchang 330013China Chengdu Geological Survey Center Chengdu 610081China School of Water Resources&Environmental Engineering East China University of TechnologyNanchang 330013China

Geochemistry, zircon U–Pb geochronology, and Hf isotope data for the Early Paleozoic granites in the Baoshan Block reveal the Early Paleozoic tectonic evolution of the Proto-Tethys. The samples are high-K, calcalkaline, strongly peraluminous rocks with A/CNK values of 1.37–1.46, are enriched in SiO2, K2O, and Rb, and are depleted in Nb, P, Ti, Eu, and heavy rare earth elements,which indicates the crystallization fractionation of the granitic magma. Zircon U–Pb dating indicates that they formed in ca. 480 Ma. The Nansa granites have εHf(t) values ranging from-16.04 to 4.36 with corresponding TC DMages of 2.10–0.81 Ga, which suggests the magmas derived from the partial melting of ancient metasedimentary with minor involvement of mantle-derived components. A synthesis of data for the Early Paleozoic igneous rocks in the Baoshan block and adjacent(Tengchong,Qiangtang, Sibumasu, Himalaya, etc.) blocks indicates that these blocks were all aligned along the proto-Tethyan margin of East Gondwana in the Early Paleozoic. The Early Paleozoic S-type granites from Nansa were generated in a high-temperature and low-pressure(HTLP) extensional tectonic setting, which resulted from Andean-type orogeny instead of the final assembly of Gondwana or crustal extension in a non-arc environment. In certain places, an expanding environment may exist in opposition to the tectonic backdrop of the lithosphere’s thickening and shortening, leading the crust to melt and decompress,mantle-derived materials to mix, and a small quantity of peraluminous granite to emerge.

关键词： Baoshan block Early Paleozoic Granite Geochemistry Zircon Geochronology Hf isotope

Ionic liquid-assisted preparation of hydroxyapatite and its catalytic performance for decarboxylation of itaconic acid

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Chinese Journal of Chemical Engineering 2024年第3期67卷 9-15页

作者： Shutong Pang hualiang An Xinqiang Zhao Yanji Wang Hebei Provincial Key Laboratory of Green Chemical Technology and Efficient Energy Saving Tianjin Key Laboratory of Chemical Process SafetySchool of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China

The synthesis of methacrylic acid from biomass-derived itaconic acid is a green route,for it can get rid of the dependence on fossil *** order to solve the problems on this route such as use of a preciousmetal catalyst and a corrosive homogeneous alkali,we prepared a series of hydroxyapatite catalysts by an ionic liquid-assisted hydrothermal method and evaluated their catalytic *** results showed that the ionic liquid[Bmim]BF_(4) can affect the crystal growth of hydroxyapatite,provide fluoride ion for fluorination of hydroxyapatite,and adjust the surface acidity and basicity,morphology,textural properties,crystallinity,and composition of ***[Bmim]BF4 dosage and hydrothermal temperature can affect the fluoride ion concentration in the hydrothermal system,thus changing the degree of fluoridation of *** fluoride-ion concentration can lead to the formation of CaF_(2) and thus significantly decrease the catalytic performance of *** hydrothermal time mainly affects the growth of hydroxyapatite crystals on the c axis,leading to different catalytic *** suitable conditions for the preparation of this fluoridized hydroxyapatite are as follows:a mass ratio of[Bmim]BF4 to calcium salt=0.2:1,a hydrothermal time of 12 h,and a hydrothermal temperature of 130℃.A maximal methacrylic acid yield of 54.7%was obtained using the fluoridized hydroxyapatite under relatively mild reaction conditions(250℃ and 2 MPa of N_(2))in the absence of a precious-metal catalyst and a corrosive homogeneous alkali.

关键词： Ionic liquid Hydroxyapatite Itaconic acid Methacrylic Decarboxylation reaction

Exposure to Acrylamide in the Sixth Total Diet Study-China,2016-2019

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China CDC weekly 2022年第9期4卷 161-164页

作者： Feng Zhu Yuxin Wang hualiang liu Bing Lyu Dawei Chen Jingguang Li Wenliang Ji Yunfeng Zhao Yongning Wu Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsu ProvinceChina NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina

Summary What is already known about this topic?Acrylamide(AA)is toxic and potentially carcinogenic and could be formed during the cooking *** is understood that almost all foods cooked at high temperature contain AA,especially fried *** exposure of AA in food threatens human *** is added by this report?In the Sixth China Total Diet Study(TDS),AA was detected in 73.3%samples of the 12 food categories with the concentrations ranging from undetected to 176.90μg/*** average dietary intake of AA was 0.175μg/kg body weight per day and a significant decrease(45.1%)was observed compared with the Fifth China *** the 12 food categories,vegetables(59.0%),cereals(18.9%),and potatoes(10.1%)were the main contributors to AA exposure at 88.0%.What are the implications for public health practice?This study highlighted the need to continuously monitor dietary acrylamide exposure in China,including changing food processing methods and making reasonable selection of foodstuffs in the daily diet.

关键词： cooking stuff Total

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苏云金芽胞杆菌微滤浓缩液表观黏度模型

农业工程学报 2005年第2期21卷 25-29页

作者：刘华亮陈守文孙明喻子牛农业微生物国家重点实验室微生物农药国家工程研究中心华中农业大学生命科学与技术学院武汉430070

在30℃、电机转速为75～750r/min下测定了苏云金芽胞杆菌发酵液及其微滤浓缩液的流变特性。分析结果表明苏云金芽胞杆菌发酵液及其微滤浓缩液为拟塑性流体,表观黏度随剪切速率增大而减小,随着浓度的上升,拟塑性增强。表观黏度随着温度... 详细信息

在30℃、电机转速为75～750r/min下测定了苏云金芽胞杆菌发酵液及其微滤浓缩液的流变特性。分析结果表明苏云金芽胞杆菌发酵液及其微滤浓缩液为拟塑性流体,表观黏度随剪切速率增大而减小,随着浓度的上升,拟塑性增强。表观黏度随着温度的上升和浓度的降低而下降,温度对表观黏度的影响符合Arrhenius方程。不同浓度浓缩液的流动活化能变化不大,浓度对表观黏度的影响比温度的影响显著。分析和计算了浓度和温度对苏云金芽胞杆菌浓缩液表观黏度综合影响的数学模型及其参数,它可用于预测在不同温度条件下苏云金芽胞杆菌发酵液在微滤过程中的表观黏度。

关键词：苏云金芽胞杆菌微滤浓缩液流变特性表观黏度