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Simultaneous Degradation, Dehalogenation, and Detoxification of Halogenated Antibiotics by Carbon Dioxide Radical Anions

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Engineering 2024年第6期37卷 78-86页

作者： Yanzhou Ding Xia Yu Shuguang Lyu huajun zhen Wentao Zhao Cheng Peng Jiaxi Wang Yiwen Zhu Chengfei Zhu Lei Zhou Qian Sui State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai 200237China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Academy of Environmental Sciences Shanghai 200233China

Despite the extensive application of advanced oxidation processes(AOPs)in water treatment,the efficiency of AOPs in eliminating various emerging contaminants such as halogenated antibiotics is constrained by a number of *** moieties exhibit strong resistance to oxidative radicals,affecting the dehalogenation and detoxification *** address these limitations of AOPs,advanced reduction processes(ARPs)have been ***,a novel nucleophilic reductant—namely,the carbon dioxide radical anion(CO_(2)^(·-))—is introduced for the simultaneous degradation,dehalogenation,and detoxification of florfenicol(FF),a typical halogenated *** results demonstrate that FF is completely eliminated by CO_(2)^(·-),with approximately 100%of Cland 46%of Freleased after 120 min of *** detoxification is observed,which exhibits a linear response to the release of free inorganic halogen ions(R2=0.97,p75%)in degrading a series of halogenated antibiotics,including chloramphenicol(CAP),thiamphenicol(THA),diclofenac(DLF),triclosan(TCS),and ciprofloxacin(CIP).The system shows high tolerance to the pH of the solution and the presence of natural water constituents,and demonstrates an excellent degradation performance in actual groundwater,indicating the strong application potential of CO_(2)^(·-)-based ARPs in real ***,this study elucidates the feasibility of CO_(2)^(·-)for the simultaneous degradation,dehalogenation,and detoxification of halogena

关键词： Carbon dioxide radical anions Advanced reduction processes Halogenated antibiotics Dehalogenation Detoxification

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基于非依赖数据采集的呼出气冷凝液蛋白质组加权基因共表达网络分析

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华东理工大学学报（自然科学版） 2022年第5期48卷 649-656页

作者：马琳孙东晓镇华君修光利华东理工大学国家环境保护化工过程环境风险评价与控制重点实验室上海200237 宾夕法尼亚州立大学医学院质谱中心美国PA 17033

呼出气冷凝液(Exhaled Breath Condensate,EBC)是一种呼吸道衬液,其收集过程无创、便捷,常常被作为肺部疾病研究的载体。建立了基于DIA(Data-Independent Acquisition)的EBC蛋白组学方法,共鉴定到2052个蛋白。通过加权基因共表达网络分... 详细信息

呼出气冷凝液(Exhaled Breath Condensate,EBC)是一种呼吸道衬液,其收集过程无创、便捷,常常被作为肺部疾病研究的载体。建立了基于DIA(Data-Independent Acquisition)的EBC蛋白组学方法,共鉴定到2052个蛋白。通过加权基因共表达网络分析(Weighted Gene Co-expression Network Analysis,WGCNA)筛选出61个关键蛋白,分析发现这些关键蛋白活跃参与多个与人类疾病相关的代谢通路。结果表明,基于DIA的EBC蛋白组学方法,结合WGCNA分析,可以有效地挖掘出EBC中与疾病相关的生物标志物,未来可应用于大规模的临床研究。

关键词：呼出气冷凝液非依赖数据采集加权基因共表达网络分析蛋白质组学生物信息学

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孕烷X受体双荧光素酶报告基因方法建立及有机磷酸酯阻燃剂的受体激活效应研究

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生态毒理学报 2023年第2期18卷 33-43页

作者：吴一凡聂青宇郑静怡镇华君修光利华东理工大学资源与环境工程学院上海200237 上海市环境保护化学污染物环境标准与风险管理重点实验室上海200237 国家环境保护化工过程环境风险评价与控制重点实验室上海200237 上海污染控制与生态安全研究院上海200092

孕烷X受体(pregnane X receptor,PXR)是一种调控生物体异源性/内源性物质代谢的核受体。环境污染物可介由PXR改变人体代谢稳态进而增加多种代谢性疾病风险,但目前尚缺乏一种灵敏、稳定的检测化学品PXR结合活性的体外实验方法。本研究基... 详细信息

孕烷X受体(pregnane X receptor,PXR)是一种调控生物体异源性/内源性物质代谢的核受体。环境污染物可介由PXR改变人体代谢稳态进而增加多种代谢性疾病风险,但目前尚缺乏一种灵敏、稳定的检测化学品PXR结合活性的体外实验方法。本研究基于重组基因技术构建了带有海肾荧光素酶基因的pBIND-hPXR表达质粒,将其与插入上游激活序列的荧光素酶报告基因质粒GAL4-UAS-Luc共转染至HEK 293T细胞,最终成功建立了一种可筛查化学品人孕烷X受体激动/拮抗作用的双荧光素酶报告基因检测方法,该方法具有灵敏度高、适用范围广和重复性好的特点。进一步检测了9种典型有机磷酸酯(organophosphate esters,OPEs)阻燃剂的hPXR激活效应,结果表明芳基类OPEs的激活活性强于氯代和烷基类OPEs,其中磷酸三甲苯酯(TCP)的20%最大效应浓度(基于阳性对照)及最大激活效应值和已知的hPXR强激动剂利福平相当。此外,首次发现2-乙基己基二苯基磷酸酯(EHDPP)在略高于人体血液最高检出浓度(80 nmol·L^(-1))的染毒组(316.2 nmol·L^(-1))即表现出显著的hPXR激活效应。本方法有助于研究化学品对PXR受体信号通路的扰动作用,并为OPEs类化学品的健康风险评估提供科学依据。

关键词：有机磷酸酯阻燃剂孕烷X受体报告基因检测化学品健康风险

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基于HepG2细胞脂质组学方法对黄浦江水质的综合评价

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生态毒理学报 2021年第4期16卷 141-150页

作者：印月镇华君修光利上海市环境保护化学污染物环境标准与风险管理重点实验室华东理工大学资源与环境工程学院上海200237 国家环境保护化工过程环境风险评价与控制重点实验室华东理工大学资源与环境工程学院上海200237 上海污染控制与生态安全研究院上海200092

环境水体中复合污染的毒性识别一直是环境科学界关注的热点。基于代谢组学的生物监测方法通过监测暴露前后生物内源性代谢物的变化,在评估复合污染导致的综合毒性效应中具有广泛的应用前景。本研究从污染物对细胞脂类代谢的影响角度出发... 详细信息

环境水体中复合污染的毒性识别一直是环境科学界关注的热点。基于代谢组学的生物监测方法通过监测暴露前后生物内源性代谢物的变化,在评估复合污染导致的综合毒性效应中具有广泛的应用前景。本研究从污染物对细胞脂类代谢的影响角度出发,采用体外肝癌细胞(HepG2)暴露和脂质组分析相结合的方法,对黄浦江干流和支流共27个采样点的水质进行了综合评价。研究发现,水样对HepG2细胞的脂代谢影响程度与采样点所属河段紧密相关。黄浦江中游水样对HepG2细胞的平均脂代谢影响程度(3.40%)高于上游(1.65%)和下游(0.78%),而流经城区的支流水样对细胞的脂代谢影响(5.20%)明显高于干流水样(1.80%)。此外,在采集的水样中超过70%的样品都导致HepG2细胞内甘油三酯(TG)大量蓄积,揭示了黄浦江水体中的复合污染物可能诱导肝脏产生脂毒性损伤。本研究为环境水质监测提供新的方法,研究结果为上海市生态环境和水质安全管理部门提供重要的参考信息。

关键词：复合污染物 HepG2细胞综合毒性评价脂质组学黄浦江

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致密储层水平井外裂缝与地层界面远探测声波测井响应特征研究

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地球物理学报 2024年第6期67卷 2439-2454页

作者：张梦生刘鹏范华军李振赵浩姜京伟冯周王克文李雨生武宏亮中国石油大学(北京)油气资源与工程全国重点实验室北京102249 中国石油勘探开发研究院北京100083 成都理工大学油气藏地质及开发工程全国重点实验室成都610059

致密砂岩和页岩等非常规储层中常发育有密集小尺度和高角度裂缝.这些裂缝一方面起到增加储层渗透性的积极作用,另一方面在油气开采、水力压裂、注二氧化碳等过程中,它们又可能引起水平井孔套变和邻井压窜等风险.因此,考察这些裂缝的水... 详细信息

致密砂岩和页岩等非常规储层中常发育有密集小尺度和高角度裂缝.这些裂缝一方面起到增加储层渗透性的积极作用,另一方面在油气开采、水力压裂、注二氧化碳等过程中,它们又可能引起水平井孔套变和邻井压窜等风险.因此,考察这些裂缝的水平井远探测声波测井响应特征,以及进一步利用远探测方法识别这些裂缝具有重要研究意义.本文构建了致密储层水平井外存在裂缝的三维数值模型,并开展了正演模拟研究.结果表明,当裂缝与井孔夹角较小时,井孔内接收器主要接收裂缝反射波.当夹角大于某临界值后,接收波形主要为来自裂缝两个端点的散射波,它们分裂为两个波包.进一步提出广义SH散射波概念,即声源的偏振方向与裂缝走向平行的横波,它总是代表了所有方位上散射能量最强的方位.水平井外同时存在裂缝和强声阻抗地层界面是更为普遍的情况.相关模拟结果表明,裂缝散射波的主要能量集中在广义SH散射波上.随着地层界面和裂缝走向差异的增大,裂缝对应的广义SH散射波更容易识别.最后,通过一口水平井远探测实例验证了正演模拟结论的准确性.本文研究对识别和评价非常规储层水平井外小尺度裂缝具有重要理论意义.

关键词：水平井远探测声波测井裂缝地层界面散射波广义SH散射波

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The genome and transcriptome of the hydatid tapeworm Echinococcus granulosus

The genome and transcriptome of the hydatid tapeworm Echinoc...

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第四届全国人畜共患病学术研讨会2014年中国狂犬病年...

作者： Wenbao Zhang Zhuangzhi Zhang huajun zhen Jun Li Hui Wang Baoxin Shi Yan Zhou Shengyue Wang Donald P.McManus Hao Wen Clinical Medical Research Institute The First Affiliated Hospital of Xinjiang Medical University Veterinary Research Institute Xinjiang Academy of Animal Sciences Shanghai–Ministry of Science and Technology Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at Shanghai

＜正＞Cystic echinococcosis （hydatid disease）,caused by the tapeworm Echinococcus granulosus,is responsible for considerable human morbidity and *** cosmopolitan disease is difficult to diagnose,treat and *** sequenced the whole genomic sequence for the worm comprising 151.6 Mb encoding 11,325 *** with the genome sequences from other taxa show that *** has acquired a spectrum of genes,including the EgAgB family,whose products are secreted by the parasite to interact and redirect host immune *** also found that genes in bile salt pathways may control the bidirectional development of E

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A Priori Subcell Limiting Approach for the FR/CPR Method on Unstructured Meshes

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Communications in Computational Physics 2022年第4期31卷 1215-1241页

作者： Guo-Quan Shi huajun Zhu zhen-Guo Yan State Key Laboratory of Aerodynamics MianyangSichuan 621000China College of Aerospace Science and Engineering National University of Defense TechnologyChangshaHunan 410073China

A priori subcell limiting approach is developed for high-order flux reconstruction/correction procedure via reconstruction(FR/CPR)methods on twodimensional unstructured ***,a modified indicator based on modal energy coefficients is proposed to detect troubled cells,where discontinuities ***,troubled cells are decomposed into nonuniform subcells and each subcell has one solution point.A second-order finite difference shock-capturing scheme based on nonuniform nonlinear weighted(NNW)interpolation is constructed to perform the calculation on troubled cells while smooth cells are calculated by the CPR *** investigations show that the proposed subcell limiting strategy on unstructured quadrilateral meshes is robust in shock-capturing.

关键词： Flux reconstruction/correction procedure via reconstruction shock capturing subcell limiting unstructured meshes

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In-situ TEM study on the evolution of dislocation loops and bubbles in CeO_(2)during Kr^(+)single-beam and Kr^(+)-H_(2)^(+)dual-beam synergetic irradiation

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Journal of Materials Science & Technology 2022年第28期123卷 49-59页

作者： Ziqi Cao Guang Ran zhen Wang Yipeng Li Xiaoyong Wu Lu Wu Xiuyin Huang huajun Mo College of Energy Xiamen UniversityXiamen 361102China The First Sub-Institute Nuclear Power Institute of ChinaChengdu 610041China Fujian Provincial Nuclear Energy Engineering Technology Research Center Xiamen 361102China

CeO_(2)is widely used as the nonradioactive surrogate fuel of UO_(2)when studying the irradiation performance of UO_(2).The evolution and characteristics of dislocation loops and bubbles in CeO_(2)foils were studied by in-situ transmission electron microscopy(TEM)observation during 400 ke V Kr^(+)&30 ke V H_(2)^(+)dual-beam synergetic irradiation and 400 ke V Kr^(+)single-beam irradiation at 1073 *** rotation of the habit plane of dislocation loops induced by above ion irradiation was found in the CeO_(2)for the first time,such as from[211]to[311]and then to[100].The rafted loops were first observed under Kr^(+)&H_(2)^(+)dual-beam synergetic irradiation,which not only had similar[111]direction,but also belonged to perfect dislocation loops(PDLs).The rafted loops were formed not only by the growth of loops that absorbed irradiation defects,but also by the combination of ***,this phenomenon of loop rafting was not obvious during Kr single-beam *** was first found that Kr^(+)irradiation induced the change of Burgers vectors of *** absorption of large PDLs to small PDLs was also *** average size and areal number density of dislocation loops and gas bubbles as a function of irradiation dose were constructed,which showed that the addition of H_(2)^(+)obviously affected the characteristics of dislocation loops and gas bubbles and the swelling of CeO_(2).

关键词： Nuclear Fuel Cerium dioxide In-situ TEM Irradiation Dislocation Bubbles

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Observer-based backstepping longitudinal control for carrier-based UAV with actuator faults

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Journal of Systems Engineering and Electronics 2017年第2期28卷 322-337页

作者： Fengying zheng Ziyang zhen huajun Gong College of Astronautics Nanjing University of Aeronautics and Astronautics Nanjing 210016 China College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The paper presents the longitudinal control for the carrier-based unmanned aerial vehicle (UAV) system with unmeasured states, actuator faults, control input constraints, and external disturbances. By combining output state observer, adaptive fuzzy control, and constraint backstepping technology, a robust fault tolerant control approach is proposed. An output state observer with fuzzy logic systems is developed to estimate unmeasured states, and command filters rather than differentiations of virtual control law are used to solve the computational complexity problem in traditional backstepping. Additionally, a robust term is introduced to offset the fuzzy adaptive estimation error and external disturbance, and an appropriate fault controller structure with matching conditions obtained from fault compensation is proposed. Based on the Lyapunov theory, the designed control program is illustrated to guarantee that all the closed-loop signals of the given system are bounded, and the output errors converge to a small neighborhood of zero. A carrier-based UAV nonlinear longitudinal model is employed to testify the feasibility and validity of the control scheme. The simulation results show that all the controllers can perform at a satisfactory level of reference tracking despite the existence of unknown aerodynamic parameters and actuator faults. © 2017 Beijing Institute of Aerospace Information.

关键词： Actuators Aircraft control Backstepping Control system analysis Control theory Controllers Error compensation Fault tolerance Flight control systems Fuzzy control Fuzzy filters Fuzzy logic State estimation Three term control systems Unmanned aerial vehicles (UAV)

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Long-term asymptomatic SARS-CoV-2 infection associated with deficiency on multiple immune cells

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Biosafety and Health 2022年第3期4卷 205-208页

作者： Gang He Xia Chuai Dan Liang Chunyu Chen Changzheng Hu Changwen Ke Bixia Ke Peilin zhen huajun Zhang Jiangmen Central Hospital affiliated with Jiangmen Hospital of Sun Yat-Sen University Jiangmen 529000China Department of Pathogenic Biology Hebei Medical UniversityShijiazhuangHebei 050017China Guangdong Center for Disease Control and Prevention Guangzhou 511430China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China

The immune responses and the function of immune cells among asymptomatic severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)infection cases,especially in immuno‐compromised individuals,remain largely *** we present a case of asymptomatic SARS‐CoV‐2 infection that lasted for at least 67 *** patient has administrated Thymalfasin as 1.6 mg per dose every other day from Day 45 to 70,plus 200 mg per dose Arbidol antiviral therapy three doses per day from Day 48 to *** the infection,no anti‐SARS‐CoV‐2 specific IgM or IgG antibodies were ***,the patient showed either a low percentage or an absolute number of non‐classical monocytes,dendritic cells(DCs),CD4^(+)T cells,and regulatory T cells(Tregs),which may account for the clinical feature and absence of antibody *** case may shed new light on the outbreak management related to control/prevention,treatment,and vaccination of SARS‐CoV‐2 and other virus infections in immunocompromised individuals.

关键词： SARS‐CoV‐2 COVID‐19 Asymptomatic infection Antibody response Immune cells

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