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Vitamin D receptor and its protective role in diabetic nephropathy

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Chinese Medical Journal 2014年第2期127卷 365-369页

作者： Guan Xiaoling Yang huajie zhang Wei Wang Huanjun Liao Lin Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Shandong University Jinan Shandong 250012 China Department of Cadres Health Care Shandong Provincial Qianfoshan Hospital Shandong University Jinan Shandong 250012 China

Objective To review the advances of studies on vitamin D receptor and its role in the pathogenesis of diabetic nephropathy.Data sources A comprehensive search of the PubMed literatures without restriction on the publication date was carried out using keywords such as vitamin D receptor and diabetic nephropathy.Study selection Articles related to vitamin D receptor and diabetic nephropathy were selected and carefully analyzed.Results The ligands as well as construction and tissue distribution of vitamin D receptor were summarized.Pathogenesis of diabetic nephropathy was analyzed.The mechanisms underlying the renoprotective role of vitamin D receptor including inhibition of renin-angiotensin system,anti-inflammation,anti-fibrosis and the reduction of proteinuria were reviewed.Mounting evidences from animal and clinical studies have suggested that vitamin D therapy has beneficial effects on the renal systems and the underlying renoprotective mechanisms of the vitamin D receptor-mediated signaling pathways is a hot research topic.Conclusion Our study suggests that vitamin D receptor has a great potential for preventing the progression of diabetic nephropathy via multiple mechanisms.

关键词： diabetic nephropathy vitamin D renin-angiotensin system proteinuria

Ru(bpy)_(3)^(2+)-sensitized{001}facets LiCoO_(2) nanosheets catalyzed CO_(2) reduction reaction with 100% carbonaceous products

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Nano Research 2022年第2期15卷 1061-1068页

作者： Shuaiyu Jiang Junxian Liu Kun Zhao Dandan Cui Porun Liu huajie Yin Mohammad Al-Mamun Sean ELowe Weiping zhang Yu Lin Zhong Jun Chen Yun Wang Dan Wang Huijun Zhao Centre for Catalysis and Clean Energy Gold Coast campusGriffith UniversityQLD 4222Australia Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science University of WollongongWollongongNSW 2500Australia Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangzhou Key Laboratory of Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China State Key Laboratory of Biochemical Engineering CAS Centre for Excellence in NanoscienceInstitute of Process EngineeringChinese Academy of ScienceBeijing 100190China

Photosensitized heterogeneous CO_(2) reduction(PHCR)has emerged as a promising means to convert CO_(2) into valuable chemicals,however,challenged by the relatively low carbonaceous product selectivity caused by the competing hydrogen evolution reaction(HER).Here,we report a PHCR system that couples Ru(bpy)32+photosensitizer with{001}faceted LiCoO_(2) nanosheets photocatalyst to simultaneously yield 21.2 and 722μmol·g^(-1)·h^(-1) of CO,and 4.42 and 108μmol·g^(-1)·h^(-1) of CH4 under the visible light and the simulated sunlight irradiations,respectively,with completely suppressed HER.The experimental and theoretical studies reveal that the favored CO_(2) adsorption on the exposed Li sites on{001}faceted LiCoO_(2) surface is responsible for the completely suppressed HER.

关键词： homogeneous-heterogeneous catalysis system ultrathin LiCoO_(2)nanosheets photocatalytic CO_(2)reduction suppressed hydrogen evolution reaction

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多层并联压电作动器快速响应的尺寸优选

轻工机械 2024年第2期42卷 68-74页

作者：张统江水东柏宏武窦晓军胡凯明江洪葛黄徐张华杰赵梦石宦荣华浙江大学航空航天学院浙江杭州310012 航天跃盛(杭州)信息技术有限公司浙江杭州310024 西安空间无线电技术研究所陕西西安710199 国家电网有限公司北京100000 中国计量大学机电工程学院浙江杭州310016 国网浙江省电力有限公司嘉兴供电公司浙江嘉兴314500

压电作动器是星载卫星天线高精度形面控制的主要元件,但其在工作时加载电压后容易引起瞬态和残余振动,影响控制稳定性和控制精度。针对压电结构在动态形状主动控制过程中的振动抑制问题,课题组设计了一种具有位移放大的多层并联压电作... 详细信息

压电作动器是星载卫星天线高精度形面控制的主要元件,但其在工作时加载电压后容易引起瞬态和残余振动,影响控制稳定性和控制精度。针对压电结构在动态形状主动控制过程中的振动抑制问题,课题组设计了一种具有位移放大的多层并联压电作动器结构,并对压电作动器在阶跃激励下的瞬态响应进行分析,揭示了中间层材料和结构尺寸等关键参数对作动器响应速度的影响规律,提出了压电双晶片作动器快速响应的尺寸优选方案。研究结果表明设计的压电作动器具有输出位移大、响应速度快的特点。该研究可为大型天线形面主动控制的高精度作动器研制提供依据和技术支撑。

关键词：多层并联压电作动器阶跃响应压电双晶片振动抑制

Effect of Y and Ce on the microstructure, mechanical properties and anisotropy of as-rolled Mg-8Li-1Al alloy

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Journal of Materials Science & Technology 2020年第4期39卷 124-134页

作者： Feng Zhong huajie Wu Yunlei Jiao Ruizhi Wu Jinghuai zhang Legan Hou Milin zhang Key Laboratory of Superlight Material and Surface Technology(Harbin Engineering University) Ministry of EducationHarbin 150001China College of Science Heihe UniversityHeihe UniversityHeihe 164300China Tianjin Institute of Aerospace Mechanical and Electrical Equipment Tianjin 300301China

The effects of combined addition of Y and Ce on the microstructure,mechanical properties and anisotropy of as-rolled Mg-8 Li-1 Al(LA81)alloy were studied.The combined addition of Y and Ce improves the mechanical properties with a low plasticity loss by solution strengthening,dispersion strengthening,grain refinement strengthening.Mg-8 Li-1 Al-0.6 Y-0.6 Ce(LA81-0.6 Y-0.6 Ce)has better mechanical properties and shows an almost isotropy.It possesses an ultimate tensile strength of 278.7 MPa and an elongation of 15.0%.Compared to LA81 alloy,the ultimate tensile strength increases by about 17.6%with an elongation reduction of only 3.5%,and a good isotropy of ultimate tensile strength and elongation(the value of ravg is near 1).

关键词： Mg-Li alloy Cross rolling Alloying Mechanical properties Anisotropy

Microstructural Characterization of the Shear Bands in Fe-Cr-Ni Single Crystal by EBSD

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Journal of Materials Science & Technology 2008年第6期24卷 819-828页

作者： huajie YANG J.H.zhang Yongbo XU Marc Andre＇ Meyers Shenyang National Laboratoryof Materials Sciences Institute of Metal Researchl Chinese Academy of Sciences Shenyang 110016 China University of California San Diego La Jolla CA92093-0411 USA

An investigation has been made into the microstructural characterization of the shear bands generated under high-strain rate （≈10^4 s^-1） deformation in Fe-15%Cr-15%Ni single crystal by EBSD-SEM （electron backscatter diffraction-scanning electron microscopy）, TEM （transmission electron in microscopy） and HREM （high- resolution electron microscopy）. The results reveal that the propagation of the shear band exhibits an asymmetrical behavior arising from inhomogenous distribution in plasticity in the bands because of different resistance to the collapse in different crystallographic directions; The γ-ε-α′phase transformations may take place inside and outside the bands, and these martensitic phases currently nucleate at intersections either between the twins and deformation bands or between the twins and ε-sheet. Investigation by EBSD shows that recrystallization can occur in the bands with a grain size of an average of 0.2μm in diameter. These nano-grains are proposed to attribute to the results of either dynamic or static recrystallization, which can be described by the rotational recrystallization mechanism. Calculation and analysis indicate that the strain rate inside the shear band can reach 2.50×10^6 s^-1, which is higher, by two or three orders of magnitude, than that exerted dynamically on the specimen tested.

关键词： High-strain rate deformation Adiabatic shear band Electron backscatter diffraction （EBSD） Recrystallization Fe-Cr-Ni single crystal

四川盆地公山庙油田中侏罗统沙溪庙组一段致密油藏流体渗流特征

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天然气勘探与开发 2024年第1期47卷 73-82页

作者：周克明袁小玲刘婷芝余华洁缪海燕张琳羚王艳何家欢肖红林宋林珂张容中国石油西南油气田公司勘探开发研究院四川成都610041 中国石油西南油气田公司致密油气勘探开发项目部四川成都610051 中国石油川庆钻探工程有限公司地质勘探开发研究院四川成都610051

针对致密油藏岩石孔隙结构复杂、流体渗流阻力大、油气产量低、开发效益较差等问题,以四川盆地中部地区(简称“川中地区”)公山庙油田中侏罗统沙溪庙组一段低渗透、特低渗透致密砂岩油藏为例,在储层岩石润湿性实验基础上,开展了流体低... 详细信息

针对致密油藏岩石孔隙结构复杂、流体渗流阻力大、油气产量低、开发效益较差等问题,以四川盆地中部地区(简称“川中地区”)公山庙油田中侏罗统沙溪庙组一段低渗透、特低渗透致密砂岩油藏为例,在储层岩石润湿性实验基础上,开展了流体低速渗流实验、恒速水驱油实验和自发渗吸实验等多项研究。研究结果表明:①川中地区公山庙油田沙一段致密油藏的储层岩石总体上呈弱亲水性特征,在完全饱和地层水条件下的水相渗流曲线为一条直线,且经过坐标原点,地层水单相渗流符合达西定律且不存在启动压力或启动压力梯度。②在通过油驱水建立束缚水饱和度的条件下,岩石孔隙表面吸附的水膜降低了油相渗流通道,两相渗流存在贾敏效应,增加了油相渗流的附加阻力。油相低速渗流曲线不过坐标原点,存在启动压力或启动压力梯度;储层岩石的渗透率越低,启动压力或启动压力梯度越大。③驱替速度和岩石渗透率对水驱油效果有较大影响,在较高的驱替速度下,注入水在大孔道中发生指进和沿裂缝发生水窜是造成水驱油效率降低的主要原因。④岩石渗透率对渗吸驱油效果有显著影响,且裂缝样品的渗吸驱油效率大于基质样品的渗吸驱油效率。⑤对致密油藏实施大规模压裂改造,所形成的高渗透缝网可有效降低流体渗流的启动压力或启动压力梯度,再辅以单井吞吐(水油渗吸交换)的开采方式,这种组合是保证致密油藏长期稳产的重要技术措施。研究成果对致密油藏以及页岩油的开发具有重要的借鉴意义。

关键词：致密油藏润湿性渗透率低速渗流启动压力渗吸实验水驱油效率

An integration system for investment casting mould design of aeroengine turbine blade

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China Foundry 2008年第2期5卷 114-118页

作者： Jiang Ruisong zhang Dinghua Wang Wenhu Shi huajie Key Laboratory of Contemporary Design and Integrated Manufacturing Ministry of Education Northwestern Polytechnical University Xi＇an 710072 China

An integration system was developed to satisfy the need of information integration in the process of designing, investment casting and monitoring aero-engine's turbo blade. The general architecture is detailed presented in this paper. The system mainly comprises of product master model, design information management, anti-deformation design of mould cavity, intelligence mould design and blade testing. The developed system can manage mould design and blade test data flow, optimize mould design process and achieve the goal of integration design.

关键词：整合系统铸造工艺涡轮叶片结构体系

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海洋地质实验测试技术及研究进展

海洋地质与第四纪地质 2024年第3期44卷 53-70页

作者：徐磊林学辉张媛媛贺行良徐婷婷张剑王飞飞梁源任宏波辛文彩朱志刚张道来李凤宋晓云李秋馀武华杰何乐龙闫大伟姜学钧江云水宁泽路晶芳王红李嘉佩王云周一博中国地质调查局青岛海洋地质研究所青岛266237 自然资源部海洋地质实验检测中心青岛266237

实验测试处在数据获取的“第一线”,承担着准确支撑科研论述的重要使命,是海洋地质工作的重要组成部分。近年来随着中国海洋地质调查事业的蓬勃发展,青岛海洋地质研究所现已建成专业学科比较齐全、海洋特色鲜明的综合性实验测试室,检测... 详细信息

实验测试处在数据获取的“第一线”,承担着准确支撑科研论述的重要使命,是海洋地质工作的重要组成部分。近年来随着中国海洋地质调查事业的蓬勃发展,青岛海洋地质研究所现已建成专业学科比较齐全、海洋特色鲜明的综合性实验测试室,检测项目涵盖无机化学分析、有机化学分析、碎屑矿物鉴定、薄岩石片鉴定、黏土矿物定量分析、粒度分析、稳定同位素分析、放射性同位素测年、释光测年、微古鉴定和岩芯管理等十多个专业类型。实验室在完成自然资源、生态、环境、农业等新领域技术与服务对接的同时,结合深海、极地、自然资源全要素调查等科研项目设置的测试任务及研究内容,开展创新机制探索改革,持续形成高水平论文和创新型专利成果,不断满足海洋基础地质调查、海洋矿产资源调查和海洋环境地质调查工作对分析测试的新要求。

关键词：实验测试技术海洋地球化学分析地质年代分析岩石矿物分析微体古生物分析

Fast Cryomediated Dynamic Equilibrium Hydrolysates towards Grain Boundary-Enriched Platinum Scaffolds for Efficient Methanol Oxidation

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Research 2019年第1期2019卷 457-465页

作者： Chao zhang huajie Huang Jianan Gu Zhiguo Du Bin Li Songmei Li Shubin Yang Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education School of Materials Science and EngineeringBeihang University100191 BeijingChina College of Mechanics and Materials Hohai UniversityNanjing 210098China

Although platinum nanocrystals have been considered as potential electrocatalysts for methanol oxidation reaction(MOR)in fuel cells,the large-scale practical implementation has been stagnated by their limited abundance,easy poisoning,and low durability.Here,grain boundary-enriched platinum(GB-Pt)scaffolds are produced in large scale via facilely reducing fast cryomediated dynamic equilibrium hydrolysates of platinum salts.Such plentiful platinum grain boundaries are originated from the fast fusion of short platinum nanowires during reduction of the individually and homogeneously dispersed platinum intermediates.These grain boundaries can provide abundant active sites to efficiently catalyze MOR and meanwhile enable to oxidize the adsorbed poisonous CO during the electrocatalytic process.As a consequence,the as-synthesized GB-Pt scaffolds exhibit an impressively high mass activity of 1027.1 mA mgPt^(−1) for MOR,much higher than that of commercial Pt/C(345.2 mA mgPt^(−1)),as well as good stability up to 5000 cycles.We are confident that this synthetic protocol can be further extended to synthesize various grain boundary-enriched metal scaffolds with broad applications in catalysis.

关键词： process. platinum durability