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Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022

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China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He huaiqi jing Biao Kan Xin Wang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Jiuquan Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

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道阻且长——鼠疫在当今社会的流行与防控

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中国热带医学 2024年第1期24卷 22-27,48页

作者：王鑫景怀琦阚飙中国疾病预防控制中心传染病预防控制所北京102206

鼠疫是由鼠疫耶尔森菌感染导致的动物源性传染病,也是我国法定报告甲类传染病和国际检疫传染病。在人类历史上曾经发生过3次世界大流行,当前除南极洲和大洋洲外,各大陆均存在鼠疫自然疫源地。马达加斯加和刚果(金)是目前世界上人间鼠疫... 详细信息

鼠疫是由鼠疫耶尔森菌感染导致的动物源性传染病,也是我国法定报告甲类传染病和国际检疫传染病。在人类历史上曾经发生过3次世界大流行,当前除南极洲和大洋洲外,各大陆均存在鼠疫自然疫源地。马达加斯加和刚果(金)是目前世界上人间鼠疫流行水平最高的地区。在20世纪中期,我国人间鼠疫流行,1950—1954年平均年报告1400.8例;1955年后,我国人间鼠疫的大规模暴发得到有效控制,1955—1999年平均年报告24.7例。2000年至今,我国人间鼠疫病例仍未销声匿迹,期间累计报告514例。基于One Health理念的鼠疫控制策略是一种更优解,主要体现为“生态学动物监测”+“人间早期诊断处置”的双重手段。有效的动物监测,对鼠疫波及人间可进行准确预测,做到早期预警;而对人间鼠疫病例进行早期诊断早期处置,在一方面可以有效控制人间疫情扩散,另一方面也能有效降低病死率。

关键词：鼠疫人间病例流行动物监测

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Persistent Urinary Tract Infection in Association with Community-Acquired NDM-5 Escherichia coli Clonal Group Following COVID-19 Infection-Beijing Municipality,China,2023

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China CDC weekly 2023年第26期5卷 565-571,I0002页

作者： Jiazhen Guo Ran Duan Dan Zhang Peng Zhang Shuai Qin Yajuan Fang Yingna Sun Lianhe Lu huaiqi jing Xin Wang Rongmeng Jiang Biao Kan Beijing Ditan Hospital Capital Medical University BeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina State Key Laboratory of Infectious Disease Prevention and Control BeijingChina

Summary What is already known about this topic?The hospital-acquired infections caused by New Delhi metallo-beta-lactamase(NDM)-producing strains are typically attributed to a single clonal lineage.What is added by this report?In this study,we encountered a unique case of community-acquired NDM-5 Escherichia coli urinary tract infection(UTI)following coronavirus disease 2019(COVID-19).The UTI persisted for a duration of at least 45 days.Genomic analyses revealed the presence of two NDM-5 strains,both sharing an identical chromosomal background but distinct,homologous,and recombined plasmids.

关键词： urinary chromosomal attributed

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Public health implications of Yersinia enterocolitica investigation:an ecological modeling and molecular epidemiology study

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Infectious Diseases of Poverty 2023年第2期12卷 134-135页

作者： Yuan Yue Jinxin Zheng Mei Sheng Xiang Liu Qiong Hao Shunxian Zhang Shuai Xu Zhiguo Liu Xuexin Hou huaiqi jing Yang Liu Xuezhang Zhou Zhenjun Li Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China Ningxia University Yinchuan People’s Republic of China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Ningxia Hui Autonomous Region Food Testing and Research Institute Yinchuan People’s Republic of China Department of Nephrology Ruijin Hospital Institute of Nephrology Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Ningxia Hui Autonomous Region Centre for Disease Control and Prevention Yinchuan People’s Republic of China Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai People’s Republic of China Department of Computer Science Hong Kong Baptist University Hong Kong People’s Republic of China

Background Yersinia enterocolitica has been sporadically recovered from animals,foods,and human clinical samples in various regions of Ningxia,China.However,the ecological and molecular characteristics of Y.enterocolitica,as well as public health concerns about infection in the Ningxia Hui Autonomous Region,remain unclear.This study aims to analyze the ecological and molecular epidemiological characteristics of Y.enterocolitis in order to inform the public health intervention strategies for the contains of related diseases.Methods A total of 270 samples were collected for isolation[animals(n=208),food(n=49),and patients(n=13)],then suspect colonies were isolated and identified by the API20E biochemical identification system,serological tests,biotyping tests,and 16S rRNA-PCR.Then,we used an ecological epidemiological approach combined with machine learning algorithms(general linear model,random forest model,and eXtreme Gradient Boosting)to explore the associations between ecological factors and the pathogenicity of Y.enterocolitis.Furthermore,average nucleotide identity(ANI)estimation,single nucleotide polymorphism(SNP),and core gene multilocus sequence typing(cgMLST)were applied to characterize the molecular profile of isolates based on whole genome sequencing.The statistical test used single-factor analysis,Chi-square tests,t-tests/ANOVA-tests,Wilcoxon rank-sum tests,and Kruskal–Wallis tests.Results A total of 270 isolates of Yersinia were identified from poultry and livestock(n=191),food(n=49),diarrhoea patients(n=13),rats(n=15),and hamsters(n=2).The detection rates of samples from different hosts were statistically different(χ^(2)=22.636,P<0.001).According to the relatedness clustering results,270 isolates were divided into 12 species,and Y.enterocolitica(n=187)is a predominated species.Pathogenic isolates made up 52.4%(98/187),while non-pathogenic isolates made up 47.6%(89/187).Temperature and precipitation were strongly associated with the pathogenicity of the isolates(P<0.001).The random forest(RF)predictio

关键词： Yersinia enterocolitica Ecological Machine learning Molecular epidemiology Core genome multilocus sequence typing Ningxia,China

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Identification of Novel Bartonella washoensis Sequence Type 22 in Marmota himalayana-Jiuquan City,Gansu Province,China,2021–2022

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China CDC weekly 2023年第20期5卷 442-445,I0001页

作者： Ran Duan Xiaojin Zheng Qun Duan Asaiti Bukai Peng Zhang Shuai Qin Xinmin Lu Dongyue Lyu Haonan Han Dan Zhang Zhaokai He Junrong Liang Deming Tang Jinxiao Xi huaiqi jing Xin Wang State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County Center for Disease Control and Prevention JiuquanChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina

Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing significantly.However,the specific Bartonella species carried by Marmota himalayana(M.himalayana),a large rodent species,and the potential risk it poses to human populations remain unknown.What is added by this report?Bartonella washoensis(B.washoensis),associated with human endocarditis,was initially identified in M.himalayana,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and lungs.The discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of B.washoensis.What are the implications for public health practice?Individuals residing within the M.himalayana plague focus are at an elevated risk for B.washoensis infection.Consequently,there is a pressing need for public health warnings and efficient clinical case identification in this population.

关键词： Barton expanded initially

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Epidemiological Characteristics of Plague in the Meriones unguiculatus Plague Focus--Inner Mongolia Autonomous Region,China,1950−2019

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China CDC weekly 2020年第49期2卷 935-945页

作者： Boxi Liu Dayu Zhang Yuhuang Chen Zhaokai He Jun Liu Dongyue Lyu Weiwei Wu Ran Duan Shuai Qin Junrong Liang huaiqi jing Xin Wang The Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention HuhhotInner MongoliaChina Shenzhen Nanshan Maternity and Child Healthcare Hospital ShenzhenGuangdongChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

From 1950 to 2019,a total of 267 plague cases in humans were reported in the Inner Mongolia Autonomous Region with 133 deaths and 10,710 Yersinia pestis isolates;21 of these cases were reported from the Meriones unguiculatus(M.unguiculatus)plague focus with 6 deaths and 6,771 isolates.According to the plague situation in the Inner Mongolia Autonomous Region and the implementation of local preventive measures,the prevalence of plague in humans in the M.unguiculatus plague focus of the Inner Mongolia Autonomous Region could be divided into four stages.The first stage was the initial stage of plague prevention and control(1950–1959),with 0.80 cases annually and a case fatality rate of 37.50%.The second stage was the plague eradication stage(1960–1979),with 0.15 cases annually and a case fatality rate of 33.33%.The third stage was the plague surveillance stage(1980-1999),with 0.25 cases annually and a case fatality rate of 20.00%.The fourth stage is the comprehensive prevention and control stage under the emergency system(2000-2019),with 0.25 cases annually and a case fatality rate of 20.00%.The surveillance of rodent density(1981-2019)and studies on plague-related factors among M.unguiculatus have shown that the higher the M.unguiculatus density,the higher the nocturnal rodent capture rate(r=0.670,p<0.05)and the higher the indirect hemagglutination assay(IHA)positive rate of M.unguiculatus(r=0.344,p<0.05);the higher the percentage of hosts infected,the lower the M.unguiculatus density(r=-0.361,p<0.05)and the lower the IHA positive rate of M.unguiculatus(r=-0.337,p<0.05);the higher the percentage of nests infected with fleas,the lower the IHA positive rate of M.unguiculatus(r=-0.348,p<0.05).Together,these results suggest that it is necessary to simultaneously monitor the pathogens,serology,and vector index of M.unguiculatus to accurately reflect the plague prevalence among local animals.Although bubonic plague is the main plague type of the M.unguiculatus plague focus,severe pneumonic plague or septic plague may be s

关键词： prevention annually Region

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我国2010－2014年不同城乡类型地区细菌性腹泻病原谱的流行特征

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中华流行病学杂志 2018年第5期39卷 651-655页

作者：秦帅段然景怀琦王鑫中国疾病预防控制中心传染病预防控制所北京102206

目的了解我国不同城乡类型地区细菌性腹泻病原谱流行特征。方法基于2010－2014年我国17省份腹泻症候群感染性腹泻病原学监测。收集门/急诊因急性腹泻就诊病例，采集粪便标本，并进行包括基本人口学信息、临床症状特征等个案调查。对... 详细信息

目的了解我国不同城乡类型地区细菌性腹泻病原谱流行特征。方法基于2010－2014年我国17省份腹泻症候群感染性腹泻病原学监测。收集门/急诊因急性腹泻就诊病例，采集粪便标本，并进行包括基本人口学信息、临床症状特征等个案调查。对粪便标本进行17种常见致泻细菌病原体的病原学检测。按就诊医院类别将病例分为传统农村、中小城镇/城乡过渡带、大型城市3种类型，比较其病原体阳性率及病原谱构成差异。应用非条件logistic回归分析，比较3种类型病例感染的风险。结果共纳入传统农村病例5 138例、中小城镇/城乡过渡带病例13 683例、大型城市病例9 253例，3种类型地区病例病原体阳性率城乡差异最大的为福氏志贺菌（阳性率依次为5.81%、2.78%、0.46%）和嗜水气单胞菌（阳性率依次为2.14%、0.96%、0.48%）。中小城镇/城乡过渡带、传统农村相对于大型城市病例感染各种细菌风险差异最大的为福氏志贺菌［OR值及其95% CI分别为6.481（4.666-9.002）、11.304（8.018-15.938）］和嗜水气单胞菌［OR值及其95% CI分别为1.992（1.401-2.832）、4.083（2.833-5.884）］。细菌病原谱中致泻性大肠埃希菌、沙门菌的构成比随城市化程度的提高而增加，志贺菌、嗜水气单胞菌则随城市化程度的提高而降低。志贺菌属血清群构成中大型城市以宋内志贺菌为主（60.00%），传统农村以福氏志贺菌为主（77.37%）。结论我国不同城镇化水平地区细菌性腹泻病原谱流行特征存在明显差异，其中以福氏志贺菌和嗜水气单胞菌的差异最为显著。

关键词：细菌性腹泻病原谱城乡类型

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Prevalence, Phenotypes and Virulence Factors Characteristics of Escherichia coli O157 strains in Yuxi City

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美国中华健康卫生杂志 2005年第4期8卷 49-54页

作者： WANG Shukun PANG Bo jing huaiqi XIANG Zhenghua YAO Yunbo LIU Hongyan LI Shunxiang Center for Disease Prevention and Control of Yuxi City Yuxi China

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噬菌体phiYe-F10的裂解谱的测定以及裂解能力与宿主毒力基因间关系分析

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病毒学报 2016年第2期32卷 185-189页

作者：查涛梁俊容肖玉春景怀琦芜湖市疾病预防控制中心芜湖241000 中国疾病预防控制中心传染病预防控制所北京102206

目的为测定小肠结肠炎耶尔森菌噬菌体phiYe-F10的裂解谱,分析噬菌体phiYe-F10裂解能力与宿主毒力基因间的关系。方法采用双层平板法观察噬菌体phiYe-F10对213株小肠结肠炎耶尔森菌,36株假结核耶尔森菌和1株鼠疫耶尔森菌的裂解能力;同时... 详细信息

目的为测定小肠结肠炎耶尔森菌噬菌体phiYe-F10的裂解谱,分析噬菌体phiYe-F10裂解能力与宿主毒力基因间的关系。方法采用双层平板法观察噬菌体phiYe-F10对213株小肠结肠炎耶尔森菌,36株假结核耶尔森菌和1株鼠疫耶尔森菌的裂解能力;同时对不同来源不同地区的小肠耶尔森菌进行黏附侵袭位点基因(ail)、肠毒素基因(ystA、ystB)、黏附素基因A(yadA)、毒力因子基因F(virF)、O∶3血清型特异性基因(rfbc)检测和血清型别鉴定。结果表明213株小肠结肠炎耶尔森菌包括O∶3血清型84株(其中rfbc+78株),O∶5血清型10株,O∶8血清型13株,O∶9血清型34株,其它及未分型的共72株。携带毒力质粒的典型致病性小肠耶尔森菌(ail+,ystA+,ystB-,yadA+,virF+)77株,毒力质粒丢失的致病性小肠结肠炎耶尔森菌(ail+、ystA+、ystB-、yadA-、virF-)15株,其它非致病基因型121株。噬菌体phiYe-F10裂解71株O∶3小肠结肠炎耶尔森氏菌,其中致病性小肠结肠炎耶尔森菌52株,非致病性小肠结肠炎耶尔森菌19株。对O∶5,O∶9血清型和其它菌株均不裂解,对O∶3的裂解率高达84.5%(71/84)。噬菌体phiYe-F10对假结核耶尔森菌和鼠疫耶尔森氏菌均不裂解。结论:phiYe-F10噬菌体是一株小肠结肠炎耶尔森菌的裂性噬菌体,在25℃时表现出一个典型的窄裂解谱,高度专一性裂解O∶3血清型小肠结肠炎耶尔森菌。

关键词：噬菌体小肠结肠炎耶尔森菌裂解谱

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小肠结肠炎耶尔森菌β-N-乙酰葡萄糖胺酶调控机制及AmpD蛋白对AmpCβ-内酰胺酶表达的作用

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中华预防医学杂志 2018年第6期52卷 653-660页

作者：张婧梁俊容段然秦帅肖萌景怀琦王鑫中国疾病预防控制中心传染病预防控制所北京102206

目的研究小肠结肠炎耶尔森菌β-N-乙酰葡萄糖胺酶（NagZ）的调控机制及AmpD蛋白对AmpCβ-内酰胺酶表达的作用.方法通过对小肠结肠炎耶尔森菌3个AmpD蛋白同系物（AmpD1～3）基因（ampD1～3）、低分子量青霉素结合蛋白（LMM PBPs）基因... 详细信息

目的研究小肠结肠炎耶尔森菌β-N-乙酰葡萄糖胺酶（NagZ）的调控机制及AmpD蛋白对AmpCβ-内酰胺酶表达的作用.方法通过对小肠结肠炎耶尔森菌3个AmpD蛋白同系物（AmpD1～3）基因（ampD1～3）、低分子量青霉素结合蛋白（LMM PBPs）基因（pbp4、pbp5a、pbp5b、pbp7）、NagZ基因（nagZ）以及ampR基因进行敲除或回补,以构建基因突变株,并利用头孢西丁对突变株进行诱导;采用检测头孢硝噻吩水解法测定诱导组和非诱导组突变株AmpCβ-内酰胺酶活性（单位为U）,采用luxCDABEreporter系统检测AmpCβ-内酰胺酶启动子活性[单位为相对光单位（RLU）],采用对硝基苯-N-乙酰-β-D-氨基葡萄糖苷为显色底物测定NagZ酶活性（单位nmol/L）.结果 AmpD1蛋白的功能较强,YEΔD1突变株的AmpCβ-内酰胺酶表达量出现上升,诱导组和非诱导组分别为（3.29±1.58）和（4.08±1.75）U.YEΔ5b、YEΔ4Δ5b、YEΔ5aΔ5b和YEΔ5bΔ7突变株AmpCβ-内酰胺酶启动子活性增强,其中YEΔ4Δ5b突变株活性最高,诱导组和非诱导组分别为（106903.16±61910.61）和（205427.45±45352.17）RLU.缺失3种基因的菌株中,YEΔ4Δ5bΔ7突变株AmpCβ-内酰胺酶启动子活性最高,诱导组和非诱导组分别为（304108.04±99274.53）和（531440.21±68891.02）RLU;缺失4种基因的菌株中,YEΔ4Δ5aΔ5bΔ7突变株AmpCβ-内酰胺酶启动子活性最高,诱导组和非诱导组分别为（1013810.99±260955.96）和（1230214.59±205526.79）RLU;敲除nagZ基因后,YEΔD1D2D3ΔZ突变株AmpCβ-内酰胺酶活性未发生明显的变化,而YEΔ4Δ5aΔ5bΔ7ΔZ突变株活性下降明显,诱导组和非诱导组分别为（0.30±0.20）和（0.29±0.21）U,基本降至野生株水平.结论在肠杆菌科细菌中发现多个AmpD蛋白参与ampC基因的三级调控机制;发现以PBP5b为主,PBP4、PBP5a和PBP7共同参与的ampC基因调控模式;同时还证实了在小肠结肠炎耶尔森菌具有NagZ依赖和非依赖两种ampC基因调控途径.

关键词：耶尔森菌小肠结肠炎青霉素结合蛋白质类 N-乙酰胞壁酸-L-丙氨酸酰胺酶氨苄青霉素头孢菌素酶 β-N-乙酰葡萄糖胺酶

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