检索结果-南通市图书馆

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Spatial and spectral investigation of turbulent kinetic energy in cavitating flow generated by Clark-Y hydrofoil

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2020年第1期32卷 175-178页

作者： Xiao-rui Bai huai-yu Cheng Bin Ji Xin-ping long State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Science and Technology on Water Jet Propulsion Laboratory Shanghai 200011China

In the present paper,the turbulent cavitating flow generated by a Clark-Y hydrofoil is investigated by large eddy simulation(LES)combined with Zwart-Gerber-Belamri(ZGB)cavitation *** order to shed light on the influence of cavitation on turbulent energy distribution among scales,energy spectrum obtained from the three-dimensional velocity field is firstly applied to turbulent cavitating *** and spectral distributions of turbulent kinetic energy are studied for both non-cavitating flow and cavitating *** is found to have a significant effect on the original turbulent flow by inducing more large-scale turbulent *** energy spectrum of cloud cavitating flow also experiences a periodic evolution as cavitation develops,and a large amount of turbulent kinetic energy is found to generate as the first shedding,cutoff and second shedding of cavities happen.

关键词： Cavitating flow energy spectrum large eddy simulation(LES) turbulent kinetic energy cloud cavitation

Spectral Theorem of Many-Body Green's Functions When Complex Eigenvalues Appear

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2009年第5期51卷 931-937页

作者： WANG huai-yu Department of Physics Tsinghua University Beijing 100084 China

In this paper, an extended spectral theorem is given, which enables one to calculate the correlation functions when complex eigenvalues appear. To do so, a Fourier transformation with a complex argument is utilized. We treat all the Matsbara frequencies, including Fermionic and Bosonic frequencies, on an equal footing. It is pointed out that when complex eigenvalues appear, the dissipation of a system cannot simply be ascribed to the pure imaginary part of the Green function. Therefore, the use of the name fluctuation-dissipation theorem should be careful.

关键词： spectral theorem many-body Green's functions correlation functions complex eigenvalues

Some notes on numerical simulation and error analyses of the attached turbulent cavitating flow by LES

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2018年第2期30卷 369-372页

作者： Xin-ping long yun long Wen-ting Wang huai-yu Cheng Bin Ji State Key Laboratory of Water Resources and Hydropower Engineering Science School of Power and Mechanical Engineering Wuhan University Wuhan 430072 China Key Laboratory of Jet Theory and New Technology of Hubei Province Wuhan University Wuhan 430072 China

In this letter, the attached turbulent cavitating flow around the Clark-Y hydrofoil is investigated by the numerical simulation with special emphasis on error analysis of large eddy simulation（LES） for the unsteady cavitation simulation. The numerical results indicate that the present simulation can capture the periodic cavity shedding behavior and show a fairly good agreement with the available experimental data. Further analysis demonstrates that the cavitation has a great influence on LES numerical error and modeling error. The modeling error and numerical error are almost on the same order of magnitude, while the modeling error often shows a little bit larger magnitude than numerical error. The numerical error and modeling error sometimes can partially offset each other if they have the opposite sign. Besides, our results show that cavitation can extend the magnitudes and oscillation levels of numerical error and modeling error.

关键词： Cavitation cavitating flow large eddy simulation (LES) error analyses verification and validation (V&V)

URANS simulations of the tip-leakage cavitating flow with verification and validation procedures

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2018年第3期30卷 531-534页

作者： huai-yu Cheng Xin-ping long yun-zhi Liang yun long Bin Ji State Key Laboratory of Water Resources and Hydropower Engineering Science School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China Hubei Key Laboratory of Waterjet Theory and New Technology Wuhan UniversityWuhan 430072China Science and Technology on Water Jet Propulsion Laboratory Shanghai 200011China

In the present paper, the Vortex Identified Zwart-Gerber-Belamri（VIZGB） cavitation model coupled with the SST-CC turbulence model is used to investigate the unsteady tip-leakage cavitating flow induced by a NACA0009 hydrofoil. A qualitative comparison between the numerical and experimental results is made. In order to quantitatively evaluate the reliability of the numerical data, the verification and validation（V＆V） procedures are used in the present paper. Errors of numerical results are estimated with seven error estimators based on the Richardson extrapolation method. It is shown that though a strict validation cannot be achieved, a reasonable prediction of the gross characteristics of the tip-leakage cavitating flow can be obtained. Based on the numerical results, the influence of the cavitation on the tip-leakage vortex（TLV） is discussed, which indicates that the cavitation accelerates the fusion of the TLV and the tip-separation vortex（TSV）. Moreover, the trajectory of the TLV, when the cavitation occurs, is close to the side wall.

关键词： Cavitation computational fluid dynamics(CFD) tip-leakage vortex(TLV) verification and validation(V&V)

Experimental investigation of the flow characteristics of jet pumps for zero flow-ratio conditions

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2023年第6期35卷 1146-1156页

作者： yun-zhi Liang Jiong Wang Zu-ti Zhang Bin Ji huai-yu Cheng Xin-ping long Key Lab of Jet Theory and New Technology of Hubei Province Wuhan UniversityWuhan430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072China State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China

Experimental research was conducted on the performance curves and the cavity evolution for different flow and geometric parameters in jet pumps for zero flow ratio(ZFR)*** pressure ratio,Pr,flow ratio,qr,were used in place of the conventional performance parameters h,q,to characterize the jet pump flow performance.A super cavitation cavity in the jet pump was observed to fill most of the flow channel,which hindered further increases of the flow rate and increased qr to one,thus,created a critical point on the new P_(r)-q_(r)^(2)*** the critical point,P_(r)was proportional to q_(r)^(2)with a coefficient that was much more sensitive to the area ratio than the relative throat length and the diffusion *** the critical point,the flow rate reached its maximum,the limiting flow rate,which only depended on the total inlet pressure and the area *** total inlet pressure was proportional to the square of the limiting flow rate with a flow coefficient that was only a quadratic function of the area ratio.

关键词： Jet pump performance curve zero flow-ratio super-cavitation

Photocatalytic CO2 reduction highly enhanced by oxygen vacancies on Pt-nanoparticle-dispersed gallium oxide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2016年第6期9卷 1689-1700页

作者： yun-Xiang Pan Zheng-Qing Sun huai-Ping Cong yu-long Men Sen Xin Jie Song Shu-Hong yu School of Chemistry and Chemical Engineering Hefei University of Technology Hefei 230009 China Division ofNanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Center for Excellence in Nanoscience University of Science and Technology of China Hefei 230026 China Institute of Nano Biomedicine and Engineering Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200240 China

Photocatalytic CO2 reduction on metal-oxide-based catalysts is promising for solving the energy and environmental crises faced by mankind. The oxygen vacancy （Vo） on metal oxides is expected to be a key factor affecting the efficiency of photocatalytic CO2 reduction on metal-oxide-based catalysts. Yet, to date, the question of how an Vo influences photocatalytic CO2 reduction is still unanswered. Herein, we report that, on Vo-rich gallium oxide coated with Pt nanoparticles （Vo-rich Pt/Ga203）, CO2 is photocatalytically reduced to CO, with a highly enhanced CO evolution rate （21.0umol.h-1） compared to those on Vo-poor Pt/Ga2O3 （3.9 gmol-h-1） and Pt/TiO2（P25）（6.7 gmol.h-1）. We demonstrate that the Vo leads to improved CO2 adsorption and separation of the photoinduced charges on Pt/Ga203, thus enhancing the photocatalytic activity of Pt/Ga203. Rational fabrication of an Vo is thereby an attractive strategy for developing efficient catalysts for photocatalytic CO2 reduction.

关键词： photocatalytic CO2reduction oxygen vacancy metal-oxide-based catalyst C02 adsorption

Bidirectional natural hybridization between sympatric Ligularia vellerea and L. subspicata

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2017年第4期39卷 214-220页

作者： huai Ning Jiaojun yu Xun Gong Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China University of Chinese Academy of Sciences Beijing 100049 China

Natural hybridization has been regarded as a crucial pathway of speciation and provides the raw materials for the evolution of biodiversity. The interspecific natural hybridization of the genus Ligularia *** universal and has been considered to be an important factor driving the high diversity of Ligularia species in the Hengduan Mountains, China. Although the natural hybridization between L. vellerea and L. subspicata was reported previously, the direction of hybridization was uncertain due to the limitation of sampling. Thus, in this study, we sampled more individuals and increased two fragments of chloroplast DNA on the basis of the previous study to further verify the natural hybridization between L. vellerea and L. subspicata and confirm the direction of hybridization. Based on DNA sequences(atpBrbcL, trnL-rpl32, trnQ-5'rps16, and nuclear ribosomal internal transcribed spacer region) data, we concluded that putative hybrids were primary products of hybridization between L. vellerea and L. subspicata and the hybridization was bidirectional. Moreover, sympatric L. tongolensis was not apparently involved in the hybridization. Surprisingly, some pure L. subspicata individuals showed the disaccordance between morphology and DNA data, which might indicate that introgression occurs between L. vellerea and L. subspicata.

关键词： Ligularia Natural hybridization Introgression cpDNA ITS

均质黏土中桩靴基础贯入阻力系数Nc的解析解

在线全文

学校读者我要写书评

暂无评论