检索结果-南通市图书馆

LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2021年第2期41卷 109-120页

作者： Yue-Tao Tan Jin-Fei Lin Ting Li Jia-jun Li Rui-Hua Xu huai-qiang ju Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhouGuangdong 510060P.R.China

Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of *** is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in ***,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at *** this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic *** addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional *** believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.

关键词： cancer metabolism enzyme long noncoding RNA metabolic reprogramming posttranslational modification

Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第3期7卷 918-933页

作者： Jin-Fei Lin Pei-Shan Hu Yi-Yu Wang Yue-Tao Tan Kai Yu Kun Liao Qi-Nian Wu Ting Li Qi Meng jun-Zhong Lin Ze-Xian Liu Heng-Ying Pu huai-qiang ju Rui-Hua Xu Miao-Zhen Qiu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouP.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated Hospital(Guangdong Gastrointestinal and Anal Hospital)Sun Yat-sen University510655 GuangzhouP.R.China Department of Pathology Sun Yat-sen University Cancer Center510060 GuangzhouP.R.China Department of Gastroenterology and Urology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaP.R.China Department of Colorectal Surgery Sun Yat-sen University Cancer Center510060 GuangzhouP.R.China

Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with ***,targeting metabolic enzymes remains an attractive approach for treating tu... 详细信息

关键词： colorectal attractive Metabolic

Effects of 1,2,4,6-tetra-O-galloyl-β-D-glucose from P. emblica on HBsAg and HBeAg Secretion in HepG2.2.15 Cell Culture

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2010年第5期25卷 375-380页

作者： Yang-fei XIANG huai-qiang ju Shen LI Ying-jun ZHANG Chong-ren YANG Yi-fei WANG Biomedicine Research ＆ Development Center Jinan University Guangzhou 510630 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A polyphenolic compound, 1,2,4,6-tetra-O-galloyl-β-D-glucose （1246TGG）, was isolated from the traditional Chinese medicine Phyllanthus emblica L. （Euphorbiaceae） and assayed for its potential as an anti-hepatitis B virus （HBV） agent. The cytotoxicity of 1246TGG on HepG2.2.15 as well as HepG2 cells was determined by observing cytopathic effects, and the effects of 1246TGG on secretion of HBsAg and HBeAg in HepG2.2.15 cells were assayed by enzyme immunoassay. Results indicates that treatment with 1246TGG （6.25 ~tg/mL, 3.13 ~tg/mL）, reduced both HBsAg and HBeAg levels in culture supernatant, yet the inhibitory effects tend to decline with the assay time. This study provides a basis for further investigation of the anti-HBV activity and possible mechanism of action of 1246TGG

关键词： 1,2,4,6-tetra-O-galloyl-13-D-glucose (1246TGG) Phyllanthus emblica Euphorbiaceae HBV Antiviral agents

VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 852-864页

作者： Pei-Shan Hu Ting Li Jin-Fei Lin Miao-Zhen Qiu De-Shen Wang Ze-Xian Liu Zhan-Hong Chen Lu-Ping Yang Xiao-Long Zhang Qi Zhao Yan-Xing Chen Yun-Xin Lu Qi-Nian Wu Heng-Ying Pu Zhao-Lei Zeng Dan Xie huai-qiang ju Hui-Yan Luo Rui-Hua Xu Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouPeople’s Republic of China Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouPeople’s Republic of China Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease the Third Affiliated Hospital of Sun Yat-sen University510060 GuangzhouPeople’s Republic of China

The acidic tumor microenvironment provides an energy source driving malignant tumor *** of cells to an acidic environment leads to the emergence of cancer stem *** expression of the vitamin D receptor(VDR)is closely related to the initiation and development of colorectal carcinoma(CRC),but its regulatory mechanism in CRC stem cells is still *** study revealed that acidosis reduced VDR expression by downregulating peroxisome proliferator-activated receptor delta(PPARD)*** of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in *** nuclear export signal in VDR was sensitive to acidosis,and VDR was exported from the *** immunoprecipitation(ChIP)and assay for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq)analyses showed that VDR transcriptionally repressed SRY-box 2(SOX2)by binding to the vitamin D response elements in the promoter of SOX2,impairing tumor growth and drug *** demonstrated that a change in the acidic microenvironment combined with overexpression of VDR substantially restricted the occurrence and development of CRC in *** findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling,resulting in a lack of efficacy of vitamin D in antineoplastic process.

关键词： SOX2 vitamin colorectal

Methionine Deficiency Facilitates Antitumor Immunity by Altering m6A Methylation of Immune Checkpoint Transcripts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methionine Deficiency Facilitates Antitumor Immunity by Alte...

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Ting Li Tan Yue-Tao Yan-Xing Chen Xiao-jun Zheng Wen Wang Kun Liao Hai-Yu Mo junzhong Lin Wei Yang Hai-Long Piao Rui-Hua Xu huai-qiang ju Sun Yat-sen University Cancer Center Department of Gastroenterology and Urology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Research Department of Medical Sciences Guangdong Provincial People's HospitalGuangdong Academy of Medical Sciences CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of Sciences Department of Colorectal Surgery Sun Yat-sen University Cancer Center Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Southern Medical University Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences

Objective:Methionine metabolism is involved in a myriad of cellular functions,including methylation reactions and redox ***,it remains unclear whether methionine metabolism,RNA methylation and antitumor immunity are molecularly ***:The antitumor immunity effect of methionine-restricted diet(MRD) feeding was assessed in murine *** mechanisms of methionine and YTH domain-containing family protein 1(YTHDF1) in tumor immune escape were determined in vitro and in ***,the MRD or YTHDF1 depletion synergizes with PD-1 blockade used to block tumor ***:We found that dietary methionine restriction reduced tumor growth and enhanced antitumor immunity by increasing the number and cytotoxicity of tumor-infiltrating CD8+ T cells in different mouse ***,the S-adenosylmethionine derived from methionine metabolism promoted the N6-methyladenosine(m6A) methylation and translation of immune checkpoints,including PD-L1 and VISTA,in tumor ***,a methionine-restricted diet or m6A-specific binding protein YTHDF1 depletion inhibited tumor growth by restoring the infiltration of CD8+ T cells,and synergized with PD-1blockade for better tumor ***,YTHDF1 expression correlated with poor prognosis and immunotherapy outcomes for cancer ***:Methionine and YTHDF1 play a critical role in anticancer immunity through regulating the functions of T *** methionine metabolism or YTHDF1 could be a potential new strategy for cancer immunotherapy.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu ju-Song Yang Fu-Min Zhang Ai-jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词：

同方期刊数据库

Effects of electron correlation on superconductivity in the Hatsugai-Kohmoto model

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2021年第10期30卷 541-547页

作者： huai-Shuang Zhu qiang Han Department of Physics Renmin University of ChinaBeijing 100872China

Understanding how electrons form pairs in the presence of strong electron correlations demands going beyond the BCS *** study a correlated superconducting model where the correlation effects are accounted for by a U term local in momentum *** electron correlation is treated exactly while the electron pairing is treated approximately using the mean-field *** self-consistent equation for the pair potential is derived and *** contrary to expectation,a weak attractive U comparable to the pair potential can destroy the superconductivity,whereas for weak to intermediate repulsive U,the pair potential can be *** fidelity of the mean-field ground state is calculated to describe the strength of the elelectron *** show that the pair potential is not equal to the single-electron superconducting gap for the strongly correlated superconductors,in contrast to the uncorrelated BCS limit.

关键词： strong correlated superconductivity exactly solvable model mean-field theory

The Semiclassical Limit in the Quantum Drift-Diffusion Model

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2009年第2期25卷 253-264页

作者： qiang Chang ju Institute of Applied Physics and Computational Mathematics P. O. Box 8009-28 Beijing 100088 P. R. China

Semiclassical limit to the solution of isentropic quantum drift-diffusion model in semicon- ductor simulation is discussed. It is proved that the semiclassical limit of this solution satisfies the classical drift-diff... 详细信息

关键词： quantum drift-diffusion weak solution semiclassical limit isentropic

Numerical simulation on directional solidification and heat treatment processes of turbine blades

在线全文

学校读者我要写书评

暂无评论

China Foundry 2024年第5期21卷 476-490页

作者： Ye-yuan Hu ju-huai Ma Qing-yan Xu School of Materials Science and Engineering Tsinghua UniversityKey Laboratory for Advanced Materials Processing TechnologyMinistry of EducationBeijing 100084China

Study on turbine blades is crucial due to their critical role in ensuring the efficient and reliable operation of aircraft ***-based single crystal superalloys are extensively used in the hot manufacturing of turbine blades due to their exceptional high-temperature mechanical *** hot manufacturing of single crystal blades involves directional solidification and heat *** manufacturing of these blades is time-consuming,capital-intensive,and often insufficient to meet industrial *** simulation techniques have gained widespread acceptance in blade manufacturing research due to their low energy consumption,high efficiency,and rapid turnaround *** article introduces the modeling and simulation of hot manufacturing in single crystal *** discussion outlines the prevalent mathematical models employed in numerical simulations related to blade hot *** encapsulates the advancements in research concerning macro to micro-level numerical simulation techniques for directional solidification and heat treatment ***,potential future trajectories for the numerical simulation of single crystal blade hot manufacturing are also discussed.

关键词： single crystal blades Ni-based superalloy directional solidification heat treatment numerical simulation