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Cu（I）-Catalyzed Regio- and Stereoselective[3+6]Cycloaddition of Azomethine Ylides with Tropone:An Efficient Asymmetric Access to Bridged Azabicyclo[4.3.1]decadienes

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Cu（I）-Catalyzed Regio- and Stereoselective[3+6]Cycloadditi...

手性中国2014学术研讨会

作者： Lu Yao huai-Long Teng Chun-jiang Wang College of Chemistry and Molecular Sciences Wuhan University

＜正＞Transition-metal-catalyzed cycloaddition reactions are the commonly-used methods for the construction of bridge-containing carbocyclic and heterocyclic structures,which exist in numerous natural products and active pharmaceutical ingredients.[1]Tropone and the related compounds in troponoid family have been recognized as valuable synthons of natural products and suitable partners in higher order cycloadditions

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基于变形的二进制代码混淆技术研究

四川大学学报（工程科学版） 2014年第1期46卷 14-21页

作者：王怀军房鼎益李光辉张聪姜河西北大学信息科学与技术学院陕西西安710127 西北大学-爱迪德物联网信息安全联合实验室陕西西安710127

二进制代码保护技术不受源码语言约束,适用性更广。结合等价变形、控制流混淆、动态加解密等技术,研究并实现了二进制代码混淆保护原型系统MEPE。在MEPE中,基于拆分或替换指令的操作,以及算术和逻辑等价式,设计等价变形规则及对应的等... 详细信息

二进制代码保护技术不受源码语言约束,适用性更广。结合等价变形、控制流混淆、动态加解密等技术,研究并实现了二进制代码混淆保护原型系统MEPE。在MEPE中,基于拆分或替换指令的操作,以及算术和逻辑等价式,设计等价变形规则及对应的等价变形模板函数,对二进制代码进行等价变形。通过理论分析,证明了变形的多样性效果;利用控制流混淆对变形后代码块进行"切片乱序",由地址跳转表管理跳转地址,并通过动态加解密对其进行保护;深入分析循环体中被保护指令对时间开销的影响,提出了与指令循环深度相关联的迭代次数与切片粒度的计算方法。MEPE具有保护强度可调节、功能可扩展、保护效果多样、性能消耗低等特点。通过实验分析迭代次数、切片粒度对时间消耗的影响,验证了对循环体中被保护指令控制的作用和意义,以及保护效果的多样性。经过MEPE处理后的二进制代码在时间损耗较小的情况下,可有效增加攻击者静态和动态分析的难度,提高了二进制可执行代码的安全性。

关键词：二进制代码混淆迭代变形变形引擎多样性

Increasing prevalence and influencing factors of childhood asthma: a cross-sectional study in Shanghai, China

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World Journal of Pediatrics 2021年第4期17卷 419-428页

作者： Ya-Bin Hu Yi-Ting Chen Shi-Jian Liu Fan jiang Mei-Qin Wu Chong-huai Yan Jian-Guo Tan Guang-Jun Yu Yi Hu Yong Yin Jia-Jie Qu Sheng-Hui Li Shi-Lu Tong Department of Clinical Epidemiology and Biostatistics Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Child health Advocacy Institute China Hospital Development InstituteShanghai Jiao Tong UniversityShanghaiChina School of Public health Shanghai Jiao Tong University School of Medicine227 South Chongqing RoadHuangpuShanghai200025China Department of Developmental and Behavioral Pediatrics Pediatric Translational Medicine InstitutionShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina MOE-Shanghai Key Laboratory of Children’s Environmental health Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Meteorology and health(Shanghai Meteorological Service) ShanghaiChina Center for Biomedical Informatics Shanghai Children’s HospitalShanghaiChina Department of Respiratory Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Municipal Education Commission ShanghaiChina School of Public health Institute of Environment and Population HealthAnhui Medical UniversityHefeiChina Center for Global health School of Public HealthNanjing Medical UniversityNanjingChina School of Public health and Social Work Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia

Background Asthma has been a global problem,especially in *** aim to evaluate the contemporary prevalence and influencing factors of asthma among children aged 3–7 years in Shanghai,*** A random sample of preschool children was included in this *** International Study of Asthma and Allergies in Childhood questionnaire was adopted to assess the childhood *** logistic regression models were used to evaluate the associations between independent variables and childhood *** Of 6389 preschool children who were invited to take part in this study,6163(response rate:96.5%)completed the questionnaire and were included in the *** overall prevalence of asthma was 14.6%which increased more than six folds from 2.1%in *** male,younger age,preterm delivery,being born in spring or autumn,being delivered by elective cesarean section without indication,miscarriage,high socioeconomic status,having allergy history,and exposure to passive smoking,latex paint,and dust were potential risk factors for childhood *** more time outdoors(>30 min/day),having indoor plants,and cleaning rooms more frequently were potential protective *** The prevalence of childhood asthma in Shanghai has increased dramatically during the past three *** findings about risk and protective factors of childhood asthma could be used to develop appropriate strategies to prevent and control childhood asthma in Shanghai and in other similar metropolitan cities.

关键词： Asthma Children Prevalence Risk/protective factors

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企业家注意力配置与创新模式的决定

外国经济与管理 2000年第6期22卷 18-24页

作者：郑江淮中国社会科学院工业经济研究所北京100836

在企业内部 ,要发现创新机会 ,就必须将当事人集中在惯例性活动上的“管理注意力”转变为集中在创新活动上的“企业家注意力”。层级制因是企业家注意力配置的结果而成为企业家职能发挥作用的手段。不同类型的层级组织有不同的创新模式... 详细信息

在企业内部 ,要发现创新机会 ,就必须将当事人集中在惯例性活动上的“管理注意力”转变为集中在创新活动上的“企业家注意力”。层级制因是企业家注意力配置的结果而成为企业家职能发挥作用的手段。不同类型的层级组织有不同的创新模式。因此 ,通过特定的层级组织对企业成员的企业家注意力进行配置与再配置。

关键词：企业0家注意力创新模式层级制

A systematic identification of cold tolerance genes in peanut using yeast functional screening system

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Oil Crop Science 2023年第3期8卷 184-190页

作者： Xin Wang Yue Liu Ruonan Yao Lei Ouyang Tingting Yu Liying Yan Yuning Chen Dongxin huai Zhihui Wang Yanping Kang Qianqian Wang Huifang jiang Yong Lei Boshou Liao Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan430062PR China State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan430062PR China

Peanut(Arachis hypogaea L.)is a thermophilic crop,and low temperature leads to a significant reduction in annual *** a few cold tolerant germplasms or cultivars have been discovered and developed,molecular mechanisms governing peanut cold tolerance is poorly *** of keys genes involved in cold tolerance is the first step to address the underlying *** this study,we isolated and characterized 157 genes with potentials to confer cold tolerance in peanut by using a yeast functional screening ***(Gene ontology)and KEGG(Kyoto encyclopedia of genes and genomes)enrichment analysis of these genes revealed that ribosome and photosynthesis proteins might play essential roles in peanut cold *** results indicated that 60 cold tolerance candidate genes were significantly induced or depressed by low ***-PCR analysis demonstrated that several candidate genes could be also regulated by salt or drought *** overexpression of two UDP-glycosyltransferases(AhUGT2 and AhUGT268)in transgenic yeast cells could enhance their tolerance to multiple abiotic *** conclusion,this study advances our understanding of the mechanisms associated with the cold stress responses in peanut,and offers valuable gene resources for genetic improvement of abiotic stress tolerance in crops.

关键词： Peanut Yeast screening system Cold tolerance UDP-glycosyltransferase Abiotic stress

中国特色社会主义法律体系建成后“立法中心主义”的转向

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河北法学 2012年第4期30卷 2-8页

作者：蒋苏淮南京大学法学院江苏南京210093

经过30年的努力,中国法制建设取得了显著的成绩,中国特色社会主义法律体系建成。如何在中国特色的法律体系基础上建设中国特色的法治体系是摆在我们面前的一个重大课题。通过对过去30年的中国立法的回顾与反思,可以看出,在今后,相对于... 详细信息

经过30年的努力,中国法制建设取得了显著的成绩,中国特色社会主义法律体系建成。如何在中国特色的法律体系基础上建设中国特色的法治体系是摆在我们面前的一个重大课题。通过对过去30年的中国立法的回顾与反思,可以看出,在今后,相对于集中立法与频繁修改而言,更重要的是通过一系列制度性安排和创造一种可能的社会环境,使业已载入宪法和法律的那些基本价值、原则逐步得到实现。

关键词：立法理性建构公众参与

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循环流化床锅炉火焰温度及黑度图像检测

工程热物理学报 2009年第11期30卷 1953-1956页

作者：姜志伟周怀春华中科技大学煤燃烧国家重点实验室湖北武汉430074

本文在图像处理技术的基础上提出了一种改进的比色法。对于充满颗粒介质的燃烧过程,该方法可从一个彩色CCD图像中获得介质温度和黑度图像。本方法不依赖于CCD的光谱特性及其三基色代表性波长,也不依赖于图像处理系统。在一台480 t/h燃... 详细信息

本文在图像处理技术的基础上提出了一种改进的比色法。对于充满颗粒介质的燃烧过程,该方法可从一个彩色CCD图像中获得介质温度和黑度图像。本方法不依赖于CCD的光谱特性及其三基色代表性波长,也不依赖于图像处理系统。在一台480 t/h燃煤循环流化床锅炉上进行了试验。与热电偶测量结果相比,使用本方法测量温度是可行的,而且其与锅炉负荷的相关性也是明显的。使用本系统得到的火焰黑度可以做进一步的研究。

关键词：循环流化床图像处理比色温度黑度

Novel therapeutic evaluation biomarkers of lipid metabolism targets in uncomplicated pulmonary tuberculosis patients

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Signal Transduction and Targeted Therapy 2021年第2期6卷 496-506页

作者： Jia-Xi Chen Yu Shuai Han Shan-Qiang Zhang Zhi Bin Li Jing Chen Wen-Jing Yi huai Huang Ting-Ting Jjiang Ji-Cheng Li Institute of Cell Biology and Department of Cardiology of the Second Afliated Hospital Zhejiang University School of Medicine310058 HangzhouChina The Medical Research Center of Yue Bei People's Hospital Shantou University Medical College512025 ShaoguanChina Department of Histology and Embryology Shaoguan University School of Medicine512025 ShaoguanChina Taizhou Hospital of Zhejiang Prowince afliated to Wenzhou Medical University 318050 TaizhouChina

Currently,the management of pulmonary tuberculosis(TB)lacks potent medications and accurate efficacy evaluation *** view of the fact that the host lipids are the important energy source of Mycobacterium tuberculosis(Mtb),UPLC-MS/MS based on lipid metabolism was used to monitor the plasma lipid spectrum of TB patients from the initial diagnosis to *** analysis showed that TB patients presented aberrant metabolism of phospholipids,glycerides,and *** the treatment,the abnormal expression of Cer(d18:1/24:0),CerP(d18:1/20:3),LPE(0:0/22:0),LPA(0:0/16:0),and LPA(0:0/18:0)in TB patients were gradually normalized,indicating that the intervention of lipid metabolism could block energy metabolism and inhibit the cell wall synthesis of ***,the increase in ceramide(Cer)levels could promote autophagosome-lysosome ***(0:0/16:0)and LPA(0:0/18:0)had a great potential in the early diagnosis(both sensitivity and specificity were 100%)and efficacy evaluation(both sensitivity and specificity were 100%)of TB,indicating that the above lipid metabolites could be used as potential biomarkers for TB.

关键词： metabolism tuberculosis patients

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新型织机的现状和发展趋势

棉纺织技术 1989年第3期17卷 5-9页

作者：姜怀上海纺织工业专科学校

本文阐述了当前新型织机的现状,发展的主要特点和趋势。

关键词：新型织机织机发展趋势