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Alteration of ERβ gene Rsal polymorphism may contribute to reduced fertilization rate and embryonic developmental competence

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Asian Journal of Andrology 2011年第2期13卷 317-321页

作者： Qiu-Fang Zhang huai-liang feng Lan Zhao Ping Liu Li Li Jie Yan Jie Qiao Center of Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 1000191 China Center for Human Reproduction North Shore University Hospital NYU School of Medicine Manhasset NY 11030 USA

This paper aims to determine the possible role of estrogen receptor-β （ERβ） gene Rsal polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited： in vitro fertilization （IVF） group, including 374 couples who underwent conventional IVF; intracytoplasmic sperm injection （ICSI） group, including 294 couples who underwent an ICSI procedure using ejaculated sperm; and azoospermic group, consisting of 197 couples who underwent ICSI using either testis or epididymis sperm. Rsal polymorphism in the ERβ gene was detected by polymerase chain reaction （PCR）-restriction fragment length polymorphism technique; fertilization and high-quality embryo rates were evaluated for each group. In each group, no significant differences were found in the overall rates of fertilization and high-quality embryos among GG, AG and AA genotypes. However, the proportion of cycles possessing a satisfactory high-quality embryo rate with the AA genotype was significantly lower than that in the wild-type GG genotype from each group. These results demonstrated that sperm possessing the ERβ RsalA genotype may have reduced fertilization ability and decreased early embryonic developmental potential, which could directly or indirectly contribute to the low fertilization rate and early embryonic developmental arrest in some cases.

关键词： embryo development estrogen receptor-β gene fertilization intracytoplasmic sperm injection in vitro fertilization poly-morphism

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Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse

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Asian Journal of Andrology 2008年第2期10卷 219-226页

作者： Yibing Han Xue-Xiong Song huai-liang feng Che-Kwok Cheung Po-Mui Lam Chi-Chiu Wang Christophe John Haines Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China Department of Animal Sciences Laiyang Agricultural College Qingdao Shandong 266109 China Center for Human Reproduction North Shore University Hospital NYU School of Medicine Manhasset NY 11030 USA Li Ka Shing Institute of Health Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Aim： To determine the possible roles of the t-complex testis expressed gene 5 （Tctex5） on sperm functions, the fulllength sequence of mRNA was studied and compared in the testis between the normal wild-type and the sterile t-haplotype mutant mice. Methods： We applied rapid amplification of cDNA ends, Northern blot and reverse transcription polymerase chain reaction to analyze the full length of Tctex5 mRNAs isolated from testes of the wild-type and the t-haplotype mice. Reverse transcription polymerase chain reaction was used to semi-quantitatively compare expression of Tctex5 transcripts in the 16 tissues and 9.5 day stage embryos in the wild-type mice. E-translation was applied to estimate the amino acid sequences. Results： One long and one short transcript of Tctex5 mRNA were discovered in mouse testis of wild-type （Tctex5^long-＋ and Tctex5^short-＋） and t-haplotype （Tctex5^long-＋ and Tctex5^short-＋） mice, respectively. Being enhanced only in the testis, Tctex5^long-＋ had 17 point mutations and one 15-bp-deletion in the exon 1 region, comparing with the Tctex5^long-＋, whereas the Tctex5^short-＋ was similar to the Tctex5^short-＋. The short isoforms of Tctex5 mRNAs in the two models encoded exactly the same peptides, but the long isoforms did not. The estimated peptide encoded by Tctex5^long-＋ had significant mutations on putative sites of phosphorylation and PP1 binding. Conclusion： We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues. （Asian J Androl 2008 Mar; 10： 219-226）

关键词： t-complex testis expressed gene 5 transcripts testis mice

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Mathematical Model,Numerical Simulation and Convergence Analysis of a Semiconductor Device Problem with Heat and Magnetic Influences

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 302-319页

作者： Chang-feng LI Yi-rang YUAN huai-ling SONG School of Economics Shandong UniversityJinan 250100China Institute of Mathematics Shandong UniversityJinan 250100China College of Mathematics and Econometrics Hunan UniversityChangsha 410082China

In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical *** important factors,heat and magnetic influences are *** mathematical model is formulated by four nonlinear partial differential equations(PDEs),determining four major physical *** influences of magnetic fields are supposed to be weak,and the strength is parallel to the *** elliptic equation is treated by a block-centered method,and the law of conservation is *** computational accuracy is improved one *** equations are convection-dominated,thus are approximated by upwind block-centered *** difference can eliminate numerical dispersion and nonphysical *** diffusion is approximated by the block-centered difference,while the convection term is treated by upwind ***,the unknowns and adjoint functions are computed at the same *** characters play important roles in numerical computations of conductor device *** the theories of priori analysis such as energy estimates,the principle of duality and mathematical inductions,an optimal estimates result is *** a composite numerical method is shown for solving this problem.

关键词： three-dimensional conductor device problem with heat and magnetic influences upwind blockcentered differences elemental conservation of mass numerical analysis

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Optimal dispatching strategy for residential demand response considering load participation

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Global Energy Interconnection 2024年第1期7卷 38-47页

作者： Xiaoyu Zhou Xiaofeng Liu huai Liu Zhenya Ji feng Li School of Electrical and Automation Engineering Nanjing Normal UniversityNanjing 210023P.R.China

To facilitate the coordinated and large-scale participation of residential flexible loads in demand response(DR),a load aggregator(LA)can integrate these loads for *** this study,a residential DR optimization scheduling strategy was formulated considering the participation of flexible loads in ***,based on the operational characteristics of flexible loads such as electric vehicles,air conditioners,and dishwashers,their DR participation,the base to calculate the compensation price to users,was determined by considering these loads as virtual energy *** was quantified based on the state of virtual energy storage during each time ***,flexible loads were clustered using the K-means algorithm,considering the typical operational and behavioral characteristics as the cluster ***,the LA scheduling strategy was implemented by introducing a DR mechanism based on the directrix *** simulation results demonstrate that the proposed DR approach can effectively reduce peak loads and fill valleys,thereby improving the load management performance.

关键词： Residential demand response Flexible loads Load participation Load aggregator

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Analysis of the one-decoy-state SARG04 quantum cryptography protocol in the presence of afterpulse effects

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Communications in Theoretical Physics 2024年第6期76卷 66-71页

作者： Hu Nian Ya-feng Nie Chun-Mei Zhang liang-liang Lu Key Laboratory of Optoelectronic Technology of Jiangsu Province School of Physical Science and TechnologyNanjing Normal UniversityNanjing 210023China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Hefei National Laboratory Hefei 230088China

The SARG04 quantum key distribution protocol can offer greater robustness against photon number splitting attacks than the BB84 protocol that is implemented with weak *** this paper,we propose a tight key analysis for the SARG04 protocol,by considering the one-decoy method and investigating its performance under the influence of a detector *** results demonstrate that an increase in block size leads to a slight increase in both the secure key rate and the maximum transmission ***,the detector afterpulse plays a crucial role in practical applications and has a more pronounced effect on the SARG04 protocol compared to the BB84 protocol.

关键词： Quantum key distribution SARG04 protocol one decoy afterpulse

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Optimizing prediction models for pancreatic fistula after pancreatectomy:Current status and future perspectives

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World Journal of Gastroenterology 2024年第10期30卷 1329-1345页

作者： feng Yang John A Windsor De-liang Fu Department of Pancreatic Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Surgical and Translational Research Centre Faculty of Medical and Health SciencesUniversity of AucklandAuckland 1142New Zealand

Postoperative pancreatic fistula(POPF)is a frequent complication after pancre-atectomy,leading to increased morbidity and *** prediction models for POPF has emerged as a critical focus in surgical *** over sixty models following pancreaticoduodenectomy,predominantly reliant on a variety of clinical,surgical,and radiological parameters,have been documented,their predictive accuracy remains suboptimal in external validation and across diverse *** models after distal pancreatectomy continue to be pro-gressively reported,their external validation is eagerly ***,POPF prediction after central pancreatectomy is in its nascent stage,warranting urgent need for further development and *** potential of machine learning and big data analytics offers promising prospects for enhancing the accuracy of prediction models by incorporating an extensive array of variables and optimizing algorithm ***,there is potential for the development of personalized prediction models based on patient-or pancreas-specific factors and postoperative serum or drain fluid biomarkers to improve accuracy in identifying individuals at risk of *** the future,prospective multicenter studies and the integration of novel imaging technologies,such as artificial intelligence-based radiomics,may further refine predictive *** these issues is anticipated to revolutionize risk stratification,clinical decision-making,and postoperative management in patients undergoing pancre-atectomy.

关键词： Pancreatic fistula Pancreaticoduodenectomy Distal pancreatectomy Central pancreatectomy Prediction model Machine learning Artificial intelligence

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Adhesive Contact of Elastic Solids with Self-Affine Fractal Rough Surfaces

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Acta Mechanica Solida Sinica 2024年第2期37卷 265-270页

作者： Xuan-Ming liang Shi-Wen Chen Si-He Wang Zhen-Yuan Gong Jun feng Gang-feng Wang Department of Engineering Mechanics SVL and MMMLXi’an Jiaotong UniversityXi’an710049China OPPO Mobile Telecommunications Corporation Ltd. Dongguan523860China

The elastic adhesive contact of self-affine fractal rough surfaces against a rigid flat is simulated using the finite element method. An array of nonlinear springs, of which the force-separation law obeys the Lennard–Jones potential, is introduced to account for the interfacial adhesion. For fractal rough surfaces, the interfacial interaction is generally attractive for large mean gaps, but turns repulsive as the gap continuously shrinks. The interfacial interactions at the turning point corresponding to the spontaneous contact are shown for various surfaces. For relatively smooth surfaces, the probability density distributions of repulsion and attraction are nearly symmetric. However, for rougher surfaces, the simulation results suggest a uniform distribution for attraction but a monotonously decreasing distribution with a long tail for repulsion. The pull-off force rises with increasing ratio of the work of adhesion to the equilibrium distance, whereas decreases for solids with a higher elastic modulus and a larger surface roughness. The current study will be helpful for understanding the adhesion of various types of rough solids.

关键词： Fractal rough surfaces Adhesion Contact mechanics Lennard-Jones potential

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A refined deviatoric hardening plastic model for sand

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2813-2821页

作者： Min Wang Tongming Qu Yuntian feng Teng liang liangtong Zhan MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou310058China Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyKowloon999077Hong KongChina Zienkiewicz Centre for Computational Engineering College of EngineeringSwansea UniversitySwanseaWalesSA18EPUK Center for Hypergravity Experimental and Interdisciplinary Research Zhejiang UniversityHangzhou310058China

The classical deviatoric hardening models are capable of characterizing the mechanical response of granular materials for a broad range of degrees of *** work finds that it has limitations in accurately predicting the volumetric deformation characteristics under a wide range of confining/consolidation *** issue stems from the pressure independent hardening law in the classical deviatoric hardening *** overcome this problem,we propose a refined deviatoric hardening model in which a pressure-dependent hardening law is developed based on experimental *** between numerical results and laboratory triaxial tests indicate that the improved model succeeds in capturing the volumetric deformation behavior under various confining/consolidation pressure conditions for both dense and loose ***,to examine the importance of the improved deviatoric hardening model,it is combined with the bounding surface plasticity theory to investigate the mechanical response of loose sand under complex cyclic loadings and different initial consolidation *** is proved that the proposed pressure-dependent deviatoric hardening law is capable of predicting the volumetric deformation characteristics to a satisfactory degree and plays an important role in the simulation of complex deformations for granular geomaterials.

关键词： Elasto-plastic deformation Isotropic hardening Deviatoric plastic strain Granular material Kinematic hardening Bounding surface

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An intelligent control method based on artificial neural network for numerical flight simulation of the basic finner projectile with pitching maneuver

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Defence Technology（防务技术） 2024年第2期32卷 663-674页

作者： Yiming liang Guangning Li Min Xu Junmin Zhao feng Hao Hongbo Shi Northwestern Polytechnical University School of Astronautics Xi’an 710072China China North Industries Group Corporation No 203 Research Institute Xi’an 710065China

In this paper,an intelligent control method applying on numerical virtual flight is *** proposed algorithm is verified and evaluated by combining with the case of the basic finner projectile model and shows a good application ***,a numerical virtual flight simulation model based on overlapping dynamic mesh technology is *** order to verify the accuracy of the dynamic grid technology and the calculation of unsteady flow,a numerical simulation of the basic finner projectile without control is carried *** simulation results are in good agreement with the experiment data which shows that the algorithm used in this paper can also be used in the design and evaluation of the intelligent controller in the numerical virtual flight ***,combined with the real-time control requirements of aerodynamic,attitude and displacement parameters of the projectile during the flight process,the numerical simulations of the basic finner projectile’s pitch channel are carried out under the traditional PID(Proportional-Integral-Derivative)control strategy and the intelligent PID control strategy *** intelligent PID controller based on BP(Back Propagation)neural network can realize online learning and self-optimization of control parameters according to the acquired real-time flight *** with the traditional PID controller,the concerned control variable overshoot,rise time,transition time and steady state error and other performance indicators have been greatly improved,and the higher the learning efficiency or the inertia coefficient,the faster the system,the larger the overshoot,and the smaller the stability *** intelligent control method applying on numerical virtual flight is capable of solving the complicated unsteady motion and flow with the intelligent PID control strategy and has a strong promotion to engineering application.

关键词： Numerical virtual flight Intelligent control BP neural network PID Moving chimera grid

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Evolution of In783 alloy in microstructure and properties enduring different service times

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Rare Metals 2024年第1期43卷 334-341页

作者： Zhong-Shuai Han Jin-feng Du Jun liang Zheng Zhang School of Material Science and Engineering Beihang UniversityBeijing 100191China Shenhua Guohua(Beijing)Electric Power Research Institute Co. Ltd.Beijing 100025China

Impact, tensile, and fatigue tests were performed in In783 alloy serving 4000, 23,000 and 48,000 h. The microstructure was then analysed by optical microscopy(OM), scanning electron microscopy(SEM), and transmission electron microscopy(TEM) to probe the relationship between microstructure and properties. The results show that a new Ni_(5)Al_(3) phase is found, which grows gradually in β phase with serving time increasing,destroying the martensitic structure of the β phase, and degenerating the toughness of the β phase(approximately13.88% reduction). Therefore, the degradation of the βphase results in a sharp dropping of the resistance to stress accelerated grain boundary oxygen(SAGBO) during serving;thus, the intergranular fracture morphology degree increases with duration of service(almost 40% increase from the fractured surface). In addition, the strength of alloy will be gradually enhanced when the γ'phase becomes relatively bulky with serving time increasing due to considerable distortion of the dislocations as a result of the spacing of individual particles, in which any movement of the dislocation will have to overcome a larger number of obstacles per unit length.

关键词： In783 Microstructure Properties βphase Ni_(5)Al_(3)phase

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