检索结果-南通市图书馆

多囊卵巢综合征患者PPAR-γ基因外显子6多态性检测

在线全文

学校读者我要写书评

暂无评论

郑州大学学报（医学版） 2007年第3期42卷 523-526页

作者：刘惠娜谭丽黄玉荣张梅王艳丽郭华锋郑州大学第二附属医院妇产科郑州450014 平顶山市第一人民医院妇产科平顶山467000 商丘市中心医院妇产科商丘476000 郑州市妇幼保健院郑州450003

目的检测多囊卵巢综合征(PCOS)患者过氧化物酶体增殖体激活受体-γ(PPAR-γ)基因外显子6多态性。方法应用聚合酶链反应-限制性内切酶片段长度多态性分析(PCR-RFLP)检测中国汉族96例PCOS患者和56例对照PPAR-γ基因外显子6的多态性,并分析... 详细信息

目的检测多囊卵巢综合征(PCOS)患者过氧化物酶体增殖体激活受体-γ(PPAR-γ)基因外显子6多态性。方法应用聚合酶链反应-限制性内切酶片段长度多态性分析(PCR-RFLP)检测中国汉族96例PCOS患者和56例对照PPAR-γ基因外显子6的多态性,并分析PPAR-γ基因的多态性与PCOS患者体质量指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)及稳态模型(HOMA-IR)、促卵泡素(FSH)等的关系。结果PCOS组PPAR-γ基因外显子6的基因型(CC、CT、TT)频率分别为69%、17%、14%,对照组以上各基因频率分别为89%、7%、4%,PCOS组中CT/TT基因型频率明显高于对照组(P<0.05)。PCOS组等位基因C和T的频率分布分别为77%和23%,对照组分别为93%和7%,PCOS组的T等位基因频率明显高于对照组(P<0.01)。PCOS患者中PPAR-γ基因外显子6突变者BMI明显高于未突变者(P<0.05)。结论中国汉族PCOS患者PPAR-γ基因外显子6的碱基突变与PCOS肥胖的发生有关,可能是PCOS的易感基因之一。

关键词：过氧化物酶体增殖体激活受体-γ基因外显子6 多囊卵巢综合征多态性胰岛素抵抗

Monogenic gene therapy for glaucoma and optic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

轻卡重型柴油机满足国五排放的策略及技术应用

在线全文

学校读者我要写书评

暂无评论

南方农机 2016年第10期47卷 93-97页

作者：郭华锋廖善彬危亮聂涛江铃汽车股份有限公司发动机开发部江西南昌330001

本文针对轻卡柴油发动机如何达成国-V排放技术路线进行了台架试验研究。试验机配置有DOC+SCR排放控制系统。针对国-V排放限值的挑战,本研究提出如下排放的应对策略:1)优化外特性,降低额定点转速可降低ESC排放点的颗粒排放的生成;2)进行... 详细信息

本文针对轻卡柴油发动机如何达成国-V排放技术路线进行了台架试验研究。试验机配置有DOC+SCR排放控制系统。针对国-V排放限值的挑战,本研究提出如下排放的应对策略:1)优化外特性,降低额定点转速可降低ESC排放点的颗粒排放的生成;2)进行硬件选型,对燃烧室,油嘴,增压器进行优化,降低颗粒排放;3)进行标定优化,对高颗粒排放工况增加后喷,通过优化后喷参数使在主喷油期生成的大部分颗粒及其它不完全燃烧产物在缸内氧化,对加速工况设置烟度限制以减少加速时瞬态喷油量和缸内空气量的不同步性,使燃烧得以在较高的瞬态过量空气系数下进行,从而有效地抑制加速工况碳烟的生成;4)进行后处理DOC选型,不同配方后处理对尾管排放影响较大,因此需要进行试验与分析得出成本与排放效果比较好的后处理。试验机在实施优化控制策略后,能够满足国五排放的限值。台架试验数据证明,本研究提出的排放优化策略是可行及实用的。

关键词：国V 排放硬件选型标定优化后处理选型

Asking one mechanism in glial cells during neuroinflammation

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

应用型本科院校机械类专业实践教学改革研究与实践

在线全文

学校读者我要写书评

暂无评论

中国教育技术装备 2018年第18期 131-133页

作者：郭华锋于萍李志李菊丽何绍华徐州工程学院机电工程学院

以应用型本科院校为例,从多个方面进行改革研究与实践,并取得令人满意的效果,包括:创新理念,制定政策;师资队伍建设,课程资源建设;顶层设计,构建实践教学体系和质量保障体系;建立毕业设计质量闭环监控体系;采用多元化培养模式,促进学生... 详细信息

以应用型本科院校为例,从多个方面进行改革研究与实践,并取得令人满意的效果,包括:创新理念,制定政策;师资队伍建设,课程资源建设;顶层设计,构建实践教学体系和质量保障体系;建立毕业设计质量闭环监控体系;采用多元化培养模式,促进学生个性化发展。

关键词：应用型本科机械类专业实践教学教学改革在线开放课程

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao guo-Wei Si Nian-Song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

Timescale Analysis of Spectral Lags

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Astronomy and Astrophysics 2004年第6期4卷 583-598页

作者： Ti-PeiLi Jin-LuQu huafeng Li-MingSong guo-QiangDing LiChen ParticleAstrophysicsLab. InstituteofHighEnergyPhysicsChineseAcademyofSciences DepartmentofPhysics＆CenterforAstrophysics TsinghuaUniversityBeijing100084／／ParticleAstrophysicsLab.InstituteofHighEnergyPhysicsChineseAcademyofSciences DepartmentofEngineeringPhysics＆CenterforAstrophysics TsinghuaUniversity DepartmentofAstronomy BeijingNormalUniversity

A technique for timescale analysis of spectral lags performed directly in the time domain is developed. Simulation studies are made to compare the time domain technique with the Fourier frequency analysis for spectral time lags. The time domain technique is applied to studying rapid variabilities of X-ray binaries and γ-ray bursts. The results indicate that in comparison with the Fourier analysis the timescale analysis technique is more powerful for the study of spectral lags in rapid variabilities on short time scales and short duration flaring phenomena.

关键词： methods data analysis binaries general x-rays stars gamma rays bursts x-rays bursts