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Nano Research 2024年第4期17卷 3428-3428页

作者： Tong Li Zhenzong Xu Ben Bin Xu Zhanhu Guo Yunhong Jiang Xuehua Zhang Maryam Bayati Terence Xiaoteng liu yan-hua liu School of Optoelectronic Science and Engineering Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of ChinaSoochow UniversitySuzhou 215006China Department of Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon TyneNE18STUK Hub for Biotechnology in the Built Environment Department of Applied SciencesNorthumbria University at NewcastleNE18STUK Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada

Erratum to Nano Research 2023,16(7):10493–10499 https://***/10.1007/s12274-023-5727-6 The article“Advancing pressure sensors performance through a flexible MXene embedded interlocking structure in a microlens array”,written by Tong Li,Zhenzong Xu,Ben Bin Xu,Zhanhu Guo,Yunhong Jiang,Xuehua Zhang,Maryam Bayati,Terence Xiaoteng liu,and yan-hua liu,was originally published electronically on the publisher’s internet portal on May 20,2023 without open access due to an unfortunate oversight during the conversion *** publisher apologizes this *** article is forthwith distributed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.

关键词： Creative performance structure

基于Diels-Alder反应的自修复聚氨酯的结构与修复行为

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高分子学报 2016年第11期26卷 1579-1586页

作者：于正洋冯利邦柴昌盛王彦平刘艳花强小虎兰州交通大学机电工程学院兰州730070 兰州城市学院培黎工程技术学院兰州730070

采用呋喃封端的聚氨酯预聚体与双马来酰亚胺反应,合成了基于Diels-Alder(DA)反应的热可逆自修复聚氨酯(PU-DA).利用FTIR、DSC和gel-solution-gel方法对其分子结构、热性能及其可逆性进行了表征,结果表明,具有热可逆性的DA键被成功引入... 详细信息

采用呋喃封端的聚氨酯预聚体与双马来酰亚胺反应,合成了基于Diels-Alder(DA)反应的热可逆自修复聚氨酯(PU-DA).利用FTIR、DSC和gel-solution-gel方法对其分子结构、热性能及其可逆性进行了表征,结果表明,具有热可逆性的DA键被成功引入到聚氨酯中,从而赋予聚氨酯具有良好的再加工性能和自修复性能.通过偏光显微镜观测对材料的自修复行为进行了考察,结果表明,由于DA反应的热可逆性,0.5 mm深度划痕的聚氨酯试样在120℃热处理300 s或130℃热处理150 s后划痕便可消失,从而实现了划痕的自修复.并且模拟实际生活中聚合物材料受到轻微损伤时的情况,通过拉伸试验对0.5 mm深度划痕有效自修复的热处理温度和时间进行了确定,并对同一受损部位多次刻划-修复的修复效率进行了详细研究,结果表明:在120℃处理15 min可达到最佳修复效果,其一次修复效率可达71%,同一受损部位经过3次刻划—修复后,其修复效率仍能达到35%.

关键词： Diels—Alder反应聚氨酯热可逆性自修复再加工性

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Broadband low-frequency sound absorption of multifunctional composite metastructure

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Science China Technological Sciences 2025年

作者： Yilong yanG Shanshan liu yan LI Tong GAO Yongdong PAN Yong LI Yabin JIN School of Aerospace Engineering and Applied Mechanics Tongji University Institute of Acoustics School of Physics Science and Engineering Tongji University Shanghai Institute of Aircraft Mechanics and Control State International Joint Research Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical University Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science and Technology

In this study, we fabricated multifunctional metastructures from carbon fiber-reinforced plastic composites using additive manufacturing technology. These metastructures are characterized by their lightweight, load-bearing capacity, and broadband low-frequency sound absorption properties. The metastructure consists of 36 unit cells, and non-local coupling mechanism was considered for designing the sound absorption performance. We developed an acoustic impedance theory tailored for the metastructure, facilitating an analysis of thermal and viscous dissipation mechanisms. It is proven theoretically and experimentally that the proposed composite metastructure can achieve a noise reduction with an average sound absorption coefficient greater than 0.9 across frequencies in the rage of 330–1500 Hz. We also studied the metastructure’s quasi-static and cyclic compression performance, confirming its efficient absorption capabilities after cyclic compression. The proposed design and additive manufacturing method for composite metastructures provides a novel pathway for creating lightweight, multifunctional structures with diverse applications, such as aerospace engineering.

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Synthetic control of chiral pore surfaces in covalent organic frameworks for enantioselective separation of chiral drugs

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Science China Chemistry 2025年

作者： Shiguo Fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia Yong Cui yan liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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Synthesis and Neuroprotective Activity of Novel C-4, C-7 Derivatives in the Tetracycline Series

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Synthesis and Neuroprotective Activity of Novel C-4, C-7 Der...

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

中国化学会第四届有机化学学术会议

作者： ZHOU, Zhan-Yun WANG, Xiao-Wei ZHANG, Zhi-Li yanG, hua CHEN, yan-Li liu, Jun-Yi (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083)

＜正＞In recent years, doxycycline and minocycline have been shown to have neuroprotective effects in models of global and focal ischemia. Although a very large number of tetracycline derivatives have been synthesized over the past years, there has been no report for dedimethylamino-derivatives of minocycline and doxycycline at C-4 or C-7.

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Coordination Structure of CO at Pt/Ionic Liquid Interface Probed by Surface Raman Spectroscopy

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Coordination Structure of CO at Pt/Ionic Liquid Interface Pr...

中国化学会第六届全国结构化学学术会议

作者： Ya-Xian Yuan,Feng-Zhu yang,Jin-hua Mei,yan liu,Jian-Lin Yao, Ren-Ao Gu College of Chemistry,Chemical Engineering and Materials Science,Soochow University, Suzhou 215123,China

＜正＞Ionic liquids（ILs） are a type of molten salts which are consisted of organic cations and organic/inorganic anions at ambient *** have attracted considerable interest in recent years,particularly in electrochemical applications and surface *** we all known,ILs are composed purely of ions in the liquid state and it is not appropriate for describing the metal electrode/ionic liquid interface by Gouy-Chapman-Sterns（GCS） ***,both theories and experiments about the electric double

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椭圆轨道上卫星的混沌姿态运动

上海交通大学学报 1999年第10期33卷 1206-1209页

作者：彭建华刘延柱上海交通大学工程力学系上海200030

基于土星卫星上所观察到的混沌运动，研究了中心引力场中Ｋｅｐｌｅｒ椭圆轨道上非对称卫星的姿态运动，其系统的Ｈａｍｉｌｔｏｎ函数可用ＳｅｒｒｅｔＡｎｄｏｙｅｒ变量写出．通过无限小接触变换，将系统等价为无力矩作用下自由... 详细信息

基于土星卫星上所观察到的混沌运动，研究了中心引力场中Ｋｅｐｌｅｒ椭圆轨道上非对称卫星的姿态运动，其系统的Ｈａｍｉｌｔｏｎ函数可用ＳｅｒｒｅｔＡｎｄｏｙｅｒ变量写出．通过无限小接触变换，将系统等价为无力矩作用下自由刚体运动，但其转动惯量仍随时间周期地变化，从而化作周期摄动的ＥｕｌｅｒＰｏｉｎｓｏｔ运动．应用Ｍｅｌｎｉｋｏｖ方法预测其存在混沌运动，并利用Ｐｏｉｎｃａｒé截面的数值计算验证此结论的正确性．

关键词：姿态运动混沌 Melnikov方程椭圆轨道卫星

砂仁及其近缘药用植物的高效薄层色谱指纹图谱研究

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中国药学杂志 2017年第3期52卷 188-192页

作者：邵艳华刘美廷杨一帆于现阔丁平广州中医药大学中药学院广州510006

目的对砂仁及其近缘药用植物的挥发油成分进行高效薄层色谱指纹图谱研究,以期解决砂仁的专属性鉴别,并为其质量控制提供依据。方法采用高效薄层色谱法,控制相对湿度为67%,环己烷-三氯甲烷-乙酸乙酯(13∶2∶2)为展开剂,5%香草醛硫酸溶液... 详细信息

目的对砂仁及其近缘药用植物的挥发油成分进行高效薄层色谱指纹图谱研究,以期解决砂仁的专属性鉴别,并为其质量控制提供依据。方法采用高效薄层色谱法,控制相对湿度为67%,环己烷-三氯甲烷-乙酸乙酯(13∶2∶2)为展开剂,5%香草醛硫酸溶液显色,于可见光下检视,薄层色谱图用Chromap 1.5色谱软件进行分析。结果建立了由9个特征斑点构成的砂仁挥发油类成分的高效薄层色谱指纹图谱,并指认出主要成分乙酸龙脑酯。通过HPTLC指纹图谱考察,不同存放时间及不同产地的砂仁药材质量参差不齐;常见砂仁混伪品间质量差别显著;砂仁及姜科其他近缘种常用药用植物挥发油类成分的化学组成亦差异明显。结论该方法可以有效地鉴别砂仁,并评价其质量。

关键词：砂仁混伪品近缘药用植物挥发油高效薄层色谱法