检索结果-南通市图书馆

同方期刊数据库

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui xu Linxi Li Yunxiang Ji Yezhong Wang Yingjia Li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

Soil conservation assessment via climate change and vegetation growth scenarios in the Nile River basin

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2021年第4期18卷 863-877页

作者： LIU hua LIU yan-xu ZHAO Wen-wu PENG Da State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China College of Geoscience and Surveying Engineering China University of Mining and Technology(Beijing)Beijing 100083China Space Engineering University Beijing 101416China

Soil conservation by vegetation can mitigate soil erosion hazard and prevent reductions in food ***,previous research applies little consideration to the interaction between vegetation and climate change in the estimation of future soil conservation ***,based on the Revised Universal Soil Loss Equation(RUSLE),Representative Concentration Pathways(RCPs,specifically RCP4.5 and RCP8.5),and the vegetation index and precipitation datasets,we built a multivariate regression equation that considers changes in vegetation growth under climate change scenarios in the context of soil *** the Nile River basin as a case study,via our established methods,we modelled and projected the impact of vegetation and climate change on future soil conservation between 2020 and 2100,where three main results were obtained:(1)under the scenarios of RCP4.5 and RCP8.5 from 2020 to 2100,soil conservation in the Nile Basin will first increase and then decrease,with its highest value in the years 2060,at 117.72(t ha^(-1)y^(-1)),and 2070,at 134.39(t ha^(-1)y^(-1)).(2)Soil conservation under RCP4.5 is lower than that under the RCP8.5 scenario,with a maximum difference of 27(t ha^(-1)y^(-1))in 2040 and a minimum difference of 0.2(t ha^(-1)y^(-1))in 2100.(3)The vegetation and climate change models in 2100 had soil conservation values of 110.77(t ha^(-1)y^(-1))under RCP4.5 and 38.70(t ha^(-1)y^(-1))under *** conclusion,although vegetation growth can increase soil conservation in the Nile River basin,the change in precipitation can offset the soil conservation enhanced by vegetation growth.

关键词： Ecosystem services Land degradation RUSLE RCPs Interaction effects

Gas-rigid-flexible compound blade coupling enhanced experimental study on chaotic mixing of multiphase flow

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第11期94卷 356-372页

作者： yan Zhang Xinyu Li Gai Zhang Mingyang Fan Jianxin xu hua Wang Faulty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming650093China

Efficient fluid mixing is essential for process *** study proposes a new method in which gas-rigid-flexible composite blades are coupled to enhance chaotic mixing in multiphase flow *** rigidity and flexibility of the blades were adjusted by intermittent gas injection,which increased the effectiveness of mixing of the liquid-liquid two-phase *** study investigates the influence of different process parameters on the mixing efficiency and quantifies the chaotic characteristics of fluid mixing through pressure-time series analysis of multiscale entropy and the 0–1 test.A high-speed camera recorded the bubble movement in the flow field,while particle image velocimetry(PIV)revealed the enhancement of the properties of the flow field in the system due to the suspended motion of the *** suitable process parameters,gas-rigid-flexible composite blade coupling significantly enhanced the mixing effect,where the mixing time of the G-RFCP system was reduced by 1.42 times compared to that of the CP *** motion,deformation,and rupture enhanced the mechanical agitation,increasing the intensity of the turbulence and chaotic ***-field analysis indicated a three-fold increase in the vorticity and a 1.04-fold increase in the velocity difference for the G-RFCP system compared with those of the CP *** study provides theoretical and experimental foundations for understanding chaotic mixing in liquid-liquid two-phase fluids.

关键词： Rigid-flexible compound blades Tracer particle Bubble dynamics Multiphase flow Chaotic mixing characteristics

PDOL-Based Solid Electrolyte Toward Practical Application:Opportunities and Challenges

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第7期16卷 109-141页

作者： hua yang Maoxiang Jing Li Wang Hong xu Xiaohong yan Xiangming He Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013People’s Republic of China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084People’s Republic of China

Polymer solid-state lithium batteries(SSLB)are regarded as a promising energy storage technology to meet growing demand due to their high energy density and *** conductivity,interface stability and battery assembly process are still the main challenges to hurdle the commercialization of *** the main component of SSLB,poly(1,3-dioxolane)(PDOL)-based solid polymer electrolytes polymerized in-situ are becoming a promising candidate solid elec-trolyte,for their high ion conductivity at room temperature,good battery elec-trochemical performances,and simple assembly *** review analyzes opportunities and challenges of PDOL electrolytes toward practical application for polymer *** focuses include exploring the polymerization mechanism of DOL,the performance of PDOL composite electrolytes,and the application of ***,we provide a perspective on future research directions that need to be emphasized for commercialization of PDOL-based electrolytes in *** exploration of these schemes facilitates a comprehensive and profound understanding of PDOL-based polymer electrolyte and provides new research ideas to boost them toward practical application in solid-state batteries.

关键词： Poly(1,3-dioxolane) Solid electrolyte Polymerization mechanism Composite electrolyte Practical application

色谱法研究杂多酸 II.杂多酸在反相高效液相色谱中的保留行为

在线全文

学校读者我要写书评

暂无评论

化学学报 1988年第6期 537-542页

作者：曾前东朱明华徐延瓞华东化工学院化学系上海

在十八烷基键合硅胶柱上,以甲醇-缓冲液作流动相,研究了杂多酸的容量因子随流动相离子强度、柱温、甲醇含量变化的规律,这些规律与我们导出的关系式相一致.对保留值作出贡献的有固定相排阻作用、分配作用以及居次要地位的杂多酸与固定... 详细信息

在十八烷基键合硅胶柱上,以甲醇-缓冲液作流动相,研究了杂多酸的容量因子随流动相离子强度、柱温、甲醇含量变化的规律,这些规律与我们导出的关系式相一致.对保留值作出贡献的有固定相排阻作用、分配作用以及居次要地位的杂多酸与固定相表面剩余硅醇基的相互作用.排阻作用与分配作用的相对重要性与流动相中甲醇含量有关.杂多酸可能形成了离子缔合物,其保留行为与一般的有机分子相似,但离子强度有影响.

关键词：杂多酸保留值容量因子流动相 II 保留行为反相高效液相色谱

Copper catalyzed borylative cyclization of 3-arylallyl carbamoyl chloride with B_(2)pin_(2):stereoselective synthesis of cis-2-aryl-3-boryl-γ-lactams

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第7期32卷 2297-2300页

作者： Mei-hua Shen Ting-Biao Wan Xiu-Rong huang yan Li Dan-hua Qian hua-Dong xu Defeng xu Jiangsu Key Laboratory of Advanced Catalytic Materials&Technology School of PharmacyChangzhou UniversityChangzhou 213164China

Borylative cyclization of E-3-arylallyl carbamoyl chlorides is achieved through copper catalyzed intramolecular carboboration with B_(2)pin_(2).2-Aryl-3-boryl-γ-lactams are formed with exclusive ***-Dppp combination ... 详细信息

关键词： Carboboration Borylative cyclization Copper catalysis Allyl carbamoyl chloride Borocupration γ-Lactam

阿克陶M_S6.7和且末M_S5.8地震前红外亮温异常分析

在线全文

学校读者我要写书评

暂无评论

内陆地震 2017年第2期31卷 130-137页

作者：张治广张元生王在华徐衍刚新疆维吾尔自治区地震局新疆乌鲁木齐830011 中国地震局兰州地震研究所甘肃兰州730000 阿克苏中心地震台新疆阿克苏843000

利用相对功率谱方法对风云卫星热红外亮温数据进行处理,发现阿克陶M_S6.7和且末M_S5.8地震前存在明显的前兆异常。异常时空演化特征为2016年9月19日在阿尔金断裂带和西昆仑断裂带交汇部位、塔里木盆地内开始出现相对功率谱高值聚集现象... 详细信息

利用相对功率谱方法对风云卫星热红外亮温数据进行处理,发现阿克陶M_S6.7和且末M_S5.8地震前存在明显的前兆异常。异常时空演化特征为2016年9月19日在阿尔金断裂带和西昆仑断裂带交汇部位、塔里木盆地内开始出现相对功率谱高值聚集现象,随后幅值和面积逐渐增大,持续至10月7日异常幅值和面积达到最大值,然后逐渐变弱,2016年10月22日后基本恢复正常,异常持续33天。异常结束后,分别于11月25日和12月20日发生阿克陶M_S6.7和且末M_S5.8地震。

关键词：热红外亮温异常地震前兆阿克陶Ms6.7 且末Ms 5.8

Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xinyu xu Yuan Ma Hui Cao Li xu Haoming Chen Sulai Liu Wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

关键词：

Improved certificateless multi-proxy signature

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2012年第4期19卷 94-105,116页

作者： xu Jie SUN Hong-xiang WEN Qiao-yan ZHANG hua School of Science Beijing University of Posts and Telecommunications Beijing 100876 China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China

Multi-proxy signature is a scheme that an original signer delegates his or her signing capability to a proxy group. In the scheme, only the cooperation of all proxy signers in the proxy group can create a signature on behalf of the original signer. Jin and Wen firstly defined the formal security model of certificateless multi-proxy signature （CLMPS） and proposed a concrete CLMPS scheme. However, their construction model is inaccurate, the concrete signature scheme has has three problems： the definition of the strengthened security a security flaw, and the proof of the security is imperfect. With further consideration, a remedial strengthened security model is redefined, and an improved scheme is also proposed, which is existentially unforgeable against adaptively chosen-warrant, chosen-message and chosen-identity attacks in the random oracles. In this condition, the computational Diffie-Hellman （CDH） assumption is used to prove full security for our CLMPS scheme.

关键词： certificateless multi-proxy signature provable security bilinear map