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Dynamic forecasting and optimal scheduling of by-product gases in integrated iron and steel works

Journal of Iron and Steel Research International 2019年第5期26卷 529-546页

作者： Qi Zhang Hui Li Jia-lin Ma hua-yan xu Bo-yang Yu Gang Wang Shan Jiang State Environmental Protection Key Laboratory of Eco-Industry Northeastern University Shenyang 110819 Liaoning China State Key Laboratory of Hybrid Process Industry Automation Systems and Equipment Technology Automation Research and Design Institute of Metallurgical Industry Beijing 100072 China Software College Northeastern University Shenyang 110169 Liaoning China Shougang Jingtang United Iron & Steel Co. Ltd. Tangshan 063200 Hebei China China United Engineering Company Hangzhou 310052 Zhejiang China

The by-product gases, which are generated in ironmaking, coking and steel making processes, can be used as fuel for the metallurgical processes and on-site power plants. However, if the supply and demand of by-product gases are imbalanced, gas flaring may occur, leading to energy wastage and environmental pollution. Therefore, optimal scheduling of by-product gases is important in iron and steel works. A BP_LSSVM model, which combines back-propagation (BP) neural network and least squares support vector machine (LSSVM), and an improved mixed integer linear programming model were proposed to forecast the surplus gases and allocate them optimally. To maximize energy utilization, the stability of gas holders and boilers was considered and a concise heuristic procedure was proposed to assign penalties for boilers and gas holders. Moreover, the optimal level of gas holder was studied to enhance the stability of the gas system. Compared to the manual operation, the optimal results showed that the electricity generated by the power plant increased by 2.93% in normal condition and by 22.2% in overhaul condition. The proposed model minimizes the total cost by optimizing the boiler load with less adjustment frequency and the stability of gas holders and can be used as a guidance in dynamic forecasting and optimal scheduling of by-product gases in integrated iron and steel works.

关键词： Iron and steel works Back-propagation neural network Least squares support vector machine Mixed integer linear programming Dynamic forecasting Optimal scheduling

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Circ_0004592:An auxiliary diagnostic biomarker for gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2757-2768页

作者： Shan Kong yan-hua xu Ming Zheng Shao-Qing Ju Heng-Chuan Shi Department of Laboratory Medicine Jiangsu Province Official HospitalNanjing 210000Jiangsu ProvinceChina Department of Laboratory Medicine Northern Jiangsu People’s HospitalYangzhou 225000Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate,and robust diagnostic biomarkers are currently ***,the clinical relevance of circular RNAs(circRNAs)as GC biomarkers remains largely *** To evaluate the potential of novel circRNA circ_0004592 in the early screening and prognosis of *** High-throughput sequencing of circRNAs was performed to screen for potential target ***_0004592 expression was examined in GC tissues,cells,and *** samples were collected from healthy subjects’patients,as well as from patients with benign lesions,precancerous lesions,and GC,whereafter the diagnostic accuracy of circ_0004592 was *** correlation between circ_0004592 levels in plasma and clinicopathological data of patients with GC was further *** Circ_0004592 was upregulated in both the tissue and plasma of patients with ***,circ_0004592 expression was higher in patients with precancerous lesions than in healthy controls while being highest in patients with *** the same patient,the postoperative plasma level of circ_0004592 was lower than that in the preoperative ***,circ_0004592 level was significantly correlated with tumor differentiation,tumor depth,and lymph node *** area under the curve(AUC)of plasma circ_0004592 exhibited high sensitivity and specificity for differentiating patients with GC from healthy *** based on circ_0004592,carcinoembryonic antigen,and cancer antigen 199 achieved a superior AUC and was highly *** Plasma circ_0004592 may represent a potential non-invasive auxiliary diagnostic biomarker for patients with GC.

关键词： Biomarker Circular RNA Diagnosis Gastric cancer Plasma

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Cloning and Sequence Analysis of the Full-Length Genome of Japanese encephalitis virus Strain SXBJ07 Isolated from Swine

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Agricultural Sciences in China 2009年第11期8卷 1392-1402页

作者： WANG Wei-hua,ZHANG yan-ming,xu Xin-gang,XING Fu-shan and TANG Qing-hai College of Veterinary Medicine,Northwest A&F University,yangling 712000,P.R.China [a]College of Veterinary Medicine Northwest A&F University Yangling 712000 P.R. China

A virus strain, showing cytopathic effect in BHK-21 cell, was isolated from swine brains in Shaanxi Province, China, in 2007. The isolate was confirmed as Japanese encephalitis virus （JEV） by immunofluorescence assay （IFA） and reverse transcription polymerase chain reaction （RT-PCR）, and named SXBJ07. The complete nueleotide and deduced amino acid sequences of the JEV strain SXBJ07 were determined. Its single open reading frame has a total of 3 432 amino acid residues. An extensive E gene based phylogenetic analysis was performed, the result showed that SXBJ07 strain belongs to genotype I. Comparison of the SXBJ07 genomic sequence with those of the 24 fully sequenced JEV strains in published databases showed nucleotide homology ranging from 99.0 to 83.7%; amino acid homology ranged from 99.8 to 94.8%. Compared SXBJ07 with SA14-14-2 strain, the current live vaccine strain in China, the homology of amino acid in envelope gene was 97.0%; and there were amino acid substitutions in 13 sites of the active domains of E protein （E1-E411）.

关键词： Japanese encephalitis virus (JEV) full-length genome sequence analysis

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Coupling effect between film boiling heat transfer and evaporation drag around a hot-particle in cold liquid

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Nuclear Science and Techniques 2003年第3期14卷 206-211页

作者： LI Xiao-yan, yanG yan-hua, xu Ji-Jun(Department of Nuclear Science and System Engineering, School of Mechanics and Power Engineering, Shanghai Jiaotong University, Shanghai 200030) Department of Nuclear Science and System Engineering School of Mechanics and Power Engineering Shanghai Jiaotong University 上海 200030

Extremely rapid evaporation could occur when high-temperature particles contact withlow-temperature liquid. This kind of phenomenon is associated with the engineering safety and the problems inhigh-transient multi-phase fluid and heat transfer. The aim of our study was to design and build an observable ex-periment facility. The first series of experiments were performed by pouring one or six high-temperature particles intoa low saturated temperature liquid pool. The particle's falling-down speed was recorded by a high-speed camera, thuswe can find the special resistant feature of the moving high-temperature particles, which is induced by the high-speedevaporation surrounding the particles. The study has experimentally verified the theory of evaporation drag model.

关键词：耦合效应薄膜状沸腾热传导蒸汽爆炸工程安全

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Correlation of FMNL2 and HERC4 expression with the infiltrative growth of cancer cells in cervical cancer tissue

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Journal of Hainan Medical University 2017年第24期23卷 89-92页

作者： Qiu-Yuan Zhou Hong Li Hong-Li Wang Wei Li yan-hua xu Department of Pathology the Central of Enshi Autonomous Prefecture Hubei ProvinceEnshiHubei Province445000

Objective: To study the correlation of FMNL2 and HERC4 expression with the infiltrative growth of cancer cells in cervical cancer tissue. Methods: Patients with cervical cancer who underwent surgical resection in our hospital between July 2014 and September 2016 were selected as the research subjects, the cervical cancer tissue and adjacent tissue were collected from the enrolled patients after operation to extract RNA, and PCR reaction kit was used to determine the mRNA expression of FMNL2, HERC4, epithelial mesenchymal transition genes and proliferation genes. Results: FMNL2, HERC4, Exosomes, Cripto-1, ZEB1, Snail, Vimentin, Piwil2, STOML-2, BCL-2, Smo and XIAP mRNA expression in cervical cancer tissue were significantly higher than those in adjacent tissue;Exosomes, Cripto-1, ZEB1, Snail and Vimentin mRNA expression in cervical cancer tissue with high FMNL2 expression were significantly higher than those in cervical cancer tissue with low FMNL2 expression;Piwil2, STOML-2, BCL-2, Smo and XIAP mRNA expression in cervical cancer tissue with high HERC4 expression were significantly higher than those in cervical cancer tissue with low HERC4 expression. Conclusion: The high expression of FMNL2 and HERC4 in cervical cancer tissue can promote the epithelial mesenchymal transition and proliferation of cancer cells respectively so as to participate in the infiltrative growth of cancer cells.

关键词： Cervical cancer Formin-like 2 HERC4 Epithelial mesenchymal transition Proliferation

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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue Han yan Su Yiming Zhou Minhui xu Jiyan xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： CHEN Wuxing CHEN Shuang YU yan ZHANG Jiangyi xu Haiyang GUO Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

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中国新生儿先天性甲状腺功能低下症与苯丙酮尿症筛查22年回顾

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中华儿科杂志 2009年第1期47卷 18-22页

作者：徐艳华秦玉峰赵正言浙江大学医学院附属儿童医院筛查科杭州310003 浙江大学医学院附属儿童医院儿童保健科杭州310003

目的总结我国开展新生儿筛查的情况，探讨我国新生儿筛查中存在的问题和对策。方法回顾性分析我国新生儿筛查的发展历史、模式、筛查方法、治疗随访与患病率等临床资料。结果我国新生儿筛查从1985年开始全面开展，筛查和治疗主要分为3... 详细信息

目的总结我国开展新生儿筛查的情况，探讨我国新生儿筛查中存在的问题和对策。方法回顾性分析我国新生儿筛查的发展历史、模式、筛查方法、治疗随访与患病率等临床资料。结果我国新生儿筛查从1985年开始全面开展，筛查和治疗主要分为3种模式，目前筛查覆盖率还较低。1985至2006年共有13229242例新生儿参加了先天性甲状腺功能低下症（CH）的筛查，检出患儿6505例，患病率为49．2／10万，同时对13666750例新生儿进行了苯丙酮尿症（PKU）筛查，检出患儿1170例，患病率为8．6／10万。全国CH患病率呈上升趋势，且西部地区患病率较高，而全国PKU患病率相对较稳定。结论新生儿筛查是预防CH和PKU患儿智力和体格发育落后的关键。应进一步提高新生儿筛查的覆盖率、筛查率和治疗率，加强健康教育，普及新生儿筛查知识，积极探索筛查新技术。

关键词：婴儿新生新生儿筛查甲状腺功能减退症苯丙酮尿症中国

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Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons

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Acta Pharmacologica Sinica 2004年第12期25卷 40-46页

作者： Yuan-gui ZHU2, Xiao-chun CHEN3, Zhi-zhe CHEN4, Yu-qi ZENG, Guang-bin SHI, yan-hua SU, xu PENG Fujian Instituteof Geriatrics, Fujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou 350001, China 2Now in Rush University Medical Center, Chicago, IL 60612,USA. Fujian Institute of Geriatrics Fujian Institute of Hematology Union Hospital Fujian Medical University Fuzhou 350001 Chin

AIM: To investigate the effect of curcumin on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in rat cortical neurons and to explore the possible mechanism. METHODS: Primary cultured rat cortical neurons were performed in vitro and cell viability was measured by MTT assay. DNA fragmentation was used to evaluate cell apoptosis. Intracellular reactive oxygen species (ROS) and mitochondrial membrane potential (?Ψm) was deter- mined by flow cytometric assay. Cellular glutathione (GSH) content was measured by spectrophotometer. Bcl-2 family proteins, cytochrome c, cleaved caspase-3, and poly (ADP-ribose) polymerase (PARP) were detected by Western blot. RESULTS: Exposure of tBHP 100 μmol/L to neurons for 60 min resulted in ?Ψm loss and cyto- chrome c release from mitochondria and subsequent activationof caspase-3 and PARP cleavation, and cell apoptosis. After removal of tBHP and then further treatment with curcumin (2.5-20 μmol/L) for 18 h, curcumin abrogated ?Ψm loss and cytochrome c release, blocked activation of caspase3, and altered the expression of Bcl-2 family. Further curcumin treatment also prevented cellular GSH and decreased intracellular ROS generation markedly. Curcumin eventually attenuated tBHP-induced apoptosis in cortical neurons. CONCLUSION: Curcumin may attenuate oxidative damages in cortical neurons by reducing intracellular production of ROS and protecting mito- chondria from oxidative damage.

关键词： Curcumin tert-butyl hydroperoxide apoptosis oxidative stress Bcl-2 family proteins mitochondria Alzheimerdisease

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