检索结果-南通市图书馆

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng wu Wen-Jia Chen Xin-Ning Yu hua-tao wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Review of ferroptosis in colorectal cancer:Friends or foes?

引用

World Journal of Gastroenterology 2023年第3期29卷 469-486页

作者： Zheng wu Ze-Xuan Fang Yan-Yu Hou Bing-Xuan wu Yu Deng hua-tao wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Ferroptosis is a newly discovered type of cell-regulated *** is characterized by the accumulation of iron-dependent lipid peroxidation and can be distinguished from other forms of cell-regulated death by different morphology,biochemistry,and ***,studies have shown that ferroptosis is associated with a variety of diseases,including liver,kidney and neurological diseases,as well as *** has been shown to be associated with colorectal epithelial disorders,which can lead to cancerous changes in the ***,the potential role of ferroptosis in the occurrence and development of colorectal cancer(CRC)is still *** elucidate the underlying mechanisms of ferroptosis in CRC,this article systematically reviews ferroptosis,and its cellular functions in CRC,for furthering the understanding of the pathogenesis of CRC to aid clinical treatment.

关键词： Ferroptosis Colorectal cancer Cell death Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes in metastasis of colorectal cancers: Friends or foes?

引用

World Journal of Gastrointestinal Oncology 2023年第5期15卷 731-756页

作者： Zheng wu Ze-Xuan Fang Yan-Yu Hou Bing-Xuan wu Yu Deng hua-tao wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Colorectal cancer(CRC),the third most common type of cancer worldwide,threaten human health and quality of *** multidisciplinary,including surgery,chemotherapy and/or radiotherapy,patients with an early diagnosis of CRC can have a good ***,metastasis in CRC patients is the main risk factor causing cancer-related *** elucidate the underlying molecular mechanisms of CRC metastasis is the difficult and research focus on the investigation of the CRC *** the other hand,the tumor microenvironment(TME)has been confirmed as having an essential role in the tumorigenesis and metastasis of malignancies,including *** the different factors in the TME,exosomes as extracellular vesicles,function as bridges in the communication between cancer cells and different components of the TME to promote the progression and metastasis of *** packaged in exosomes can be derived from different sources and transported into the TME to perform oncogenic or tumor-suppressor roles *** article focuses on CRC exosomes and illustrates their role in regulating the metastasis of CRC,especially through the packaging of miRNAs,to evoke exosomes as novel biomarkers for their impact on the metastasis of CRC progression.

关键词： Exosome Colorectal cancer Metastasis miRNA Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2022年第11期14卷 2138-2156页

作者： Ze-Xuan Fang Chun-Lan Li Zheng wu Yan-Yu Hou hua-tao wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Several genes,important for development,are reduced or silenced in adulthood,and their abnormal expression has been related to the occurrence and development of malignant *** sine oculis homeobox homolog(SIX)proteins belong to the homeobox family and play important roles in the development of different ***,SIXs are predicted to have chromatin-binding and DNA-binding transcription factor activity with reported roles in ***,a comprehensive analysis of SIXs in colorectal cancers(CRCs)has not been *** To explore the expression pattern of six SIX proteins in CRCs and their relationship with the clinicopathological parameters of CRC patients as well as investigate the potential utilization of SIXs as novel prognostic indicators in *** The expression level of SIXs in normal tissues of different organs and related cancerous tissues was analyzed in the Human Protein ***-Meier Plotter and GEPIA2 were used to analyze the prognostic values of *** analyze the potential signaling pathways with SIX family involvement,LinkedOmics was used to perform Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of SIX4-related ***,immunohistochemical experiments were performed on CRC tissues and adjacent normal tissues,and we examined the SIX4 expression level in 87 pairs of patients with tissue *** relationship between SIX4 and clinicopathological parameters in CRC patients was tested using theχ2 test and Fisher’s exact probability to verify the results of the database *** The RNA levels of SIX1-4 and SIX6 were relatively low in normal human tissues,while SIX5 was highly expressed at both the RNA and protein ***,the protein level of SIX4 was found to be elevated in various *** CRC tissues,SIX1,SIX2 and SIX4 were elevated in cancer tissues compared with adjacent normal *** all SIXs,a high level of SIX4 was found to be associated w

关键词： Sine oculis homeobox homolog Colorectal cancer Development Treatment Expression Prognostic indicator

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Potential of six-transmembrane epithelial antigen of the prostate 4 as a prognostic marker for colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2022年第9期14卷 1675-1688页

作者： Ze-Xuan Fang Chun-Lan Li Wen-Jia Chen hua-tao wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Immune cells play a role in the regulation of tumor cell behavior, and accumulating evidence supports their significance in predicting outcomes and therapeutic efficacy in colorectal cancers(CRC). Human six-transmembrane epithelial antigen of the prostate(STEAP) proteins have been recognized and utilized as promising targets for cell-and antibody-based immunotherapy. One STEAP family member, STEAP4, is expected to be an attractive biomarker for the immunotherapy of prostate and breast cancer. However, the immunotherapeutic role of STEAP4 for colorectal carcinomas has not been *** To explore the expression pattern of STEAPs in CRC and their relationship with immune infiltration, and investigate the potential utilization of STEAPs as novel prognostic indicators in colorectal *** The expression level of STEAPs in CRC was evaluated using various openresource databases and online tools to explore the expression characteristics and prognostic significance of STEAPs, as well as their correlation with immunerelated biomarkers, such as immune infiltration. Immunohistochemical(IHC) experiments were subsequently performed to verify the database *** The levels of STEAPs in CRC were inconsistent. The expression of STEAPs 1-3 in CRC was not significantly different from that in normal tissues. However,STEAP4 mRNA levels were significantly lower in CRC than in normal tissue and were positively correlated with immune-related biomarkers, such as immune cell infiltration, immune stimulation, major histocompatibility complex levels, and chemokines. Interestingly, the expression of STEAP4 in microsatellite instability-high CRC subtype was higher than that in microsatellite stability subtype. IHC staining was performed on colon cancer tissue samples and showed that high expression of STEAP4 in adjacent tissues positively correlated with immune-related biomarkers, including MLH1, MLH6, and PMS2, but negatively correlated with programm

关键词： Six-transmembrane epithelial antigen of the prostate Colorectal cancer Immunotherapy Target Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small nucleolar RNA and its potential role in the oncogenesis and development of colorectal cancer

引用

World Journal of Gastroenterology 2024年第2期30卷 115-127页

作者： Yang-Zheng Lan Zheng wu Wen-Jia Chen Ze-Xuan Fang Xin-Ning Yu hua-tao wu Jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Small nucleolar RNAs(snoRNAs)represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification,thereby contributing significantly to the maintenance of cellular functions related to protein *** have been discovered to possess the ability to influence cell fate and alter disease progression,holding immense potential in controlling human *** is suggested that the dysregulation of snoRNAs in cancer exhibits differential expression across various cancer types,stages,metastasis,treatment response and/or prognosis in *** the other hand,colorectal cancer(CRC),a prevalent malignancy of the digestive system,is characterized by high incidence and mortality rates,ranking as the third most common cancer *** research indicates that snoRNA dysregulation is associated with CRC,as snoRNA expression significantly differs between normal and cancerous ***,assessing snoRNA expression level and function holds promise for the prognosis and diagnosis of ***,current comprehension of the potential roles of snoRNAs in CRC remains *** review offers a comprehensive survey of the aberrant regulation of snoRNAs in CRC,providing valuable insights into the discovery of novel biomarkers,therapeutic targets,and potential tools for the diagnosis and treatment of CRC and furnishing critical cues for advancing research into CRC and the judicious selection of therapeutic targets.

关键词： Small nucleolar RNAs Colorectal cancer Dysregulation Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diverse roles of FOXO family members in gastric cancer

引用

World Journal of Gastrointestinal Oncology 2021年第10期13卷 1367-1382页

作者： Yu-Han Chen Chun-Lan Li Wen-Jia Chen Jing Liu hua-tao wu Department of Clinical Medicine Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Changjiang Scholar's LaboratoryDepartment of PhysiologyShantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Gastric cancer(GC)is the fifth most diagnosed cancer and the third leading causeof cancer-related death *** progress has been made in diagnosis,surgical resection,systemic chemotherapy,and immunotherapy,patientswith GC still have a poor *** overall 5-year survival rate in patientswith advanced GC is less than 5%.The FOXO subfamily,of the forkhead boxfamily of transcription factors,consists of four members,FOXO1,FOXO3,FOXO4,and *** subfamily plays an important role in many cellular processes,such as cell cycle,cell growth,apoptosis,autophagy,stress resistance,protectionfrom aggregate toxicity,DNA repair,tumor suppression,and metabolism,in bothnormal tissue and malignant *** studies support a role for FOXOs astumor suppressors based on their ability to inhibit angiogenesis and metastasis,and promote apoptosis,yet several other studies have shown that FOXOs mightalso promote tumor progression in certain *** elucidate the diverseroles of FOXOs in GC,this article systematically reviews the cellular functions ofFOXOs in GC to determine potential therapeutic targets and treatment strategiesfor patients with GC.

关键词： FOXO Gastric cancer Regulation Therapy Expression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diverse expression patterns of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier

引用

World Journal of Gastroenterology 2021年第25期27卷 3888-3900页

作者： Guo-Lian Gan hua-tao wu Wen-Jia Chen Chun-Lan Li Qian-Qian Ye Yi-Feng Zheng Jing Liu Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Changjiang Scholar’s Laboratory Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Physiology Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Abnormal expression patterns of mucin 2(MUC2)have been reported in a variety of malignant tumors and precancerous *** MUC2 expression in the intestinal mucosa,caused by various pathogenic factors,is related to mechanical dysfunction of the intestinal mucosa barrier and increased intestinal mucosal ***,the relationship between MUC2 and the intestinal mucosal barrier in patients with colorectal cancer(CRC)is not *** To explore the relationship between MUC2 and intestinal mucosal barrier by characterizing the multiple expression patterns of MUC2 in *** Immunohistochemical staining was performed on intestinal tissue specimens from 100 CRC patients,including both cancer tissues and adjacent normal ***-linked immunosorbent assays were performed on preoperative sera from 66 CRC patients and 20 normal sera to detect the serum levels of MUC2,diamine oxide(DAO),and D-lactate(D-LAC).The relationship between MUC2 expression and clinical parameters was calculated by theχ2 test or Fisher’s exact *** value of MUC2 was evaluated by Kaplan-Meier curve and log-rank *** Immunohistochemical staining of 100 CRC tissues showed that the expression of MUC2 in cancer tissues was lower than that in normal tissues(54%vs 79%,P<0.05),and it was correlated with tumor-node-metastasis(TNM)stage and lymph node metastasis in CRC patients(P<0.05).However,the serum level of MUC2 in CRC patients was higher than that in normal controls,and was positively associated with serum levels of human DAO(χ2=3.957,P<0.05)and D-LAC(χ^(2)=7.236,P<0.05),which are the biomarkers of the functional status of the intestinal mucosal *** the serum level of MUC2 was correlated with TNM stage,tumor type,and distant metastasis in CRC patients(P<0.05).Kaplan-Meier curves showed that decreased MUC2 expression in CRC tissues predicted a poor *** MUC2 in tissues may play a protective role by participating in the intesti

关键词： Colorectal cancer Mucin 2 Mucin Expression Intestinal mucosal barrier Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive analysis of cell-extracellular matrix protein Ras suppressor-1 in function and prognosis of gastrointestinal cancers

引用

World Journal of Methodology 2023年第4期13卷 223-237页

作者： Ya Xu Yan-Yu Hou Zheng wu Ze-Xuan Fang hua-tao wu Jing Liu Department of Radiation Oncology Shenshan Medical CenterMemorial Hospital of Sun Yat-sen UniversityShanwei 516600Guangdong ProvinceChina Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Ras suppressor 1(RSU1),a highly conserved protein,plays an important role in actin cytoskeleton remodeling and cell-extracellular matrix *** of RSU1 activity can cause changes in cell adhesion and migration,thereby enhancing tumor proliferation and ***,the correlation between RSU1 and gastrointestinal cancers(GICs),as well as its prognostic role related to tumor-infiltrating immune cells(TIICs)remains *** To shows RSU1 plays a potential promoting role in facilitating tumor immune escape in *** Differential expression of RSU1 in different tumors and their corresponding normal tissues was evaluated by exploring the Gene Expression Profiling Interactive Analysis(GEPIA)*** correlation between RSU1 expression and prognosis of GIC cancer patients was evaluated by Kaplan-Meier ***,RSU1-correlated genes were screened and functionally characterized via enrichment *** correlation between RSU1 and TIICs was further characterized using the Tumor Immune Estimation Resource(TIMER).In addition,the correlation between RSU1 and immune cell surface molecules was also analyzed by *** High RSU1 expression was associated with poor overall survival of gastric cancer patients,exhibiting a hazard ratio(HR)=1.36,first progression HR=1.53,and post progression survival HR=***,high RSU1 Levels were associated with prognosis of gastric cancer in females,T4 and N3 stages,and Her-2-negative *** immune-infiltrating cells,RSU1 expression level was positively correlated with infiltration of CD4+T cells,macrophages,neutrophils,and dendritic cells(DCs)in colorectal adenocarcinoma and stomach ***1 expression was also predicted to be strongly correlated with immune marker sets in M2 macrophage,DCs and T cell exhaustion in *** In gastrointestinal cancers,RSU1 is increased in tumor tissues,and predicts poor survival of *** RSU1 may be involved

关键词： Ras suppressor 1 Gastrointestinal cancer Immune infiltration Prognosis Actin cytoskeleton remodeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune responses of six-transmembrane epithelial antigen of the prostate 4 functions as a novel biomarker in gastric cancer

引用

World Journal of Clinical Oncology 2023年第8期14卷 297-310页

作者： Ze-Xuan Fang Yan-Yu Hou Zheng wu Bing-Xuan wu Yu Deng hua-tao wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Immune cells play an important role in regulating the behavior of tumor *** to emerging evidence,six-transmembrane epithelial antigen of the prostate 4(STEAP4)performs a crucial part in tumor microenvironmental immune response and tumorigenesis,and serves as the potential target for cellular and antibody ***,the immunotherapeutic role of STEAP4 in gastric cancer(GC)remains *** To investigate the expression of STEAP4 in GC and its relationship with immune infiltrating cells,and explore the potential value of STEAP4 as an immune prognostic indicator in *** The expression level of STEAP4 was characterized by immunohistochemistry in tumors and adjacent non-cancerous samples in 96 GC *** Immune Estimation Resource was used to study the correlation between STEAP4 and tumor immune infiltration level and immune infiltration gene signature.R package was used to analyze the relationship between STEAP4 expression and immune and stromal scores in GC(GSE62254)by the ESTIMATE algorithm,and Kaplan-Meier Plotter and Gene Expression Profiling Interactive Analysis were applied to analyze the effect of STEAP4 on clinical *** Immunohistochemistry analysis showed that STEAP4 expression was higher in GC tissues than in adjacent tissues,and STEAP4 expression was positively correlated with the clinical stage of *** GC,the expression of STEAP4 was positively correlated with the infiltration levels of B cells,CD4+T cells,macrophages,neutrophils,and dendritic *** expression level of STEAP4 was strongly correlated with most of the immune *** addition,STEAP4 expression was inversely correlated with tumor purity,but correlated with stromal score(r=0.43,P<0.001),immune score(r=0.29,P<0.001)and estimate score(r=0.39,P<0.001).Moreover,stromal,immune,and estimate scores were higher in the STEAP4 high expression group,whereas tumor purity was higher in the STEAP4 Low expression *** relationship betwe

关键词： Six-transmembrane epithelial antigen of the prostate 4 Gastric cancer Immune infiltration Prognosis Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：