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Long noncoding RNA HAND2-AS1 re duce d the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 567-574页

作者： hua-qiang bi Zhong-Hui Li Hui Zhang Department of Hepatobiliary Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China Department of Radiology First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China Department of Vascular Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China

Background:Hepatocellular carcinoma(HCC)is one of the most prevalent human cancers with high *** non-coding RNA heart and neural crest derivatives expressed 2 anti-sense 1(HAND2-AS1)is down-regulated in several cancers including HCC,yet the precise mechanisms how HAND2-AS1 regulates cell survival in HCC remains poorly ***:The expression levels of HAND2-AS1 and miR-300 were measured using quantitative real-time *** protein levels of suppressor of cytokine signaling 5(SOCS5),Bcl-2,Bax and cleaved caspase-3 were determined by Western *** viability and cell proliferation were assessed using cell counting kit-8 and clone formation assay,*** apoptosis was detected using flow *** interactions between HAND2-AS1 and miR-300,miR-300 and SOCS5 were validated using luciferase reporter ***:HAND2-AS1 was down-regulated in HCC tissues and cell lines,and the expression level of HAND2-AS1 was positively correlated to patient ***2-AS1 over-expression reduced viability and proliferation in HCC *** HAND2-AS1 level induced apoptosis in HCC cells,accompanied with increased Bax and cleaved caspase-3 levels and decreased Bcl-2 *** also validated that HAND2-AS1 acted as a sponge of miR-300,and there was a negative correlation between expression levels of HAND2-AS1 and miR-300 in HCC ***,we found that SOCS5 was a downstream target of *** addition,miR-300 mimics abolished HAND2-AS1-mediated inhibition of cell viability and ***-300 mimics also reversed the HAND2-AS1-induced apoptosis in HCC ***:lncRNA HAND2-AS1 inhibits proliferation in HCC through regulating miR-300/SOCS5 axis.

关键词： Hepatocellular carcinoma Cell survival Heart and neural crest derivatives expressed 2 anti-sense 1 microRNA-300 Suppressor of cytokine signaling 5

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定向电场下W_(6)C_(6)团簇的超卤素调制及非线性光学特性

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原子与分子物理学报 2025年第3期42卷 72-76页

作者：蔡璧钧段宇静魏强重庆理工大学理学院重庆400050

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且... 详细信息

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且在特定强度下,OEEF可以将W_(6)C_(6)团簇转变为超卤素.通过对EA值的非线性拟合可以实现对W_(6)C_(6)团簇的连续调制.进一步对不同外电场下W_(6)C_(6)团簇的最高占据分子轨道(HOMO)和最低未占据分子轨道(LUMO)能级进行分析,发现OEEF降低了W_(6)C_(6)团簇LUMO能级是其EA值增大的主因.此外,OEEF可以显著增大W_(6)C_(6)团簇的平均极化率和第一超极化率,尤其是第一超极化率,改变其非线性光学性质.

关键词：定向外电场超原子密度泛函理论 NLO W_(6)C_(6)团簇

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Dysfunction of hippocampal interneurons in epilepsy

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Neuroscience Bulletin 2014年第6期30卷 985-998页

作者： Yu-qiang Liu Fang Yu Wan-Hong Liu Xiao-hua He bi-Wen Peng Department of Physiology School of Basic Medical SciencesWuhan University Department of Pathology Zhongnan Hospital of Wuhan University Department of Immunology School of Basic Medical SciencesWuhan University Department of Pathophysiology School of Basic Medical SciencesWuhan University

Gamma-amino-butyric acid（GABA）-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation and inhibition in CA1 neuronal circuitry is considerably altered during epileptic changes. This review discusses interneuron diversity, the causes of interneuron dysfunction in epilepsy, and the possibility of using GABAergic neuronal progenitors for the treatment of epilepsy.

关键词： interneuron diversity therapy GABA progenitor cell

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食品4D打印技术在食品工业中的应用进展

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食品工业科技 2025年第1期46卷 424-430页

作者：童强肖帅磊毕野吴豪董秀萍大连工业大学机械工程与自动化学院辽宁大连116034 海洋食品加工与安全控制全国重点实验室国家海洋食品工程技术研究中心辽宁省海产品精深加工产业共性技术创新平台大连市中式预制食品技术创新中心辽宁大连116034 大连工业大学食品交叉科学研究院辽宁大连116034

4D打印技术作为在3D打印的基础上增加了“时间”这个维度的新兴打印技术,不仅可以在三维空间内构建复杂结构,还能通过材料的预设形变来实现打印物体的自我组装和形态变化。4D打印技术作为新一代的增材制造技术,因演变过程完全可预测、... 详细信息

4D打印技术作为在3D打印的基础上增加了“时间”这个维度的新兴打印技术,不仅可以在三维空间内构建复杂结构,还能通过材料的预设形变来实现打印物体的自我组装和形态变化。4D打印技术作为新一代的增材制造技术,因演变过程完全可预测、可设计和可控制的特点,其潜力和影响力正在不断扩大。近年来,4D打印技术在现代食品加工领域也得到了广泛的研究和应用,通过4D打印实现食品结构、营养成分、口感等特性的精准控制。本文综述了食品4D打印技术原理、要素及优势,分析了食品4D打印在现代食品加工领域中的应用进展,包括4D打印材料特性、外界刺激等方面,并重点探讨了4D打印智能食品的微观结构控制与口感之间的关系,最后展望了食品4D打印技术发展趋势和挑战,旨在为现代食品加工领域提供参考借鉴。

关键词： 4D打印增材制造食品加工外界刺激微结构控制

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Simulated Heat Sink in the Southern Ocean and Its Contribution to the Recent Hiatus Decade

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Atmospheric and Oceanic Science Letters 2015年第3期8卷 174-178页

作者： OU Nian-Sen LIN Yi-hua bi Xun-qiang State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics (IAP) Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Environment and Sustainable Development for Agriculture Chinese Academy of Agriculture Sciences Climate Change Research Center Institute of Atmospheric Physics Chinese Academy of Sciences

A set of numerical experiments is designed and carried out to understand a heat sink in the Southern Ocean in the recent hiatus decade. By using an oceanic general circulation model, the authors focus on the contributions from two types of forcing: wind stress and thermohaline forcing. The simulated results show that the heat sink in the upper Southern Ocean comes mainly from thermohaline forcing; while in the deeper layers, wind stress forcing also plays an important role. These different contributions may be due to different physical processes for the heat budget. The combination of these two types of forcing shows a significant heat sink in the Southern Ocean in the recent hiatus decade, and this is consistent with the observations and conclusions of a similar recently published study.

关键词： heat sink Southem Ocean wind stress forc- ing thermohaline forcing OGCM

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Controlling Spiral Waves by Modulations Resonant with the Intrinsic System Mode

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Chinese Physics Letters 2004年第7期21卷 1224-1227页

作者： XIAOJing-hua HUGang HUBam-bi ScienceSchool BeijingUniversityofPostsandTelecommunicationsBeijing100876 DepartmentofPhysics BeijingNormalUniversityBeijing100875 CentreofNonlinearStudiesandDepartmentofPhysics HongKongBaptistUniversityHongKong

We investigate the spiral wave control in the two-dimensional complex Ginzburg–Landau equation. External drivings which are not resonant with spiral waves but with intrinsic system modes are used to successfully annihilate spiral waves and direct the system to various target states. The novel control mechanism is intuitively explained and the richness and flexibility the control results are emphasized.

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Government Subsidy’s Effect on the Channel Strategies of Energy-Saving Supply Chain

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Journal of Systems Science and Systems Engineering 2023年第6期32卷 729-770页

作者： Zijian bi Xiaohui Yu qiang Zhang Zihan Su State Grid Jibei Electric Power Co. LtdTangshan063000China Institute for Carbon Peak and Neutrality&Logistics School Beijing101149China School of Management&Economics Beijing Institute of TechnologyBeijing100081China

As subsidy is a popular form of stimulating consumption,not only for home appliances market,the effectiveness of selling promotion subsidies need to be *** this paper,we check the role of promotion subsidies in the offline channel layout by establishing three models,i.e.,no subsidy,customer rebate and retailer *** kinds of online-to-offline strategies are considered,which are retailer’s opening separate and sharing offline *** is gotten that:both customer rebate and retailer subsidy increase the possibility of opening offline channels by sharing offline store strategy,but customer rebate takes high price than no subsidy while retailer subsidy is on the *** the growing subsidy,both customer rebate and retailer subsidy could make offline channels opened by separate or sharing offline store strategy,but the customer rebate brings more *** customer rebate and retailer subsidy require less social welfare to open offline channel,but the customer rebate brings more consumer surplus of opening offline channels than retailer subsidy for a given market ***,government should give the subsidy to customer,not to retailer,even if it brings the increasing of product’price.

关键词： biform game online-to-offline strategies social welfare service

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Recent developments in natural products for white adipose tissue browning

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Chinese Journal of Natural Medicines 2020年第11期18卷 803-817页

作者： MA Peng HE Ping XU Chun-Yang HOU bi-Yu qiang Gui-Fen DU Guan-hua State Key Laboratory of bioactive Substance and Function of Natural Medicines Instiute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College and Bejing Key Laboratory of Drug Target and Screening ResearchBeijing 100050China Beijing Obstetrics and Gyecology Hospital Capital Medical UniversityBeijing 100026China

Excess accumulation of white adipose tissue(WAT) causes obesity which is an imbalance between energy intake and energy expenditure. Obesity is a serious concern because it has been the leading causes of death worldwide, including diabetes, stroke,heart disease and cancer. Therefore, uncovering the mechanism of obesity and discovering anti-obesity drugs are crucial to prevent obesity and its complications. Browning, inducing white adipose tissue to brown or beige(brite) fat which is brown-like fat emerging in WAT, becomes an appealing therapeutic strategy for obesity and metabolic disorders. Due to lack of efficacy or intolerable side-effects, the clinical trials that promote brown adipose tissue(BAT) thermogenesis and browning of WAT have not been successful in humans. Obviously, more specific means still need to be developed to activate browning of white adipose tissue. In this review, we summarized seven kinds of natural products(alkaloids, flavonoids, terpenoids, long chain fatty acids, phenolic acids, else and extract) promoting white adipose tissue browning which can ameliorate the metabolic disorders, including obesity, dislipidemia, insulin resistance and diabetes. Since natural products are important drug sources and the browning property plays a significant role in not only obesity treatment but also in type 2 diabetes(T2 DM) improvement, natural products of inducing browning may be an irreplaceable drug discovery orientation for obesity, diabetes and even other metabolic disorders.

关键词： Natural products Browning Brown adipose tissue White adipose tissue Obesity

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Validation for a tropical belt version of WRF: sensitivity tests on radiation and cumulus convection parameterizations

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Atmospheric and Oceanic Science Letters 2019年第3期12卷 192-200页

作者： SUN bi-Yun bi Xun-qiang College of Atmosphere Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan ProvinceChengdu University of Information TechnologyChengduChina Climate Change Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

Version 3.9 of WRF-ARW is run with a tropical belt configuration for a period from 2012 to 2016 in this study. The domain covers the entire tropics between 45°S and 45°N with a spatial resolution of about 45 km. In order to verify two radiation schemes and four cumulus convection schemes, eight experiments are performed with different combinations of physics parameterization schemes. The results show that eight experiments present reasonable spatial patterns of surface air temperature and precipitation in boreal summer, with the spatial correlation coefficient (COR) between simulated and observed temperature exceeding 0.95, and that between simulated and observed precipitation ranges from 0.65 to 0.82. The four experiments with the RRTMG radiation scheme show a better performance than the other four experiments with the CAM radiation scheme. In the four experiments with the RRTMG radiation scheme, the COR between simulated and observed surface air temperature is about 0.98, and that between simulated and observed precipitation ranges from 0.76 to 0.82. Comparatively, the two experiments using the new Tiedtke cumulus parameterization scheme can simulate better diurnal variation of precipitation in boreal summer than the other six experiments. In particular, for the diurnal cycle of precipitation over land and ocean, the experiment using the RRTMG radiation scheme and the new Tiedtke cumulus convection scheme shows that the peaks of precipitation rate appear at 0400 LST and 1600 LST, in agreement with observation.

关键词： WRF model cumulus convection parameterization radiation scheme diurnal cycle of precipitation

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A Reliable Iteration Algorithm for One-bit Compressive Sensing on the Unit Sphere

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 801-822页

作者： Yan-cheng LU Ning bi An-hua WAN School of Mathematics Sun Yat-sen UniversityGuangzhou 510275China

The one-bit compressed sensing problem is of fundamental importance in many areas,such as wireless communication,statistics,and so ***,the optimization of one-bit problem coustrained on the unit sphere lacks an algorithm with rigorous mathematical proof of convergence and *** this paper,an iteration algorithm is established based on difference-of-convex algorithm for the one-bit compressed sensing problem constrained on the unit sphere,with iterating formula■,where C is the convex cone generated by the one-bit measurements andη_(1)>η_(2)>1/*** new algorithm is proved to converge as long as the initial point is on the unit sphere and accords with the measurements,and the convergence to the global minimum point of the l_(1)norm is discussed.

关键词： one-bit compressed sensing difference of convex algorithm iteration algorithm ■1-minimization

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