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Chinese Chemical Letters 2017年第3期28卷 633-641页

作者： Yong Zhu Zhi-Shan Bai hua-lin wang State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China

An improved biosorbent of thiourea modified chitosan microsphere（TMCM） with high specific surface,favorable mechanical strength and excellent adsorption performance had been synthesized via microfluidic technology. Polyethylene glycol was used as a significant component added in aqueous solution of chitosan to produce such microspheres through droplets forming, chemical crosslinking and pores creating. For the improvement of adsorption capacity, thiourea was considered as an excellent choice in increasing amino functional group by graft modification. The SEM, FTIR and EDS were employed to detect distinct features of TMCM. Copper（Ⅱ） was used to test the adsorption performance of TMCM. The experimental results indicated that TMCM exhibited higher adsorption capacity（q_e= 60.6 mg g_（-1）） and faster adsorption rate than that non-modified chitosan microsphere（NMCM）.The adsorption kinetic was described well by the pseudo-second order kinetic model, which suggested that chemical adsorption along with electrons transferring was dominant in adsorption process.

关键词： Thiourea modification Chitosan microsphere High specific surface area Microfluidic technology Adsorption

From Diabetes to Diabetic Complications:Role of Autophagy

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Current Medical Science 2023年第3期43卷 434-444页

作者： lin-hua wang Yang-yang wang Lian LIU Quan GONG Clinical Molecular Immunology Center Yangtze UniversityJingzhou 434023China Department of Pharmacology School of Basic MedicineHealth Science CenterYangtze UniversityJingzhou 434023China Department of Immunology School of Basic MedicineHealth Science CenterYangtze UniversityJingzhou 434023China

Diabetes and its complications reduce quality of life and are *** present,diabetes treatment consists of hypoglycemic agents to control blood glucose and the use of insulin-sensitizing drugs to overcome insulin *** diabetes,autophagy is impaired and thus there is poor intracellular environment ***β-cells and insulin target tissues are protected by enhancing *** decreasesβ-cell apoptosis,promotesβ-cell proliferation,and alleviates insulin *** in diabetes is regulated by the mammalian target of rapamycin(mTOR)/adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)pathway and *** enhancers can likely be used as a treatment for diabetes and its *** review examines the evidence linking autophagy to diabetes.

关键词： autophagy diabetes diabetic complications mechanism

Case Report:Subglottic adenoid cystic carcinoma mistaken for asthma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 707-710页

作者： hua-lin wang lin XU Fu-jun LI Department of Otorhinolaryngology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography （CT） revealed that her upper airway was obstructed by a laryngeal tumor. The patient was diagnosed with a subglottic adenoid cystic carcinoma and treated with complete surgical excision and adjuvant radiation therapy. Follow-up endoscopy and laryngeal magnetic resonance imaging （MR1） at six months showed no recurrence of the tumor. The diagnosis of subglottic adenoid cystic carcinoma should be considered in patients who are characterized by dyspnea, cough, and stridor, but do not respond to regular anti-asthmatic therapy.

关键词： Subglottic adenoid cystic carcinoma Larynx Asthma

Improvement of the Injection and Transport Characteristics of Electrons in Organic Light-Emitting Diodes by Utilizing a NaC1 N-Doped Layer

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Chinese Physics Letters 2014年第4期31卷 178-181页

作者： XIAO Zhi-Hui WU Xiao-Ming hua Yu-lin wang Li BI Wen-Tao BAI Juan-Juan MU Xue YIN Shou-Gen School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384Key Laboratory of Display Materials and Photoelectric Devices .Ministry of Education Tianjin 300384 Tianjin Key Laboratory of Photoelectric Materials and Devices Tianjin 300384

The injection and transport characteristics of electrons are enhanced by using sodium chloride （NaC1） as an n-type dopant doped into a 4, 7-diphnenyl-1, lO-phe-nanthroline （Bphen） electron-transporting layer, which improves the performance of organic light-emitting diodes （OLEDs）. Meanwhile, a NaCl-doped Bphen layer can effectively influence electrical characteristics of the devices, and significantly improve the current and power efficiency. The turn-on voltage and the operation voltage of the optimal device are decreased drastically from 6.5 V and 10.8 V to 3.3 V and 5 V, respectively, compared with those of the reference device. The maximum current efficiency and power efficiency of the optimal device are 7.0 cd/A and 4.4 Im/W at the current density of 16.70 mA/cm~, which are about I. 7 and 4 times higher than those of the reference device, respectively. Moreover, the enhancement of the injection and transport ability for electrons is attributed not only to the reduced energy barrier between A1 cathode and Bphen, but also to the increased mobility of electrons by the doping effect of NaCl. Therefore, both the electron injection and transport ability are enhanced, which improve the carrier balance in OLEDs and lead to the better device efficiency.

关键词： ORGANIC light emitting diodes SALT DOPING agents (Chemistry) ENERGY consumption ELECTRON mobility

Synthesis and Structure of a Novel Supramolecular Compound [Co(2,2′-bipy)(H_2O)_4 ][trans-1,4-chdc] and Separation of Isomer of 1,4-Cyclohexanedicarboxylic Acid

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Chemical Research in Chinese Universities 2006年第4期22卷 415-418页

作者： YU Miao LIU Shu-xia ZHANG Chun-dan GAO Bo SUN Chun-yan XIE lin-hua wang Chun-ling CHENG Hai-yan Key Laboratory of Polyoxometalates Science of Ministry of Education College of Chemistry Northeast Normal University Changchun 130024 P. R. China

A supramolecular compound, [ Co（2,2＇-bipy）（ H2O）4 ] [ trans-1,4-chdc ] （ compound 1 ）（ 2,2＇-bipy = 2,2＇- bipyridine, 1,4-chdcH2 = 1,4-cyclohexanedicarboxylic acid）, was synthesized and characterized by single-crystal Xray diffraction analysis, IR spectrometry, TG analysis, and elemental analyses. Single-crystal X-ray diffraction analysis revealed that [ Co（ 2,2＇-bipy）（ H2O）4 ]^2＋ units and adjacent 1,4-chdc^2- formed a single layer by hydrogen bonding and electrostatic interactions along the ac-plane, and two symmetry-related single layers interacted with each other by hydrogen bonding, resulting in a double layer, which further formed a 3-D structure by π-π stacking. The most attractive structural feature of compound 1 is that 1,4-chdc2- possesses only tram-conformation although there are both c/s- and tram-conformations in the raw material.

关键词： Isomer separation 1,4-chdcH2 Supramolecular compound Hydrogen bonding

Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors

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World Journal of Gastroenterology 2020年第31期26卷 4656-4668页

作者： huai-Liang Li lin-hua wang Yi-lin Hu Ying Feng Xiao-Hong Li Yi-Fei Liu Peng Li Qin-Sheng Mao Wan-Jiang Xue Department of Gastrointestinal Surgery Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina Department of Intensive Care Unit Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina Department of Surgical Comprehensive Laboratory Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina Department of Pathology Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal neoplasms of the gastrointestinal *** resection and tyrosine kinase inhibitors are defined as the main treatments but cannot cure patients with advanced GIST,which eventually develops into recurrence and acquired drug ***,it is necessary to identify prognostic biomarkers and new therapeutic targets for *** chemokine receptor type 8(CCR8)protein participates in regulation of immune *** studies on CCR8 in nonsmall cell lung cancer and colorectal cancer showed that it was highly expressed in tumor-infiltrating regulatory T cells and correlated with a poor *** To detect CCR8 expression in GIST tissues and analyze its relationships with clinicopathological features and prognosis in patients with *** Tissue samples were used for the tissue microarrays *** microarrays were then subjected to immunohistochemical analyses to detect CCR8 ***,Kaplan–Meier analysis was utilized to calculate the survival rate of patients with complete follow-up data,and the potential prognostic value of CCR8 was evaluated by Cox regression ***,a Gene Ontology/Kyoto Encyclopedia of Genes and Genomes single-gene enrichment chart of CCR8 was constructed using the STRING *** CCR8-positive signals were detected as brown or brown-yellow particles by immunohistochemistry located in the *** 125 tissue samples,74 had CCR8 high expression and 51 had low or negative *** analyses suggested CCR8 was significantly correlated with tumor size,mitotic index,AFIP-Miettinen risk classification and tumor ***–Meier and multivariate analyses showed that patients with low or negative CCR8 expression,mitotic index<5/high-power fields(HPF)and tumor diameter<5 cm had a better *** on the STRING database,CCR8 was significantly enriched in biological processes such as tumor im

关键词： Gastrointestinal stromal tumors CC chemokine receptor type 8 Malignant phenotype Prognosis STRING database Immune regulation

Reduction of Residual Stress in Low Alloy Steel with Magnetic Treatment in Different Directions

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Journal of Wuhan University of Technology(Materials Science) 2009年第6期24卷 857-862页

作者：宋燕利华林 School of Materials Science and Engineering Wuhan University of Technology

The behavior that different magnetic treatment directions induce various amounts of welding residual stress reductions in low alloy steel was studied. Reductions of 26%-28% in the longitudinal stress σ x were obtained when low frequency alternating magnetic treatment was applied perpendicularly to the welding bead, whereas reductions of 20%-21% in σ x were measured by using the same treatment parameters except that the field direction was applied parallel to the bead. It is proposed that different extent of stress reductions caused by the above two treatment directions is attributed primarily to the alteration of the energy absorbed by domains from the external magnetic field, which part of energy can arouse plastic deformation in microstructures by the motion of domain walls.

关键词： magnetic treatment direction magnetic domain residual stress spontaneous magnetization micro plastic deformation

Virion Proteomics of Large DNA Viruses

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Virologica Sinica 2009年第4期24卷 268-284页

作者： Ran-ran wang Zhi-hong HU hua-lin wang Fei DENG State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071China

Large DNA viruses normally have complex structures with many of protein components derived from both viral and host origins. The development in proteomics, especially mass spectrometry identification techniques provide powerful tools for analyzing large viruses. In this review, we have summarized the recent achievements on proteomic studies of large DNA viruses, such as herpesvirus, poxvirus, nimavirus and baculoviruse. The proteomics of baculovirus occlusion-derived virions (ODV) were emphasized. Different mass spectrometry techniques used on various baculoviruses were introduced, and the identified structurally associated proteins of baculoviruses are summarized.

关键词： Virion proteomics Large DNA viruses Baculoviruses

Genetic Modification of Baculovirus Expression Vectors

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Virologica Sinica 2012年第2期27卷 71-82页

作者： Shu-fen Li hua-lin wang Zhi-hong Hu Fei Deng State Key Laboratory of Virology and Joint-Lab of Invertebrate Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China

As a protein expression vector, the baculovirus demonstrates many advantages over other vectors. With the development of biotechnology, baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells. These modifications include utilization of different promoters and signal peptides, deletion or replacement of viral genes for increasing protein secretion, integration of polycistronic expression cassette for producing protein complexes, and baculovirus pseudotyping, promoter accommodation or surface display for enhancing mammalian cell targeting gene delivery. This review summarizes the development and the current state of art of the baculovirus expression system. Further development of baculovirus expression systems will make them even more feasible and accessible for advanced applications.

关键词： Baculovirus Protein expression Promoters Signal peptides Gene delivery

Comparison of transperitoneal and retroperitoneal laparoscopic living donor nephrectomy

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Chinese Medical Journal 2007年第24期120卷 2314-2316页

作者： GAO Zhen-li WU Ji-tao LIU Yu-jie lin Chun-hua wang lin SHI Lei MEN Chang-ping ZHANG Peng YANG Dian-dong wang Ke Department of Urology Yantai Yuhuangding Hospital Yantai 264000 China

Since its introduction in 1995, laparoscopic living donor nephrectomy （LDN） has been shown to alleviate postoperative pain, shorten hospital stay, reduce loss and improve cosmesis while hastening the recovery of normal activities of donors. However, there has been much controversy over minimally invasive surgery with transperitoneal or retroperitoneal approach for nephrectomy. In this non-randomized retrospective study, we analyzed some parameters of the donors who had undergone transperitoneal LDN compared with those who had had retroperitoneoscopic nephrectomy.

关键词： kidney transplantation laparoscopy nephrectomy living donors