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Theoretical Studies on Expressions of Condensed-Phase Photoionization Cross Section

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Communications in Theoretical Physics 2006年第4X期46卷 727-730页

作者： MA Xiao-Guang WANG Mei-Shan WANG De-hua QU zhao-jun Department of Physics Yantai Normal University Yantai 264025 China

A set of general expressions for photoionization cross sections of atoms or molecules embedded in a medium and a dielectric influence function are derived based on Maxwell＇s equations and the Beer-Lambert＇s law in this work. The applications are performed for the photoionization process of solid gold both in the Clausius-Mossotti （virtual cavity） model and the Glauber-Lewenstein （real cavity） model firstly. The results show that the present theoretical expressions of photoionization cross section can be used to describe the photoionization process of atoms in condensed matter properly.

关键词： condensed-phase photoionization optical constant dielectric constant

Innate and adaptive immune escape mechanisms of hepatitis B virus

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World Journal of Gastroenterology 2022年第9期28卷 881-896页

作者： hua-jun zhao Yi-Fei Hu Qiu-Ju Han Jian Zhang Institute of Immunopharmaceutical Sciences School of Pharmaceutical SciencesShandong UniversityJinan 250012Shandong ProvinceChina

Chronic hepatitis B virus(HBV)infection is an international health problem with extremely high mortality and morbidity *** current clinical chronic hepatitis B(CHB)treatment strategies can partly inhibit and eliminate HBV,viral breakthrough may result due to non-adherence to treatment,the emergence of viral resistance,and a long treatment *** CHB infection arises as a consequence of complex interactions between the virus and the host innate and adaptive immune ***,understanding the immune escape mechanisms involved in persistent HBV infection is important for designing novel CHB treatment strategies to clear HBV and achieve long-lasting immune *** review details the immunological and biological characteristics and escape mechanisms of HBV and the novel immune-based therapies that are currently used for treating HBV.

关键词： Hepatitis B virus Innate immunity Adaptive immunity Immune tolerance Therapeutic strategy

UNSTEADY INTERMITTENT FLOW IN A ROTATING CURVED PIPE

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Journal of Hydrodynamics 2004年第2期16卷 158-165页

作者： YINJian-an SHENXin-rong CHENhua-jun ZHANGBen-zhao DepartmentofMechanics ZhejiangUniversityHangzhou310027Chinae-mail：mec-zbzq@emb***

The effects of rotation and intermittent frequency on the flow transition ofsecondary flow and, main flow were examined in detail. Certain hitherto unknown flow patterns werefound. A numerical study was performed to study the characteristics of unsteady intermittent flow ina rotating curved pipe. Due to the rotation, both the Coriolis force and the centrifugal forcecould contribute to the unsteady intermittent flow and some complicated phenomena can be found. Theresults indicate that the unsteady intermittent flow are mainly characterized by five parameters:the Dean number Dn, the curvature κ, the maximal force ratio F (of the Coriolis force to thecentrifugal force in a cycle), the intermittent frequency parameter η (the ratio of a pulslatingtime to the cycle period), and the Womersley number α. Present works shows the natures of theunsteady intermittent flow in a rotating curved pipe.

关键词： unsteady flow secondary flow rotating pipes

FLUID FLOW IN ROTATING HELICAL SQUARE DUCTS

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Journal of Hydrodynamics 2003年第3期15卷 49-56页

作者： Chen hua-jun, Zhang Ben-zhao, Zhang Jin-suo Department of Mechanics, Zhejiang University, Hangzhou 310027, China, Department of Mechanics Zhejiang University Hangzhou 310027 China

A numerical study is made for a fully developed laminar flow in rotatinghelical pipes. Due to the rotation, the Coriolis force can also contribute to the secondary *** interaction between rotation, torsion, and curvature complicates the flow characteristics. Theeffects of rotation and torsion on the flow transitions are studied in details. The results showthat there are obvious differences between the flow in rotating ducts and in helical ducts withoutrotation. Certain hitherto unknown flow patterns are found. The effects of rotation and torsion onthe friction factor are also examined. Present results show the characteristics of the fluid flow inrotating helical square ducts.

关键词： secondary flow rotating ducts helical ducts

Effect of void size and Mg contents on plastic deformation behaviors of Al-Mg alloy with pre-existing void:Molecular dynamics study

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Chinese Physics B 2022年第6期31卷 580-588页

作者： Ning Wei Ai-Qiang Shi Zhi-Hui Li Bing-Xian Ou Si-Han zhao jun-hua zhao Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology Jiangnan UniversityWuxi 214122China China Aerodynamics Research and Development Center Mianyang 621000China National Laboratory for Computational Fluid Dynamics Beijing 100191China National Graphene Products Quality Supervision and Inspection Center Special Equipment Safety Supervision Inspection Institute of Jiangsu ProvinceWuxi 214174China

The plastic deformation properties of cylindrical pre-void aluminum-magnesium(Al-Mg)alloy under uniaxial tension are explored using molecular dynamics simulations with embedded atom method(EAM)*** factors of Mg content,void size,and temperature are *** results show that the void fraction decreases with increasing Mg in the plastic deformation,and it is almost independent of Mg content when Mg is beyond 5%.Both Mg contents and stacking faults around the void affect the void *** phenomena are explained by the dislocation density of the sample and stacking faults distribution around the *** variation trends of yield stress caused by void size are in good agreement with the Lubarda ***,temperature effects are explored,the yield stress and Young’s modulus obviously decrease with *** results may enrich and facilitate the understanding of the plastic mechanism of Al-Mg with defects or other alloys.

关键词： Al-Mg alloys molecular dynamics nanovoid plastic deformation

Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells

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World Journal of Gastroenterology 2021年第24期27卷 3581-3594页

作者： Qiu-Ju Han Yong-Liang Mu hua-jun zhao Rong-Rong zhao Quan-Juan Guo Yu-Hang Su Jian Zhang Institute of Immunopharmaceutical Sciences School of Pharmaceutical SciencesShandong UniversityJinan 250012Shandong ProvinceChina Department of Emergency Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Fasudil,as a Ras homology family member A(RhoA)kinase inhibitor,is used to improve brain microcirculation and promote nerve regeneration *** evidence shows that Rho-kinase inhibition could improve liver *** To evaluate the anti-fibrotic effects of Fasudil in a mouse model of liver fibrosis induced by thioacetamide(TAA).METHODS C57BL/6 mice were administered TAA once every 3 d for 12 *** 1 wk after induction with TAA,Fasudil was intraperitoneally injected once a day for 3 wk,followed by hematoxylin and eosin staining,sirius red staining,western blotting,and quantitative polymerase chain reaction(qPCR),and immune cell activation was assayed by fluorescence-activated cell ***,the effects of Fasudil on hepatic stellate cells and natural killer(NK)cells were assayed in *** First,we found that TAA-induced liver injury was protected,and the positive area of sirius red staining and type I collagen deposition were significantly decreased by Fasudil ***,western blot and qPCR assays showed that the levels of alpha smooth muscle actin(α-SMA),matrix metalloproteinase 2(MMP-2),MMP-9,and transforming growth factor beta 1(TGF-β1)were inhibited by ***,flow cytometry analysis revealed that NK cells were activated by Fasudil treatment in vivo and in ***,Fasudil directly promoted the apoptosis and inhibited the proliferation of hepatic stellate cells by decreasingα-SMA and TGF-β*** Fasudil inhibits liver fibrosis by activating NK cells and blocking hepatic stellate cell activation,thereby providing a feasible solution for the clinical treatment of liver fibrosis.

关键词： Liver fibrosis Natural killer cells Fasudil Hepatic stellate cells

Treatment of polycystic liver disease with resection-fenestration and a new classification

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World Journal of Gastroenterology 2008年第32期14卷 5066-5072页

作者： Tuan-Jie Li Hai-Bin Zhang jun-hua Lu jun zhao Ning Yang Guang-Shun Yang Eastern Hepatobiliary Hospital Second Military Medical University Shanghai 200438 China

AIM: To evaluate outcomes in patients with autosomal dominant polycyst liver disease (APLD) treated by combined hepatic resection and fenestration. A new classification was recommended to presume postoperative complications and long outcome of patients. METHODS: Twenty-one patients with APLD were treated by a combined hepatic resection and fenestration technique. All patients were reviewed retrospectively, and clinical symptoms, performance status and morbidity were recorded. A new classifi cation of APLD is recommended here. RESULTS: All patients were discharged when free of symptoms. The mean follow-up time was 55.7 mo and three patients had a recurrence of symptoms at 81, 68 and 43 mo after operation, respectively. The overall morbidity rate was 76.2%. Two patients with Type B-Ⅱ and Type B-Ⅰ developed biliary leakage. Four patients had severe ascites, including three with Type B-Ⅲ and one with Type B-Ⅱ, Nine patients had pleural effusion, including one with Type A-Ⅰ; one with Type B-Ⅰ; fi ve with Type B-Ⅱ; one with Type A-Ⅲ and one with Type B-Ⅲ. Three patients with Type B had recurrence of symptoms, while none with Type A had severe complications. CONCLUSION: Combined hepatic resection and fenestration is an acceptable procedure for treatment of APLD. According to our classifi cation, postoperative complications and long outcome can be predicted before surgery.

关键词： Autosomal dominant polycyst liverdisease Autosomal dominant polycyst kidney disease Fenestration

Ba3KSb4S9Cl: A New Pentanary Antimony Sulfide

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Ba3KSb4S9Cl: A New Pentanary Antimony Sulfide

Preliminary Study on Resistance of the Rice Stem Borer (Chilo Suppressalis) to Fipronil

中国化学会第九届全国无机化学学术会议

作者： hua-jun zhao Ling Chen Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Antimony sulfides have draw considerable attentions not only for their potential application as thermoelectric materials, such as Sb2Te3,[1] Mo3Sb5Te2,[2] and Ag SbxBi3-xS5[3] and nonlinear optical（NLO） materials, such as RE4 Ga Sb S9（RE = Pr, Nd, Sm, Gd–Ho）,[4] Ba23Ga8Sb2S38[5] and RE4 In Sb S9（RE = La, Pr, Nd）[6] but also because of their diverse structural chemistry, which arises partly from the stereoactive lone pair of electrons of the Sb3+ ion. Given that the strong ionic Ba or K-Cl bonding that are helpful to achieve a large band gap, we introduced Ba2+, K+ and Cl- into Sb/S system and discovered a new pentanary antimony sulfide: Ba3KSb4S9 Cl. It crystallizes in the orthorhombic space group Pnnm. The structure contains one-dimensional（1D） [Sb4S9]6– ribbons running down the [001] direction separated by Ba2+, K+, and Cl-, respectively.

关键词： Antimony sulfides NLO SHG

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Rice science 2005年第4期12卷 295-298页

作者： JIANG Wei-hua HAN zhao-jun HAO Ming-li Key Laboratory of Monitoring and Management of Plant Disease and Insects Ministry of Agriculture Nanjing AgriculturalUniversity Nanjing 210095 China E mail. jwh@njau.edu.en

By means of topical application, fipronil resistance was surveyed in the rice stem borer, Chilo suppressalis, from 12 diferent areas in east China from 2001 to 2004. The rice stem borers in most regions of Jiangsu and Anhui were still susceptible to fipronil. But in Wuxi, Jiangsu Province and Cixi, Zhejiang Province, their sensitivity became decreased （resistance ratios were 3.1 and 3.6, respectively）, and the medium level of resistance （resistance ratio was 21.2） was found in Cangnan, Zhejiang Province. So, it was still at the early stage for fipronil resistance development in this pest. Synergism experiments showed that piperonyl butoxide（PBO） had a little effect on both susceptible and resistant borers （synergism ratios were 1.1-1.2）. Though triphenyl phosphate （TPP） and diethyl meleate （DEM） had no effect on the susceptible borers, they had significant synergism on fipronil in the resistant population to fipronil （synergism ratios were 1.8 and 1.6, respectively）, indicating esterase and glutathion S-transferase may be involved in the resistance mechanism. Bioassay with currently used insecticides indicated that triazophos （because of high resistance）, trichlorphon and acephate had very low toxicity to resistant borers. But diazinon, pyridaphenthion, decamethrin and avermeatin showed high toxicity and had no cross resistance to fipronil, which could be considered as substitute insecticides in the resistance managment.

关键词： Chilo suppressalis fipronil resistance relative toxicity