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Icariin accelerates bone regeneration by inducing osteogenesisangiogenesis coupling in rats with type 1 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 769-782页

作者： Sheng Zheng Guan-Yu Hu jun-hua li Jia Zheng Yi-Kai li Department of Traditional Chinese Orthopedics and Traumatology Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Peking University First HospitalBeijing 100034China

BACKGROUND Icariin(ICA),a natural flavonoid compound monomer,has multiple pharmacological ***,its effect on bone defect in the context of type 1 diabetes mellitus(T1DM)has not yet been *** To explore the role and potential mechanism of ICA on bone defect in the context of *** The effects of ICA on osteogenesis and angiogenesis were evaluated by alkaline phosphatase staining,alizarin red S staining,quantitative real-time polymerase chain reaction,Western blot,and ***-related assays were conducted to investigate the relationship between osteogenesis and angiogenesis.A bone defect model was established in T1DM *** model rats were then treated with ICA or placebo and micron-scale computed tomography,histomorphometry,histology,and sequential fluorescent labeling were used to evaluate the effect of ICA on bone formation in the defect *** ICA promoted bone marrow mesenchymal stem cell(BMSC)proliferation and osteogenic *** ICA treated-BMSCs showed higher expression levels of osteogenesis-related markers(alkaline phosphatase and osteocalcin)and angiogenesis-related markers(vascular endothelial growth factor A and platelet endothelial cell adhesion molecule 1)compared to the untreated *** was also found to induce osteogenesis-angiogenesis coupling of *** the bone defect model T1DM rats,ICA facilitated bone formation and CD31hiEMCNhi type H-positive capillary ***,ICA effectively accelerated the rate of bone formation in the defect *** ICA was able to accelerate bone regeneration in a T1DM rat model by inducing osteogenesis-angiogenesis coupling of BMSCs.

关键词： Icariin Osteogenesis-angiogenesis coupling Type 1 diabetes mellitus Bone defect Bone regeneration

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Potential plausible role of Wharton’s jelly mesenchymal stem cells for diabetic bone regeneration

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World Journal of Stem Cells 2024年第8期16卷 824-826页

作者： Sheng Zheng Guan-Yu Hu jun-hua li Yi-Kai li Department of Traditional Chinese Orthopedics and Traumatology Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

This letter addresses the review titled“Wharton’s jelly mesenchymal stem cells:Future regenerative medicine for clinical applications in mitigation of radiation injury”.The review highlights the regenerative potential of Wharton’s jelly mesenchymal stem cells(WJ-MSCs)and describes why WJ-MSCs will become one of the most probable stem cells for future regenerative *** potential plausible role of WJ-MSCs for diabetic bone regeneration should be noticeable,which will provide a new strategy for improving bone regeneration under diabetic conditions.

关键词： Wharton’s jelly mesenchymal stem cells Vascular endothelial growth factor Osteogenesis Angiogenesis Diabetic bone regeneration

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Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DsS-inducedcolitis

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Precision Clinical Medicine 2024年第2期7卷 146-158页

作者： jun-hua li Yu Chen Zheng-hao Ye li-ping Chen Jia-xin Xu Jian Han lin Xie Shuai Xing De-an Tian Ursula Seidler Jia-zhi liao Fang Xiao Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Background:Myeloid differentiation factor 88(MyD88)is the core adaptor for Toll-like receptors defending against microbial invasion and initiating a downstream immune response during microbiota-host ***,the role of MyD88 in the pathogenesis of inflammatory bowel disease is *** study aims to investigate the impact of MyD88 on intestinal inflammation and ***:MyD88 knockout(MyD88^(-/-))mice and the MyD88 inhibitor(TJ-M2010-5)were used to investigate the impact of MyD88 on acute dextran sodium sulfate(Dss)-induced *** activity index,colon length,histological score,and inflammatory cytokines were examined to evaluate the severity of *** transcriptome analysis and 16S rDNA sequencing were used to detect the potential ***:In an acute DSS-colitis model,the severity of colitis was not alleviated in MyD88^(-/-)mice and TJ-M2010-5-treated mice,despite significantly lower levels of NF-kB activation being exhibited compared to control ***,16S rDNA sequencing and RNA transcriptome analysis revealed a higher abundance of intestinal Proteobacteria and an up-regulation of the nucleotide oligomerization domain-like receptors(NLRs)signaling pathway in colitis mice following MyD88 *** blockade of the NLRs signaling pathway or elimination of gut microbiota with broad-spectrum antibiotics in DsS-induced colitis mice treated with TJ-M2010-5 ameiorated the disease severity,which was not improved solely by MyD88 *** treatment with broad-spectrum antibiotics,downregulation of the NLR signaling pathway was ***:Our study suggests that the suppression of MyD88 might be associated with unfavorable changes in the composition of gut microbiota,leading to NLR-mediated immune activation and intestinal inflammation.

关键词： microbiota innate immunity myeloid differentiation factor 88,MyD88 inhibitor NOD-like receptor inflammatory bowel disease

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Assessment of structural damage using natural frequency changes

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Acta Mechanica Sinica 2012年第1期28卷 118-127页

作者： Shu-Qing Wang hua-jun li Department of Ocean Engineering Ocean University of China266100 QingdaoChina

The present paper develops a new method for damage localization and severity estimation based on the employment of modal strain energy. This method is able to determine the damage locations and estimate their severities, requiring only the information about the changes of a few lower natural frequencies. First, a damage quantification method is formulated and iterative approach is adopted for determining the damage extent. Then a damage localization algorithm is proposed, in which a damage indicator is formulated where unity value corresponds to the true damage scenario. Finally, numerical studies and model tests are conducted to demonstrate the effectiveness of the developed algorithm.

关键词： Damage assessment Damage detection Strain energy - Modal analysis - Natural frequency

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Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion

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Biomedical and Environmental Sciences 2007年第1期20卷 47-51页

作者： HONG WAN SHAO-DONG ZHANG jun-hua li Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China

Objective To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion. Methods Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination. Results BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp. Conclusions Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.

关键词： Schwann cell MBP GAP-43

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Fe Promotion Effect in Mn/USY for Low-temperature Selective Catalytic Reduction of NO with NH_(3)

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Chinese Chemical Letters 2006年第7期17卷 991-994页

作者： Qi Chun liN Ji Ming HAO jun hua li Department of Environmental Science and Engineering Tsinghua University Beijing 100084

A series of catalysts of Mn/USY and Mn-Fe/USY prepared by impregnation were studied for low-temperature selective catalytic reduction （SCR） of NO with NH3 in the presence of excess of oxygen. It was found that the addition of Fe enhanced the catalytic performance at low-temperature. Mn-Fe/USY catalyst yielded nearly 100% NO conversion in a range of temperature from 423 to 573 K at a space velocity of 36 000 cm3g^-1·h^-1. Coexistence of manganese and iron oxides enhanced the dispersion of the supported oxides, no visible phase of the oxides can be observed on catalyst. The addition of Fe enhanced the number and strength of the Bronsted and Lewis acid sites on the surface of the catalyst, which might promote the absorption of NH3 to form active intermediate and enhance the catalytic performance at low-temperature.

关键词： Low-temperature SCR Mn/USY Mn-Fe/USY SCR of NO with NH3.

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Induction of Functional Recovery by Co-transplantation of Neural Stem Cells and Schwann Cells in a Rat Spinal Cord Contusion Injury Model

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Biomedical and Environmental Sciences 2007年第3期20卷 242-249页

作者： JIN li CHONG-RAN SUNN HAN ZHANG KAM-SZE TSANG jun-hua li SHAO-DONG ZHANG YI-hua AN Beijing Neurosurgical Institute Capital University of Medical Science Beijing 100050 China Blood and Marrow Transplantation Department of Anatomical and Cellular Pathology the Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Objective To study the transplantation efficacy of neural stem cells （NSCs） and Schwann cells （SC） in a rat model of spinal cord contusion injury. Methods Multipotent neural stem cells （NSCs） and Schwann cells were harvested from the spinal cords of embryonic rats at 16 days post coitus and sciatic nerves of newborn rats, respectively. The differential characteristics of NSCs in vitro induced by either serum-based culture or co-culture with SC were analyzed by immunofluorescence. NSCs and SCs were co-transplanted into adult rats having undergone spinal cord contusion at T9 level. The animals were weekly monitored using the Basso-Beattie-Bresnahan locomotor rating system to evaluate functional recovery from contusion-induced spinal cord injury. Migration and differentiation of transplanted NSCs were studied in tissue sections using immunohistochemical staining. Results Embryonic spinal cord-derived NSCs differentiated into a large number of oligodendrocytes in serum-based culture upon the withdrawal of mitogens. In cocultures with SCs, NSCs differentiated into neuron more readily. Rats with spinal cord contusion injury which had undergone transplantation of NSCs and SCs into the intraspinal cavity demonstrated a moderate improvement in motor functions. Conclusions SC may contribute to neuronal differentiation of NSCs in vitro and in vivo. Transplantation of NSCs and SCs into the affected area may be a feasible approach to promoting motor recovery in patients after spinal cord injury.

关键词： Spinal cord injury Transplantation Neural stem cells Schwann cells Cell differentiation

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Enhancement of Activity of SnO_(2)-doped In_(2)O_(3)/Al_(2)O_(3) Catalyst for NO Reduction with Propene in the Presence of H_(2)O and SO_(2)

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Chinese Chemical Letters 2005年第11期16卷 1535-1538页

作者： Xiang Yu CUI jun hua li Ji Ming HAO li Xin FU Department of Environmental Science and Engineering Tsinghua University Beijing 100084

The novel bimetallic Sn-Im/Al2O3 catalysts prepared by three methods for NO reduction by propene were investigated. The results showed that the catalytic activity was enhanced significantly in the presence of H2O on sol-gel catalyst, and the maximum NO conversion increased from 46% to 92%, even in the presence of 100 ppm SO2, NO conversion was still 80%.

关键词： Selective catalytic reduction De-NOx lean burn In2O3/Al2O3 Sn-Ir/A12O3.

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Synthesis and Crystal Structure of a Novel 1D Magnesium(II) Coordination Polymer Constructed by L-Cysteic Acid

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Chinese Journal of Structural Chemistry 2007年第8期26卷 907-910页

作者： li Hai-Ye liAO Bei-ling JIANG Yi-Min ZHANG Shu-hua li jun-Xia College of Chemistry and Chemical Engineering Guangxi Normal University Guilin 541004 China

A novel coordination polymer [Mg（L）（H2O）2]·H2O] （LH2=L-cysteic acid） has been synthesized and characterized by elemental analysis, IR and single-crystal X-ray *** crystal crystallizes in orthorhombic system, space group P212121, with a=5.962（3）, b=11.224（6）, c=13.664（7）A, V=914.3（8）A^3, Z=4, Mr=245.50, Dc=1.783 g/cm^3,μ=0.445 mm-1,flack parameter=0.32（16）, F（000）=512, the final R=0.0458 and wR=0.1172 for 1578 observed reflections with I 〉 2σ（Ⅰ）. The Mg（Ⅱ） atom shows an octahedral geometry defined by two carboxyl O atoms from two different L-cysteic acid ligands, one carboxyl O atom and one amino N atom from the adjacent ligand, and two aqua ligands. The Mg（Ⅱ） atoms are bridged by L-cysteic acid ligands, leading to a 1D infinite zigzag chain. In the structure there are extensive hydrogen bonds,through which the complex completes its 3D framework structure.

关键词： magnesium(Ⅱ) complex L-cysteic acid synthesis crystal structure

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Structure engineering of cathode host materials for li-S batteries

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Rare Metals 2024年第4期43卷 1370-1389页

作者： Jia-jun Long hua Yu Wen-Bo liu School of New Energy and Materials Southwest Petroleum UniversityChengdu610500China School of Mechanical Engineering Sichuan UniversityChengdu610065China

Although lithium-sulfur batteries are one of the favorable candidates for next-generation energy storage devices,a few key challenges that have not been addressed have limited its *** challenges include lithium dendrite growth in the anode side,volume change of the active material,poor electrical conductivity,dissolution and migration of poly sulfides,and slow rate of solid-state reactions in the cathode *** the electrochemical performance of lithium-sulfur batteries is greatly affected by the design of the cathode host material,it has also been widely discussed in addressing the abovementioned *** this paper,three design ideas of cathode host materials in terms of microstructure,crystal structure and electronic structure are introduced and ***,the current progress of these three structural design strategies and their effects on the electrochemical performance of lithium-sulfur batteries are discussed in ***,future directions in the structural design of cathode materials for lithium-sulfur batteries are discussed and further perspectives are provided.

关键词： lithium-sulfur batteries Structure engineering Cathode Host materials

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