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Targeting the P2X7 receptor in microglial cells to prevent brain inflammation

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Neural Regeneration Research 2020年第7期15卷 1245-1246页

作者： Lin-hua jiang Sébastien Roger School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsSino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and NeurobiologyXinxiang Medical UniversityXinxiangHenan ProvinceChina EA4245 TransplantationImmunology and InflammationFaculty of MedicineUniversity of ToursToursFrance

Microglial cells are the key innate immune cells in the brain and they are crucial in maintaining brain parenchyma *** physiological conditions,microglial cells assume a ramified morphology with a small cell body and an extensive network of fine processes,which secrete neurotrophic factors and patrol the surroundings in search for pathogens and eliminate cellular debris via *** cells express a repertoire of pattern recognition receptors(PRRs)that enable them to detect diverse danger-associated molecular patterns(DAMPs)released from damaged cells or cells under stress,or pathogen-associated molecular patterns generated by pathogens during infection.

关键词： IL ATP APP Targeting the P2X7 receptor in microglial cells to prevent brain inflammation

Determination of hydroxyl radicals in TiO2/Ti photoelectrocatalytic oxidation system using Fe（phen）3^2＋ spectrophotometry

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Journal of Environmental Sciences 2006年第1期18卷 158-161页

作者： jiang Yan-li LIU Hui-ling WANG Qun-hui jiang Zhao-hua Department of Environmental Engineering Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China School of Life Science and Chemistry Harbin University Harbin 150086 China

A new method of determining the cumulate concentration of hydroxyl radicals in the TiO2/Ti photoelectrocatalytic（PEC） oxidation system was established by o-phenanthroline-Fe（Ⅱ）（Fe（phen）3^2＋） spectrophotometry and using anion exchange membrane. Fe （phen）3^2＋ can be oxidized to o-phenanthroline-Fe（Ⅲ）（Fe（phen）3^3＋） by strong oxidization of hydroxyl radicals（·OH）. Then the cumulate concentration of hydroxyl radicals can be calculated through determining the change of the Fe（phen）3^3＋ absorbency at 509 nm. In addition, the research results showed the production rate of hydroxyl radicals was affected obviously by pH of solution, the cumulate concentration of hydroxyl radicals was the largest at nearby the initial pH 6.3 （isoelectric point）, and the change direction of pH after illumination tended to nearby isoelectric point.

关键词： TiO2 / Ti catalyst photoelectrocatalysis o-phenanthroline-Fe hydroxyl radical anion exchange membrane

Genetic analysis and fine-mapping of a dwarfing with withered leaf-tip mutant in rice

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Journal of Genetics and Genomics 2008年第12期35卷 715-721页

作者： Liang jiang Longbiao Guo hua jiang Dali Zeng jiang Hu Liwen Wu Jian Liu Zhenyu Gao Qian Qian State Key Lab of Rice Biology China National Rice Research Institute Hangzhou 310006 China Graduate School of Chinese Academy of Agricultural Sciences Beijing 100081 China

A dwarf mutant of rice （Oryza sativa L.） by mutagenesis of ethylene methylsulfonate （EMS） treatment from Nipponbare was identified. The mutant exhibited phenotypes of dwarfism and withered leaf tip （dwll）. Based on the intemode length of dwll, this mutant belongs to the dm type of dwarfing. Analysis of elongation of the second sheath and m-amylase activity in endosperm showed that the phenotype caused by dwll was insensitive to gibberellin acid treatment. Using a large F2 population derived from a cross between the dwll and an indica rice variety, TN1, the DWL1 gene was mapped to the terminal region of the long arm of chromosome 3. Fine-mapping delimited it into a 46 kb physical distance between two STS markers, HL921 and HL944, where 6 open reading frames were predicted. Cloning of DWL1 will contribute to dissecting molecular mechanism that regulates plant height in rice, which will be beneficial to molecular assisted selection of this important trait.

关键词： mutant dwarf fine mapping rice

Effective spin dephasing mechanism in confined two-dimensional topological insulators

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 70-75页

作者： JunJie Qi HaiWen Liu hua jiang XinCheng Xie Institute of Physics Chinese Academy of Sciences Beijing 100190 China Center for Advanced Quantum Studies Department of Physics Beijing Normal University Beijing 100875 China College of Physics optoelectronics and Energy Soochow University Suzhou 215006 China International Center for Quantum Materials and School of Physics Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China

A Kramers pair of helical edge states in quantum spin Hall effect （QSHE） is robust against normal dephasing but not robust to spin dephasing. In our work, we provide an effective spin dephasing mechanism in the puddles of two-dimensional （2D） QSHE, which is simulated as quantum dots modeled by 2D massive Dirac Hamiltouian. We demonstrate that the spin dephasing effect can originate from the combination of the Rashba spin-orbit coupling and electron-phonon interaction, which gives rise to inelastic backscattering in edge states within the topological insulator quantum dots, although the time-reversal symmetry is preserved throughout. Finally, we discuss the tunneling between extended helical edge states and local edge states in the QSH quantum dots, which leads to backscattering in the extended edge states. These results can explain the more robust edge transport in InAs/GaSb QSH systems.

关键词： quantum spin Hall effect bound helical states spin dephasing Rashba spin-orbit coupling electron-phonon interaction

Numerical study of Klein quantum dots in graphene systems

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Science China(Physics,Mechanics & Astronomy) 2019年第6期62卷 93-101页

作者： JiaoJiao Zhou ShuGuang Cheng WenLong You hua jiang School of Physical Science and Technology Soochow University Department of Physics Northwest University

The Klein quantum dot(KQD) refers to a quantum dot(QD) having quasi-bound states with a finite trapping time, which has been observed in experiments focusing on graphene recently. In this paper, we develop a numerical method to study the quasibound states of the KQD in graphene systems. By investigating the variation of the local density of states(LDOS) in a circular QD, we obtain the dependence of the quasi-bound states on the QD parameters, such as the electron energy, the radius and the confined potential. Based on these results, not only the experimental phenomena can be well explained, but also the crossover between quasi-bound states and real bound states is demonstrated when the intervalley scattering is included. We further study the evolution of the LDOS as the shape of the KQD varies from a circle to a semicircle. The ways of forming closed interference paths of carriers are suppressed during the deformation, and thus the corresponding quasi-bound states are eliminated. Our study reveals the mechanism of the whispering gallery mode on the quasi-bound states in graphene systems.

关键词： Klein quantum dot quasi-bound state graphene whispering gallery mode

Effects of Rare Earth,Titanium,and Magnesium Additions on Microstructures and Properties of High-boron Medium-carbon Alloy

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Journal of Iron and Steel Research International 2016年第11期23卷 1226-1233页

作者： Xiao-li SHI Ye-hua jiang Rong ZHOU Faculty of Materials Science and Engineering Kunming University of Science and Technology

In order to improve the toughness and wear resistance of high-boron medium-carbon alloy （HBMCA）, a novel wear-resistant HBMCA comprising granular borocarbide was obtained by titanium, magnesium, and rare earth modifications. These modifications gave rise to greatly refined as-cast eutectic borocarbide structures and a less interconnected continuous borocarbide network. Heat treatment mostly produced broken and spheriodized borocarbides that tended to exist as isolated particles in modified HBMCA. The heat treated modified HBMCA exhibited enhanced hardness than pristine and impact toughness was improved significantly to 12.5 J/cm^2. In addition, it displayed 2.39 and 1.7 times greater wear resistance than high-speed steel （HSS） and high nickel-chromium alloy steel （Cr25） at high temperature （500℃）, respectively. Here, the modification mechanisms involving Re2O3, TiN, and MgO/ MgS heterogeneous nuclei were discussed.

关键词： modification eutectic borocarbide spheroidization toughness wear resistance

The DFF-PSP Iterative Separation and Theoretical Bound for PCMA with Long Memory

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Chinese Journal of Electronics 2016年第5期25卷 880-885页

作者： CUI Penghui jiang hua CAO Kai LI Taozhu National Digital Switching Engineering Technological Research Center

This paper proposes the Decision feedbackfeedforward per-survivor processing(DFF-PSP) iterative separation algorithm and the Monte Carlo integrationbased method to compute the theoretical bound for Paired carrier multiple access(PCMA) Single channel blind separation(SCBS) which is highly complex with long memory. The truncated PSP is employed while the pre- and post- cursors are disregarded to control the *** delayed decisions feedforward and local decisions feedback filters are designed to process the pre- and postcursors. The Bit-interleaved code modulation iterative decoder(BICM-ID) is combined with the second soft decision of the truncated PSP to obtain a better *** mixture signal model is regarded as a Multiple-access channel(MAC) with memory, and the theoretical performance bound is obtained via entropy inequality, Monte Carlo integration and Fano inequality. Simulation results show that the DFF-PSP iterative separation provides the good tradeoff between complexity and performance.

关键词： Paired carrier multiple access(PCMA) Single channel blind separation(SCBS) Decision feedbackfeedforward Per-survivor processing Bit-interleaved code modulation iterative decoder(BICM-ID) Multiple-access channel(MAC) Theoretical performance bound

Running-in Test and Fractal Methodology for Worn Surface Topography Characterization

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Chinese Journal of Mechanical Engineering 2010年第5期23卷 600-605页

作者： JI Cuicui ZHU hua jiang Wei LU Binbin School of Mechanical and Electrical Engineering China University of Mining and Technology Xuzhou 221116 China School of Mechanical Engineering University of Leeds Leeds LS2 9JZ UK

Studying and understanding of the surface topography variation are the basis for analyzing tribological problems,and characterization of worn surface is *** geometry offers a more accurate description for surface roughness that topographic surfaces are statistically self-similar and can be quantitatively evaluated by fractal *** change regularity of worn surface topography is one of the most important aspects of running-in ***,the existing research normally adopts only one friction matching pair to explore the surface topography change,which interrupts the running-in wear process and makes the experimental result lack authenticity and *** this paper,to investigate the change regularity of surface topography during the real running-in process,a series of running-in tests by changing friction pairs under the same operating conditions are conducted on UMT-II Universal Multifunction *** surface profile data are acquired by MiaoXAM2.5X-50X Ultrahigh Precision Surface 3D Profiler and analyzed using fractal dimension D,scale coefficient C and characteristic roughness Ra ＊based on root mean square（RMS） *** characterization effects of the three parameters are discussed and *** results obtained show that there exists remarkable fractal feature of surface topography during running-in process,both D and Ra ＊increase gradually,while C decreases slowly as the wear-in process goes on,and all parameters tend to be stable when the wear process steps into the normal wear *** ＊illustrates higher sensitivity for rough surface characterization compared with the other two *** addition,the running-in test carried with a set of identical surface properties is more scientific and reasonable than the traditional *** proposed research further indicates that the fractal method can quantitatively measure the rough surface,which also provides an evidence for running-in process identification and tribology d

关键词： running-in worn surface topography RMS method fractal dimension scale coefficient characteristic roughness

Polyfluorene based conjugated polymer nanoparticles for two-photon live cell imaging

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Science China Chemistry 2018年第1期61卷 88-96页

作者： Shuang Li Xiao-Fang jiang Qing-hua Xu Institute of Polymer optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China National University of Singapore (Suzhou) Research Institute Suzhou 215123 China Department of Chemistry National University of Singapore Singapore 117543 Singapore

Two-photon excitation microscopy(2 PEM) has been known as a noninvasive and powerful bio-imaging tool for studying living cells, intact tissues and living animals because of their unique advantages such as localized excitation, deep tissue penetration as well as less photo-damage. However, the major limitations that hinder its practical applications in biological systems are low two-photon absorption cross sections of conventional fluorescence probes. Conjugated polymer nanoparticles(CPNs) consisting of highly fluorescent conjugated polymers are promising fluorescent probes for 2 PEM due to their unique advantages including large two-photon absorption cross sections, high fluorescence quantum yield, good photo-stability and biocompatibility, facile chemical synthesis, tunable optical properties as well as versatile surface modifications. This account summarizes the recent efforts of our group on development of novel polyfluorene based CPNs as 2 PEM contrast agents for live cell imaging.

关键词： conjugated polymers nanoparticles two-photon absorption fluorescence microscopy bio-imaging