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Whole breast ultrafractionation radiotherapy after breast-conserving surgery in early breast cancer: A single-center, prospective, observational study from China

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Malignancy Spectrum 2024年第2期1卷 113-122页

作者： Rui-Zhi Zhao Cheng huang Tian-Lan Tang Gui-Qing Shi Si-Lin Chen Yu-Ping Lin Ying Wang Liu-Qing Jiang Jin-hua Chen Chun-Sen Xu Fang-Meng Fu zhong-hua han Shun-Guo Lin Chuan Wang Yong Yang Department of Radiation Oncology Fujian Medical University Union HospitalFujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors(Fujian Medical University)Clinical Research Center for Radiology and Radiotherapy of Fujian Province(DigestiveHematological and Breast Malignancies)FuzhouFujianChina Department of Follow-Up Center Fujian Medical University Union HospitalFuzhouFujianChina Department of Breast Surgery Fujian Medical University Union HospitalFuzhouFujianChina

Objective:This single-center,prospective,observational study was designed to investigate the toxicities,patient-reported outcome(PRO),and dosimetric analysis of whole breast ultrafractionation radiotherapy(RT)after breast-conserving surgery(BCS)in early breast cancer(BC).Patients and methods:Patients diagnosed with BC stage I,II and treated with BCS were enrolled.A dose of 26 Gray(Gy)in five fractions was prescribed to the whole breast and tumor *** endpoints included toxicities,PRO,and dosimetric *** was measured by the European Organization for Research and Treatment of Cancer general quality of life questionnaire(EORTC QLQ-C30)and the BC-specific questionnaire(EORTC QLQ-BR23)***:Between January 2022 and June 2023,62 female patients were *** median age was 45 *** patients(83.9%)were diagnosed with pathological stage I *** median planning target volume(PTV)was 456.4 *** minimum,maximum,and mean doses,and D95(dose of PTV irradiated volume more than 95%)to PTV were 20.2,28.8,27.2,and 26.3 Gy,*** median mean lung dose and percentage lung volume receiving 8 Gy(V8)were 3.6 Gy and 13.4%,*** median mean heart dose,V1.5(percentage of organ volume irradiated with 1.5 Gy or higher),and V7(percentage of organ volume irradiated with 7 Gy or higher)were 0.6 Gy,6.8%,and 0.4%,*** effects before RT showed no obvious differences compared to that post *** toxicities of grade 3 or higher *** patients had asymptomatic radiation pneumonia(grade 1),and 12 patients had radiation dermatitis(grade 1).No factor was significantly related to radiation dermatitis or radiation *** the EORTC QLQ-C30 and QLQ-BR23 questionnaires,all function and symptom scores before RT had no significant differences compared with that after RT,1−2 months after RT,and 3−4 months after *** RT did not worsen *** 1-year crude local control was 100%.Conclusion:Whole br

关键词： ultrafractionation radiotherapy breast cancer breast-conserving surgery toxicities patient-reported outcome

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High-dimensional aerodynamic data modeling using a machine learning method based on a convolutional neural network

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Advances in Aerodynamics 2022年第1期4卷 845-875页

作者： Bo-Wen Zan zhong-hua han Chen-Zhou Xu Ming-Qi Liu Wen-Zheng Wang Institute of Aerodynamic and Multidisciplinary Design Optimization National Key Laboratory of Science and Technology On Aerodynamic Design and ResearchSchool of AeronauticsNorthwestern Polytechnical UniversityXi’an710072China Aircraft Swarm Intelligent Sensing and Cooperative Control Key Laboratory of Sichuan Province School of Aeronautics and AstronauticsUniversity of Electronic Science and Technology of ChinaChengdu611731China

Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation. This article develops a machine learning approach based on a convolutional neural network (CNN) to address this problem. A CNN can implicitly distill features underlying the data. The number of parameters to be trained can be significantly reduced because of its local connectivity and parameter-sharing properties, which is favorable for solving high-dimensional problems in which the training cost can be prohibitive. A hypersonic wing similar to the Sanger aerospace plane carrier wing is employed as the test case to demonstrate the CNN-based modeling method. First, the wing is parameterized by the free-form deformation method, and 109 variables incorporating flight status and aerodynamic shape variables are defined as model input. Second, more than 7000 sample points generated by the Latin hypercube sampling method are evaluated by performing computational fluid dynamics simulations using a Reynolds-averaged Navier-Stokes flow solver to obtain an aerodynamic database, and a CNN model is built based on the observed data. Finally, the well-trained CNN model considering both flight status and shape variables is applied to aerodynamic shape optimization to demonstrate its capability to achieve fast optimization at multiple flight statuses.

关键词： Aerodynamic data modeling High-dimensional problem Machine learning Convolutional neural network Computational fluid dynamics

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Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

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Journal of Iron and Steel Research International 2024年第7期31卷 1811-1823页

作者： zhong-lin Wang Zhi-hua Gong Quan Li han-sheng Bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation

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Hyperspectral image super resolution using deep internal and self-supervised learning

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 128-141页

作者： Zhe Liu Xian-hua han Graduate School of Science and Technology for Innovation Yamaguchi UniversityYamaguchiJapan Graduate School of Artificial Intelligence and Science Rikkyo UniversityTokyoJapan

By automatically learning the priors embedded in images with powerful modelling ca-pabilities,deep learning-based algorithms have recently made considerable progress in reconstructing the high-resolution hyperspectral(HR-HS)*** previously collected large-amount of external data,these methods are intuitively realised under the full supervision of the ground-truth ***,the database construction in merging the low-resolution(LR)HS(LR-HS)and HR multispectral(MS)or RGB image research paradigm,commonly named as HSI SR,requires collecting corresponding training triplets:HR-MS(RGB),LR-HS and HR-HS image simultaneously,and often faces dif-ficulties in *** learned models with the training datasets collected simultaneously under controlled conditions may significantly degrade the HSI super-resolved perfor-mance to the real images captured under diverse *** handle the above-mentioned limitations,the authors propose to leverage the deep internal and self-supervised learning to solve the HSI SR *** authors advocate that it is possible to train a specific CNN model at test time,called as deep internal learning(DIL),by on-line preparing the training triplet samples from the observed LR-HS/HR-MS(or RGB)images and the down-sampled LR-HS ***,the number of the training triplets extracted solely from the transformed data of the observation itself is extremely few particularly for the HSI SR tasks with large spatial upscale factors,which would result in limited reconstruction *** solve this problem,the authors further exploit deep self-supervised learning(DSL)by considering the observations as the unlabelled training ***,the degradation modules inside the network were elaborated to realise the spatial and spectral down-sampling procedures for transforming the generated HR-HS estimation to the high-resolution RGB/LR-HS approximation,and then the reconstruction errors of the observations were formulated for mea

关键词： computer vision deep learning deep neural networks hyperspectral image enhancement

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The medium-temperature dependence of jet transport coefficient in high-energy nucleus-nucleus collisions

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Nuclear Science and Techniques 2024年第7期35卷 173-191页

作者： Man Xie Qing-Fei han En-Ke Wang Ben-Wei Zhang han-zhong Zhang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum Matter South China Normal UniversityGuangzhou510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan430079China

The medium-temperature T dependence of the jet transport coefficient̂q was studied via the nuclear modification factor RAA(p_(T))and elliptical flow parameter v_(2)(p_(T))for large transverse momentum p_(T) hadrons in high-energy nucleus-nucleus *** a next-to-leading-order perturbative QCD parton model for hard scatterings with modified fragmentation functions due to jet quenching controlled by q,we check the suppression and azimuthal anisotropy for large p_(T) hadrons,and extract q by global fits to RAA(pT)and v_(2)(pT)data in A+A collisions at RHIC and LHC,*** numerical results from the best fits show that q∕T^(3) goes down with local medium-temperature T in the parton jet *** with the case of a constant q∕T^(3),the going-down T dependence of q∕T^(3) makes a hard parton jet to lose more energy near T_(c) and therefore strengthens the azimuthal anisotropy for large pT *** a result,v_(2)(p_(T))for large pT hadrons was enhanced by approximately 10%to better fit the data at RHIC/*** the first-order phase transition from QGP to the hadron phase and the additional energy loss in the hadron phase,v_(2)(p_(T))is again enhanced by 5-10%at RHIC/LHC.

关键词： Jet quenching Jet transport parameter Hadron suppression Elliptic flow coefficient Energy loss asymmetry

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Functional paragangliomas of the urinary bladder:a report of 9 cases

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Chinese Journal of Cancer 2010年第8期29卷 729-734页

作者： Jian-hua Deng han-zhong Li Yu-Shi Zhang Guang-hua Liu Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 P. R. China

Background and Objective: Functional paraganglioma of the urinary bladder (FPUB) is a rare tumor. Misdiagnosis of FPUB before operation can lead to serious intraoperative consequences. In this article, we reported our experience in preoperative diagnosis and surgical treatment of FPUB. Methods: Clinical data of nine patients with FPUB treated between June 1985 and January 2009 at Peking Union Medical College Hospital were analyzed. Results: All patients underwent urinary catecholamine (CA) detection, B-ultrasound, CT and/or MRI scan; 5 underwent nailfola microcirculation inspection; 4 underwent 131I-metaiodobenzyl guanidine (MIBG) detection; and 6 underwent 111In-DTPA-Octreotide (OCT) scintiscan. According to the UICC bladder tumor classification, 5 patients had T2, 3 had T3, and 1 had T4 disease. All patients underwent surgical treatment, and 1 received 131I-MIBG therapy. All patients had paroxysmal hypertension and palpitation and six had cold sweat, headache, and dizziness after emphatic urination. The definitive diagnosis was made by histopathologic examination of the removed tumors and was confirmed in 7 cases by the immunohistochemical staining of chromogranin A, Ki-67 and S100 protein. The tumor consisted of discrete aggregates of zellballen cells separated by a network of vascular channels. One patient had metastases in the pelvic lymph nodes, liver and colon. Follow-up ranged from 7 to 289 months (mean, 127.2 ± 34.2). Six of the nine cases reported here were found in the usual locations. One patient had multiple tumors. The catecholamine level was elevated under basal conditions in 8 patients and during endoscopic resection of the tumor in 1 patient; it returned to normal after surgery in 8 patients. Three patients had recurrence and 1 had metastasis following surgery. Conclusions: Early preoperative diagnosis of FPUB is difficult, but it should be suspected in patients with typical tetrad symptoms: headache and micturition syncope, sweating, palpitation an

关键词：膀胱肿瘤手术治疗 S100蛋白儿茶酚胺病理检查临床资料 DTPA 手术切除

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Monocular Distance Estimated Based on PTZ Camera

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Computers, Materials & Continua 2024年第5期79卷 3417-3433页

作者： Qirui zhong Xiaogang Cheng Yuxin Song han Wang Bell Honors School Nanjing University of Posts and Telecommunications Nanjing210003China College of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing210003China College of Automation and College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing210003China

This paper introduces an intelligent computational approach for extracting salient objects fromimages and estimatingtheir distance information with PTZ (Pan-Tilt-Zoom) cameras. PTZ cameras have found wide applications innumerous public places, serving various purposes such as public securitymanagement, natural disastermonitoring,and crisis alarms, particularly with the rapid development of Artificial Intelligence and global infrastructuralprojects. In this paper, we combine Gauss optical principles with the PTZ camera’s capabilities of horizontal andpitch rotation, as well as optical zoom, to estimate the distance of the *** present a novel monocular objectdistance estimation model based on the Focal Length-Target Pixel Size (FLTPS) relationship, achieving an accuracyrate of over 95% for objects within a 5 km range. The salient object extraction is achieved through a simplifiedconvolution kernel and the utilization of the object’s RGB features, which offer significantly faster computingspeeds compared to Convolutional Neural Networks (CNNs). Additionally, we introduce the dark channel beforethe fog removal algorithm, resulting in a 20 dB increase in image definition, which significantly benefits distanceestimation. Our system offers the advantages of stability and low device load, making it an asset for public securityaffairs and providing a reference point for future developments in surveillance hardware.

关键词： Public security location information PTZ camera image processing

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Carbon efficiency modeling and optimization of solar-powered cellular networks

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Science China(Information Sciences) 2024年第5期67卷 228-243页

作者： Yuxi ZHAO Xiaohu GE Wen YAN Tao han Yi zhong School of Electronic Information and Communications Huazhong University of Science and Technology huawei Technology Co. Ltd.

As wireless communication traffic experiences rapid growth, the carbon emissions caused by the communication industry are also on the rise. To achieve “carbon neutrality”, researchers are considering the use of renewable energy sources to power cellular networks, thereby reducing carbon emissions. However, a challenge arises when using renewable energy, specifically owing to the unpredictable nature of both the energy consumption of the cellular network and the power generation from renewable sources. This inconsistency results in low renewable energy utilization and reduced carbon efficiency. Herein, we construct a carbon efficiency model of solar-powered cellular networks using practical data from solar radiation. We propose a mechanism that alternately optimizes the performance of the renewable energy network and the cellular network. This approach is based on convex optimization theory and the Dinkelback algorithm, and it leads to the design of a carbon efficiency optimization algorithm. This algorithm aims to improve the carbon efficiency of cellular networks and reduce their carbon emissions. Simulation results demonstrate that our optimization scheme yields a maximum improvement of 2.56 × 108bps/g in the carbon efficiency of the cellular network as compared to conventional power allocation schemes such as the traditional water filling method and heuristic energy sharing and charge/discharge algorithms.

关键词： cellular networks renewable energy carbon efficiency convex optimization theory dinkelbach

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Chinese expert consensus on immunotherapy for advanced non-small cell lung cancer with oncogenic driver mutations(2023 edition)

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Chinese Medical Journal 2024年第9期137卷 1016-1018页

作者： The Society of Cancer Precision Medicine of Chinese Anti-Cancer Association The Lung Cancer Expert Group of Chinese Medical Association Publishing House Baohui han hua zhong 不详 Department of Respiratory Medicine Shanghai Chest HospitalSchool of MedicineShanghai JiaoTong UniversityShanghai 20030China Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine

Non-small cell lung cancer(NSCLC)with oncogenic driver mutations was previously deemed“forbidden territory”for immunotherapy.[1]With the continuous generation of evidence,immunotherapy is expected to bring hope for such NSCLC with oncogenic driver mutations after acquired tyrosine kinase inhibitor(TKI)***,given the intricate interplay between driven mutations,targeted therapy,and immune microenvironment,the efcacy of immunotherapy in advanced NSCLC patients with diverse oncogenic driver mutations remains a topic of ongoing *** this context,Chinese Expert Consensus on Immunotherapy for Advanced NSCLC with Oncogenic Driver Mutations(2022 edition)wasrst launched in 2022 by the Society of Cancer Precision Medicine of Chinese Anti-Cancer Association and the Lung Cancer Expert Group of Chinese Medical Journals,aiming to provide standardized treatment guidance for clinical practice.

关键词： immunotherapy cancer lung

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Resurgence of pertussis:reasons and coping strategies

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World Journal of Pediatrics 2024年第7期20卷 639-642页

作者： Chun-Zhen hua han-Qing He Qiang Shu Department of Infectious Diseases National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou310052China Department of Immunization Program Zhejiang Provincial Center for Disease Control and PreventionHangzhou310051China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou310052China

Pertussis(whooping cough)is an acute and contagious respiratory disease caused by the pathogen Bordetella pertussis(***).*** can infect individuals of all *** with pertussis may experience severe and persistent coughing and paroxysms;for newborns and infants,pertussis may be *** development and widespread administration of the pertussis vaccine had once successfully brought pertussis under control,maintaining it at a low level for many ***,resurgence of pertussis has been reported in many countries even with high vaccination coverage *** resurgence of pertussis was first reported in the United States(USA)in 1993[1].During 2000–2016,the baseline incidence increased and the age distribution of pertussis changed in the USA[2].Other countries including Canada[3],Australia[4],European Union countries,and South Korea have also reported a rise in pertussis outbreaks[2,5].

关键词： pertussis Canada surge

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