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Functional paragangliomas of the urinary bladder:a report of 9 cases

Chinese Journal of Cancer 2010年第8期29卷 729-734页

作者： Jian-hua Deng han-zhong Li Yu-Shi Zhang Guang-hua Liu Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 P. R. China

Background and Objective: Functional paraganglioma of the urinary bladder (FPUB) is a rare tumor. Misdiagnosis of FPUB before operation can lead to serious intraoperative consequences. In this article, we reported our experience in preoperative diagnosis and surgical treatment of FPUB. Methods: Clinical data of nine patients with FPUB treated between June 1985 and January 2009 at Peking Union Medical College Hospital were analyzed. Results: All patients underwent urinary catecholamine (CA) detection, B-ultrasound, CT and/or MRI scan; 5 underwent nailfola microcirculation inspection; 4 underwent 131I-metaiodobenzyl guanidine (MIBG) detection; and 6 underwent 111In-DTPA-Octreotide (OCT) scintiscan. According to the UICC bladder tumor classification, 5 patients had T2, 3 had T3, and 1 had T4 disease. All patients underwent surgical treatment, and 1 received 131I-MIBG therapy. All patients had paroxysmal hypertension and palpitation and six had cold sweat, headache, and dizziness after emphatic urination. The definitive diagnosis was made by histopathologic examination of the removed tumors and was confirmed in 7 cases by the immunohistochemical staining of chromogranin A, Ki-67 and S100 protein. The tumor consisted of discrete aggregates of zellballen cells separated by a network of vascular channels. One patient had metastases in the pelvic lymph nodes, liver and colon. Follow-up ranged from 7 to 289 months (mean, 127.2 ± 34.2). Six of the nine cases reported here were found in the usual locations. One patient had multiple tumors. The catecholamine level was elevated under basal conditions in 8 patients and during endoscopic resection of the tumor in 1 patient; it returned to normal after surgery in 8 patients. Three patients had recurrence and 1 had metastasis following surgery. Conclusions: Early preoperative diagnosis of FPUB is difficult, but it should be suspected in patients with typical tetrad symptoms: headache and micturition syncope, sweating, palpitation an

关键词：膀胱肿瘤手术治疗 S100蛋白儿茶酚胺病理检查临床资料 DTPA 手术切除

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Meta-analysis of stapled hemorrhoidopexy vs LigaSure hemorrhoidectomy

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World Journal of Gastroenterology 2013年第29期19卷 4799-4807页

作者： Jun Yang Pei-Jing Cui hua-zhong han Da-Nian Tong Department of Surgery Sixth People's Hospital Shanghai Jiao Tong University Department of Geriatrics Ruijin Hospital Shanghai Jiao Tong University

AIM: To compare outcome of stapled hemorrhoidopexy (SH) vs LigaSure hemorrhoidectomy (LH) by a meta-analysis of available randomized controlled trials (RCTs). METHODS: Databases, including PubMed, EMBASE, the Cochrane Library, and the Science Citation Index updated to December 2012, were searched. The main outcomes measured were operating time, early postoperative pain, postoperative urinary retention and bleeding, wound problems, gas or fecal incontinence, anal stenosis, length of hospital stay, residual skin tags, prolapse, and recurrence. The meta-analysis was performed using the free software Review Manager. Differences observed between the two groups were expressed as the odds ratio (OR) with 95%CI. A fixedeffects model was used to pool data when statistical heterogeneity was not present. If statistical heterogeneity was present (P han for LH (P han in the SH group [2/111 (1.8%) vs 16/105 (15.2%); P = 0.0004; OR= 0.17, 95%CI: 0.06-0.45). The incidence of recurrence after the procedures was significantly lower in the LH group than in the SH group [2/173 (1.2%) vs 13/174 (7.5%); P = 0.003; OR= 0.21, 95%CI: 0.07-0.59]. CONCLUSION: Both SH and LH are probably equally valuable techniques in modern hemorrhoid surgery. However, LigaSure might have slightly favorable immediate postoperative results and technical advantages.

关键词： Stapled hemorrhoidopexy Ligasure hemorrhoidectomy Hemorrhoids Meta-analysis

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Does hyoscine butylbromide really improve polyp detection during colonoscopy? A meta-analysis of randomized controlled trials

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World Journal of Gastroenterology 2014年第22期20卷 7034-7039页

作者： Pei-Jing Cui Jing Yao hua-zhong han Yi-Jun Zhao Jun Yang Department of Geriatrics Ruijin HospitalShanghai Jiao Tong University School of Medicine Department of Surgery Sixth People’s HospitalShanghai Jiao Tong University

AIM: To investigate the benefits of hyoscine butylbromide in polyp detection during colonoscopy by a meta-analysis of available randomized controlled trials (RCTs).

关键词： Hyoscine butylbromide Polyp detection Adenoma detection Colonoscopy

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Biliary stenting with or without sphincterotomy for malignant biliary obstruction:A meta-analysis

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World Journal of Gastroenterology 2014年第38期20卷 14033-14039页

作者： Pei-Jing Cui Jing Yao Yi-Jun Zhao hua-zhong han Jun Yang Department of Geriatrics Ruijin HospitalShanghai Jiao Tong University School of Medicine Department of Surgery Sixth People’s HospitalShanghai Jiao Tong University

AIM: To investigate the benefits of endoscopic sphincterotomy (EST) before stent placement by meta-analysis of randomized controlled trials (RCTs).

关键词： Biliary stent Endoscopic sphincterotomy Endoscopic retrograde cholangiopancreatography Malignant biliary obstruction

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High-dimensional aerodynamic data modeling using a machine learning method based on a convolutional neural network

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Advances in Aerodynamics 2022年第1期4卷 845-875页

作者： Bo-Wen Zan zhong-hua han Chen-Zhou Xu Ming-Qi Liu Wen-Zheng Wang Institute of Aerodynamic and Multidisciplinary Design Optimization National Key Laboratory of Science and Technology On Aerodynamic Design and ResearchSchool of AeronauticsNorthwestern Polytechnical UniversityXi’an710072China Aircraft Swarm Intelligent Sensing and Cooperative Control Key Laboratory of Sichuan Province School of Aeronautics and AstronauticsUniversity of Electronic Science and Technology of ChinaChengdu611731China

Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation. This article develops a machine learning approach based on a convolutional neural network (CNN) to address this problem. A CNN can implicitly distill features underlying the data. The number of parameters to be trained can be significantly reduced because of its local connectivity and parameter-sharing properties, which is favorable for solving high-dimensional problems in which the training cost can be prohibitive. A hypersonic wing similar to the Sanger aerospace plane carrier wing is employed as the test case to demonstrate the CNN-based modeling method. First, the wing is parameterized by the free-form deformation method, and 109 variables incorporating flight status and aerodynamic shape variables are defined as model input. Second, more than 7000 sample points generated by the Latin hypercube sampling method are evaluated by performing computational fluid dynamics simulations using a Reynolds-averaged Navier-Stokes flow solver to obtain an aerodynamic database, and a CNN model is built based on the observed data. Finally, the well-trained CNN model considering both flight status and shape variables is applied to aerodynamic shape optimization to demonstrate its capability to achieve fast optimization at multiple flight statuses.

关键词： Aerodynamic data modeling High-dimensional problem Machine learning Convolutional neural network Computational fluid dynamics

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Alternative splicing of VEGFA,APP and NUMB genes in colorectal cancer

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World Journal of Gastroenterology 2015年第21期21卷 6550-6560页

作者： Yi-Jun Zhao hua-zhong han Yong Liang Chen-Zhang Shi Qing-Chao Zhu Jun Yang Department of Surgery Shanghai Jiao Tong UniversityAffiliated Sixth People’s Hospital Department of Gastrointestinal Surgery the Affiliated Hospital of Xuzhou Medical College

AIM:To investigate alternative splicing in vascular endothelial growth factor A(VEGFA),amyloid beta precursor protein(APP),and Numb homolog(NUMB) in colorectal cancer(CRC).METHODS:Real-time quantitative reverse transcriptase polymerase chain reaction(q RT-PCR) and PCRrestriction fragment length polymorphism analyses were performed to detect the expression of VEGFA,APP,and NUMB mR NA in 20 CRC tissues and matched adjacent normal tissues,as well as their alternative splicing ***:q RT-PCR analysis revealed that the expression of APP,NUMB,and VEGFA 165 b m RNA were significantly downregulated,while VEGFA m RNA was upregulated,in CRC tissues(all P han in adjacent normal tissues(P < 0.05).Compared with adjacent normal tissues,the expression of NUMB-PRRS in CRC tissues was significantly decreased(P < 0.05),and the expression of NUMB-PRRL was increased(P < 0.05).CONCLUSION:Alternative splicing of VEGFA,APP,and NUMB may regulate the development of CRC,and represent new targets for its diagnosis,prognosis,and treatment.

关键词： Alternative splicing Amyloid beta precursorprotein Colorectal cancer Numb homolog Vascular endothelial growth factor A

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao han Qin zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Whole breast ultrafractionation radiotherapy after breast-conserving surgery in early breast cancer: A single-center, prospective, observational study from China

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Malignancy Spectrum 2024年第2期1卷 113-122页

作者： Rui-Zhi Zhao Cheng huang Tian-Lan Tang Gui-Qing Shi Si-Lin Chen Yu-Ping Lin Ying Wang Liu-Qing Jiang Jin-hua Chen Chun-Sen Xu Fang-Meng Fu zhong-hua han Shun-Guo Lin Chuan Wang Yong Yang Department of Radiation Oncology Fujian Medical University Union HospitalFujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors(Fujian Medical University)Clinical Research Center for Radiology and Radiotherapy of Fujian Province(DigestiveHematological and Breast Malignancies)FuzhouFujianChina Department of Follow-Up Center Fujian Medical University Union HospitalFuzhouFujianChina Department of Breast Surgery Fujian Medical University Union HospitalFuzhouFujianChina

Objective:This single-center,prospective,observational study was designed to investigate the toxicities,patient-reported outcome(PRO),and dosimetric analysis of whole breast ultrafractionation radiotherapy(RT)after breast-conserving surgery(BCS)in early breast cancer(BC).Patients and methods:Patients diagnosed with BC stage I,II and treated with BCS were enrolled.A dose of 26 Gray(Gy)in five fractions was prescribed to the whole breast and tumor *** endpoints included toxicities,PRO,and dosimetric *** was measured by the European Organization for Research and Treatment of Cancer general quality of life questionnaire(EORTC QLQ-C30)and the BC-specific questionnaire(EORTC QLQ-BR23)***:Between January 2022 and June 2023,62 female patients were *** median age was 45 *** patients(83.9%)were diagnosed with pathological stage I *** median planning target volume(PTV)was 456.4 *** minimum,maximum,and mean doses,and D95(dose of PTV irradiated volume more than 95%)to PTV were 20.2,28.8,27.2,and 26.3 Gy,*** median mean lung dose and percentage lung volume receiving 8 Gy(V8)were 3.6 Gy and 13.4%,*** median mean heart dose,V1.5(percentage of organ volume irradiated with 1.5 Gy or higher),and V7(percentage of organ volume irradiated with 7 Gy or higher)were 0.6 Gy,6.8%,and 0.4%,*** effects before RT showed no obvious differences compared to that post *** toxicities of grade 3 or higher *** patients had asymptomatic radiation pneumonia(grade 1),and 12 patients had radiation dermatitis(grade 1).No factor was significantly related to radiation dermatitis or radiation *** the EORTC QLQ-C30 and QLQ-BR23 questionnaires,all function and symptom scores before RT had no significant differences compared with that after RT,1−2 months after RT,and 3−4 months after *** RT did not worsen *** 1-year crude local control was 100%.Conclusion:Whole br

关键词： ultrafractionation radiotherapy breast cancer breast-conserving surgery toxicities patient-reported outcome

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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中红外波段大气碳同位素激光吸收光谱研究

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光谱学与光谱分析 2017年第11期37卷 3365-3369页

作者：夏滑董凤忠韩荦吴边孙鹏帅张志荣崔小娟中国科学院安徽光学精密机械研究所安徽省光电子器件与材料重点实验室安徽合肥230031 中国科学技术大学安徽合肥230026

大气碳同位素在环境污染源汇示踪和地球化学发展等方面的应用越来越广泛,在其探测技术方面,激光吸收光谱技术具有体积小、可在线、灵敏度高等优点,在气体同位素探测中越来越受到重视。工作中研究了2.7μm波段的分布式反馈激光器(distrib... 详细信息

大气碳同位素在环境污染源汇示踪和地球化学发展等方面的应用越来越广泛,在其探测技术方面,激光吸收光谱技术具有体积小、可在线、灵敏度高等优点,在气体同位素探测中越来越受到重视。工作中研究了2.7μm波段的分布式反馈激光器(distributed feedback laser,DFB)可调谐半导体激光器的性能,在遵循12 CO_2和13 CO_2同位素分子吸收谱线特征和同位素分子谱线选择原则的基础上,确定了合适的激光器输出波长。结合光程390.3m的新型多次反射池,实现了大气中CO_2分子的δ^(13)C同位素丰度探测。

关键词：激光吸收光谱多次反射池碳同位素探测中红外DFB激光器

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