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Basaloid squamous carcinoma of esophagus:a clinicopathological,immunohistochemical and electron microscopic study of sixteen cases

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World Journal of Gastroenterology 1998年第5期4卷 34-40页

作者： ZHANG xin hua, sun Gui Qin, ZHOU Xiao Jun, GUO Hui Fang and ZHANG Tai He

AIM To further clarify the clinicopathological, immunohistochemical and electron microscopic features, and prognostic aspect of basaloid squamous carcinoma (BSC), a rare esophageal *** We reviewed 763 documented cases of esophageal malignancies from year (1977-1996) from our hospital, and discovered 16 (2.1%) cases of BSC. The clinicopathological features of these cases were evaluated. Immunohistochemistry (S-P method), histochemical stains, and electron microscopy were used to further characterize the *** The tumors were classified into stages Ⅰ (n=1), ⅡA (n=6), ⅡB (n=2), Ⅲ (n=5), and Ⅳ (n=2) according to the criteria of the UICC TNM classification system of malignant tumors (1987). Most neoplasms were located in the mid third of the esophagus. Grossly, they had a similar appearance of conventional esophageal carcinoma, but showed a typical cytoarchitectural pattern of BSC histologically. The most important histologic feature of this tumor is carcinoma with a basaloid pattern, intimately associated with squamous cell carcinoma, dysplasia, or focal squamous differentiation. The basaloid cells were round to oval in shape with scant cytoplasm, arranged mainly in the form of solid, smooth-contoured lobules with peripheral palisading. A panel of immunostains were used for the basaloid component of the tumor with the following results: CK(Pan) 14/16 (+); EMA 16/16 (+); Vimentin 4/16 (+); S-100 protein 7/16 (+). CEA and smooth muscle actin were negative. Electron microscopy (EM) revealed that the basaloid cells were poorly differentiated, with a few desmosomes and fibrils, and numerous free and polyribosome. Of the 11 patients with adequate follow-up 8 died within 2 years, with an average survival time of 16.2 months. No stage Ⅱ, Ⅲ or Ⅳ cases survived beyond 5 years. The one-year survival rate was 60% and two-year 20%.CONCLUSION The BSC of esophagus is a distinct clinicopathological entity with poor prognosis. The cellular differentiation and bi

关键词： esophageal neoplasms/pathology esophageal neoplasms/ultrastructure carcinoma, squamous cell/pathology carcinoma, squamous cell/ultrastructure

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“小二胎”:内涵、特征、成因及启示——基于江西省T村的实证分析

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南方人口 2012年第1期27卷 1-9页

作者：孙新华华中科技大学社会学系湖北武汉430074

本文利用一个村庄的个案访谈与统计资料探讨了农村新近出现的"小二胎"现象的内涵、特征与成因。结果表明,一、二胎生育间隔大于等于7年的"小二胎"大量涌现,其中计划外生育占据多数,且随着间隔的拉长其所占比重更大。与此相对应的是生育... 详细信息

本文利用一个村庄的个案访谈与统计资料探讨了农村新近出现的"小二胎"现象的内涵、特征与成因。结果表明,一、二胎生育间隔大于等于7年的"小二胎"大量涌现,其中计划外生育占据多数,且随着间隔的拉长其所占比重更大。与此相对应的是生育妇女以30岁以上的大龄妇女为主。作为农民的理性选择,"小二胎"是农民在内在动机与外在条件共同交织下的合力结果,其中农民的生育意愿是核心,基层计生环境的放松为诱因,家庭经济条件的改善为此提供了经济基础。希望本研究能从微观视角为思考我国计生政策的下一步走向提供一些启发。

关键词： “小二胎” 生育间隔内涵特征成因

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Urodynamic assessment of bladder storage function after radical hysterectomy for cervical cancer

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Chinese Medical Journal 2020年第19期133卷 2274-2280页

作者： Ting-Ting Cao Hong-Wu Wen Yu-Nong Gao Qiu-Bo Lyu Hui-xin Liu Sha Wang Shi-Yan Wang hua-xin sun Na Yu Hai-Bo Wang Yi Li Zhi-Qi Wang Olivia H.Chang Xiu-Li sun Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China The Key Laboratory of Female Pelvic Floor Disorders Disease Beijing 100044China The Research Center of Female Pelvic Floor Disorders Disease of Peking University Beijing 100044China Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Gynecology Peking University Cancer Hospital&InstituteBeijing 100142China Department of Gynecology Beijing HospitalBeijing 100005China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China Department of Peking University Medical Information Center Peking UniversityBeijing 100191China Department of Peking University Clinical Research Institute Peking UniversityBeijing 100191China Center for Urogynecology and Pelvic Reconstructive Surgery Cleveland ClinicClevelandOH 44195USA.

Background:After radical hysterectomy for cervical cancer,the most common complication is lower urinary tract ***-operatively,bladder capacity can alter bladder function for a prolonged *** study aimed to identify factors affecting bladder storage ***:A multicenter,retrospective cohort study was *** of patients with stages IA2 to IIB cervical cancer with urodynamic study results were retrospectively collected from nine hospitals between June 2013 and June 2018 according to the inclusion ***,surgical,and oncological data were *** univariate and multivariate logistic regression was used to identify clinical factors associated with bladder storage ***:Two hundred and three patients with cervical cancer had urodynamic testing ***-five(46.8%)patients were diagnosed with stress urinary incontinence(SUI).The incidence of low bladder compliance(LBC)was 23.2%.Twenty-seven(13.3%)patients showed detrusor overactivity(DO).Fifty-seven patients(28.1%)presented with a decreased maximum cystometric capacity(DMCC).The probability of composite bladder storage dysfunction was 68.0%.Multivariate analysis confirmed that laparoscopy represents a protective factor for SUI with an odds ratio of 0.498(P=0.034).Patients who underwent a nerve-sparing procedure were less odds to experience SUI(P=0.014).A significant positive correlation between LBC and DO was observed(P<0.001).A greater length of the resected vagina and chemoradiotherapy were common risk factors for LBC and DO,while radiotherapy exerted a stronger effect than ***,patients who received chemoradiotherapy frequently developed a *** follow-up time was not correlated with bladder storage ***:A nerve-sparing procedure without longer resected vagina is recommended for protecting the bladder storage function.

关键词： Radical hysterectomy Cervical cancer Urodynamic Bladder storage function

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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沪通长江大桥天生港专用航道桥弦杆制孔精度控制技术

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世界桥梁 2017年第3期45卷 44-47页

作者：朱新华孙蕾蕾中铁宝桥(扬州)有限公司江苏扬州225107

沪通长江大桥天生港专用航道桥为(140+336+140)m刚性梁柔性拱桥,主梁为带竖杆的华伦式桁架,横向采用三片主桁结构。钢桁梁弦杆为典型的箱形整体节点构造,接头较多,孔群空间关系复杂,为保证弦杆钻孔精度,腹板孔群制孔时,杆件组焊并修整... 详细信息

沪通长江大桥天生港专用航道桥为(140+336+140)m刚性梁柔性拱桥,主梁为带竖杆的华伦式桁架,横向采用三片主桁结构。钢桁梁弦杆为典型的箱形整体节点构造,接头较多,孔群空间关系复杂,为保证弦杆钻孔精度,腹板孔群制孔时,杆件组焊并修整合格后,首先将杆件吊至高精密的划线平台处进行整体划线,然后利用专用整体节点杆件双机联动立柱式数控钻床进行钻制。顶、底板及横梁接头孔群采用成熟的划线工艺和高精度样板钻制。斜向接头板组装时,首先采用斜向接头板先孔法,然后用高精度定位样板组装。实践表明,弦杆制孔精度控制技术及孔径偏差控制措施,有效地保证了弦杆的钻孔精度和孔群的相对位置关系。

关键词：钢桁梁弦杆整体节点钻孔精度数控钻床划线工艺施工控制

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高吸水纤维的研制及其吸水性能的测试

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天津工业大学学报 2005年第1期24卷 13-15页

作者：张爽邓新华孙元天津工业大学材料科学与化学工程学院天津300160

采用水溶液聚合法,以丙烯酸(AA)、2 丙烯酰胺 2 甲基丙磺酸(AMPS)、丙烯酰胺(AM)和聚乙烯醇(PVA)为原料,以过硫酸钾为引发剂,分别合成AA/AMPS共聚物和AA/AMPS/AM共聚物,然后进行湿法纺丝,制得高吸水纤维并测定其吸(盐)水倍率.研究结果表... 详细信息

采用水溶液聚合法,以丙烯酸(AA)、2 丙烯酰胺 2 甲基丙磺酸(AMPS)、丙烯酰胺(AM)和聚乙烯醇(PVA)为原料,以过硫酸钾为引发剂,分别合成AA/AMPS共聚物和AA/AMPS/AM共聚物,然后进行湿法纺丝,制得高吸水纤维并测定其吸(盐)水倍率.研究结果表明,在实验配比条件下,二元共聚吸水纤维随AMPS加入量增大,吸(盐)水倍率也随之增大;三元共聚吸水纤维随AMPS加入量增大,吸(盐)水倍率先增大后减小.

关键词：高吸水纤维丙烯酸丙烯酰胺 2-丙烯酰胺-2-甲基丙磺酸吸水倍率

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Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi Ran sun Lianfei Ding Mukun He Jiaming Li hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi sun Luqian Feng hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen sun Liang Xue Wenyao Zhang Pan Xiong xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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米氮平与氟西汀治疗伴有广泛焦虑障碍的抑郁症各35例的疗效比较

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中国新药与临床杂志 2004年第12期23卷 853-855页

作者：钮富荣沈鑫华孙松涛湖州市第三人民医院精神科浙江湖州313000

目的 :比较米氮平与氟西汀治疗伴有广泛焦虑障碍的抑郁症的疗效。方法 :70例同时符合DSM Ⅳ重症抑郁障碍及广泛焦虑障碍诊断标准的抑郁症病人随机分为 2组 ,米氮平组 35例 [男性 12例 ,女性 2 3例 ,年龄 (4 3±s 14 )a],予米氮平 15～4 ... 详细信息

目的 :比较米氮平与氟西汀治疗伴有广泛焦虑障碍的抑郁症的疗效。方法 :70例同时符合DSM Ⅳ重症抑郁障碍及广泛焦虑障碍诊断标准的抑郁症病人随机分为 2组 ,米氮平组 35例 [男性 12例 ,女性 2 3例 ,年龄 (4 3±s 14 )a],予米氮平 15～4 5mg ,po ,qd。氟西汀组 35例 [男性 10例 ,女性 2 5例 ,年龄 (4 4± 12 )a],予氟西汀 2 0～ 6 0mg ,po ,qd ;均 8wk为一个疗程。结果 :米氮平组有效率为94 % (33/35 ) ,氟西汀组有效率为 89% (31/35 ) ,2组有效率比较差异无显著意义 (P >0 .0 5 )。结论 :米氮平治疗伴有广泛焦虑障碍的抑郁症 ,起效快。

关键词：氯西汀抑郁症焦虑随机对照试验米氮平

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