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World Journal of Acupuncture-Moxibustion 2020年第2期30卷 158-162页

作者： Hao-cheng TANG wei-hua zhang School of Acupuncture-Moxibustion and Tuina Shaanxi University of Traditional Chinese MedicineXianyang 712046Shaanxi ProvinceChina Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina

The professor wei-hua zhang’s experiences in treatment of primary dysmenorrhea with"warmingunblocking needling method"was introduced in this *** believes that obstruction is the crucial in pathogenesis of primary dysmenorrhea no matter of the excess or the deficiency *** and unblocking principle is the essential in ***,an unique therapeutic method is innovated,named warming-unblocking needling method,including three-layer and two-direction warming needling technique at Sanyinjiao(三阴交SP6),two-layer rotating warming-unblocking technique at Zhongji(中极CV3)and one-layer and two-direction warming needling technique at Ciliao(次髎BL32).In this set of needling procedure,acupoint is viewed as a three-dimensional hierarchical structure.A layered and multidirectional needling technique is adopted at main acupoints to enhance the sensations of diqi and to generate heat effect in the ***,moxibustion is combined to intensify warming and unblocking ***,the supplementary acupoints are used in response to *** of the acupoints coordinately warm up the uterus,promote meridian circulation and stop ***,this therapeutic method achieves relatively excellent effect and deserves to be promoted in practice.

关键词： Famous doctor’s clinical experiences Primary dysmenorrhea Warming-unblocking method wei-hua zhang

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-wei zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

A numerical approach to the interaction between airflow and a high-speed train subjected to crosswind

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第7期14卷 482-493页

作者： Tian LI Ji-ye zhang wei-hua zhang State Key Laboratory of Traction Power Southwest Jiaotong University

Aerodynamic forces and dynamic performances of railway vehicles are coupled and affected by each other. On the one hand, aerodynamic forces change the displacements of a train. On the other hand, displacements affect aerodynamic forces. Based on vehicle-track coupling dynamics and aerodynamics, a numerical approach to the interaction between airflow and a high-speed train is presented in this paper. Aerodynamic forces and dynamic performances of a high-speed train subjected to crosswind were numerically simulated. Results showed that the interaction between airflow and a high-speed train has a significant influence on displacements and aerodynamic forces of the head coach. Therefore, it is necessary to consider the interaction between airflow and a high-speed train subjected to crosswind.

关键词： High-speed train Crosswind Aerodynamics Co-simulation Interaction

Multi-objective optimization design method of the high-speed train head

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 631-641页

作者： Meng-ge YU Ji-ye zhang wei-hua zhang State Key Laboratory of Traction Power Southwest Jiaotong University

With the continuous improvement of the train speed, the dynamic environment of trains turns out to be aerodynamic domination. Solving the aerodynamic problems has become one of the key factors of the high-speed train head design. Given that the aerodynamic drag is a significant factor that restrains train speed and energy conservation, reducing the aerodynamic drag is thus an important consideration of the high-speed train head design. However, the reduction of the aerodynamic drag may increase other aerodynamic forces (moments), possibly deteriorating the operational safety of the train. The multi-objective optimization design method of the high-speed train head was proposed in this paper, and the aerodynamic drag and load reduction factor were set to be optimization objectives. The automatic multi-objective optimization design of the high-speed train head can be achieved by integrating a series of procedures into the multi-objective optimization algorithm, such as the establishment of 3D parametric model, the aerodynamic mesh generation, the calculation of the flow field around the train, and the vehicle system dynamics. The correlation between the optimization objectives and optimization variables was analyzed to obtain the most important optimization variables, and a further analysis of the nonlinear relationship between the key optimization variables and the optimization objectives was obtained. After optimization, the aerodynamic drag of optimized train was reduced by up to 4.15%, and the load reduction factor was reduced by up to 1.72%.

关键词： High-speed train Multi-objective optimization Parametric model Aerodynamic drag Load reduction factor

Extremely metal-poor star candidates in the SDSS

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Research in Astronomy and Astrophysics 2013年第3期13卷 313-322页

作者： Si-Yao Xu hua-wei zhang Xiao-wei Liu Department of Astronomy School of Physics Peking University Kavli Institute of Astronomy and Astrophysics Peking University

For a sample of metal-poor stars （-3.3 ≤ [Fe/H] ≤-2.2） that have highresolution spectroscopic abundance determinations, we have measured equivalent widths of the Ca II K, Mg I b and near-infrared Ca II triplet lines using low-resolution spectra from the Sloan Digital Sky Survey （SDSS）, calculated effective temperatures from （g - z）o color, deduced stellar surface gravities by fitting stellar isochrones, and determined metallicities based on the aforementioned quantities. Metallicities thus derived from the Ca II K line are in much better agreement with the results deter- mined from high-resolution spectra than the values given in the SDSS Data Release 7. The metallicities derived from the Mg I b lines have a large dispersion owing to the large measurement errors, whereas those deduced from the Ca II triplet lines are too high due to both non-local thermodynamical equilibrium （NLTE） effects and mea- surement errors. Abundances after correction for the NLTE effect for the Mg I b lines and Ca II triplet lines are also presented. Following this method, we have identified six candidates of ultra-metal-poor stars with [Fe/H] - -4.0 from a sample of 166 metal-poor star candidates. One of them, SDSS J102915＋172927, was recently con- firmed to be an ultra-metal-poor （[Fe/H] 〈 -4.0） star with the lowest metallicity ever measured. Follow-up high-resolution spectroscopy for the other five ultra-metal-poor stars in our sample will therefore be of great interest.

关键词： stars: abundances -- stars: Population -- techniques: spectroscopic

Study on the operational safety of high-speed trains exposed to stochastic winds

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Acta Mechanica Sinica 2014年第3期30卷 351-360页

作者： Meng-Ge Yu Ji-Ye zhang Ke-Yue zhang wei-hua zhang State Key laboratory of Traction Power Southwest Jiaotong University Emei Campus of Southwest Jiaotong University

The characteristic wind curve （CWC） was com- monly used in the previous work to evaluate the operational safety of the high-speed trains exposed to crosswinds. How- ever, the CWC only provide the dividing line between safety state and failure state of high-speed trains, which can not evaluate the risk of derailment of high-speed trains when ex- posed to natural winds. In the present paper, a more realistic approach taking into account the stochastic characteristics of natural winds is proposed, which can give a reasonable and effective assessment of the operational safety of high-speed trains under stochastic winds. In this approach, the longitudi- nal and lateral components of stochastic winds are simulated based on the Cooper theory and harmonic superposition. An algorithm is set up for calculating the unsteady aerody- namic forces （moments） of the high-speed trains exposed to stochastic winds. A multi-body dynamic model of the rail vehicle is established to compute the vehicle system dynamic response subjected to the unsteady aerodynamic forces （mo- ments） input. Then the statistical method is used to get the mean characteristic wind curve （MCWC） and spread range of the high-speed trains exposed to stochastic winds. It is found that the CWC provided by the previous analyticalmethod produces over-conservative limits. The methodol- ogy proposed in the present paper can provide more signif- icant reference for the safety operation of high-speed trains exposed to stochastic winds.

关键词： High-speed trains Stochastic winds Unsteadyaerodynamic forces Mean characteristic wind curve

Transverse Bending Characteristics in U-channel Forming of Tailor Rolled Blank

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Journal of Iron and Steel Research International 2016年第12期23卷 1249-1254页

作者： hua-wei zhang Ying-ping GUAN Jia-lu WU Xiang-hua LIU School of Control Engineering Northeastern University at Qinhuangdao College of Mechanical Engineering Yanshan University Research Institute of Science and Technology Northeastern University

Research on the formability of tailor rolled blank （TRB） is of good practical significance and application value because of the enormous potential of TRB in the aspect of automobile lightweight. However, the forming of TRB is problematic because of the varying properties; especially, springback is a main challenge. The transverse bending （bending axis is perpendicular to the rolling direction） of TRB U channel was studied through simulation and experiment. The forming characteristics of TRB U channel during transverse bending were analyzed. The mechanisms of forming defects, including bending springback and thickness transition zone （TTZ） movement, were revealed. On this basis, effects of blank geometric parameters on springbaek and TTZ movement were discussed. The results indicate that springback and TTZ movement happen during transverse bending of TRB U-channel. Nonuni form stress distribution is the most fundamental reason for the occurrence of springback of TRB during transverse bending. Annealing can eliminate nonuniform stress distribution, and thus diminish springbaek of TRB, especially springback on the thinner side. Therefore, springback of the whole TRB becomes more uniform. However, annealing can increase the TTZ movement. Blank thickness and TTZ position are the main factors affecting the formability of TRB U-channel during transverse bending.

关键词： tailor rolled blank transverse bending springback U-channel annealing thickness transition zone

Crack defect of tailor rolled blank in deep drawing process

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Journal of Iron and Steel Research International 2018年第12期25卷 1237-1243页

作者： hua-wei zhang Jia-lu Wu Xin-gang Wang School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819LiaoningChina

The deformation process of tailor rolled blank (TRB)is different from that of a monolithic blank as a result of the variable thickness in the rolling direction,and thus,the mechanism of the crack phenomenon needs to be further *** crack defect of TRB square box was studied by numerical simulation and stamping *** stress state of TRB square box was *** this basis,the forming characteristics of TRB square box were *** effects of blank size and blank holder force (BHF)on the thickness thinning of TRB were ***,the *** the crack defect for TRB square box was *** indicate that non-uniformity is the most prominent characteristic during forming of TRB square *** larger the blank size and BHF on the thinner side are,the more inclined TRB is to crack. Excessive BHF or insufficient BHF on the thicker side can also lead to the occurrence of the crack *** on the thinner side slightly greater than that on the thicker side (40 kN on the thinner side and 20 kN on the thicker side)is advantageous to restrict the excessive thickness thinning of TRB and acquire a better *** location inclined to crack for TRB square box is the round comer of the wall on the thinner side.

关键词： Tailor rolled blank Square box Crack Blank size Blank holder force

Study on Nonuniform Deformation of Tailor Rolled Blank During Uniaxial Tension

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Acta Metallurgica Sinica(English Letters) 2015年第9期28卷 1198-1204页

作者： hua-wei zhang Xiang-hua Liu Li-Zhong Liu Ping Hu Jia-Lu Wu School of Mechanical Engineering and Automation Northeastern University Research Institute of Science and Technology Northeastern University School of Automotive Engineering Dalian University of Technology

The deformation characteristics of tailor rolled blank （TRB） in the course of uniaxial tension were studied by means of analysis, test and simulation. The mechanical analytical model of TRB during uniaxial tension was set up, and the deformation formulae for the thinner side and for the thicker side were derived to quantify the deformation of TRB. On this basis, uniaxial tension tests on TRB and ordinary blanks （the thinner side and the thicker side of TRB） were conducted. Lagrange polynomial interpolation method was adopted to construct the stress-strain fields of unannealed and annealed TRBs for solving TRB material parameters, and then, uniaxial tension simulation on TRB was completed. Deformations and properties of unannealed TRB were compared with those of annealed TRB, and the thinner side and the thicker side were also compared. Finally, the research results were explained by metallurgical structure. The results show that nonuniform deformation happens in TRB during uniaxial tension, and the necking occurs on the thinner side. The agreement of analysis, test and simulation confirms the correctness of the analytical model and the deformation formulae. The findings of this paper can lay the foundation for the future study on TRB stamping formability and provide a way for TRB modeling.

关键词： Tailor rolled blank (TRB) Nonuniform deformation Uniaxial tension Annealing Metallographical

Stereoselective cycloaddition of N-acyliminium cations withα,β-unsaturated ketones and esters

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Chinese Chemical Letters 2009年第7期20卷 805-808页

作者： Ling Feng Qian Yue hua Zhou wei zhang State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

The cycloaddition of N-acyliminium cations with some deactivated alkenes such as α,β-unsaturate ketones and esters has been investigated. In most cases, the N-acyliminium cations produced from 3-hydroxy-2-arylisoindol-1-ones in the presence of ***2 could be reacted with α,β-unsaturated ketones and esters to afford stereoselectively the cycloaddition products 6-acylisoindolo[2,1- a]quinolin-11-ones in moderate to high yields. C 2009 wei zhang. Published by Elsevier B.V, on behalf of Chinese Chemical Society. All rights reserved.

关键词： Cycloaddition N-acyliminium cation 3-Hydroxy-2-arylisoindol- 1-one α,β-Unsaturated ketones 6-Acylisoindolo[2,1-a]quinolin- 11- ones