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The effects of simultaneous operation on dissociated vertical deviation with horizontal and torsional strabismus

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 637-642页

作者： Lu-Qin Wan Xiao-Mei Wan hua-qing gong Li-Xin Xie Medical College of qingdao University Qingdao 266000Shandong ProvinceChina qingdao Eye Hospital Shandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina

AIM: To investigate the therapeutic effects of simultaneous horizontal and vertical operations on dissociated vertical deviation(DVD) associated with other ***: Forty-five cases of DVD with horizontal and torsional strabismus underwent combined operation were collected retrospectively. All clinical records were analyzed. All patients were followed up for 6 to 24 mo. Wilcoxon signed-ranks test was performed to evaluate the changes of vertical and horizontal deviation. χ~2 test was used to evaluate the changes of binocular visual function. RESULTS: Forty-five cases included 36 patients with intermittent exotropia and binocular inferior oblique overaction(IOOA), 5 patients with concomitant esotropia and binocular IOOA, 4 patients with intermittent exotropia and monocular superior oblique palsy. The superior rectus recession(SRR) combined with horizontal rectus recession and the myectomy of inferior oblique or anterior transposition were operated simultaneously to correct all types of strabismus. There were 43 cases who achieved normal eye position in vertical direction, while 2 cases were with undercorrection of 5~Δ to 6~Δ. In patients with horizontal strabismus, 2 cases of exotropia were with overcorrection of 6~Δ to 8~Δ, 1 case of esotropia was with undercorrection of 6~Δ, and 1 case of monocular superior oblique palsy with compensatory head posture was not significantly improved. The binocular visual function of most patients recovered after operation. The difference of the binocular visual function and eye position were significant compared with that before operation(P<0.05).CONCLUSION: The simultaneous operation on DVD with horizontal and torsional strabismus is successful.

关键词： dissociated vertical deviation inferior oblique overaction strabismus operation

Lymphocyte infiltration and activation in iris-ciliary body and anterior chamber of mice in corneal allograft rejection

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 681-686页

作者： Fu-hua Wang Min Chen Ting Liu Xin-Jie Zang hua-qing gong Wei-Yun Shi qingdao University Medical College Shandong Eye Hospital Shandong Eye Institute Shandong Academy of Medical Science qingdao Eye Hospital Shandong Eye Institute Shandong Academy of Medical Science State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Shandong Eye Institute Shandong Academy of Medical Sciences

AIM: To investigate the infiltration and activation of lymphocyte in iris-ciliary body and anterior chamber after allogenic penetrating keratoplasty (PK), for further revealing the role of iris-ciliary body in corneal allograft immune rejection. METHODS: In the mice models of PK, BALB/C mice received orthotopic isografts (n =35) or C57BL/6 donor allografts (n=25). Grafts were examined daily for 3 weeks by slit-lamp microscopy and scored for opacity. The infiltration of CD4(+) T lymphocyte in iris-ciliary body and anterior chamber was examined by immunohistology and the mRNA of CD80 and CD86 in both cornea graft and iris-ciliary body by RT-PCR was analyzed in allograft recipient at days 3, 6, 10 and the day when graft rejection occurred. Isograft recipients were examined as control at the corresponding time points. Transmission electron microscope was used to study the ultrastructure, especially cell infiltration, of iris-cilary body and corneal graft at day 3, 7 and the day when rejection occurred after allogenic PK. RESULTS: Rejection was observed in all the allograft recipients followed more than 10 days, at a median time of 15 days (range 12-18 days), but not in any of isografts. CD4(+) T cells were first detected at day 6 after transplantation in limbus and Ciliary body, and then in the stroma of recipient, iris, anterior chamber and corneal allograft with an increased number until graft rejection occurred. CD80 and CD86 mRNA were detected under RT-PCR examination in both graft and iris-ciliary body of allograft recipient, but not in any of isograft recipient. Three days after operation, lymphocytes and monocytes macrophages were visible in iris blood vessels and the anterior chamber, and vascular endothelial cell proliferation and activation were significant under transmission electron microscopy examination. At day 7, corneal endothelial cells became thinner. Lymphocytes and mononuclear macrophages were found with great number in the anterior chamber and adher

关键词： lymphocyte corneal transplantation penetrating graft rejection iris-ciliary body anterior chamber

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： qing Qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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图形视觉诱发电位在猫双眼视觉研究中的作用

国际眼科杂志 2013年第5期13卷 865-868页

作者：李林林温晏宫华青青岛大学医学院中国山东省青岛市266071 山东省眼科研究所中国山东省青岛市266071

目的:通过建立猫不同种类的视觉破坏动物模型,探讨图形视觉诱发电位在双眼视觉研究中的作用。方法:健康家猫18只,于4周龄时随机建立正常、形觉剥夺性弱视及光学性斜视模型3组,每组动物各6只,分别在6周龄、10周龄和16周龄时记录各组动物... 详细信息

目的:通过建立猫不同种类的视觉破坏动物模型,探讨图形视觉诱发电位在双眼视觉研究中的作用。方法:健康家猫18只,于4周龄时随机建立正常、形觉剥夺性弱视及光学性斜视模型3组,每组动物各6只,分别在6周龄、10周龄和16周龄时记录各组动物的P波振幅和潜时。结果:随年龄增长,正常组P波潜时缩短,振幅增大,双眼振幅大于单眼反应之和;弱视组在10周龄时右眼振幅低于左眼,差异有统计学意义(P<0.05),潜时无统计学差异;16周龄时右眼(即弱视眼)振幅和潜时均低于左眼,双眼振幅表现为部分总和;光学性斜视组单眼间的P波潜时和振幅相比较以及与正常组相比无明显差异,双眼总和在10周龄和16周龄时小于单眼反应之和。结论:图形视觉诱发电位是评价动物双眼视觉的一种有效手段。

关键词：图形视觉诱发电位双眼视觉弱视光学性斜视

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一种自动测量代偿头位装置的研制

国际眼科杂志 2010年第9期10卷 1707-1709页

作者：尚艳峰代春华王宜强宫华青山东省眼科研究所青岛眼科医院中国山东省青岛市266071

目的:研制一种能够自动、精确地测量出不同程度代偿头位的检查装置。方法:根据人头、颈部生理活动特点,利用液态罗盘能精确记录不同轴向活动范围的性能,将其安装在头盔中研制成头位倾斜自动测量仪。测量仪主要由感应器(液态罗盘部)、头... 详细信息

目的:研制一种能够自动、精确地测量出不同程度代偿头位的检查装置。方法:根据人头、颈部生理活动特点,利用液态罗盘能精确记录不同轴向活动范围的性能,将其安装在头盔中研制成头位倾斜自动测量仪。测量仪主要由感应器(液态罗盘部)、头盔、数据处理器、稳压装置等组成。头、颈部活动时,活动范围的大小由埋置在头盔内的感应器感知,经数据线传向数据处理装置,即电子计算机,经过瞬间的数据处理而得出头颈部活动范围的结果,此结果与自制的带有刻度盘的头颈部可自由活动的模特型具进行比较,验证检测数据的准确性。结果:将模特型具头部配戴装有液态罗盘的头盔装置,转动前在自动测量仪上记录保存此时的检测数值,然后将模特头部按自身所带的刻度盘进行三维的不同角度扭转,再分别在自动测量仪上与刻度盘上记录扭转后的数值,转动后与转动前数据的差值即为头位的倾斜角度值,两项记录的差值≤1°。结论:该仪器能简单而精确地对人头、颈部活动进行三维空间方向的测量,且测量范围远较人体头颈部的生理活动范围大。已获国家实用发明专利(专利号:200820022027.0)。

关键词：代偿头位测量仪斜视

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桑叶挂面制作及热泵干燥工艺研究

食品科技 2017年第9期42卷 153-158页

作者：刘清化龚丽龙成树刘军广东省现代农业装备研究所广州510630

研究了桑叶挂面的制作和干燥工艺,单因素试验结果表明桑叶粉比例、魔芋粉比例和干燥温度对桑叶挂面的平均干燥速率和蒸煮特性都有影响,正交试验方差分析得到干燥温度是影响平均干燥速率的显著因素,综合对产品的感官评定获得较优桑叶挂... 详细信息

研究了桑叶挂面的制作和干燥工艺,单因素试验结果表明桑叶粉比例、魔芋粉比例和干燥温度对桑叶挂面的平均干燥速率和蒸煮特性都有影响,正交试验方差分析得到干燥温度是影响平均干燥速率的显著因素,综合对产品的感官评定获得较优桑叶挂面生产工艺参数:桑叶粉占比为20%,魔芋粉含量为0.25%,干燥温度为40℃,较优工艺制作桑叶挂面的自然断条率为0%,熟断条率为3.41%,蒸煮时间为3.67 min,蒸煮损失率为5.17%,平均干燥速率为19.23%/h,所得优化工艺对桑叶挂面的生产应用具有重要意义。

关键词：桑叶挂面热泵蒸煮特性干燥速率

不同镇痛药超前镇痛在斜视矫正术中的临床效果探讨

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国际眼科杂志 2013年第5期13卷 897-900页

作者：李春建于辉陈平宫华青济南大学山东省医学科学院医学与生命科学学院中国山东省济南市250022 山东省医学科学院山东省眼科研究所中国山东省青岛市266071

目的:比较帕瑞昔布钠、布托啡诺、杜冷丁三种镇痛药的超前镇痛对斜视矫正术中、术后的药物疗效,探讨一种高效、低副作用的斜视手术镇痛剂。方法:本研究经我院医学伦理委员会批准、获得患者及家属同意,选取共同性斜视患者,年龄18～50岁,... 详细信息

目的:比较帕瑞昔布钠、布托啡诺、杜冷丁三种镇痛药的超前镇痛对斜视矫正术中、术后的药物疗效,探讨一种高效、低副作用的斜视手术镇痛剂。方法:本研究经我院医学伦理委员会批准、获得患者及家属同意,选取共同性斜视患者,年龄18～50岁,美国麻醉师协会麻醉危险度分级(ASA Classification of Anesthesia Risk)Ⅰ级,拟行斜视矫正术者,采用随机、双盲、对照的研究方法,随机分为4组(n=20):帕瑞昔布组(P组)、布托啡诺组(B组)、杜冷丁组(D组)、生理盐水组(N组),分别于术前30min臀大肌肌肉注射,P组注射用帕瑞昔布钠40mg、B组注射用布托啡诺1mg、D组杜冷丁50mg、N组生理盐水2mL。记录术前1d(T0)基础心率(heart rate,HR)、平均动脉压(meananerial pressure,MAP);术中(T1)记录疼痛数字模拟评分(numeric rating scales,NRS)、眼心反射(culocardiac reflex,OCR)及恶心呕吐、出汗不良反应;术后2h(T2)、4h(T3)、8h(T4)观察NRS、HR、MAP及恶心、呕吐不良反应。结果:T1,P,B,D各组NRS均较N组低,差异有统计学意义(P0.05);T2,恶心呕吐症状D组较P,B,N三组明显,N组较P,B两组明显,差异有统计学意义(P0.05);T3,D,N两组NRS均较T2增大,与P,B两组比较差异有统计学意义(P0.05);T4,各观察指标差异无统计学意义(P>0.05)。术后P,B组NRS在各时间点差异无统计学意义(P>0.05)。结论:帕瑞昔布钠单剂量超前镇痛应用于局部麻醉下斜视矫正术,具有良好的术中和术后镇痛效果,可替代精麻类管制镇痛药布托啡诺和杜冷丁,并能减轻术后恶心呕吐症状。

关键词：斜视手术超前阵痛帕瑞昔布钠布托啡诺杜冷丁

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烟焦油对体外人视网膜色素上皮细胞的损害

国际眼科杂志 2009年第3期9卷 454-457页

作者：胡媛媛杨玲玲宫华青山东省眼科研究所山东省眼科学重点实验室-省部共建国家重点实验室培育基地中国山东省青岛市266071

目的:研究烟焦油对体外培养的人视网膜色素上皮细胞(human retinal pigmentepithelium,HRPE)超微形态结构的影响,以及趋化因子MCP-1的细胞外表达水平。方法:将体外培养的HRPE分为空白对照组、二甲亚砜(dime-thylsulfoxide,DMSO)对照组... 详细信息

目的:研究烟焦油对体外培养的人视网膜色素上皮细胞(human retinal pigmentepithelium,HRPE)超微形态结构的影响,以及趋化因子MCP-1的细胞外表达水平。方法:将体外培养的HRPE分为空白对照组、二甲亚砜(dime-thylsulfoxide,DMSO)对照组和焦油实验组,其中焦油实验组中焦油浓度分别为1,10,50mg/L,经48h培养后,与空白对照组及DMSO对照组进行比较,使用倒置显微镜及透射型电子显微镜观察HRPE的形态以及超微结构变化,并用ELISA法选择检测各组培养上清中细胞因子MCP-1的表达量。结果:倒置显微镜显示焦油实验组随着焦油浓度的增大,发生变性坏死的HRPE细胞数量逐渐增多,并且细胞的形态发生明显改变;电镜显示焦油实验组随着焦油浓度的增大,RPE细胞形态扁平,微绒毛减少,胞质稀疏、减少,细胞核细长、核染色质稀疏,染色质浓缩,可见空泡,细胞呈萎缩状态;ELISA结果显示随着焦油浓度的增大,RPE分泌至胞外的MCP-1逐渐减少,差异有统计学意义(P<0.05)。结论:烟焦油可改变视网膜色素上皮细胞正常的形态和生理功能,造成色素上皮细胞的严重损害。

关键词：吸烟烟焦油年龄相关性黄斑变性视网膜色素上皮细胞 MCP-1