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Hydrogel dressings on neurotrophic keratitis in an experimental animal model

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1396-1402页

作者： hua-qin xia xiao-Dan Jiang Yi-Fan Song Xue-Min Li Yan-Jie Tian Department of Ophthalmology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third HospitalBeijing 100191China

AIM:To investigate the therapeutic effects of hydrogel dressings on neurotrophic keratitis in ***:Male Wistar rats,aged 42–56d,were randomly divided into control,experimental,and treatment groups,each consisting of five *** experimental and treatment groups underwent neurotrophic keratitis modeling in both *** successful modeling,biomedical hydrogels formed with polyvinyl alcohol and polyvinyl pyrrolidone were used in treatment group for *** irritation response and keratitis index scores,Schirmer’s test,tear film break-up time(BUT),sodium fluorescein staining,and hematoxylin and eosin(HE)staining were used to evaluate the effectiveness of the ***:The neurotrophic keratitis model was successfully established in rats with severe ophthalmic nerve injury,characterized by keratitis,ocular irritation,reduced tear secretion measured by decreased BUT and Schirmer test values,corneal epithelial loss,and disorganized collagen fibers in the stromal *** treatment with hydrogel dressings,significant improvements were observed in keratitis scores and ocular irritation symptoms in model *** the recovery of tear secretion,as measured by the Schirmer’s test,did not show statistical differences,BUT was significantly *** staining confirmed a reduction in the extent of corneal epithelial loss after *** staining revealed the restoration of the structural disorder in both the epithelial and stromal layers to a certain ***:Hydrogel dressing reduces ocular surface irritation,improves tear film stability,and promotes the repair and restoration of damaged epithelial cells by maintaining a moist and clean environment on the ocular surface in the rat model.

关键词： neurotrophic keratitis hydrogel corneal epithelial cells rat

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Pudendal nerve lesions in young men with erectile dysfunction:imaging with 3T magnetic resonance neurography

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Asian Journal of Andrology 2023年第5期25卷 650-652页

作者： Guo-Quan huang Tao Gong Shan-Shan Wang qin-hua xia Liang-Jie Lin Guang-Bin Wang Department of MR Shandong Provincial HospitalShandong UniversityJinan 250021China Department of Radiology Wuhu HospitalEast China Normal University(The Second People's HospitalWuhu)Wuhu 241000China Departments of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Andrology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Philips Healthcare Beijing 100016China.

Dear Editor,Erectile dysfunction(ED)is a major health problem worldwide that reduces the quality of life of many *** is recognized as a consistent or recurrent inability to achieve and/or maintain a penile erection sufficient for sexual *** data have shown that ED is associated with increasing age.?Nevertheless,the prevalence of ED is increasing in younger men(<40 years of age),with previous estimates as high as 30%.More recent studies have also reported organic causes in 5%-72%of ED patients<40 years old,and suggested involvement of the pudendal nerve(PN)as primary cause.3.4 The aim of this study was to evaluate the clinical utility of magnetic resonance neurography(MRN)for visualizing and quantifying PN changes in young men with ED.

关键词： involvement dysfunction younger

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1180-1189页

作者： hua-qin xia Jia-Rui Yang Ke-Xin Zhang Rui-Lan Dong Hao Yuan Yu-Chen Wang Hong Zhou Xue-Min Li Department of Ophthalmology Peking University Third HospitalBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs Department of PharmacologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Diabetic retinopathy(DR)is one of the most common complications of diabetes and major cause of blindness among people over 50 years *** studies showed that the vascular endothelial growth factor(VEGF)played a central role in the pathogenesis of DR,and application of anti-VEGF has been widely acknowledged in treatment of DR targeting retinal ***,anti-VEGF therapy has several limitations such as drug *** is essential to develop new drugs for future clinical *** vitreous takes up 80%of the whole globe volume and is in direct contact with the retina,making it possible to explore the pathogenesis of DR by studying related factors in the *** article reviewed recent studies on DR-related factors in the vitreous,elaborating the VEGF upstream hypoxia-inducible factor(HIF)pathway and downstream pathways phosphatidylinositol diphosphate(PIP2),phosphoinositide-3-kinase(PI3 K),and mitogenactivated protein kinase(MAPK)***,factors other than VEGF contributing to the pathogenesis of DR in the vitreous were also summarized,which included factors in four major systems,kallikrein-kinin system such as bradykinin,plasma kallikrein,and coagulation factor XII,oxidative stress system such as lipid peroxide,and superoxide dismutase,inflammation-related factors such as interleukin-1β/6/13/37,and interferon-γ,matrix metalloproteinase(MMP)system such as MMP-9/***,we also introduced other DR-related factorssuch as adiponectin,certain specific amino acids,noncoding RNA and renin(pro)receptor in separate studies.

关键词： diabetic retinopathy vitreous molecular pathway vascular endothelial growth factor

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Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

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Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： Yi-Lang qin Ping Zhu Chen-Xi Ouyang xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical *** investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

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Analysis of the cause of crack in cold rolling of QSn6.5-0.1 strip

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Journal of Central South University of Technology 2001年第2期8卷 94-98页

作者： ZHANG Sheng hua 1,qin Ye xia 1,LOU hua fen 2,LU Jun pan 2,ZHONG Wei jia 2 (1 Department of Materials Science and Engineering, Central South University, Changsha 410083, China 2.Luoyang Copper Processing Company, Luoyang 471000, China) Department of Materials Science and Engineering Central South University Changsha China Luoyang Copper Processing Company Luoyang China

In order to know the cause of cracks in cold rolling of QSn6.5 0.1 copper alloy strip, a lot of experiments and analysis were done. The microstructure changes of QSn6.5 0.1 were investigated by means of metallurgical microscope. The morphology of cracks and surface defects were examined using scanning electron microscope. Macroscopic residual stresses produced in every process during manufacturing in the QSn6.5 0.1 strip were measured by X ray diffraction method and hole drilling method. The results show that the cracks in the QSn6.5 0.1 cold rolling strip were caused due to the derivation of metallurgical defects, such as SnO 2, S, fine looses,the inverse segregation unable to clear up when milling, and the accumulation of all kinds of resi dual stresses. When the accumulation of the residual stress reaches the material′s breaking strength, the cracks will be generated. Several measures to avoid the development of these kinds of cracks were put forward, such as: controlling the casting technology, improving homogenization annealing procedure (680 ℃/7 h) and milling quality(using the second milling when necessary), working out a more reasonable rolling technology to ensure intermediate annealing in time.

关键词： QSn6.5 0.1 cold rolling strip crack metallurgical defect residual stress

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Role of micro-Ca/In alloying in tailoring the microstructural characteristics and discharge performance of dilute Mg-Bi-Sn-based alloys as anodes for Mg-air batteries

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Journal of Magnesium and Alloys 2024年第1期12卷 251-266页

作者： Fei-er Shangguan Wei-li Cheng Yu-hang Chen Ze-qin Cui Hui Yu Hong-xia Wang Li-fei Wang Hang Li hua Hou School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are *** grain size and texture intensity of the Mg-Bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing *** that,in addition to nanoscale Mg_(3)Bi_(2)phase,a new microscale Mg_(2)Bi_(2)Ca phase forms in the Ca-containing *** electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical *** In to alloy the Mg-Bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca *** micro-alloying of Ca/In to Mg-Bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly *** In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.

关键词： Mg-air batteries Mg-Bi-Sn based alloys Electrochemical behaviors Discharge properties

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High critical current density in Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

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Rare Metals 2024年第2期43卷 692-701页

作者： Ying-Tong Lv Teng-Fei Zhang Zhao-Tong Hu Guang-Lin xia Ze-Ya huang Zhen-hua Liu Li-hua Que Cai-Ting Yuan Fang-qin Guo Takayuki Ichikawa Xue-Bin Yu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China Centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials Science Fudan UniversityShanghai200433China Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and ***,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical ***,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(Li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(Li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric Li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable Li/LLZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) Critical current density Solid-state electrolytes(SSEs) Lithium-sulfur batteries

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Modifying Lyapunov exponent of chaotic map by self-cascading

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Science China(Technological Sciences) 2024年第7期67卷 2203-2214页

作者： YI ChenLong LI ChunBiao LI YongXin xia Ming hua ZhongYun School of Electronic and Information Engineering Nanjing University of Information Science&TechnologyNanjing 210044China School of Artificial Intelligence Nanjing University of Information Science&TechnologyNanjing 210044China School of Computer Science and Technology Harbin Institute of Technology Shenzhen Graduate SchoolShenzhen 518055China

The self-cascade(SC) method is an effective technique for chaos enhancement and complexity increasing in chaos ***, the controllable self-cascade(CSC) method allows for more accurate control of Lyapunov exponents of the discrete map. In this work, the SC and CSC systems of the original map are derived, which enhance the chaotic performance while preserving the fundamental dynamical characteristics of the original map. Higher Lyapunov exponent of chaotic sequences corresponding to higher frequency are obtained in SC and CSC systems. Meanwhile, the Lyapunov exponent could be linearly controlled with greater flexibility in the CSC system. The verification of the numerical simulation and theoretical analysis is carried out based on the platform of CH32.

关键词： self-cascade controllable self-cascade chaos enhancement chaos control

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Excess pore pressure behavior and evolution in deep coalbed methane reservoirs

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International Journal of Mining Science and Technology 2024年第6期34卷 763-781页

作者： Changqing Liu Zhaobiao Yang Yong qin xia Yan Yunhai Wang Zhe Wang Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process Ministry of EducationChina University of Mining and TechnologyXuzhou 221008China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China National Engineering Research Center of Coalbed Methane Development&Utilization Beijing 100095China PetroChina Coalbed Methane Company Limited Beijing 102200China SINOPEC East China Oil and Gas Company Nanjing 210000China

Deep coalbed methane(DCBM),an unconventional gas reservoir,has undergone significant advancements in recent years,sparking a growing interest in assessing pore pressure dynamics within these *** some production data analysis techniques have been adapted from conventional oil and gas wells,there remains a gap in the understanding of pore pressure generation and evolution,particularly in wells subjected to large-scale hydraulic *** address this gap,a novel technique called excess pore pressure analysis(EPPA)has been introduced to the coal seam gas industry for the first time to our knowledge,which employs dual-phase flow principles based on consolidation *** technique focuses on the generation and dissipation for excess pore-water pressure(EPWP)and excess pore-gas pressure(EPGP)in stimulated deep coal *** have been developed respectively and numerical solutions have been provided using the finite element method(FEM).Application of this model to a representative field example reveals that excess pore pressure arises from rapid loading,with overburden weight transferred under undrained condition due to intense hydraulic fracturing,which significantly redistributes the weight-bearing role from the solid coal structure to the injected fluid and liberated gas within artificial pores over a brief ***,field application indicates that the dissipation of EPWP and EPGP can be actually considered as the process of well production,where methane and water are extracted from deep coalbed methane wells,leading to consolidation for the artificial ***,history matching results demonstrate that the excess-pressure model established in this study provides a better explanation for the declining trends observed in both gas and water production curves,compared to conventional practices in coalbed methane reservoir engineering and petroleum *** research not only enhances the understanding of DCBM re

关键词： Deep coalbed methane Consolidation Excess pore-water pressure Excess pore-gas pressure Production data analysis

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Atomistic study of inverse size effect induced by interfacial plasticity in pearlitic multi-principal element alloy

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Rare Metals 2024年第7期43卷 3341-3355页

作者： Chen Yang Qiao-Sheng xia Cun-Hong Yin Dong-Peng hua College of Mechanical Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Advanced Manufacturing Technology Ministry of EducationGuizhou UniversityGuiyang 550025China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China

Owing to the fine nano-laminated structure,the pearlitic multi-principal element alloy(PMPEA) exhibits excellent mechanical and tribological ***,the incomplete understanding of the size effect of its lamella thickness and the unclear understanding of the plasticity-interface interaction mechanism limit further optimization of *** this study,the FeCoNi/Ni_3Ti interface-mediated plastic deformation behavior in PMPEA and the variation of mechanical and tribological properties with lamella thickness within the nanoscale range using molecular dynamics(MD) simulation were *** results indicate that the mechanical and tribological properties of the PMPEA with lamella thicknesses below 10 nm have a significant inverse size effect,i.e.,the smaller the lamella thickness,the weaker the *** is because the plastic carrier-interface interaction mechanism changes from a strengthening mechanism that hinders dislocations to a weakening mechanism that promotes dislocations with the decreases in the lamella thickness,and the weakening effect becomes more pronounced as the lamella thickness decreases and the number of interfaces *** particular,the deformation behavior of Ni_3Ti lamellae changes from crystal-like to amorphous-like with decreasing ***,in the sample with larger lamella thickness,the occurrence of hierarchical slips in the body-centered cubic(BCC) phase due to the multiprincipal elements effect can better alleviate the stress concentration caused by the dislocation accumulation at the interface,so that the phase interface exhibits outstanding load-bearing *** the dislocation pattern in BCC phase shows a firm high-density cell,which makes the substrate exhibit a stable tribological response.

关键词： Multi-principal element alloy Nano-laminated structure Molecular dynamics simulation Nanoindentation and nanoscratch

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