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New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 122-132页

作者： Xin-Chang Shang-Guan Jun-Rong Zhang Chao-Nan lin Shuai Chen Yong Wei Wen-Xuan Chen lin Pan Li-Qin huang Shao-hua Zheng Xian-Qiang Chen Department of Emergency Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina College of Physics and Information Engineering Fuzhou UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer(OCRC).The existing assessment still relies on the colorectal obstruction scoring system(CROSS)which is based on a comprehensive analysis of patients’complaints and eating *** data collection relies on subjective descriptions and lacks objective ***,a scoring system for the evaluation of computed tomography-based obstructive degree(CTOD)is urgently required for *** To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term *** Of 173 patients were *** was obtained using k-means,the ratio of proximal to distal obstruction,and the proportion of nonparenchymal areas at the site of *** was integrated with the CROSS to analyze the effect of emergency intervention on ***-term and long-term outcomes were compared between the *** CTOD severe obstruction(CTOD grade 3)was an independent risk factor[odds ratio(OR)=3.390,95%confidence interval(CI):1.340-8.570,P=0.010]via multivariate analysis of short-term outcomes,while CROSS grade was *** the CTOD-CROSS grade system,for the non-severe obstructive(CTOD 1-2 to CROSS 1-4)group,the complication rate of emergency interventions was significantly higher than that of non-emergency interventions(71.4%vs 41.8%,P=0.040).The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group(35.7%vs 8.9%,P=0.020).However,CTOD grade was not an independent risk factor of overall survival and progression-free *** CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.

关键词： Obstructive colorectal cancer Scoring system Computed tomography-based obstructive degree Colorectal obstruction scoring system Emergency intervention

基于神经网络模型的宽带非高斯随机过程疲劳损伤分析

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船舶力学 2025年第1期29卷 85-97页

作者：袁奎霖彭士凤大连理工大学工业装备结构分析国家重点实验室船舶工程学院辽宁大连116024

对于遭受各种随机环境载荷的海洋结构物而言,在设计阶段对其进行疲劳损伤评估尤为重要。海洋结构物的响应经常呈现出宽带特性和非高斯统计特征。因此,本文提出一种基于神经网络模型的宽带非高斯随机过程疲劳损伤评估方法。采用多种功率... 详细信息

对于遭受各种随机环境载荷的海洋结构物而言,在设计阶段对其进行疲劳损伤评估尤为重要。海洋结构物的响应经常呈现出宽带特性和非高斯统计特征。因此,本文提出一种基于神经网络模型的宽带非高斯随机过程疲劳损伤评估方法。采用多种功率谱与不同带宽参数、S-N曲线斜率参数以及非高斯过程偏度与峰度的组合对所提出的神经网络模型进行训练和测试。分析输入层神经元、隐藏层神经元个数以及隐藏层层数对模型预报精度的影响,确定最优的神经网络结构。以时域雨流计数法计算的疲劳损伤结果作为基准,采用真实双模态功率谱进行数值试验,并与多种频域疲劳损伤分析方法进行比较,证明本文所建立的神经网络模型具有更好的准确性和鲁棒性。

关键词：神经网络宽带非高斯过程疲劳损伤雨流计数法

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浅议组织公民行为视角下的高校学生干部队伍建设——以湖北科技学院为例

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技术与创新管理 2013年第2期34卷 136-140,149页

作者：张建军彭华林湖北科技学院经济与管理学院湖北咸宁437105

对高校学生干部组织公民行为的研究,能够使学校管理层更细致地了解学生干部的状况,更重要的是可以将学校管理效能提高到一个新的层面。通过问卷调研,运用SPSS软件中的方差分析法找出对高校学生干部表现有重要影响的因素,并通过回归分析... 详细信息

对高校学生干部组织公民行为的研究,能够使学校管理层更细致地了解学生干部的状况,更重要的是可以将学校管理效能提高到一个新的层面。通过问卷调研,运用SPSS软件中的方差分析法找出对高校学生干部表现有重要影响的因素,并通过回归分析法剔除了高校学生干部组织公民行为中表现不显著的一个维度即不生事争利,得出对高校学生干部组织公民行为有显著影响的八个因素,并针对这八个因素提出具体的改进措施。

关键词：组织公民行为高校学生干部方差分析回归分析

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The Association between Problematic Internet Use,Resilience,and Fatigue in First-Year Medical College Students in China:A Moderated Mediation Model

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International Journal of Mental Health Promotion 2025年第1期27卷 51-63页

作者： Xiumei Chen Xiaobing Lu Yufu Ning Lifeng Wang Jeffrey H.Gamble Xianhe Chen Xingyong Jiang I-hua Chen Peijin lin School of Information Engineering Shandong Youth University of Political ScienceJinan250103China Faculty of Education Qufu Normal UniversityQufu273165China Department of Applied Foreign Language Studies Nanjing UniversityNanjing210023China Department of English National Changhua University of EducationChanghua50007Taiwan No.1 Senior High School Nanchang330000China Yangan Primary School of Qionglai City Qionglai611535China Chinese Academy of Education Big Data Qufu Normal UniversityQufu273165China School of Education and Psychology Minnan Normal UniversityZhangzhou363000China

Background:Resilience is crucial for medical college students to thrive in the highly stressful environment of medical ***,the prevalence of problematic internet use(PIU)in this population may negatively impact their *** study investigated the influence of problematic online gaming(PG)and problematic social media use(PSMU)on the resilience of medical college students in ***:A sample of 5075 first-year medical college students from four Chinese universities was *** served as the independent variable,resilience as the dependent variable,fatigue as the mediator,and PSMU as the *** equation modeling was conducted using LISREL ***,a moderated mediation model was evaluated using the jAMM module in jamovi ***:The study’s findings revealed significant negative correlations between resilience and the variables of PG,PSMU,and *** mediated the relationship between PG and resilience(B=−0.04,95%CI=[−0.05,−0.03]).PSMU moderated the direct relationship between PG and resilience with the interaction term PG×PSMU significant(B=−0.004,t=−6.501,p<0.001)and the first stage(PG→fatigue)of the mediation with PG×PSMU significant(B=0.055,t=8.351,p<0.001).The detrimental effects of PG on resilience were more pronounced among individuals with lower levels of ***:This study concluded that addressing PIU,particularly PG,is essential for fostering resilience in medical college *** PSMU itself is maladaptive,the underlying social media engagement may serve a protective role through social support in mitigating the adverse effects of PG on resilience.

关键词： Problematic internet use problematic online gaming problematic social media use fatigue resilience structural equation modeling conditional mediation

New progresses of fine-grained sediment gravity-flow deposits and their importance for unconventional shale oil and gas plays

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Petroleum Science 2025年第1期22卷 1-15页

作者： Tian Yang Ying-lin Liu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Chengdu University of Technology) Institute of Sedimentary Geology Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of Technology

Fine-grained sediments are widely distributed and constitute the most abundant component in sedimentary systems, thus the research on their genesis and distribution is of great significance. In recent years, fine-grained sediment gravity-flows(FGSGF) have been recognized as an important transportation and depositional mechanism for accumulating thick successions of fine-grained sediments. Through a comprehensive review and synthesis of global research on FGSGF deposition, the characteristics,depositional mechanisms, and distribution patterns of fine-grained sediment gravity-flow deposits(FGSGFD) are discussed, and future research prospects are clarified. In addition to the traditionally recognized low-density turbidity current and muddy debris flow, wave-enhanced gravity flow, lowdensity muddy hyperpycnal flow, and hypopycnal plumes can all form widely distributed FGSGFD. At the same time, the evolution of FGSGF during transportation can result in transitional and hybrid gravityflow deposits. The combination of multiple triggering mechanisms promotes the widespread development of FGSGFD, without temporal and spatial limitations. Different types and concentrations of clay minerals, organic matters, and organo-clay complexes are the keys to controlling the flow transformation of FGSGF from low-concentration turbidity currents to high-concentration muddy debris flows. Further study is needed on the interaction mechanism of FGSGF caused by different initiations, the evolution of FGSGF with the effect of organic-inorganic synergy, and the controlling factors of the distribution patterns of FGSGFD. The study of FGSGFD can shed some new light on the formation of widely developed thin-bedded siltstones within shales. At the same time, these insights may broaden the exploration scope of shale oil and gas, which have important geological significances for unconventional shale oil and gas.

关键词： Fine-grained sediment gravity-flow Depositional mechanism Transportation and evolution Distribution pattern Shale oil and gas

Alpiniae oxyphyllae Fructus ameliorates renal lipid accumulation in diabetic kidney disease via activating PPARα

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Asian Pacific Journal of Tropical Biomedicine 2025年第1期15卷 11-23,I0008-I0012页

作者： Zi-Jie Yan lin Zhang Xin-Yao Han Yu Kang Shu-Man Liu Tian-peng Ma Man Xiao Yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China First Clinical College of Medicine of Guizhou University of Traditional Chinese Medicine Guiyang 550002China Heilongjiang Academy of Traditional Chinese Medicine Harbin 150001China Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Basic Medicine and Life SciencesHainan Medical UniversityHaikou 571199China

Objective:To investigate the effects of Alpiniae oxyphyllae Fructus(AOF)on renal lipid deposition in diabetic kidney disease(DKD)and elucidate its molecular ***:The mechanism of AOF in treating DKD was explored by network pharmacological enrichment analysis,molecular docking,and molecular dynamics *** effects of AOF on renal function and lipid deposition were assessed in a mouse model of DKD and high glucose-stressed HK-2 *** viability and lipid accumulation were detected by CCK8 and oil red O *** expressions of PPARαand fatty acid oxidation-related genes(ACOX1 and CPT1A)were detected by quantitative RT-PCR,Western blot,and ***,PPARαknockdown was performed to examine the molecular mechanism of AOF in treating ***:Network pharmacological enrichment analysis,molecular docking,and molecular dynamics simulation showed that the active compounds in AOF targeted PPARαand thus transcriptionally regulated ACOX1 and *** lowered blood glucose,improved dyslipidemia,and attenuated renal injury in DKD ***-containing serum accentuated high glucose-induced decrease in cell viability and ameliorated lipid ***,it significantly upregulated the expression of PPARα,ACOX1,and CPT1A in both in vivo and in vitro experiments,which was reversed by PPARα***:AOF may promote fatty acid oxidation via PPARαto ameliorate renal lipid deposition in DKD.

关键词： Diabetic kidney disease Alpiniae oxyphyllae Fructus Natural medicine Lipid accumulation PPARα Fatty acid oxidation

The application of moxibustion in infectious skin diseases

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Infectious Diseases Research 2025年第1期6卷 35-42页

作者： Bai Tang Hui Yuan Juan Ji peng lin Lu Pei Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China

The skin,being the largest organ in the human body,is susceptible to a wide array of diseases,particularly infectious skin *** of these skin conditions are chronic and challenging to treat,markedly impacting the quality of life for those ***,some chronic skin diseases necessitate the prolonged use of antibiotics,rendering antibiotic resistance *** the problem of antibiotic resistance grows increasingly severe,finding alternative treatment options to antibiotics becomes ***,an integral component of traditional Chinese medicine,stands out as a distinctive external *** a storied history in the realm of dermatological treatment,moxibustion has amassed a wealth of clinical expertise and holds certain advantages,offering viable options for managing skin ***,given the diversity of skin diseases,the application of moxibustion in dermatology requires further exploration and comprehensive ***,the quality of current moxibustion research needs enhancement,necessitating the conduct of high-quality randomized controlled trials to facilitate the integration of moxibustion into dermatological *** mechanism of action for moxibustion is intricate,encompassing thermal effect,light effect,and the pharmacological effect resulting from the burning of *** article aims to encapsulate the mechanisms of moxibustion and its utilization in prevalent infectious skin conditions,while also outlining existing challenges and prospective avenues for development.

关键词： moxibustion infectious skin diseases clinical research mechanism traditional Chinese medicine

Phototherapy:progress,challenges,and opportunities

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Science China Chemistry 2025年第03期 826-865页

作者： Xi Yuan Jun-Liang Zhou lin Yuan Jiangli Fan Juyoung Yoon Xiao-Bing Zhang Xiaojun peng Weihong Tan Department of Laboratory Medicine Zhongnan Hospital of Wuhan University Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan University Wuhan University Shenzhen Research Institute State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsDalian University of Technology Department of Chemistry and Nanoscience Ewha Womans University

Phototherapy has emerged as a promising modality in modern medicine,attracting significant attention due to its non-invasiveness,exceptional spatiotemporal controllability,and reduced side *** technologies have been developed in phototherapy,encompassing three main approaches:photodynamic therapy,photothermal therapy,and photoactivatable prodrug-based *** this review,we present photosensitizers,photothermal agents,and photoactivatable prodrugs,along with photo-responsive carriers used in ***,we discuss the advantages of phototherapy in combating cancer,infections,and other ***,we highlight the benefits of combining phototherapy with other treatments,as single-mode therapeutic modalities often fail to achieve satisfactory ***,we address the current challenges in developing effective phototherapy agents,particularly regarding their clinical *** believe that advancements in phototherapy will promote non-invasive theranostic techniques for clinical studies.

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In-situ formation of a new cation renders perovskite solar modules with a record efficiency and long-term stability

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Science China Chemistry 2025年第2期68卷 409-410页

作者： Shanxiao lin Xixing Wen Xiuwen Xu College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Over the past 14 years,the efficiency of perovskite solar cells has surged from 3.8% to 26.7%[1],establishing it as an unrivaled choice for next-generation ***,maintaining the long-term stability of perovskite solar modules(PSMs)remains a *** particular,the thermal-and light-induced changes in crystal structure,composition,and optoelectronic properties are the primary causes of device degradation,currently considered the Achilles’heel that hinders its commercialization[2–4].Now,writing in Science,Ding et al.[5]achieve a milestone by overcoming the thermal-and light-induced degradation,rendering the PSM with a record efficiency of 23.2% and a T80(time to 20% efficiency loss)over 4,000 h at 85℃ and 85%relative humidity(RH)under light *** key behind this milestone is to utilize the cation reactivity to in-situ form methyl tetrahydrotriazinium([MTTZ]+,a new cation)and dimethylammonium([DMA]+)in precursor solution(Figure 1a).These cations remarkably modulate perovskite crystallization and stabilize the perovskite.

关键词： perovskite stability modules