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Acta Biochimica et Biophysica Sinica 2007年第1期39卷 37-45页

作者： Yinyuan WU Da XING Lei liU tongsheng chen and Wei R.chen moe key laboratory of laser life science &institute of life science,south china normal university,guangzhou 510631,china moe key laboratory of laser life science & institute of laser life science South China Normal UniversityGuangzhou 510631 China

Ultraviolet (UV) irradiation is a DNA-damaging agent that triggers apoptosis through both themembrane death receptor and mitochondrial apoptotic signaling ***,a pro-apoptotic Bcl-2family member,is important in most cell types to apoptosis in response to DNA *** this study,arecombinant plasmid,YFP-Bid-CFP,comprised of yellow and cyan fluorescent protein and a full length Bid,was used as a fluorescence resonance energy transfer analysis (FRET) *** the FRET techniquebased on YFP-Bid-CFP,we found that Bid activation was initiated at 9±1 h after UV irradiation,and theaverage duration of the activation was 75±10 *** activation coincided with a collapse of the mitochondrialmembrane potential with an average duration of 50±10 min. When cells were pretreated with Z-IETD-fmk(caspase-8 specific inhibitor) the process of Bid activation was completely inhibited,but the apoptosis wasonly partially affected.Z-DEVD-fmk (caspase-3 inhibitor) and Z-FA-fmk (non asp specific inhibitor) didnot block Bid ***,the endogenous Bid activation with or without Z-IETD-fmk in responseto UV irradiation was confirmed by Western *** summary, using the FRET technique,we observedthe dynamics of Bid activation during UV-induced apoptosis and found that it was a caspase-8 dependentevent.

关键词： ultraviolet irradiation Bid activation apoptosis caspase-8 fluorescence resonance energy transfer analysis

Compact ultrafast neutron sources via bulk acceleration of deuteron ions in an optical trap

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Matter and Radiation at Extremes 2024年第5期9卷 22-31页

作者： Zhiyu Lei Hanghang Ma Xiaobo Zhang lin Yu Yihang Zhang Yutong li Suming Weng Min chen Jie Zhang Zhengming sheng key laboratory for laser Plasmas and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Centre of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Tsung-Dao Lee institute Shanghai Jiao Tong UniversityShanghai 201210China college of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

A scheme for a quasi-monoenergetic high-flux neutron source with femtosecond duration and highly anisotropic angular distribution is *** scheme is based on bulk acceleration of deuteron ions in an optical trap or density grating formed by two counter-propagating laser pulses at an intensity of-10^(16)W~cm^(2)in a near-critical-density *** deuterons are first pre-accelerated to an energy of tens of keV in the ambipolar fields formed in the optical *** energy is boosted to the MeV level by another one or two laser pulses at an intensity of-10^(20)W~cm^(2),enabling fusion reactions to be triggered with high *** contrast to previously proposed pitcher–catcher configurations,our scheme can provide spatially periodic acceleration structures and effective collisions between deuterons inside the whole target ***,neutrons are generated directly inside the optical *** simulations show that neutron pulses with energy 2–8 MeV,yield 10^(18)–10^(19)n/s,and total number 106–107 in a duration-400 fs can be obtained with a 25μm ***,the neutron pulses exhibit unique angularly dependent energy spectra and flux distributions,predominantly along the axis of the energy-boosting *** microsize femtosecond neutron pulses may find many applications,such as high-resolution fast neutron imaging and nuclear physics research.

关键词： acceleration scheme angular

Direct measurement of the break-out 19F(p,γ)20Ne reaction in the china Jinping underground laboratory(CJPL)

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Nuclear science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji chen Hao Zhang li‑Yong Zhang Jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑Yue li Jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑cheng Zhang Xin‑Zhi Jiang Luo‑huan Wang Zi‑Ming li Lu‑Yang Song liang‑Ting Sun Qi Wu Jia‑Qing li Bao‑Qun Cui li‑hua chen Rui‑Gang Ma Er‑Tao li Gang lian Yao‑De sheng Zhi‑Hong li Bing Guo Wei‑Ping liu key laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China china institute of Atomic Energy Beijing 102413China college of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear science and Technology University of Chinese Academy of SciencesBeijing 100049China college of science Southern University of Science and TechnologyShenzhen 518055China institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China key laboratory of Nuclear Physics and Ion‑Beam Application(moe) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out 19F(p,γ)20 Ne reaction with respect to the competing 19F(p,α)16 O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the china Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear 19F(p,γ)20 Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the 19F(p,γ)20 Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate china Jinping underground laboratory(CJPL) JUNA

Non-destructive buffer enabling near-infrared-transparent inverted inorganic perovskite solar cells toward 1400 h light-soaking stable perovskite/Cu（In,Ga）Se2 tandem solar cells

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Journal of Energy Chemistry 2024年第10期97卷 622-629页

作者： Yu Zhang Zhaoheng Tang Zhongyang Zhang Jiahong Tang Minghua li Siyuan Zhu Wenyan Tan Xi Jin tongsheng chen Jinsong Hu Chao Zhou Chunlei Yang Qijie liang Xugang Guo Weimin li Weiqiang chen Yan Jiang moe key laboratory of laser life science & Guangdong Provincial key laboratory of laser life science Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University School of Materials science and Engineering Beijing Institute of Technology Songshan Lake Materials laboratory Department of Materials science and Engineering Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology Beijing Advanced Innovation Center for Soft Matter science and Engineering College of Chemical Engineering College of Materials Science and Engineering Beijing University of Chemical Technology Department of Physics Liaoning University Beijing National laboratory for Molecular sciences (BNLMS) Institute of Chemistry Chinese Academy of Sciences School of Physics and Materials science Guangzhou University Shenzhen institute of Advanced Technology Chinese Academy of Sciences

Near-infrared（NIR） transparent inverted all-inorganic perovskite solar cells（PSCs） are excellent top cell candidates in tandem *** essential challenge is the replacement of metal contacts with transparent conductive oxide（TCO） electrodes,which requires the introduction of a buffer layer to prevent sputtering *** this study,we show that the conventional buffers（i.e.,small organic molecules and atomic layer deposited metal oxides） used for organic-inorganic hybrid perovskites are not applicable to all-inorganic perovskites,due to non-uniform coverage of the vulnerable layers underneath,deterioration upon ion bombardment and moisture induced perovskite phase transition,A thin film of metal oxide nanoparticles by the spin-coating method serves as a non-destructive buffer layer for inorganic ***-inorganic inverted near-infrared-transparent PSCs deliver a PCE of 17.46% and an average transmittance of 73.7% between 780 and 1200 *** combination with an 18.56% Cu（In,Ga）Se2bottom cell,we further demonstrate the first all-inorganic perovskite/CIGS 4-T tandem solar cell with a PCE of 24.75%,which exhibits excellent illumination stability by maintaining 86.7% of its initial efficiency after 1400 *** non-destructive buffer lays the foundation for efficient and stable NIR-transparent inverted inorganic perovskite solar cells and perovskite-based tandems.

关键词： Buffer layer CsPbI3 perovskite Inverted perovskite solar cells Stability Tandem solar cells

Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear science and Techniques 2024年第5期35卷 60-73页

作者： huan-Bo Feng Hong-Bang liu Dong Wang Zi-li li Shu-lin liu Qian liu Hang-Zhou li Bin-Long Wang Yan-Jun Xie Zong-Wang Fan Hui Wang Ran chen Di-Fan Yi Rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin li En-Wei liang Present Address:Guangxi key laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of science Huzhou UniversityHuzhou 313000China institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical science University of Chinese Academy of SciencesBeijing 100049China The 13th Research institute of china Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

Single Cell Analysis of Bid Activation in living Cells during UV-induced Apoptosis

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Single Cell Analysis of Bid Activation in Living Cells durin...

Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

The 3rd Asian and Oceanian Conference on Photobiology

作者： Yinyuan Wu Da Xing Lei liu and tongsheng chen moe key laboratory of laser life science & institute of laser life science south china normal university guangzhou 510631 china

＜正＞Bid is a proapoptotic member of the BH3-only subfamily of the Bcl-2 proteins, and is important for most cell types to apoptose in response to DNA damage. In this study, using a combination of single cell analysis and Fluorescence Spectroscopy techniques, we investigated the dynamics of Bid activation during UV-induced apoptosis. A recombinant plasmid YFP-Bid-CFP comprised of cyan and yellow fluorescent protein and a full length Bid, was used as FRET probe. Using FRET technique based on YFP-Bid-CFP, we found that Bid activation was initiated at 8-10 h after UV irradiation, and reached maximum activation in 1 h. Furthermore, when cells were pretreated with caspase-8 specific inhibitor （Z-IETD-fmk）. the process of Bid activation was completely inhibited. In summary, using FRET technique, we observed the dynamics of Bid activation during UV-induced apoptosis and it was a caspase-8 dependent event. FRET technique was an effective method to study protein activation in living cells during apoptosis.

关键词： UV irradiation Bid activation apoptosis caspase-8 single cell analysis

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Rare Metals 2024年第4期43卷 1815-1827页

作者： sheng-Feng Zhou Yu Long Yan-liang Yi cheng Deng lian-Xi Hu institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China moe key laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics Engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials science and Engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2,and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(liHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12 vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72 to 9.36 and 11.19 GPa,*** a result,the microhardness of coating increases from HV536.25 to HV 738.16,the wear rate decreases from32.4×10^(-3)to 6.1×10^(-3)mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance laser-induction hybrid cladding

Intravascular photoacoustic and optical coherence tomography imaging dual-mode system for detecting spontaneous coronary artery dissection: A feasibility study

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Journal of Innovative Optical Health sciences 2024年第1期17卷 77-86页

作者： Yongwei Wang Yuyang Wan Zhongjiang chen moe key laboratory of laser life science&institute of laser life science South China Normal University Guangzhou 510631P.R.China college of biophotonics south china normal university guangzhou 510631 P.R.China School of Medical Technology and Engineering Fujian Medical university Fuzhou 350004 P.R.China

In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary artery dissection(SCAD)*** provides high-resolution and high-penetration images of intramural hematoma(IMH)at different depths,so it is especially useful for imaging deep blood clots associated with imaging *** can readily visualize the double-lumen morphology of blood vessel walls to identify intimal *** also demonstrate the capability of this dual-mode endoscopic system using mimicking phantoms and biological samples of blood clots in ex vivo porcine *** results of the experiments indicate that the combined IVPAI and IVOCT technique has the potential to provide a more accurate SCAD assessment method for clinical applications.

关键词： Spontaneous coronary artery dissection(SCAD) intravascular optical coherence tomography(IVOCT) intravascular photoacoustic imaging(IVPAI)

OKMC simulation of vacancy-enhanced Cu solute segregation affected by temperature/irradiation in the Fe–Cu system

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Nuclear science and Techniques 2022年第11期33卷 158-169页

作者： Zi-Qin Shen Jie Gao Sha-Sha Lv liang chen Dong-Yue chen De-sheng Ai Zheng-Cao li key Lab of Advanced Materials(moe) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Nuclear and New Energy institute Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China key laboratory of Beam Technology Ministry of EducationCollege of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China School of Materials science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Engineering and Management The University of TokyoTokyo 113-8656Japan

The effects of annealing and irradiation on the evolution of Cu clusters in a-Fe are investigated using object kinetic Monte Carlo *** our model,vacancies act as carriers for chemical species via thermally activated diffusion jumps,thus playing an important role in solute *** the end of the Cu cluster evolution,the simulations of the average radius and number density of the clusters are consistent with the experimental data,which indicates that the proposed simulation model is applicable and *** the simulation of the annealing process,it is found that the evolution of the cluster size roughly follows the 1/2 time power law with the increase in radius during the growth phase and the 1/3 time power law during the coarsening *** addition,the main difference between neutron and ion irradiation is the growth and evolution process of the copper-vacancy *** aggregation of vacancy clusters under ion irradiation suppresses the migration and coarsening of the clusters,which ultimately leads to a smaller average radius of the copper *** proposed simulation model can supplement experimental analyses and provide a detailed evolution mechanism of vacancy-enhanced precipitation,thereby providing a foundation for other elemental precipitation research.

关键词： Object kinetic Monte Carlo Irradiation effect Solute segregation Reactor pressure vessel