检索结果-南通市图书馆

Radiomics based on biparametric MRI for the detection of significant residual prostate cancer after androgen deprivation therapy:using whole-mount histopathology as reference standard

引用

Asian Journal of Andrology 2023年第1期25卷 86-92页

作者： Zhang-Zhe Chen Wei-Jie Gu Bing-Ni Zhou Wei Liu hua-lei gan Yong Zhang Liang-Ping Zhou Xiao-Hang Liu Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical College of Fudan UniversityShanghai 200032China Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China MR Research GE HealthcareShanghai 200032China

We aimed to study radiomics approach based on biparametric magnetic resonance imaging(MRI)for determining significant residual cancer after androgen deprivation therapy(ADT).Ninety-two post-ADT prostate cancer patients underwent MRI before prostatectomy(62 with significant residual disease and 30 with complete response or minimum residual disease[CR/MRD]).Totally,100 significant residual,52 CR/MRD lesions,and 70 benign tissues were selected according to ***,381 radiomics features were extracted from T2-weighted imaging,diffusion-weighted imaging,and apparent diffusion coefficient(ADC)*** features were selected using a support vector machine with a recursive feature elimination algorithm(SVM-RFE).Then,ADC values of significant residual,CR/MRD lesions,and benign tissues were compared by one-way analysis of *** regression was used to construct models with SVM features to differentiate between each pair of ***,the efficiencies of ADC value and radiomics models for differentiating the three tissues were assessed by area under receiver operating characteristic curve(AUC).The ADC value(mean±standard deviation[s.d.])of significant residual lesions([1.10±0.02]×10^(-3)mm^(2)s^(−1))was significantly lower than that of CR/MRD([1.17±0.02]×10^(-3)mm^(2)s^(−1)),which was significantly lower than that of benign tissues([1.30±0.02]×10^(-3)mm^(2)s^(−1);both P0.05),but superior to ADC value in differentiating significant residual from CR/MRD(AUC:0.748 vs 0.558;P=0.041).Radiomics approach with biparametric MRI could promote the detection of significant residual prostate cancer after ADT.

关键词： androgen deprivation therapy diffusion-weighted imaging prostate cancer radiomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prognostic value of primary tumor surgery in seminoma patients with distant metastasis at diagnosis:a population-based study

引用

Asian Journal of Andrology 2020年第6期22卷 602-607页

作者： Sheng-Ming Jin Jia-Ming Wei Jun-Long Wu Bei-He Wang hua-lei gan Pei-Hang Xu Fang-Ning Wan Wei-Jie Gu Yu Wei Chen Yang Yi-Jun Shen Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Urology Huashan HospitalFudan UniversityShanghai 200040China

The aims of this study were to determine the prog no stic value of primary tumor surgery and identify optimal can didates for such surgery among patients with semi noma and dista nt metastasis at diag no *** ide ntified 521 patients with seminoma and distant metastasis at diagnosis between 2004 and 2014 from the Surveillanee,Epidemiology,and End Results *** these patients,434 had undergone surgery,whereas 87 had *** prognostic value of primary tumor surgery was assessed by Kaplan-Meier methods,log-rank analyses,and multivariate Cox's proportional hazards *** curves and forest plots were also *** analysis indicated that patients who underwent surgery had a better 5-year overall survival and cancer-specific survival tha n those who did *** analyses dem on strated that primary tumor surgery is an in depende nt prog no stic factor for overall survival and cancer-specific survival,along with age at diagnosis,Mstage,and marital *** addition,primary tumor surgery still had con siderable prog no stic value in the subgroup of patie nts with lymph node ***,forest plots demonstrated that patie nts with Mia stage,N1 or N2-3 stage,and a youn ger age at diagnosis(<60 years)may ben efit from primary tumor *** con elusion,our findings indicate that primary tumor surgery is correlated with improved survival in patients with seminoma and distant ***,primary tumor surgery is an independent prognostic indicator for patients with seminoma and distant metastasis.

关键词： distant metastasis primary tumor surgery prognosis seminoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new procedure for exploring chaotic attractors in nonlinear dynamical systems under random excitations

引用

Acta Mechanica Sinica 2011年第4期27卷 593-601页

作者： Chun-Biao gan hua lei Department of Mechanical Engineering Zhejiang University310027 Hangzhou China Institute of Applied Mechanics SAAZhejiang University310027 Hangzhou China

Due to uncertain push-pull action across boundaries between different attractive domains by random excitations, attractors of a dynamical system will drift in the phase space, which readily leads to colliding and mixing with each other, so it is very difficult to identify irregular signals evolving from arbitrary initial states. Here, periodic attractors from the simple cell mapping method are further iterated by a specific Poincare map in order to observe more elaborate structures and drifts as well as possible dynamical bifurcations. The panorama of a chaotic attractor can also be displayed to a great extent by this newly developed procedure. From the positions and the variations of attractors in the phase space, the action mechanism of bounded noise excitation is studied in detail. Several numerical examples are employed to illustrate the present procedure. It is seen that the dynamical identification and the bifurcation analysis can be effectively performed by this procedure.

关键词： Dynamical system Bounded noise excitationPoincare map Chaotic attractor. Bifurcation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A kind of noise-induced transition to noisy chaos in stochastically perturbed dynamical system

引用

Acta Mechanica Sinica 2012年第5期28卷 1416-1423页

作者： Chun-Biao gan Shi-Xi Yang hua lei Department of Mechanical Engineering Zhejiang University Department of Engineering Mechanics Zhejiang University

We investigate a kind of noise-induced transition to noisy chaos in dynamical systems. Due to similar phenomenological structures of stable hyperbolic attractors excited by various physical realizations from a given stationary random process, a specific Poincar6 map is established for stochastically perturbed quasi-Hamiltonian system. Based on this kind of map, various point sets in the Poincar6＇s cross-section and dynamical transitions can be analyzed. Results from the customary Duffing oscillator show that, the point sets in the Poincare＇s global cross-section will be highly compressed in one direction, and extend slowly along the deterministic period-doubling bifurcation trail in another direction when the strength of the harmonic excitation is fixed while the strength of the stochastic excitation is slowly increased. This kind of transition is called the noise-induced point-overspreading route to noisy chaos.

关键词： Stochastic excitation - Dynamical system - Specific Poincare map Noise-induced transition to chaos

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of supported angle on stability and dynamical bifurcations of cantilevered pipe conveying fluid

引用

Applied Mathematics and Mechanics(English Edition) 2015年第6期36卷 729-746页

作者： Chunbiao gan Shuai JING Shixi YANG hua lei The State Key Laboratory of Fluid Power Transmission and Control School of Mechanical Engineering Zhejiang University Department of Engineering Mechanics Zhejiang University

The effects of the supported angle on the stability and dynamical bifurcations of an inclined cantilevered pipe conveying fluid are investigated. First, a theoretical model of the pipe is developed through the force balance and stress-strain relationship. Second, the response surfaces, stability, and critical lines of the typical hanging system （H-S） and standing system （S-S） are discussed based on the modal analysis. Last, the bifurcation diagrams of the pipe are presented for different supported angles. It is shown that pipes will undergo a series of bifurcation processes and show rich dynamic phenomena such as buckling, Hopf bifurcation, period-doubling bifurcation, chaotic motion, and divergence motion.

关键词： cantilevered pipe conveying fluid supported angle modal analysis responsecharacteristics dynamical bifurcation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

引用

NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： Wang, Xiao Zeng, Jia gan, Donglin Ling, Kun He, Mingfang Li, Jianshu Lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Grazing Intensity on Soil Water Regime and Flux in Inner Mongolia Grassland,China

引用

Pedosphere 2012年第2期22卷 165-177页

作者： gan lei PENG Xin-hua S.PETH R.HORN State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing210008(China) Institute of Plant Nutrition and Soil Science Christian-Albrechts-University zu KielOlshausenstrasse 4024118 Kiel(Germany)

In the past few decades, the increase in grazing intensity has led to soil degradation and desertification in Inner Mongolia grassland, China, due to population growth and shift in the socio-economic system. Two sites with different grazing intensities, continuous grazing site （CG） with 1.2 sheep ha-1 year-1 and heavy grazing site （HG） with 2.0 sheep ha-1 year-1, were investigated at the Inner Mongolia Grassland Ecosystem Research Station （43° 37′ 50″ N, 116° 42′ 18″ E） situated in the northern China to i） characterize the temporal distribution of soil water content along soil profile; and ii） quantify the water fluxes as affected by grazing intensity. Soil water content was monitored by time domain refiectometry （TDR） probes. Soil water retention curves were determined by pressure membrane extractor, furthermore processed by RETC （RETention Curve） software. Soil matric potential, plant available water and water flux were calculated using these data. Both sites showed an identical seasonal soil water dynamics within four defined hydraulic periods： i） wetting transition coincided with a dramatic water increase due to snow and frozen soil thawing from March to April; 2） wet summer, rainfall in accordance with plant growth from May to September; 3） drying transition, a decrease of soil water from October to November due to rainfall limit; and 4） dry winter, freezing from December to next February. Heavy grazing largely reduced soil water content by 43%-48% and plant available water by 46%-61% as compared to the CG site. During growing season net water flux was nearly similar between HG （242 mm） and CG （223 mm） sites between 5 and 20 cm depths. However, between 20 and 40 cm depths, the upward flux was more pronounced at HG site than at CG site, indicating that water was depleted by root uptake at HG site but stored at CG site. In semi-arid grassland ecosystem, grazing intensity can affect soil water regime and flux, particularly in the growing season.

关键词： heavy grazing plant available water semi-arid grassland soil matric potential soil water content

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of surface roughness on CMAS corrosion behavior for thermal barrier coating applications

引用

Journal of Advanced Ceramics 2021年第3期10卷 472-481页

作者： lei GUO Guang LI Zhilin gan School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Advanced Joining Technology Key Lab of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin 300072China

Calcium-magnesium-alumina-silicate (CMAS) corrosion is an important cause for thermal barrier coating (TBC) failure,which has attracted increased *** this study,some thermal barrier coating (TBC) materials including YSZ (yttria partially stabilized zirconia),GdPO_(4),and LaPO_(4) were prepared into bulks,and the effects of their surface roughness on wettability and spreading characteristics of molten CMAS were ***-fabricated and polished bulks with different surface roughness were exposed to CMAS corrosion at 1250 ℃ for 1 and 4 h,following by macro and micro *** revealed that compared with the as-fabricated bulks,molten CMAS on the polished samples had lower wettability and a smaller spreading area,mainly attributable to the reduced capillary force to drive the melt ***,GdPO_(4) and LaPO_(4) bulks exhibited lower CMAS wettability than YSZ *** is thus considered that reducing the surface roughness is beneficial to CMAS corrosion resistance of TBCs.

关键词： thermal barrier coating(TBC) calcium-magnesium-alumina-silicate(CMAS) surface roughness wetting spreading

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced Crystallization Rate of Poly(L-lactide)/Hydroxyapatite-graftpoly(D-lactide) Composite with Different Processing Temperatures

引用

Chinese Journal of Polymer Science 2020年第6期38卷 599-610页

作者： Min Wang lei-Chu You Yu-Qi Guo Ni Jiang Zhi-hua gan Zhen-Bo Ning State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China

Hydroxyapatite-graft-poly(D-lactide)(HA-g-PDLA)was synthesized by ring-opening polymerization with HA as initiator and stannous octanoate(Sn(Oct)2)as *** analysis(TGA)and Fourier transform infrared spectroscopy(FUR)results indicate that PDLA chains are successfully grafted onto HA particles by covalent *** two different processing temperatures(190 and 230℃),the effect of the grafted PDLA chains on the crystallization behavior of poly(L-lactide)/HA-g-PDLA(PLLA/HA-g-PDLA)composite was investigated in the current study,comparing to neat PLLA and its four composites(PLLA/HA,PLLA/HA-g-PLLA,PLLA/PDLA,and PLLA/HA/PDLA).The crystallization rate of PLLA/HA-g-PDLA composite is highly enhanced comparing to PLLA,PLLA/HA and PLLA/HA-g-PLLA composites in which there are no stereocomplex(SC)*** addition,when the processing temperature rises from 190℃ to 230℃,the acceleration of PLLA crystallization in PLLA/HA-g-PDLA composite is not influenced so much as other composites containing SC crystallites,such as PLLA/HA/PDLA or PLLA/*** differential scanning calorimetry(DSC)results demonstrate that even without SC crystallites,the crystallization of PLLA can still be accelerated a lot in this *** may be related to the interaction between the grafted PDLA chains and the amorphous PLLA chains in PLLA/HA-g-PDLA *** isothermal crystallization kinetics studies indicate that the nature of nucleation and crystal growth of PLLA/HAg-PDLA composite are more likely 3D crystalline growth with heterogeneous nucleation mode,which are different from PLLA or other *** investigation could shed new light on the application of PLLA/HA composites.

关键词： HA particles Stereocomplexation Composite Crystallization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear magnetic network models for flux-switching permanent magnet machines

引用

Science China(Technological Sciences) 2016年第3期59卷 494-505页

作者： zhang gan hua wei cheng ming School of Electrical Engineering Southeast University Nanjing 210096 China

In this paper, firstly, a basic nonlinear magnetic network model considering iron saturations is proposed for a three-phase 12-stator-slot/10-rotor-pole flux-switching permanent magnet(FSPM) machine. This model is built under cylindrical coordinates and enables the open-circuit air-gap flux-density distributions, phase permanent magnet(PM) flux-linkage, and electromotive-force(EMF) to be predicted with acceptable accuracy. However, large discrepancies are found in the predictions of armature inductances. Then, the basic model is modified by taking into account the localized saturation effect. As a result, the electromagnetic performance can be predicted more accurately, especially for the air-gap flux-density distributions. Furthermore, two improved models are proposed by adding bypass-bridge branches in stator network, to enhance the calculating accuracy of both saturated and unsaturated armature inductances. Finally, the predicted results from the four magnetic network models are validated by both 2D finite element analysis(FEA) and experimental measurements on a machine prototype. Overall, comparisons indicate that the model with bypass-bridge branches between stator teeth and back irons exhibits best performances.

关键词： air-gap flux density finite element analysis flux switching nonlinear magnetic network permanent magnet

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：