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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu kai Zhao Guoqiang liu Youming Lu Xinyan li kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

石灰乳法处理红土镍矿沉镍废水回收氢氧化镁的研究

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有色金属（冶炼部分） 2017年第7期 67-71页

作者：刘凯华李淑梅李辉沈阳有色金属研究院沈阳110141

采用石灰乳处理红土镍矿沉镍废液回收氢氧化镁,考察了各因素对氢氧化镁纯度及过滤速度的影响。结果表明,在转化温度为80℃、转化时间80min、-0.1mm石灰乳用量为理论量的95%、滴加速度4mL/min的条件下,可制得纯度99.2%的氢氧化镁,溶液过... 详细信息

采用石灰乳处理红土镍矿沉镍废液回收氢氧化镁,考察了各因素对氢氧化镁纯度及过滤速度的影响。结果表明,在转化温度为80℃、转化时间80min、-0.1mm石灰乳用量为理论量的95%、滴加速度4mL/min的条件下,可制得纯度99.2%的氢氧化镁,溶液过滤速度为7.37m3/(m2·h)。

关键词：石灰乳红土镍矿沉镍废水氢氧化镁

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基于二次特征提取的表情识别

计算机工程与设计 2018年第8期39卷 2621-2627页

作者：梁华刚孙凯李怀德长安大学电子与控制工程学院陕西西安710064

为解决非均匀光照下和训练库外个体表情识别率低的问题,提出自适应阈值LBP和二次特征提取的表情识别方法。采用自适应阈值LBP作为表情主要特征,Kirsch响应后的Canny特征作为辅助特征,剔除表情无关区域后,用两个深度信念网络(deep belief... 详细信息

为解决非均匀光照下和训练库外个体表情识别率低的问题,提出自适应阈值LBP和二次特征提取的表情识别方法。采用自适应阈值LBP作为表情主要特征,Kirsch响应后的Canny特征作为辅助特征,剔除表情无关区域后,用两个深度信念网络(deep belief network,DBN)进行二次特征提取和表情分类,利用验证集确定两个DBN所占权重。在CK+表情库和自制表情库上与其它方法的对比实验结果表明,该方法对库外实验个体具有更强的泛化性。

关键词：表情识别自适应阈值二次特征提取辅助特征深度信念网络

Cloning and expression of mLRRC4 in the developing mouse nervous system

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Cloning and expression of mLRRC4 in the developing mouse ner...

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： huang He, Xiong Wei, Wu Ming-hua, Gan kai, li Dan, li Gui-yuan Cancer Research Institute, Department of Anatomy & neurobiology, Xiangya School of Medicine, Central South University, Changsna 410078, China

＜正＞To elucidate the role of LRRC 4 in neural system of adult and embryo, we cloned mouse LRRC4 gene and used Northern Blot, RT-PCR and in situ hybridization to study its expression profiles. Mouse LRRC4 mRNA was absent in heart, spleen, lung, liver, stomach, kidney, uterus and muscle, whereas detected in cerebrum, cerebellum, and spinal cord, especially strongly detected in hippocampus and the Purkinje cells in cerebellum. RT-PCR analysis revealed that mRNA of mLRRC4 was not expressed or expressed at very low level before E9.5, while increased after that. In E12.5 mouse embryo, the mLRRC4 transcript was detected in telencephalon, mesencephalon, metencephalon, myelencephalon, neural tube, lens, neuroretina, pigmented retina and highest in the dorsal root ganglia. During RA/P19 cell neuronal differentiation model, mLRRC4 was expressed after P19 cells aggregated for 4 d, and relatively stable at replated stag. Taking the expression patterns into consideration, mLRRC4 may participate in the development of both brain and eye, and play an important role in maintenance of the normal function of neural and optical system.

关键词： leucine-rich repeat(LRR) tissue-specific gene development

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding Pan Pan li Bo Peng hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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广州地区CYP2C9/VKORC1基因多态性及行个体化治疗患者凝血指标的改变

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中国医院药学杂志 2016年第21期36卷 1894-1897页

作者：李国豪杨娜明凯华梁丽华雷秀霞广州市第一人民医院药剂科广东广州510180 广州市第一人民医院检验科广东广州510180

目的：调查广州地区汉族人群与华法林代谢相关的CYP2C9/VKORC1基因多态性分布特征,并了解经验用药患者与根据基因型进行个体化抗凝治疗患者凝血指标（TT、PT、PT-INR、FIB）的改变。方法：选取2015年1月至12月住院或门诊676例患者,采用... 详细信息

目的：调查广州地区汉族人群与华法林代谢相关的CYP2C9/VKORC1基因多态性分布特征,并了解经验用药患者与根据基因型进行个体化抗凝治疗患者凝血指标（TT、PT、PT-INR、FIB）的改变。方法：选取2015年1月至12月住院或门诊676例患者,采用基因芯片法进行CYP2C9/VKORC1基因多态性检测,分析基因型频率和等位基因频率,了解广州地区汉族人群CYP2C9/VKORC1基因多态性分布特征和凝血情况。随机选取初期2.5~3 mg·d-1经验用药组（A组）服用华法林患者91例;经验用药一段时间后进行了CYP2C9/VKORC1基因多态性检测,并根据基因型行个体化用药（B组）。2组患者均按要求定期检测凝血指标。结果：广州地区汉族人群CYP2C9/VKORC1基因型＊1＊1/AA占74.567%;＊1＊1/GA占16.57%;＊1＊3/AA占6.21%;＊1＊3/GA和＊1＊1/GG各占1.18%;＊1＊2/AA和＊1＊3/AA各占0.15%。凝血指标（TT、PT、PT-INR、FIB）A组依次为（13.97±1.43）s、（16.74±8.34）s、（1.47±0.77）INR、（3.34±0.90）s,B组依次为（13.76±1.17）s、（21.71±11.40）s、（1.96±0.90）INR、（3.63±0.92）s;经配对资料t检验,TT2组间无显著差异（P〉0.05）;PT和PT-INR2组间均有非常显著差异（P〈0.01）;FIB A组与B组间有显著差异（P〈0.05）。A组、B组患者在治疗过程中PTINR控制在2~3 INR抗凝治疗理想范围的分别占13.6%和23.57%,经χ2检验有显著差异（P〈0.05）。结论：广州地区汉族人群CYP2C9/VKORC1呈基因多态性,因此华法林按传统经验用药抗凝治疗模式存在一定的盲目性和潜在的危险性,以基因为导向的个体化抗凝治疗为临床在调整华法林抗凝治疗方案提供了科学依据,减少不良事件的发生率。

关键词： CYP2C9/VKORC1 基因多态性个体化治疗华法林凝血指标

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一种粉蒸肉加工中挥发性物质变化分析

食品科技 2017年第9期42卷 100-107页

作者：张哲奇臧明伍张凯华李丹陈文华李笑曼中国肉类食品综合研究中心北京食品科学研究院北京100068

以粉蒸肉为研究对象,采用固相微萃取法提取和富集加工过程中4个时间点(腌制后、蒸制20 min、蒸制40 min、蒸制60 min)粉蒸肉中挥发性物质,借助气相色谱-质谱联用法对其进行测定。结果显示:共检测到98种挥发性风味物质,其中包括碳氢类物... 详细信息

以粉蒸肉为研究对象,采用固相微萃取法提取和富集加工过程中4个时间点(腌制后、蒸制20 min、蒸制40 min、蒸制60 min)粉蒸肉中挥发性物质,借助气相色谱-质谱联用法对其进行测定。结果显示:共检测到98种挥发性风味物质,其中包括碳氢类物质40种、醛类物质20种、酯类物质16种、醇类6种、醚类6种、含氮及杂环化合物4种、酮类3种、酸类物质2种、酚类1种。4个时间点挥发性物质种类和数量均呈上升趋势,依次为52、53、57、62种,4个时间点相对含量最高的挥发性物质依次为碳氢类、醛类、醚类、醚类。粉蒸肉挥发性化合物中相对含量较高的几类物质中,醚类物质在加工中总峰面积呈增加趋势,醇类、酯类和碳氢类物质为先下降后上升,而醛类呈现上升-下降-上升的波动变化。

关键词：粉蒸肉挥发性化合物固相微萃取-气相色谱-质谱法