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不同宿主来源产气荚膜梭菌生物被膜形成前后药物敏感性分析

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动物医学进展 2025年第1期46卷 38-42页

作者：吴莹邵长军刘文华青岛农业大学动物医学院山东青岛266109 烟台市农科院山东烟台264200

为了检测5株不同宿主来源产气荚膜梭菌形成生物被膜能力及其对抗菌药物的敏感性差异,首先用纸片扩散法药敏试验测定5株不同来源的产气荚膜梭菌对7种抗菌药物的敏感性;筛选高敏药物测定各菌株的最小抑菌浓度(MIC);利用结晶紫染色法检测... 详细信息

为了检测5株不同宿主来源产气荚膜梭菌形成生物被膜能力及其对抗菌药物的敏感性差异,首先用纸片扩散法药敏试验测定5株不同来源的产气荚膜梭菌对7种抗菌药物的敏感性;筛选高敏药物测定各菌株的最小抑菌浓度(MIC);利用结晶紫染色法检测不同来源产气荚膜梭菌生物被膜形成能力和高敏药物对生物被膜的抑制和清除能力。药敏结果显示,5株不同宿主来源产气荚膜梭菌均对氨苄西林高度敏感,对其余6种抗菌药物有不同程度耐药;氨苄西林对不同菌株的MIC值在0.031~2.000μg/mL之间;所有菌株均能生成生物被膜,但生物被膜生成能力有差异;不同菌株在各自4、2、1 MIC下生物被膜的生成受到不同程度抑制,而亚抑菌浓度的氨苄西林能刺激生物被膜的生成,氨苄西林对已经生成的生物被膜不能完全清除。结果表明,不同来源产气荚膜梭菌形成生物被膜前后对药物敏感性不同,可为产气荚膜梭菌的临床用药选择及使用剂量提供一定的参考依据。

关键词：产气荚膜梭菌生物被膜最小抑菌浓度耐药性

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新教材背景下中小学教师教材执行力探赜

教学与管理 2025年第1期 39-43页

作者：王中华刘玲玲贵州师范大学教育学院贵阳550025

在2024年秋季学期新教材启用的背景下,中小学教师的教材执行力对于构建高质量教材体系具有重要的现实意义,对于引领教材改革、落实培养学生核心素养及促进教材创新发展发挥着关键作用。当前,教师的教材执行力主要体现在教材执行前的认... 详细信息

在2024年秋季学期新教材启用的背景下,中小学教师的教材执行力对于构建高质量教材体系具有重要的现实意义,对于引领教材改革、落实培养学生核心素养及促进教材创新发展发挥着关键作用。当前,教师的教材执行力主要体现在教材执行前的认知能力、教材执行中的运用能力和教材执行后的反馈能力等三个维度。然而,教师在教材执行过程中存在认知迷思、运用失当和反馈匮乏的问题,导致教材执行效果不理想。基于此,转变思维方式、活用教材栏目、强化理论指导及改进评价机制成为提升中小学教师教材执行力、推动教材教学高质量发展的重要动力和关键策略。

关键词：新教材中小学教师教材执行力

A New Method for Calculations of Two-Electron Systems in Magnetic Field

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Chinese Physics Letters 1999年第9期16卷 638-640页

作者： qiao Hao-xue liu Lian-jun ZHANG Zhe-hua LI Bai-wen Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071 Department of Physics Wuhan UniversityWuhan 430071

A method suitable for two-electron systems in a range running from low to high fields is ***=-1 triplet state of H-ion and He atom are used to introduce the new *** the matrix elements in our calculations are formulated as products of simple,independent one-dimensional numerical integrals and analytic *** a result,lower energies compared to those obtained with spherical coordinates in low fields,and cylindrical coordinates in high fields are presented.

关键词： coordinates Electron cylindrical

Post-Processing Time-Aware Optimal Scheduling of Single Robotic Cluster Tools

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 597-605页

作者： Qing hua Zhu Yan qiao NaiQi Wu Yan Hou School of Computer Science and Technology Guangdong University of TechnologyGuangzhou 510006China Institute of Systems Engineering Macao University of Science and TechnologyTaipa 999078MacaoChina State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China

Integrated circuit chips are produced on silicon *** cluster tools are widely used since they provide a reconfigurable and efficient environment for most wafer fabrication *** advances in new semiconductor materials bring about new functionality for integrated *** a wafer is processed in a processing chamber,the wafer should be removed from there as fast as possible to guarantee its high-quality integrated ***,maximization of the throughput of robotic cluster tools is *** work aims to perform post-processing time-aware scheduling for such tools subject to wafer residencytime *** do so,closed-form expression algorithms are derived to compute robot waiting time accurately upon the analysis of particular events of robot waiting for singlearm cluster *** are given to show the application and effectiveness of the proposed algorithms.

关键词： Cluster tool discrete event systems optimization robotic systems scheduling

Nitric Oxide Signaling in Plant Responses to Abiotic Stresses

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Journal of Integrative Plant Biology 2008年第10期50卷 1238-1246页

作者： Weihua qiao liu-Min Fan Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University Beijing 100871 China

Nitric oxide （NO） plays important roles in diverse physiological processes in plants. NO can provoke both beneficial and harmful effects, which depend on the concentration and location of NO in plant cells. This review is focused on NO synthesis and the functions of NO in plant responses to abiotic environmental stresses. Abiotic stresses mostly induce NO production in plants. NO alleviates the harmfulness of reactive oxygen species, and reacts with other target molecules, and regulates the expression of stress responsive genes under various stress conditions.

关键词： abiotic stress H2O2 nitric oxide reactive oxygen species signal transduction.

In vitro maturation of human oocytes maintaining good development potential for rescue intracytoplasmic sperm injection with fresh sperm

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World Journal of Clinical Cases 2022年第7期10卷 2166-2173页

作者： Yun-qiao Dong Chuang-Qi Chen Yu-Qiang huang Dun liu Xi-Qian Zhang Feng-hua liu Department of Assisted Reproductive Center Guangdong Women and Children HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND The outcomes of the use of commercial in vitro maturation(IVM)medium to culture immature oocytes obtained from conventional ovulation induction,followed by rescue intracytoplasmic sperm injection(RICSI),are not *** is thus difficult to widely adopt this approach in clinical ***,it is necessary to explore methods for improving the clinical outcome of *** To study the effect of sperm on the developmental potential of in vitro-matured oocytes in conventional *** This was a retrospective study of patients whose immature oocytes were harvested from conventional oocyte stimulation cycles and underwent ICSI at our hospital between June 2018 and August *** was performed using sperm collected on the day of oocyte harvest(old)and sperm collected on the day of RICSI(fresh)and oocytes matured in vitro after 24 h of culture in conventional *** rates of in vitro oocyte maturation,normal fertilization,normal cleavage,day-3 top-quality embryos,and useful blastocyst formation were compared between the two *** In total,102 germinal vesicle(GV)-stage immature oocytes were cultured in the old sperm *** the fresh sperm group,122 GV-stage immature oocytes were collected and cultured in vitro for 24 *** were no significant differences in the general conditions of males and females between the two groups(P>0.05).The oocyte maturation,normal fertilization,and normal cleavage rates of the old and fresh groups were 51.0%vs 55.7%,61.5%vs 64.7%,and 93.8%vs 93.2%,*** of the rates differed significantly(P>0.05)between the two ***,the day-3 top-quality embryo and useful blastocyst rates of the old and fresh sperm groups were 16.6%vs 63.4%;6.67%vs 34.6%,*** day-3 top-quality embryos and useful blastocyst rates of the old sperm group were significantly lower than those of the fresh group(P<0.05).CONCLUSION In vitro maturation with conventional culture medium combined with the use of

关键词： In vitro oocyte maturation Sperm injections Intracytoplasmic Semen analysis In vitro fertilization Human oocyte

3D trajectory inversion of an adjacent well using scattered P-wave

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Petroleum Science 2023年第2期20卷 857-865页

作者： Lu Cheng Xiao-hua Che Wen-Xiao qiao Teng Zhao State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Key Laboratory of Earth Prospecting and Information Technology Beijing102249China

In oil and gas exploitation,cluster well technology can significantly reduce costs and improve *** effective adjacent well detection method can greatly reduce the risk of collision between adjacent *** study proposes a method to invert the 3D trajectory of an adjacent well using a scattered P-wave obtained by borehole azimuthal acoustic reflection *** obtaining the scattered P-wave from the raw data of the target well using the wave field separation technology,the waveform data in an imaging profile can be obtained by the downhole acoustic directional reception *** imaging technology is then used to obtain the image of the formation in the imaging ***,by analyzing the images of the formation in the imaging profile of the different azimuths,the well spacing and azimuth of the target well can be ***,the 3D trajectory of the target well can be obtained by solving the inversion *** method was validated by processing the field data from a deviated well in a deep *** comparison of the inversion and actual trajectories of the target well demonstrated that the maximum deviation of the inversion trajectory is 0.9 m in the north-south direction,0.78 m in the east-west direction,1.45 m in the well spacing,and 2.48°in the *** field data inversion result demonstrated that the method can effectively use the azimuth reflection acoustic data to invert the 3D trajectory of an adjacent well,which indicates that the borehole azimuthal acoustic reflection imaging technology has great potential within the context of adjacent well detection.

关键词： Acoustic imaging Acoustic reflection logging Directional reception Adjacent well

Sliding mode-based adaptive tube model predictive control for robotic manipulators with model uncertainty and state constraints

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Control Theory and Technology 2023年第3期21卷 334-351页

作者： Erlong Kang Yang liu Hong qiao State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Research and Application for Robotic Intelligence of Hand-Eye-Brain Interaction Beijing 100190China The School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

In this paper,the optimal tracking control for robotic manipulators with state constraints and uncertain dynamics is investigated,and a sliding mode-based adaptive tube model predictive control method is ***,utilizing the high-order fully actuated system approach,the nominal model of the robotic manipulator is constructed as the predictive *** on the nominal model,a nominal model predictive controller with the sliding mode is designed,which relaxes the terminal constraints,and realizes the accurate and stable tracking of the desired trajectory by the nominal ***,an auxiliary controller based on the node-adaptive neural networks is constructed to dynamically compensate nonlinear uncertain dynamics of the robotic ***,the estimation deviation between the nominal and actual states is limited to the tube invariant *** the same time,the recursive feasibility of nominal model predictive control is verified,and the ultimately uniformly boundedness of all variables is proved according to the Lyapunov ***,experiments show that the robotic manipulator can achieve fast and efficient trajectory tracking under the action of the proposed method.

关键词： Tube-based model predictive control-Robotic manipulator Sliding mode Node-adaptive neural networks Model uncertainty

Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients

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World Journal of Gastroenterology 2020年第46期26卷 7338-7351页

作者： Guo-hua Li Shi-Jia huang Xiang Li Xiao-Song liu qiao-Ling Du Department of Reproductive Immunology Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 200040China Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 200040China

BACKGROUND Intrahepatic cholestasis in pregnancy(ICP)is the most common liver disease during pregnancy,and its exact etiology and course of progression are still poorly *** To investigate the link between the gut microbiota and serum metabolome in ICP *** In this study,a total of 30 patients were recruited,including 15 patients with ICP(disease group)and 15 healthy pregnant patients(healthy group).The serum nontarget metabolomes from both groups were *** of the 16S rRNA V3-V4 region was performed using fecal samples from the disease and healthy *** comparing the differences in the microbiota and metabolite compositions between the two groups,the relationship between the gut microbiota and serum metabolites was also *** The Kyoto Encyclopedia of Genes and Genomes analysis results showed that the primary bile acid biosynthesis,bile secretion and taurine and hypotaurine metabolism pathways were enriched in the ICP patients compared with the healthy *** addition,some pathways related to protein metabolism were also enriched in the ICP *** principal coordination analysis results showed that there was a distinct difference in the gut microbiota composition(beta diversity)between the ICP patients and healthy *** the phylum level,we observed that the relative abundance of Firmicutes was higher in the healthy group,while Bacteroidetes were enriched in the disease *** the genus level,most of the bacteria depleted in ICP are able to produce short-chain fatty acids(e.g.,Faecalibacterium,Blautia and Eubacterium hallii),while the bacteria enriched in ICP are associated with bile acid metabolism(e.g.,Parabacteroides and Bilophila).Our results also showed that specific genera were associated with the serum *** Our study showed that the serum metabolome was altered in ICP patients compared to healthy controls,with significant differences in the bile,taurine and hypotau

关键词： Intrahepatic cholestasis in pregnancy Metabolome Gut microbiota Bile acids