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TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang Yiyin zhang Xiaoxiao Fan Yang Fan Ning hua Duguang Li Shengxi Jin Yirun Li Peng Chen Yongle Chen Xiaobo Cai Yi zhang Linhua Jiang Wei Yang Peilin Yu Hui Lin department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China department of Biophysics and department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK department of Toxicology and department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical engineering and Instrument science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed ***,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 Lipid Hepatic

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Solar-driven photothermal catalytic CO_(2) conversion:a review

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Rare Metals 2024年第7期43卷 2913-2939页

作者： Bachirou Guene Lougou Bo-Xi Geng Ru-Ming Pan Wei Wang Tian-Tian Yan Fang-hua Li Hao zhang Oraléou SanguéDjandja Yong Shuai Meisam Tabatabaei Daniel Sabi Takou School of Energy science and engineering Harbin Institute of TechnologyHarbin 150001China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China School of Electrical engineering and Automation Harbin Institute of TechnologyHarbin 150001China Guangdong Provincial Key Laboratory of Distributed Energy Systems Engineering Research Center of None-Food Biomass Efficient Pyrolysis and Utilization Technology of Guangdong Higher Education InstitutesDongguan University of TechnologyDongguan 523808China Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia Terengganu21030 Kuala NerusMalaysia department of Biomaterials Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesChennai600077India école Polytechnique d'Abomey-Calavi University of Abomey-Calavi2009CotonouBenin

It is highly desirable to seek green and sustainable technologies,such as employing photo thermal effects to drive energy catalysis processes to address the high energy demand and associated environmental impacts induced by the current *** photothermocatalysis process is an emerging research area with great potential in efficiently converting solar energy through various catalytic ***,achieving simultaneously high conversion efficiency,cyclability,and durability is still a daunting ***,tremendous work is still needed to enhance solar photo thermal catalytic conversion and promote its large-scale *** review developed the principles of coupling solar photon and thermal fields underlying the photothermal effect,exploration of efficient nanocatalysts,development of optofluidic reactor model,and photo thermal synergistic-driven CO_(2) reduction *** ultimate goal was to provide an effective approach that can effectively convert solar energy into photocarriers/hot-electrons and heat,and importantly,can couple them to regulate catalysis reaction pathways toward the production of value-added fuel and chemical energy.

关键词： Photochemistry Photothermal CO_(2)catalytic conversion Nanomaterial Solar fuels and chemicals

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Phase separation and domain crystallinity control enable open-air-printable highly efficient and sustainable organic photovoltaics

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InfoMat 2024年第3期6卷 131-143页

作者： Jie Lv Xiaokang Sun hua Tang Fei Wang Guangye zhang Liangxiang Zhu Jiaming huang Qianguang Yang Shirong Lu Gang Li Frédéric Laquai Hanlin Hu Hoffmann Institute of Advanced Materials Shenzhen Polytechnic UniversityShenzhenthe People's Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenthe People's Republic of China School of Materials science and engineering Xiangtan UniversityXiangtanthe People's Republic of China KAUST Solar Center Physical Sciences and Engineering Division(PSE)Materials Science and Engineering Program(MSE)King Abdullah University of Science and Technology(KAUST)ThuwalKingdom of Saudi Arabia College of New Materials and New Energies Shenzhen Technology UniversityShenzhenthe People's Republic of China department of Electronic and Information engineering The Hong Kong Polytechnic UniversityHong Kong SARthe People's Republic of China department of Material science and Technology Taizhou UniversityTaizhouthe People's Republic of China

Organic solar cells(OSCs)have emerged as a promising solution for sustainable energy production,offering advantages such as a low carbon footprint,short energy payback period,and compatibility with ***,the use of hazardous solvents continues to dominate the best-performing OSCs,mainly because of the challenges of controlling phase separation and domain crystallinity in *** this study,we combined the solvent vapor treatment of CS2 and thermal annealing to precisely control the phase separation and domain crystallinity in PM6:M-Cl and PM6:O-Cl systems processed with the eco-solvent *** method resulted in a maximum power conversion efficiency(PCE)of 18.4%,which is among the highest values reported for sustainable binary ***,the fabrication techniques were transferred from spin coating in a nitrogen environment to blade printing in ambient air,retaining a PCE of 16.0%,showing its potential for high-throughput and scalable *** addition,a comparative analysis of OSCs processed with hazardous and green solvents was conducted to reveal the differences in phase *** work not only underscores the significance of sustainability in OSCs but also lays the groundwork for unlocking the full potential of open-air-printable sustainable OSCs for commercialization.

关键词： open-air printable organic solar cells sustainability

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Anti-inflammatory and DNA Repair Effects of Astragaloside IV on PC12 Cells Damaged by Lipopolysaccharide

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Current Medical science 2024年第4期44卷 854-863页

作者： Hai-long LI Li-hua SHAO Xi CHEN Meng WANG Qi-jie QIN Ya-li YANG Guang-run zhang Yang HAI Yi-hong TIAN department of Geriatrics The Affiliated Hospital of Gansu University of Chinese MedicineLanzhou730000China Key Laboratory for Mining Innovation and Transformation of Traditional Chinese Medicine in Gansu Province and the New Product Creation Engineering Laboratory of Traditional Chinese Medicine in Gansu ProvinceLanzhou730000China department of Neurology the First People’s Hospital of LanzhouLanzhouGansu730000China School of Public Health Gansu University of Chinese MedicineLanzhou730000China People’s Hospital of Gansu Province Lanzhou730000China Scientific Research and Experimental Center Gansu University of Chinese MedicineLanzhou730000China

Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and bioinformatics *** PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 *** morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival ***12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 *** concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for subsequent *** activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western *** differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,P0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulat

关键词： PC12 cells astragaloside IV inflammation DNA damage

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Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-Bing Xiao Hai-Tao Cao Rui Xue Jin-Ting Cai Ge-Ge Wang Marina Manganaro Shao-hua zhang Zhi-Hao Ouyang Li-Ping Fu Jun-Hui Fan Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of Information engineering Guangzhou Panyu PolytechnicGuangzhou 511483China department of Physics Zhejiang Normal UniversityJinhua 321004China College of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China Astronomy science and Technology Research Laboratory of department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+21.35,Ton 599,B21420+32,and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+25,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+25,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant ***,for PKS 1441+25,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+21.35 and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

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A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy

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Cancer Communications 2024年第3期44卷 438-442页

作者： Yingqiang Liu Linjiang Tong Mengge zhang Qi zhang Qiupei Liu Fang Feng Yan Li Mengzhen Lai Haotian Tang Yi Chen Meiyu Geng Wenhu Duan Jian Ding hua Xie Division of Antitumor Pharmacology&State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China University of Chinese Academy of sciences BeijingP.R.China department of Chemical and Environmental engineering University of Nottingham Ningbo ChinaNingboZhejiangP.R.China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdongP.R.China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandongP.R.China Small-Molecule Drug Research Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China

Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune *** in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug *** emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors.

关键词： alterations KRAS sarcoma

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基于多示例学习图卷积网络的隐写者检测

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自动化学报 2024年第4期50卷 771-789页

作者：钟圣华张智深圳大学计算机与软件学院深圳518060 香港理工大学电子计算学系中国香港999077

隐写者检测通过设计模型检测在批量图像中嵌入秘密信息进行隐蔽通信的隐写者,对解决非法使用隐写术的问题具有重要意义.本文提出一种基于多示例学习图卷积网络(Multiple-instance learning graph convolutional network,MILGCN)的隐写... 详细信息

隐写者检测通过设计模型检测在批量图像中嵌入秘密信息进行隐蔽通信的隐写者,对解决非法使用隐写术的问题具有重要意义.本文提出一种基于多示例学习图卷积网络(Multiple-instance learning graph convolutional network,MILGCN)的隐写者检测算法,将隐写者检测形式化为多示例学习(Multiple-instance learning, MIL)任务.本文中设计的共性增强图卷积网络(Graph convolutional network, GCN)和注意力图读出模块能够自适应地突出示例包中正示例的模式特征,构建有区分度的示例包表征并进行隐写者检测.实验表明,本文设计的模型能够对抗多种批量隐写术和与之对应的策略.

关键词：图像隐写者检测图卷积网络多示例学习示例包表征

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New Catalyst for the Copolymerization of Styrene with Carbon Monoxide

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Chinese Chemical Letters 1998年第6期9卷 577-578页

作者： Rong hua ZHENG Yi Feng zhang Li Ming JIANG Zhi Quan SHEN(department of Polymer science and engineering, Zhejiang University, Hangzhou 310027) department of Polymer science Zhejiang University Hangzhou 310027 China

Neodymium phosphonate [Nd(P-204)(3)] combined by di(n-butyl) magnesium [Mg(n-Bu)(2)] with hexamethylphosphoramide (HMPA) was first found to be an effective catalyst. The results of infrared spectrum and elemental anal... 详细信息

关键词： carbon monoxide styrene neodymium phosphonate catalyst the St-CO copolymer

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Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo zhang Wen He Yong-Hao Gui Quan Lu Yong Yin Jian-hua zhang Xiao-Yan Dong Ying-Wen Wang Ying-Zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic engineering at School of Life sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina department of Nursing Children's Hospital of Fudan UniversityShanghaiChina department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

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The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy

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Tungsten 2024年第2期6卷 342-354页

作者： Song-Wei Ge Ping Hu Jie Deng Shi-Lei Li Hai-Rui Xing Jia-Yu Han Xing-Jiang hua Li Wang Jun-Zhou Yang Bo Jin Wen zhang Kuai-She Wang School of Metallurgy engineering Xi’an University of Architecture and TechnologyXi’an 710055China National and Local Joint engineering Research Center for Functional Materials Processing Xi’an University of Architecture and TechnologyXi’an 710055China Western Xinxing Rare and Precious Metals Co. Ltd.Shangluo 726000China Northwest Institute for Non-Ferrous Metal Research Xi’an 710016China

As the range of applications for molybdenum and its alloys has expanded,the corrosive environment for molybdenum alloys has become more *** the past,the content of doping elements has been studied to investigate their infl uence on the corrosion performance of titanium–zirconium–molybdenum(TZM)*** this paper,it is considered that the second phase in the alloy is the main factor aff ecting the corrosion performance of TZM *** comparing the corrosion behavior of molybdenum metal and TZM alloy,the eff ect of the secondary phase on corrosion behaviors of TZM alloy has been *** results show that the second phase reduces the corrosion resistance of the TZM *** potential of the second phase is 73.7 mV higher than that of the Mo matrix,which contributes to the formation of microscopic electric *** the action of microscopic electric couples,pitting corrosion is preferentially formed at the interface between the second phase and the matrix,which accelerates the corrosion of the *** paper provides a theoretical basis for the application of TZM alloys in corrosive environments.

关键词： Secondary phase Electrochemical corrosion Titanium–zirconium–molybdenum(TZM) Galvanic corrosion Corrosion resistance

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