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Treatment of multisystem inflammatory syndrome in children

World Journal of Pediatrics 2024年第4期20卷 325-339页

作者： Tong Tong yi-hua Jin Min Wang Fang-Qi Gong Department of Cardiology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNo.3333 Binsheng RoadHangzhou 310052China

Background Multisystem inflammatory syndrome in children(MIS-C),a relatively uncommon but severe pediatric complication,is associated with coronavirus disease 2019(COVID-19).A variety of treatment approaches,including intravenous immunoglobulins(IVIGs),glucocorticoids(GCs)and biologic agents,such as anakinra and infliximab,have been described for the management of COVID-19-related *** therapy is also ***,a well-developed treatment system has not been established,and many issues remain *** recently published articles related to the treatment of MIS-C have been ***,in this review,we identified relevant articles published recently and summarized the treatment of MIS-C more comprehensively and *** sources We reviewed the literature on the treatment of MIS-C through 20 September *** PubMed/Medline,Web of Science,EMBASE,and Cochrane Library databases were searched with the combination of the terms"multisystem inflammatory syndrome","MIS-C","PIMS-TS","therapy","treatment","drug","IVIG","GCs","intravenous immunoglobulin","corticosteroids","biological agent",and"aspirin".Results The severity of MIS-C varies,and different treatment schemes should be used according to the specific *** research and data collection are vital to better understand the pathophysiology and optimal management of *** MIS-Cis a disease involving multiple systems and has great *** the accumulation of additional experience,we have garnered fresh insights into its treatment ***,there remains a critical need for greater standardization in treatment protocols,alongside the pressing necessity for more robust and meticulously conducted studies to deepen our understanding of these protocols.

关键词： Coronavirus disease 2019-Corticosteroids Intravenous immunoglobulin Multisystem inflammatory syndrome in children-Treatment

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Electrochemically recycling degraded superalloy and valorizing CO_(2)in the aff ordable borate-modified molten electrolyte

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Tungsten 2024年第2期6卷 382-393页

作者： Xiang Chen Yuan Sun Long Wang Xin Qu Yan Zhao Hong-Wei Xie Di-hua Wang hua-yi yin Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang 110819China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China School of Resource and Environmental Science Wuhan UniversityWuhan 430072China

Integrating electrochemical reduction of CO_(2)and electrochemical oxidation to recycle degraded superalloys is a promising solution to ease resource scarcity and safeguard environmental ***,we propose an electrochemical technique for the conversion of bulk superalloy scraps and CO_(2)into oxide powder at the anode and solid carbon at the cathode,*** particular,a borax-modifi ed CaCl_(2)-based molten salt electrolyte is used for enhancing the electrochemical oxidation of superalloy *** a temperature of 700℃and a voltage of 2.8 V,90.55 wt.%of alloy scraps were oxidized in a molten CaCl_(2)–NaCl–CaCO_(3)–Na_(2)B_(4)O_(7)with an acid–base ratio(K_(a/b))of *** synergy of Cl−and B_(4)O_(7)2−of electrolyte prevents the passivation of the alloy anode and enables continuous ***,the Ni and Co in the anode products are recovered by sulfation roasting with recovery efficiencies of 85.58%and 95.27%for Ni and Co,***,modulating the alkalinity of the electrolyte for enhancing oxidation/pulverization of alloy scrap anode provides new insight into electrochemically recovering superalloy scraps.

关键词： Superalloy scraps Recycling Molten salt Alkalinity Electrochemical oxidation Cobalt

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Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： yi-Long Wang Meng-ying Zhu Zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo yi hua Lu Xu Cong-ying Zhao Li-hua Jiang Xin Zhang Guo-Xia Sheng Pei-Fang Jiang Zheng-Yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

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Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study

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World Journal of Pediatrics 2024年第6期20卷 621-632页

作者： huan Wang Yan-Ping Ruan Sheng Ma Ya-Qi Wang Xiao-Yu Wan yi-hua He Jing Li Zhi-Yong Zou Institute of Child and Adolescent Health School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthPeking UniversityNo.38 Xueyuan RdHaidian DistrictBeijing 100191China Echocardiography Medical Center Beijing Anzhen Hospital.Capital Medical UniversityMaternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalNo.2 Anzhen RdChaoyang DistrictBeijing 100029China

Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this *** Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this *** was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using *** regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with *** 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),*** smoking cessation seemingly mitigated the increased risk of *** Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关键词： Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking

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Abnormal function of EPHA2/p.R957P mutant in congenital cataract

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： Jing-Jin Zhang Zong-Fu Cao Bi-Ting Zhou Ju-hua Yang Zhong Li Shuang Lin Xiao-Le Chen Nan-Wen Zhang Qin Ye Xu Ma yi-hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

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Research progress on the mechanism of exercise fatigue and the role of probiotics in counteracting it

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Food and Health 2024年第3期6卷 33-41页

作者： Zi-Xia Chen Jing Yang Jia-Jia Song hua-yi Suo College of Food Science Southwest UniversityChongqing400715China Chongqing Engineering Research Center for Processing&Storage of Distinct Agricultural Products Chongqing Technology and Business UniversityChongqing 400067China

Exercise fatigue is a physiological phenomenon where the body cannot maintain a specific level after being stimulated by excessive *** five main theories include“energy depletion”,“accumulation of metabolites”,“homeostasis disorder of the internal environment”,“free radicals”,and“central nervous system protection inhibition”.The imbalance of intestinal flora caused by vigorous exercise can further lead to ***,maintaining healthy intestinal flora is crucial for athlete health and *** studies have demonstrated that probiotics can regulate intestinal flora and alleviate exercise fatigue;however,there are no systematic reviews on the anti-fatigue effects of *** on the mechanisms of exercise-induced fatigue,this article summarizes the effects and mechanisms by which probiotics combat exercise fatigue,aiming to provide research ideas for the development of probiotics that prevent exercise fatigue.

关键词： probiotics gut microbiota exercise fatigue mechanism

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Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

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Reproductive and Developmental Medicine 2024年第2期8卷 111-120页

作者： Dan Mo Zhong-Hong Zeng Xin Sui Rong Li yi-hua Yang Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Nanning 530021China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Beijing 100191China

The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be *** to previous studies,folliculogenesis is an energy-demanding *** fact,well-balanced follicular energy metabolism is associated with ovarian function and female ***,glucose metabolism has been widely described as the main source of energy during ***,the follicular glucose metabolism profiles change dynamically during follicular *** abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in *** signaling pathways in follicles appear to form a link between glucose metabolism and ***,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental *** review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway

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Making Elimination of Perinatal Hepatitis B Infection a Reality:The Chinese Contribution

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Maternal-Fetal Medicine 2024年第2期6卷 67-69页

作者： Jie Tang Kuanhui Xiang yi-hua Zhou Department of Obstetrics and Gynecology Wujin Hospital Affiliated with Jiangsu UniversityChangzhou 213017China Department of Obstetrics and Gynecology Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213000China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Peking University-YHLO Joint Laboratory for Molecular Diagnostic of Infectious Disease Peking UniversityBeijing 100191China Departments of Laboratory Medicine and Infectious Diseases and Obstetrics&Gynecology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China

Chronic hepatitis B virus(HBV)infection,referred to the presence of hepatitis B surface antigen(HBsAg)over 6 months,is a serious health issue because of its severe sequelae such as cirrhosis and hepatocellular *** of mother-to-child transmission(MTCT)of HBV is most important to control hepatitis B because a vast majority of HBV acquisition in infancy will become chronic carriers.

关键词： mother hepatitis cirrhosis

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民国政府的治藏政策与藏传佛教中国化的历史进程

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中国藏学 2024年第1期 11-21,208,209页

作者：邱熠华中国藏学研究中心图书馆北京100101

民国时期,在西藏地方与中央政府关系较为困难的背景下,由汉藏民间僧俗大众掀起,并得到历届民国政府支持的汉藏佛教文化交流活动迅速发展,不仅推进了汉藏佛教界的交流与互动,而且有助于加强西藏与内地各族民众的交流与了解,为中华民族多... 详细信息

民国时期,在西藏地方与中央政府关系较为困难的背景下,由汉藏民间僧俗大众掀起,并得到历届民国政府支持的汉藏佛教文化交流活动迅速发展,不仅推进了汉藏佛教界的交流与互动,而且有助于加强西藏与内地各族民众的交流与了解,为中华民族多元一体格局的形成发展奠定了重要的文化、心理基础,推动了藏传佛教中国化的历史进程。在历届民国政府支持下,以九世班禅、诺那呼图克图、喜饶嘉措等为代表的藏传佛教僧人在内地弘法讲经、传播藏传佛教及西藏文化,传播的人群范围不再局限于以往的皇室、高官等阶层,而是拓展至内地更广大的各阶层民众。传统的藏传佛教法会具有了团结民众、抵御日本侵略等时代意涵。1936年,国民政府制定颁布《喇嘛转世办法》,沿袭清代治理西藏之策,以国家法律管理藏传佛教活佛转世事宜。同年,国民政府还颁布《补助汉藏僧侣游学规则》。这些政策措施极大地促进了汉藏佛教文化交流,加强了西藏与内地的联系。

关键词：民国时期汉藏佛教文化交流治藏政策活佛转世藏传佛教中国化

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Leukopenia-a rare complication secondary to invasive liver abscess syndrome in a patient with diabetes mellitus:A case report

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3343-3349页

作者： Chun-Yan Niu Bang-Tao Yao hua-yi Tao Xin-Gui Peng Qing-hua Zhang Yue Chen Lu Liu Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Department of Ophthalmology Nanjing Lishui People’s HospitalNanjing 211200Jiangsu ProvinceChina Department of Medical Imaging Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Thrombocytopenia is a common complication of invasive liver abscess syndrome(ILAS)by Klebsiella pneumoniae(***)infection,which indicates severe infection and a poor ***,the presence of leukopenia is *** are rare reports on leukopenia and its clinical significance for ILAS,and there is currently no recognized treatment *** and broad-spectrum antimi-crobial therapy may be an effective therapy for treating ILAS and improving its *** SUMMARY A 55-year-old male patient who developed fever,chills,and abdominal distension without an obvious cause presented to the hospital for *** tests revealed thrombocytopenia,leukopenia,and multiple organ *** examinations revealed an abscess in the right lobe of the liver and thromboph-lebitis,and *** was detected in the blood *** the patient was diabetic and had multi-system involvement,he was diagnosed with ILAS accom-panied by leukopenia and *** antibiotic treatment and sys-temic supportive therapy,the symptoms disappeared,and the patient’s condition almost completely *** Leukopenia is a rare complication of ILAS,which serves as an indicator of adverse prognostic outcomes and the severity of infection.

关键词： Invasive liver abscess syndrome Klebsiella pneumoniae Leukopenia Thrombocytopenia Treatment Prognosis Case report

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