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Risk Factors of Precancerous Gastric Lesions in A Population at High Risk of Gastric Cancer

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Chinese Journal of Cancer Research 2010年第4期22卷 267-273页

作者： Jian Liu Li-Ping Sun Yue-hua Gong yuan yuan Cancer Institute The First Affiliated Hospital China Medical University Shenyang 110001

Objective： In cancer prevention, the targeting of precancerous lesions has been recognized as the most promising method. However, little attention has been paid to the risk factors of precancerous gastric lesions, especially in rural China where there is high prevalence of precancerous gastric lesions. We therefore conducted a cross-sectional study in Liaoning province, China, to investigate the potential risk and protective factors of these precancerous gastric lesions. Methods： A total of 1,179 subjects with high risk of gastric cancer from Zhuanghe County were included in this study. Standard questionnaires were used in collecting epidemiological factors and the data were then analyzed by the unconditional logistic regression model. Results： Smoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects, and the association of smoking or drinking and the precancerous gastric lesions increased in strength with the daily consumption and duration. As the factors such as age, gender, smoking, alcohol were controlled, a multivariable analysis revealed that there was a significant correlation between the deep-fry food intake and the gastric epithelial dysplasia with the odds ratio （OR） of 1.78 [95% confidence interval （CI）： 1.01-3.12]. Garlic eating was shown to confer protection against the development of gastric ulcer （OR=0.55, 95% CI： 0.33-0.92）. Conclusion： Smoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects. Deep-fry food intake might be one of the risk factors for the precancerous gastric lesions and garlic eating was shown to confer protection against the development of gastric ulcer among rural Chinese population.

关键词： Risk factors Precancerous gastric lesions High risk of gastric cancer

Facilitated Ion Transfer Across the Micro-liquid/Liquid Interface Supported at the Tip of a Silanized Micropipette

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Chemical Research in Chinese Universities 2003年第1期19卷 59-62页

作者： SU Bin SHAO yuan-hua StateKeyLaboratoryofElectroanalyticalChemistry ChangchunInstituteofAppliedChemistryChineseAcademyofSciencesChangchun130022P.R.China StateKeyLaboratoryofElectroanalyticalChemistry

Glass micropipettes with silanized inner walls can be filled with an organic solvent for voltammetric measurements in an aqueous solution. This arrangement was employed to investigate systematically the mechanism of facilitated potassium ion transfer by an ionophore dibenzo 18 crown 6(DB18C6) across a micro water/1,2 dichloroethane(W/DCE) interface supported at the tip of a silanized micropipette. Our experimental results verify that this facilitated ion transfer across the liquid/liquid interface did occur by an interfacial complexation dissociation process(TIC TID mechanism). The ratio of the diffusion coefficient of DB18C6 to that of its complexed ion in the DCE phase was calculated to be 1.74±0.07.

关键词： Silanization Micropipette Facilitated K + transfer Mechanism

Influence of Oxide Morphologies on Galvanizability of Third Generation Automotive Steel

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Journal of Iron and Steel Research International 2014年第11期21卷 1059-1064页

作者： She-ming JIANG Shi-jie FENG Xun-hua yuan yuan-peng LI Zhen-hua LI Qi-fu ZHANG National Engineering Laboratory of Advanced Coating Technology for Metal Materials Central Iron and Steel Research Institute Faculty of Material Science and Engineering Kunming University of Science and Technology

Focusing on improving the galvanizability of the third generation automotive steel, the effect of surface ox ide morphologies on the galvanizability was studied. The results show that the surface oxide types of sample steels by X ray photoelectron spectroscopy （XPS） analysis after annealing in different conditions are the same. Only MnO, MnO2 and Cr2O3 were detected and no complex oxide exists on the surface. Morphologies of surface oxides can greatly influence the galvanizability of the third generation automotive steel. Nodule-like oxide surface can contribute to better wettability and inhibition layer than vitreous film like oxide surface. Galvanized panels of nodule-like oxide surface steels only show pinhole sized bare spots, while panels galvanized from vitreous film-like oxide surface steels reveal larger areas of bare spots and uncoated areas. Inhibition layer observed in galvanized panels of nodule-like oxide surface steels is compact but not homogeneous; some inhibition layer grains are fine, and others are coarse, while the inhibition layer grains of panels galvanized from vitreous film-like oxide surface steels have a non-compact morphology with some particularly fine equiaxed crystals which developed deficiently.

关键词： galvanizing third generation automotive steel oxide morphology galvanizability

Enthalpies Estimation of Formation of Monosubstituted Alkanes by Interaction Potential Index

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Chinese Journal of Chemical Physics 2012年第2期25卷 153-160,I0003页

作者： Ya-xin Wu Chen-zhong Cao hua yuan School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China School of Chemistry and Chemical Engineering Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of EducationHunan University of Science and Technologyand Hunan Provincial University Key Laboratory of QSAR/QSPRXiangtan 411201China

The interaction potential index IPI（X） of 16 Br, C1, I, NO2, CN, CHO, COOH, CH3, CH： kinds of substituents X （X---OH, SH, NH2, ：CH2, C-CH, Ph, COCH3, COOCH3） were proposed, which are derived from the experimental enthalpies of formation △fHФ （g） values of monosubstituted straight-chain alkanes. Based on the IPI（X） and polarizability effect index, a simple and effective model was constructed to estimate the △fHФ （g） values of monosubstituted alkanes RX （including the branched derivatives）. The present model takes into account not only the contributions of the alkyl R and the substituent X, but also the contribution of the interaction between R and X. Its stability and prediction ability was confirmed by the results of leave-one-out method. Compared with previous reported studies, the obtained equation can be used to estimate enthalpies of formation for much more kinds of monosubstituted alkanes with less parameters. Thus, it is recommended for the calculation of the △fHФ（g） for the RX.

关键词： Interaction potential index Substituent Monosubstituted alkane Enthalpy offormation Polarizability effect index

Dynamics and Stability of Potential Hyper-networked Evolutionary Games

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International Journal of Automation and computing 2017年第2期14卷 229-238页

作者： Ting Liu yuan-hua Wang Dai-Zhan Cheng Key Laboratory of Systems and Control Institute of Systems ScienceChinese Academy of Sciences Institute of Control Science and Engineering Shandong University

This paper considers the modeling and convergence of hyper-networked evolutionary games （HNEGs）. In an HNEG the network graph is a hypergraph, which allows the fundamental network game to be a multi-player one. Using semi-tensor product of matrices and the fundamental evolutionary equation, the dynamics of an HNEG is obtained and we extend the results about the networked evolutionary games to show whether an HNEG is potential and how to calculate the potential. Then we propose a new strategy updating rule, called the cascading myopic best response adjustment rule （MBRAR）, and prove that under the cascading MBRAR the strategies of an HNEG will converge to a pure Nash equilibrium. An example is presented and discussed in detail to demonstrate the theoretical and numerical results.

关键词： (Hyper-) Networked evolutionary game (HNEG) potential cascading myopic best response adjustment rule (MBRAR),Nash equilibrium semi-tensor product of matrices.

Pyrochlore-based high-entropy ceramics for capacitive energy storage

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Journal of Advanced Ceramics 2022年第7期11卷 1179-1185页

作者： Yiying CHEN Junlei QI Minhao ZHANG Zixi LUO yuan-hua LIN State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-performance dielectrics are widely used in high-power systems,electric vehicles,and aerospace,as key materials for capacitor *** application scenarios under these extreme conditions require ultra-high stability and reliability of the ***,a novel pyrochlore component with high-entropy design of Bi1.5Zn_(0.75)Mg_(0.25)Nb_(0.75)Ta_(0.75)O_(7)(BZMNT)bulk endows an excellent energy storage performance of Wrec≈2.72 J/cm3 together with an ultra-high energy efficiency of 91%at a significant enhanced electric field Eb of 650 kV/***,the temperature coefficient(TCC)of BZMNT(~−220 ppm/℃)is also found to be greatly improved compared with that of the pure Bi1.5ZnNb1.5O7(BZN)(~−300 ppm/℃),demonstrating its potential application in temperature-reliable *** high-entropy design results in lattice distortion that contributes to the polarization,while the retardation effect results in a reduction of grain size to submicron scale which enhances the *** high-entropy design provides a new strategy for improving the high energy storage performance of ceramic materials.

关键词： high entropy bismuth-based pyrochlore high-temperature stability energy storage

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

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Chinese Journal of Cancer Research 2012年第4期24卷 323-331页

作者： Li Che Yan-hua yuan Jun Jia Jun Ren Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Medical OncologyPeking University Cancer Hospital & Institute

Objective： The activation of hedgehog （HH） pathway is implicated in the development of human malignancies including hepatocellular carcinoma （HCC）. However, the clinical impact of HH activation in HCC patients is still unclear. This study was conducted to confirm whether the expression of HH pathway components was associated with HCC progression and clinical outcome. Methods： This study was a sample-expanded and prolonged follow up of one of our previous studies. It included 46 HCC patients who underwent surgical treatment from 2002 to 2005. The expression of sonic HH （SHIq）, patched-1 （PTCHI）, smoothened （SMOH） and glioma-associated oncogene-1 （GLI1） genes in tumor and adjacent normal tissues extracted from the patients were examined by reverse transcription- polymerase chain reaction （RT-PCR） to explore the relationship between these genes and the clinical prognosis of HCC. Results： The expression levels ofSHH, PTCH1, SMOH and GLI1 in HCC tissues were 60.87%, 50.00%, 32.61% and 54.35%, respectively. The expression levels of SHH-related molecules were relatively intense in cancer tissue, but insignificantly correlated with any clinicopathological factors of tumor. Transcriptional factor GLI1 was the only molecule associated with poor prognosis among the HCC patients. The expression of GLI1 gene in tumor tissues was significantly related with disease-free survival （DFS）（P=0.042） and overall survival （OS）（P=0.030）. The simultaneous expression of GLI1 in tumor and adjacent normal liver tissues correlated with DFS （P〈0.029） and OS （P〈0.025）. Conclusions： HH signaling activation is an important event in the development of human HCC. The expression of GLI1 in SHH pathway is possibly involved in HCC progression, which may be a useful prognostic indicator of HCC.

关键词： Hepatocellular carcinoma hedgehog GLII sonic hedgehog patched smoothened prognosis

Effects of allitridi on cell cycle arrest of human gastric cancer cells

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World Journal of Gastroenterology 2005年第35期11卷 5433-5437页

作者： Min-Wen Rui Ma Li-Ping Shun Yue-hua Gong yuan yuan Cancer Institute of the First Affiliated Hospital of ChinaMedical University Shenyang 110001 Liaoning Province China

AIM： To determine the effect of allitridi on cell cycle of human gastric cancer （HGC） cell lines MGC803 and SGC7901 and its possible mechanism. METHODS： Trypan blue dye exclusion was used to evaluate the proliferation, inhibition of cells and damages of these ceils were detected with electron microscope, Flow cytometry and cell mitotic index were used to analyze the change of cell cycle, immunohistochemistry, and RT- PCR was used to examine expression of the p21^WAF1 gene, RESULTS： MGC803 cell growth was inhibited by allitridi with 24 h ICso being 6.4μg/mL, SGC7901 cell growth was also inhibited by allitridi with 24 h IC50 being 7.3μg/mL, After being treated with allitridi at the concentration of 12μg/mL for 24 h, cells were found to have direct cytotoxic effects, including broken cellular membrane, swollen and vesiculated mitochondria and rough endoplasmic reticula, and mass lipid droplet, When cells were treated with allitridi at the concentration of 3, 6, and 9μg/mL for 24 h, the percentage of Go/G1 phase cells was decreased and that of G2/M phase cells was significantly increased （P = 0.002） compared with those in the group, When cells were treated with allitridi at the concentration of 6μg/mL, cell mitotic index was much higher （P = 0.003） than that of control group, indicating that allitridi could cause gastric cancer cell arrest in M phase, Besides, the expression levels of p21^WAF1 gene of MGC803 cells and p21^WAF1 gene of SGC7901 cells were remarkably upregulated after treatment, CONCLUSION： Allitridi can cause gastric cancer cell arrest in M phase, and this may be one of the mechanisms for inhibiting cell proliferation, Effect of allitridi on cells in M phase may be associated with the upregulation of p21^WAF1 genes. This study provides experimental data for clinical use of allitridi in the treatment of gastric carcinoma.

关键词： Allitridi Gastric cancer cells Cell cycle p21^WAF1

The Yield and Water Use Efficiency to First Cutting Date of Siberian Wildrye in North China

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Agricultural Sciences in China 2011年第11期10卷 1716-1722页

作者： LI Zi-zhong ZHANG Wei-hua GONG yuan-shi Department of Soil and Water Sciences China Agricultural University Beijing 100193 P.R.China

A field experiment study was conducted in Bashang Plateau in North China in 2008 to determine the effect of three first cutting dates on the growth and water use efficiency （WUE） of Siberian wildrye （Elymus sibiricus L.） in the agropastoral ecotone of North China （APENC）. The experiment was conducted in a split plot design with three replications with water supply regime as the main plot treatment and first cutting date as the subplot treatment. Two water supply regimes were used, which included rain-fed treatment as control （CK） and a single irrigation and straw mulch treatment （W）. Three first cutting date treatments were conducted at early heading stage on July 1 （E）, at late heading stage on July 12 （L）, and at flowering stage on July 27 （F）, respectively. The results showed that the forage yield and WUE were the lowest at early heading stage harvest, while the highest at flowering stage either in CK or W treatment. Under combined CK and W treatments, average forage yields of the F subplots were 2 900 and 6 703 kg ha-~, and the values of WUE were 0.82 and 2.28 kg m-3, respectively. Under the CK treatment, forage yields of the E and L subplots were 43.8 and 41.9% lower than the F subplots, and their values of WUE were 46.2 and 50.3% lower than F, respectively. Under the W treatment, the forage yields of the E and L subplots were 74.9 and 61.6% lower, and their values of WUE were 78.1 and 63.3% lower, respectively, as compared with F subplots. Therefore, earlier first cutting did not increase the regrowth of Siberian wildrye and improve the mismatch between rainy season and the period of high growth potential of the grass in the semiarid APENC.

关键词： siberian wildrye first cutting date forage yield water use efficiency North China