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One-step synthesis of α,β-unsaturated arylsulfones by a novel multicomponent reaction of aromatic aldehydes,chloroacetonitrile,benzenesulfinic acid sodium salt

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Chinese Chemical Letters 2012年第12期23卷 1352-1354页

作者： Lei Zhang mao hua Ding Hong Yun Guo College of Chemical Engineering and Materials Zhejiang University of Technology

A new and green method for the synthesis of α,β-unsaturated arylsulfones had been achieved through the condensation of aromatic aldehydes, chloroacetonitrile, benzenesulfinic acid sodium salt in the presence of 1-butyl-3-methyl imidazolium hydroxide （[bmim]OH） in EtOH under reflux. The ionic liquid was recovered and recycled for subsequent reactions. The advantages of this protocol were non-toxic, easy work-up and good yields.

关键词： Ionic liquids Benzenesulfinic acid sodium salt α,β-Unsaturated arylsulfones

On Generalized Vector Equilibrium Problems

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Acta Mathematicae Applicatae Sinica 2006年第1期22卷 21-26页

作者： An-hua Wan Jun-yi Fu Wei-hua mao Department of Applied Mathematics South China Agricultural University Guangzhou 510642 China Department of Mathematics Nanchang University NaIlchang 330047 China

A new generalized vector equilibrium problem involving set-valued mappings and the proper quasi concavity of set-valued mappings in topological vector spaces are introduced; its existence theorems and the convexity of... 详细信息

关键词： Vector equilibrium problem set-valued mapping topological vector space KKM theorem

T-cell and B-cell repertoire diversity are selectively skewed in children with idiopathic nephrotic syndrome revealed by high-throughput sequencing

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World Journal of Pediatrics 2023年第3期19卷 273-282页

作者： Qing Ye Dong-Jie Wang Bing Lan Jian-hua mao Department of Clinical Laboratory Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China Department of Nephrology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China

Background Clinical studies suggest that the dysfunction of T cells and B cells may play an essential role in the pathogenesis of idiopathic nephrotic syndrome(INS),but laboratory evidence is ***,this study explored T-cell receptor(TCR)and B-cell receptor(BCR)profiling in children with idiopathic nephrotic *** High-throughput sequencing technology was used to profile the TCR and BCR repertoires in children with *** blood was collected from ten INS patients,including five vinculin autoantibody-positive patients and five vin-culin autoantibody-negative patients,before and after *** and BCR libraries were constructed by 5'-RACE and sequenced by a DNBSEQ-T7 sequencer,and sequence analyses were performed using ReSeqTools,FastP,MiXCR,and *** The TRA(T-cell receptorα),TRG(T-cell receptor y),and IGH(immunoglobulin heavy chain)repertoires of the INS group were occupied by highly abundant clonotypes,whereas small clonotypes occupied the healthy group,especially TRA.A significant increase in the Shannon-Weaver index was observed for the TRA and TRG repertoires after treatment in vinculin autoantibody-negative patients,but a significant increase in the IGH repertoire after treatment was observed in vinculin autoantibody-positive *** frequency of some V-J pairs was significantly enriched in steroid-sensitive nephrotic syndrome *** usage frequency of the V and J genes was skewed in patients,which seemed not related to immunosuppressive ***,after effective treatment,dynamic changes in the size of the individual clonotype were *** T-cell and B-cell immunity contribute to the pathogenesis of different INSs.

关键词： B-cell receptor repertoire Complementary determining region 3 Idiopathic nephrotic syndrome T-cell receptor repertoire

Early prediction of acute kidney injury in children: known biomarkers but novel combination

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World Journal of Pediatrics 2018年第6期14卷 617-620页

作者： Qian Lin Jian-hua mao Department of Nephrology Children's HospitalZhejiang University School of MedicineNo.57 Zhugan LaneHangzhou 310003China

Acute kidney injury (AKI) is a global public health concern with rapid decline in glomerular filtration rate and signifi-cant increase in serum creatinine and blood urea nitrogen, which is an independent risk factor for short-term and long-term mortality (1, 2)In addition to kidney disease, AKI can occur secondary to a variety of diseases, such as multi-organ dysfunction, respiratory distress syndrome, sepsis, losing of gastrointestinal fluids, cardiac surgery, using of nephrotoxic drugs and tumors. The most common causes for AKI of children include sepsis, ischemia and reperfusion injury and tubulointerstitial lesions (3)Additionally, morbidity and mortality were high in critically ill patients, especially for those who were admitted to pediatric intensive care unit (PICU) and underwent cardiac surgery (2–4)Although renal replacement therapies have greatly improved and can pro-vide relief for most patients, the mortality remained high for critically ill children as high as 10%, about six times higher than non-AKI patients (2)In the past few years, studies have reported that even mild elevation of serum creatinine levels may increase the risk of complications and mortality (5)In a prospective cohort study, 10.3% of survivors from AKI in the PICU eventually progress to chronic kidney disease [6].

关键词： Early prediction acute kidney injury novel combination

Pd Close Coupled Catalyst

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Chinese Chemical Letters 2006年第9期17卷 1271-1274页

作者： Zhong hua SHI mao Chu GONG Yao Qiang CHEN College of Chemistry Sichuan University Chengdu 610064

A catalyst comprised novel high surface area alumina support was prepared to control emission of automobiles. The results showed that prepared catalyst could satisfy the requirements of a high performance close couple... 详细信息

关键词： Close coupled catalyst cold start high surface area support exhaust gas.

基于多场耦合求解的大规格镁合金扁锭差相脉冲电磁半连续铸造

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中国有色金属学报 2024年第6期34卷 1982-1997页

作者：段文超李金宝潘艳林朱新杰韩峰毛华邱明坤周古昕郎玉婧张志强中国兵器科学研究院宁波分院宁波315103 东北大学材料电磁过程研究教育部重点实验室沈阳110819

本文以大规格镁合金扁锭半连续铸造为研究对象,采用基于多场耦合的数值模拟技术模拟了差相脉冲磁场作用下镁合金扁锭半连续铸造过程中的宏观物理场,研究了差相脉冲磁场相位差对电磁力、温度场、凝固过程、溶质元素分布及宏观偏析的影响... 详细信息

本文以大规格镁合金扁锭半连续铸造为研究对象,采用基于多场耦合的数值模拟技术模拟了差相脉冲磁场作用下镁合金扁锭半连续铸造过程中的宏观物理场,研究了差相脉冲磁场相位差对电磁力、温度场、凝固过程、溶质元素分布及宏观偏析的影响。结果表明:相位差对凝固中后期影响更明显。当相位差从0°增至72°时,凝固初期换热有所减弱;而凝固中后期换热增强,液穴深度明显变浅,中心部位凝固速度加快,横截面内温度场变均匀。此外,适当提高相位差至72°有利于缓解两相区内贫溶质的问题,减少凝固后横截面内最大负偏析率和整体偏析率;相位差继续增大到108°不仅明显削弱了凝固前期的换热强度,而且还会削弱凝固中后期的换热强度,使液穴变深,凝固速度减慢,偏析率增大。

关键词：数值模拟多场耦合镁合金扁锭半连续铸造差相脉冲电磁

A Triphenylphosphonium Functionalized AIE Conjugated Macrocyclic Tetramal&mide for Mitochondrial-targeting Bioimaging

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Chinese Journal of Chemistry 2022年第1期40卷 39-45页

作者： Wei Zeng mao-hua Lin Ling-Yun Zhu Mei-Jin Lin Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhouFujian 350116China College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian 350116China

Developme nt of subcellular orga nelle-targeted bioimagi ng probes is of great imports nee in the field of early detection of diseases and exploring the behaviors of subcellular ***,we present a triphenyIphosphonium functionalized conjugated macrocyclic tetramaleimide(TPP-CMT)as a mitochondrial-targeting bioimaging *** core of TPP-CMT is obtained by connecting two pyrenes and two benzenes through four *** unique structure endows TPP-CMT with exceptional far red/near-i nfirared aggregati on-induced emissi on(FR/NIR-AIE)***-CMT is an excelle nt fluoresce nt emitter in most solve nts and eve n in solid *** qua ntum yield of TPP-CMT was higher tha n 27% when dissolved in comm on middle-polarity orga nic solve nt and this value remained at 28.2% in its solid *** in troducti on of four triphe ny Iphosph onium on maleimide positions endows TPP-CMT with mitochondrial-targeting *** to the FR/NIR-AIE characteristics and the mitochondri-al-targeti ng ability,this well-desig ned fluoresce nt probe was successfully employed for mitochondrial targeti ng bioimaging of HeLa and HepG2 cells.

关键词： Fluorescent probes Macrocycles Photophysics FR/NIR-AIE Mitochondrial-targeting bioimaging

Efficacy and safety of huaiqihuang granule as adjuvant treatment for primary nephrotic syndrome in children: a meta-analysis and systematic review

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World Journal of Pediatrics 2021年第3期17卷 242-252页

作者： Jiao Lin Li-Min huang Jing-Jing Wang Jian-hua mao Department of Nephrology National Clinical Research Center For Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background huaiqihuang(HQH)granule is a traditional Chinese herbal complex that has been used as an adjuvant treatment in clinics for the primary nephrotic syndrome(PNS)for many ***,the effectiveness and safety of HQH have not been systematically *** review aimed to evaluate the effectiveness and safety of HQH in paediatric patients with *** The following databases were searched from inception to Mar 2019:MEDLINE,Cochrane Library,EMBASE,CNKI,Wanfang Database,the Chinese Scientific Journal Database and the Chinese biomedical literature service *** the randomized controlled trials(RCTs)eligible for inclusion were *** primary outcomes were relapse,infection,remission and adverse *** secondary outcomes included serum immunoglobulin levels(IgA,IgG or IgM),T-lymphocyte subtype(CD3+,CD4+,CD8+,CD4+/CD8+),IL-10,TNF-α,TNF-γ,total cholesterol and time of proteinuria turning *** Fourteen RCTs(885 patients)were *** with HQH reduced the chance of relapse[relative risk(RR):0.47;95%CI:0.34,0.66;P<0.001]and infections(RR:0.47;95%Cl:0.35,0.62;P<0.001).No significant difference was found in adverse *** also increased the serum levels of IgA[weighted mean difference(WMD):0.40;95%Cl:0.20,0.60;P<0.001]and IgG(WMD:1.58;95%Cl:1.38-1.78;P<0.001),as well as CD4+[standard mean difference(SMD):0.90;95%Cl:0.12-1.68;P=0.02],CD3+(WMD:4.04;95% CI:3.27-4.82;P<0.001),and the CD4^(+)/CD8^(+)ratio(WMD:0.31;95% CI:0.21-0.41;P<0.001),but decreased the level of CD8+cells(WMD:-3.39;95% CI:-5.73-1.05;P=0.004).No statistically significant difference was found in IgM(WMD:0.05;95% CI:-0.13,0.24;P=0.57).Conclusions HQH could reduce the rate of relapse and the frequency of infection in children with *** apparent adverse effects were ***,the beneficial influence of HQH may act through *** multi-center,large-sample,high-quality studies are needed to confirm the effectiveness and safety of

关键词： Children huaiqihuang Nephrotic syndrome Meta-analysis

内生真菌对醉马草不同生长期土壤酶活性和养分的影响

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草地学报 2024年第6期32卷 1770-1778页

作者：刘荣贵邓茂桦张瀚文郑蓉唐仲龙王超王剑峰兰州大学草种创新和草地农业生态系统全国重点实验室/兰州大学草地微生物研究中心/兰州大学草地农业科技学院甘肃兰州730020 临夏州农业科学院甘肃临夏731100

醉马草-内生真菌共生体是研究生态系统中地上与地下生物联系的独特模式,但该共生体对不同生长期土壤酶活性和养分含量的影响知之甚少。本研究采集休眠期和返青期携带内生真菌(E+)和未携带内生真菌(E-)醉马草的生境土壤,测定E+和E-醉马... 详细信息

醉马草-内生真菌共生体是研究生态系统中地上与地下生物联系的独特模式,但该共生体对不同生长期土壤酶活性和养分含量的影响知之甚少。本研究采集休眠期和返青期携带内生真菌(E+)和未携带内生真菌(E-)醉马草的生境土壤,测定E+和E-醉马草土壤酶活性和养分含量。结果表明:在休眠期和返青期,内生真菌显著增加了醉马草土壤速效磷含量,较E-醉马草分别提高34.7%和36.7%。在返青期内生真菌增加了醉马草土壤硝态氮含量,较E-醉马草提高了32.3%。此外,返青期温度升高增强了E+和E-醉马草土壤蔗糖酶和碱性磷酸酶活性,这提高了土壤N、P的有效性,为醉马草的生长返青提供基本养分。以上结果表明内生真菌通过调节土壤养分提高土壤肥力,返青期土壤酶活性和养分含量的变化保证了醉马草顺利返青。本研究为深入理解禾草-内生真菌共生体的生态学作用提供理论依据。

关键词：醉马草内生真菌土壤酶活性和养分含量休眠期和返青期

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