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Transplantation of Goat Bone Marrow Mesenchymal Stem Cells (gMSCs) Help Restore Spermatogenesis in Endogenous Germ Cells-Depleted Mouse Models

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Journal of Integrative Agriculture 2013年第3期12卷 483-494页

作者： WANG Fang LIU Chao ZHANG Shan-shan LIU Wei-shuai hua jin-lian College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering and Technology Northwest A&F University Department of Pathology Yangling Demonstration Zone Hospital

Mesenchymal stem cells （MSCs） derived from bone marrow are a well-characterized population of adult stem cells that can be maintained and propagated in culture for a long time with the capacity to form a variety of cell types. This study investigated the characteristics of dairy goat bone marrow MSCs （gMSCs） and their differentiation potential toward germ cells in vitro, and to test their potential in vivo, these ceils were transplanted into seminiferous tubes of endogenous germ cells-depleted mouse models. The results showed that characteristic gMSC lines were established and a small population of gMSCs transdifferentiated into male germ cell-like cells which expressed Stra8 after induction with retinoic acid （RA）, as analysed by reverse transcription-polymerase chain reaction （RT-PCR） and immunofluorescence. Further, we transplanted the gMSCs into endogenous germ cells-depleted mouse models. A variety of analysis demonstrated that gMSCs might differentiate into male germ cells and helped spermatogenesis in endogenous germ cells depleted mouse models at 30 d after transplantation. The gMSCs could be used as a potential source of cells for reproductive studies and a neoadjuvant therapy for the spermatogenesis anomaly. Moreover, these cells may offer a new strategy for male infertility and an alternative approach for production of transgenic animals.

关键词： dairy goat bone marrow mesenchymal stem cells (gMSCs) spermatogenesis male germ cells spermatozoa

Magnetic Field Effects on Quantum-Dot Spin Valves

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Communications in Theoretical Physics 2009年第3期51卷 555-562页

作者： GAO jin-hua,~1 SUN Qing-Feng,~1 and XIE Xin-Cheng~(1,2)1 Beijing National Lab for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences,Beijing 100080, China2 Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, USA Beijing National Lab for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100080 China Department of Physics Oklahoma State University Stillwater Oklahoma 74078 USA

We study the magnetic field effects on the spin-polarized transport of the quantum dot (QD) spin valve inthe sequential tunneling regime. A set of generalized master equation is derived. Based on that, we discuss the collinearand noncollinear magnetic field effects, respectively. In the collinear magnetic field case, we find that the Zeeman splittingcan induce a negative differential conductance (NDC), which is quite different from the one found in previous *** has a critical polarization in the parallel arrangement and will disappear in the antiparallel configuration. In thenoncollinear magnetic field case, the current shows two plateaus and their angular dependence is analyzed. Althoughsometimes the two current plateaus have similar angular dependence, their mechanisms are different. Our formalism isalso suitable for calculating the transport in magnetic molecules, in which the spin splitting is induced not by a magneticGeld but by the intrinsic magnetization.

关键词： spin value spintronics quantum dot

Transient expression and antigenic characterization of HBsAg of HBV nt551 A to G mutant

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World Journal of Gastroenterology 1999年第1期5卷 78-79页

作者： FANG De Xing 1, LI Fa Qing 1, TAN Wei Guo 1, CHEN hua Biao 1, jin Hui Ying 1, LI Su Qin 1, LIN Hou Ji 2 and ZHOU Zhen Xian 2

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关键词： hepatitis B virus HbsAg point mutation antibodies.monoclonal

Electrochemical anodic oxidation assisted fabrication of memristors

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International Journal of Extreme Manufacturing 2024年第3期6卷 250-272页

作者： Shuai-Bin hua Tian jin Xin Guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Owing to the advantages of simple structure,low power consumption and high-density integration,memristors or memristive devices are attracting increasing attention in the fields such as next generation non-volatile memories,neuromorphic computation and data ***,the deposition of memristive films often requires expensive equipment,strict vacuum conditions,high energy consumption,and extended processing *** contrast,electrochemical anodizing can produce metal oxide films quickly(e.g.10 s) under ambient *** means of the anodizing technique,oxide films,oxide nanotubes,nanowires and nanodots can be fabricated to prepare *** film thickness,nanostructures,defect concentrations,etc,can be varied to regulate device performances by adjusting oxidation parameters such as voltage,current and *** memristors fabricated by the anodic oxidation technique can achieve high device consistency,low variation,and ultrahigh yield *** article provides a comprehensive review of the research progress in the field of anodic oxidation assisted fabrication of ***,the principle of anodic oxidation is introduced;then,different types of memristors produced by anodic oxidation and their applications are presented;finally,features and challenges of anodic oxidation for memristor production are elaborated.

关键词： anodic oxidation anodized aluminium oxide memristor resistive switching electrical properties

The Limitations and Ethical Considerations of ChatGPT

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Data Intelligence 2024年第1期6卷 201-239页

作者： Shangying hua Shuangci jin Shengyi Jiang Guangdong University of Foreign Studies Guangzhou 510000China

With the advancements of artificial intelligence technology,ChatGPT,a new practice of artificial intelligence,holds immense potential across multiple *** user-friendly human-machine interface,rapid response capabilities,and delivery of high-quality answers have attracted considerable attention and widespread *** by many as a groundbreaking advancement in AI,ChatGPT represents a new milestone in the ***,as with any technological evolution,the emergence of ChatGPT brings not only benefits,but also inevitable security risks and ethical *** paper provides specific information about ChatGPT,including its technology,limitations,ethical issues,governance paths and future ***,we firstly offered a thorough exploration of the technical implementation details of GPT series ***,we provided an intricate analysis elucidating the reasons for limitations and scrutinized the consequential impacts,such as malicious misuse,privacy violation,and so ***,we explore diverse governance paths to mitigate the impacts of ChatGPT and present future *** review aims to equip users with crucial knowledge,facilitating well-informed decision-making,effectively handling of potential challenges in employing ChatGPT,and staying abreast with the rapidly evolving landscape of this technology.

关键词： ChatGPT ChatGPT Technology Limitations Ethical considerations Artificial Intelligence

Impaired reproduction in transgenic mice overexpressing γ-aminobutyric acid transporter Ⅰ (GAT1)

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Cell Research 2004年第1期14卷 54-59页

作者： Jia hua HU~(1,*), jin Fu ZHANG~(2,*), Ying hua MA~1, Jie JIANG~1, Na YANG~1, Xin Bo LI~3, Zhi Guang YU CHI~4, Jian FEI~(1,5,**), Li He GUO~(1,**) ~1Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. ~2Department of Urology, Tongji Hospital, Tongji University, 389 Xincun Road, Shanghai 200065, China. ~3New Drug R & D Center, North China Pharmaceutical Group Corporation, 388 Heping East Road, Shijia Zhuang 050015, Hebei, China. ~4School of life sciences, Fudan University, 220 Handan Road, Shanghai 200433, China. ~5Shanghai Research Center for Biomodel Organism, Shanghai 201203, China. Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Shanghai Research Center for Biomodel Organism Shanghai 201203 China Department of Urology Tongji Hospital Tongji University 389 Xincun Road Shanghai 200065 China New Drug R & D Center North China Pharmaceutical Group Corporation 388 Heping East Road Shijia Zhuang 050015 Hebei China School of life sciences Fudan University 220 Handan Road Shanghai 200433 China

It is well documented that γ-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABA_A and GABA_B receptors were present in testis and sperm, and might mediate the acrosome reaction induced by GABA and progesterone. GABA transporter Ⅰ (GAT1) also existed in testis and sperm, but its physiological function was unknown. In the present study, we used GAT1 overexpressing mice to explore GAT1 function in male reproductive system. We found that the expression level of GAT1 continuously increased in wild-type mouse testis from 1 month to 2 months after birth. GAT1 overexpression in mouse affected testis development, which embodied reduced testis mass and slowed spermatogenesis in transgenic mice. Moreover, transgenic mice showed increase of the percentage of broken sperm. The further study revealed that the reproductive capacity was impaired in GAT1 overexpressing mice. In addition, testosterone level was significantly low in transgenic mice compared with that in wi

关键词： GABA GAT1 testes sperm reproduction transgenic.

Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 241-268页

作者： Ming-hua Yang Si-ming huang jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China College of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

High-resolution remote thermometry based on Bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： Cui-Mi Shi Shu-hua Xue jin-Yun Wang Liang-jin Xu Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

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三维语义场景复原网络

光学精密工程 2018年第5期26卷 1231-1241页

作者：林金花王延杰长春工业大学应用技术学院吉林长春130000 中国科学院长春光学精密机械与物理研究所吉林长春130031

从不完整的视觉信息中推断出物体的三维几何形状是机器视觉系统应当具备的重要能力,而识别出场景中物体的语义是机器视觉系统的核心。传统方法通常将二者分离实现,本文将场景复原与目标语义紧密结合,提出了一种三维语义场景复原网络模型... 详细信息

从不完整的视觉信息中推断出物体的三维几何形状是机器视觉系统应当具备的重要能力,而识别出场景中物体的语义是机器视觉系统的核心。传统方法通常将二者分离实现,本文将场景复原与目标语义紧密结合,提出了一种三维语义场景复原网络模型,仅以单一深度图作为输入,实现对三维场景的语义分类和场景复原。首先,建立一种端到端的三维卷积神经网络,网络的输入是深度图,使用三维上下文模块来对相机视锥体内的区域进行学习,进而输出带有语义标签的三维体素;其次,建立了带有密集体积标签的合成三维场景数据集,用于训练本文的深度学习网络模型;最后通过实验表明,与现有的语义分类和场景复原方法相比,语义场景的复原接收区域增加了2.0%。结果表明:三维学习网络的复原性能良好,语义标注的准确率较高。

关键词：机器视觉场景复原深度图语义分类卷积神经网络