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Chinese Chemical Letters 1998年第8期9卷 723-724,275页

作者： Guo Feng ZHAO hua zheng yang Lin Xiu WANG Yong Hong LI(Institute of Elemento-Organic Chemistry, National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianin 300071) Nankai Univ Inst Elementoorgan Chem Natl Key Lab Elementoorgan Chem Tianjin 300071 Peoples R China

In view of the isosterism of sulfonyl group (-SO2-) and phosphoryl group [-P(O)(OR)-,R=H, CH3, C2H5, etc], a new type of ureas, that is, N-phosphoryl-N'-(4,6-dimethoxypyrimidin-2yl) ureas 2 were synthesized and shown ... 详细信息

关键词： isosterism bioisosterism sulfonylurea phosphorylurea ALS inhibitors

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Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-yang Li Tian-Shuo Feng Ji Gao Xin-Xiang yang Xiang-Cheng Li Zhen-hua Deng Yong-Xiang Xia zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

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Role of Vickers Ligament in the Pathogenesis of Madelung Deformity

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Current Medical Science 2024年第4期44卷 735-740页

作者： Ge XIONG Wei zheng Li-hua GONG Department of Hand Surgery Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China Department of Pathology Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

Objective The Vickers ligament is thought to hinder the growth of palmar ulnar radius by tethering the lunate to the radius,leading to Madelung *** purpose of this study was to clarify the nature of the Vickers ligament and investigate its pathogenesis in Madelung deformities based on our observation of the Vickers *** All 22 patients(33 wrists)with Madelung deformities treated surgically between 2018 and 2022 were *** diagnosis was confirmed radiographically in all *** three-dimensional computed tomography(3D-CT)data of 16 patients(19 wrists)were *** resonance imaging(MRI)data were available for 9 patients(14 wrists).Wrist arthroscopy was used in 4 *** Vickers ligament was resected and submitted for histopathological examination in 8 *** outcomes,3D-CT,MRI,arthroscopy,surgical findings,and histopathology of the Vickers ligament were *** The 3D-CT revealed that the Vickers ligament originated in the metaphysis and formed a metaphyseal defect at the palmar ulnar *** the sequential MR coronal images,the Vickers ligament could be divided into 3 branches,extending to the lunate,triquetrum and ulnar *** and surgical findings revealed that the nature of the Vickers ligament was the stretched palmar ligament of the *** histopathology results revealed ligamentous tissue and fibrocartilaginous metaplasia with a structure similar to that of the triangular fibrocartilage complex(TFCC).Conclusions The Vickers ligament is not a separate aberrant *** nature of the Vickers ligament is a combination of the stretched TFCC ligament(palmar radioulnar ligament,ulnotriquetral ligament and ulnolunate ligament)and radiolunate *** possible pathogenesis of Madelung deformity might be focal early epiphyseal closure at the middle part of the sigmoid notch,which leads to focal growth retardation of the radius and pulls palmar ligaments proximally to for

关键词： Vickers ligament Madelung deformity pathogenesis computed tomography magnetic resonance imaging

Advances of biomarkers in nasopharyngeal carcinoma’s early detection

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Science Bulletin 2024年第2期69卷 141-145页

作者： Xiao-Hui zheng Allan Hildesheim Wei-hua Jia State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Costa Rican Agency for Biomedical Investigation INCIENSA FoundationSan Jose 10108Costa Rica

Nasopharyngeal carcinoma(NPC),a highly invasive and metastatic cancer,is widely prevalent in South China,Southeast Asia,and North *** patients with stages I and II are often ***,NPC patients are usually diagnosed with advanced-stage(stages III and IV)at their first *** of NPC at early stage is the key to improve the survival of ***-Barr virus(EBV)plays an essential role in NPC occurrence in endemic ***-based biomarkers,including EBV antibody in serum and EBV DNA in plasma,have been specifically proposed for NPC early ***,we summarize recent advances in biomarkers for the early detection of NPC.

关键词： patients nasopharyngeal Nasopharyngeal

Factors That Affect the Computational Prediction of Hot Spots in Protein-Protein Complexes

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Computational Molecular Bioscience 2012年第1期2卷 23-34页

作者： Jianping Lin Pi Liu hua-zheng yang Nagarajan Vaidehi College of Pharmacy Nankai University Tianjin China Department of Immunology Beckman Research Institute of the City of Hope Duarte USA State Key Laboratory of Elemento-Organic Chemistry Elemento-Organic Chemistry Institute Nankai University Tianjin China

Protein-protein complexes play an important role in the physiology and the pathology of cellular functions, and therefore are attractive therapeutic targets. A small subset of residues known as “hot spots”, accounts for most of the protein-protein binding free energy. Computational methods play a critical role in identifying the hotspots on the proteinprotein interface. In this paper, we use a computational alanine scanning method with all-atom force fields for predicting hotspots for 313 mutations in 16 protein complexes of known structures. We studied the effect of force fields, solvation models, and conformational sampling on the hotspot predictions. We compared the calculated change in the protein-protein interaction energies upon mutation of the residues in and near the protein-protein interface, to the experimental change in free energies. The AMBER force field (FF) predicted 86% of the hotspots among the three commonly used FF for proteins, namely, AMBER FF, Charmm27 FF, and OPLS-2005 FF. However, AMBER FF also showed a high rate of false positives, while the Charmm27 FF yielded 74% correct predictions of the hotspot residues with low false positives. Van der Waals and hydrogen bonding energy show the largest energy contribution with a high rate of prediction accuracy, while the desolvation energy was found to contribute little to improve the hot spot prediction. Using a conformational ensemble including limited backbone movement instead of one static structure leads to better predicttion of hotpsots.

关键词： Hotspot Prediction Computational Mutagenesis Concoord Ensemble Protein-Protein Complexes

Gastric metastasis of small cell lung carcinoma:Three case reports and review of literature

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World Journal of Gastroenterology 2024年第31期30卷 3717-3725页

作者： Shan yang Qing-Yun He Qing-Jing Zhao Han-Tao yang zheng-Yi yang Wen-Yi Che hua-Mei Li Hui-Chao Wu Department of Gastroenterology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of The First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Zhejiang Provincial People's Hospital Bijie HospitalBijie 551700Guizhou ProvinceChina Department of Gastroenterology Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Small cell lung carcinoma(SCLC)is highly susceptible to metastasis in the early stages of the ***,the stomach is an uncommon site of metastasis in SCLC,and only a few cases of this type of metastasis have been ***,SCLC gastric metastases have not been systematically characterized and are easily missed and *** SUMMARY We report three cases of gastric metastasis from SCLC in this *** first patient presented primarily with cough,hemoptysis,and epigastric *** other two patients presented primarily with abdominal discomfort,epigastric distension,and *** patients underwent gastroscopy and imaging ***,the immunohistochemical results of the lesions in three patients were suggestive of small cell ***,the three patients were diagnosed with gastric metastasis of SCLC through a comprehensive *** three patients did not receive appropriate treatment and died within a short *** Here,we focused on summarizing the characteristics of gastric metastasis of SCLC to enhance clinicians'understanding of this disease.

关键词： Small cell lung cancer Gastric neoplasms Neoplasm metastasis Diagnosis Case report

A Novel Nucleophilic Substitution of 3-Halo-6-phenoxypyridazines

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Chinese Chemical Letters 1999年第1期10卷 13-14页

作者： Kang Tat REN Hut Ying LI Jun QI Hong Hai SONG Xiang WANG hua zheng yang(Institute of Elemento-Organic Chemistry,State Key Laboratory of Elemento-Organic Chemistry, Tianjin, 300071) Nankai Univ Inst Elementoorgan Chem State Key Lab Elementoorgan Chem Tianjin 300071 Peoples R China

A novel nucleophilic substitution of pyridazines is found, in which phenoxy group is dislodged rather than the halogen atom, on treating 3-halo-6-phenoxypyridazines with alkoxy anion. The reactivity of substituents on benzene ring and the halogen atom of pyridazines are studied. Reasonable explanation based on the quantum chemical calculations are given.

关键词： nucleophilic substitution 3-halo-6-phenoxypyridazines mechanisms

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Deactivation mechanism for water splitting:Recent advances

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Carbon Energy 2024年第7期6卷 53-82页

作者： Yansong Jia yang Li Qiong Zhang Sohail Yasin Xinyu zheng Kai Ma zhengli hua Jianfeng Shi Chaohua Gu Yuhai Dou Shixue Dou Hydrogen Energy Institute Zhejiang UniversityHangzhouChina Institute of Process Equipment Zhejiang UniversityHangzhouChina Donghai Laboratory ZhoushanChina Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala LumpurMalaysia Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghaiChina

Hydrogen(H2)has been regarded as a promising alternative to fossil-fuel *** H2 produced via water electrolysis(WE)powered by renewable energy could achieve a zero-carbon *** attention has been focused on developing highly active catalysts to facilitate the reaction kinetics and improve the energy efficiency of ***,the stability of the electrocatalysts hampers the commercial viability of *** studies have elucidated the origin of catalyst *** this review,we first discuss the WE mechanism,including anodic oxygen evolution reaction(OER)and cathodic hydrogen evolution reaction(HER).Then,we provide strategies used to enhance the stability of *** that,the deactivation mechanisms of the typical commercialized HER and OER catalysts,including Pt,Ni,RuO_(2),and IrO_(2),are ***,the influence of fluctuating energy on catalyst degradation is highlighted and in situ characterization methodologies for understanding the dynamic deactivation processes are described.

关键词： deactivation mechanism hydrogen evolution in situ characterization oxygen evolution water splitting

Preparation of bifunctional electrocatalyst by recycling heavy metal ions from wastewater using EDTAD-functionalized MOF as highly efficient adsorbent

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Rare Metals 2024年第10期43卷 5105-5116页

作者： Yue Qian Pei-Xue Fu Rui-Ze Yin Han-Ni yang Si-yang Li Wei-Wei Xiong Fen-Fen zheng Jun-Hao Zhang Ai-hua Yuan huan Pang School of Environmental and Chemical Engineering Jiangsu University of Science and Technology School of Chemistry and Chemical Engineering Yangzhou University

The recovery and subsequent reuse of heavy metal ions from industrial wastewater are crucial for promoting sustainable development,but they also presen significant *** this article,ethylenediaminetetraacetic dianhydride （EDTAD）,which possesses strong metal chelating ability,is covalently attached to MIL-101-NH2（Fe）,resulting in a significant improvement in the removal rate of heavy metal ions in ***,the recovered waste metal ions are transformed into high-performance FeNi3/NiFe2O4@NC dual-functional oxygen evolution reaction （OER） and oxygen reduction reaction （ORR） ***,FeNi3/NiFe2O4@NC exhibits outstanding OER performance,with only a264 mV overpotential at 10 mA·*** functiona theory （DFT） calculations reveal that the synergistic effect of the FeNi3/NiFe2O4@NC heterostructure can enhance conductivity,optimize the free energy of*to OH*during OER reaction,and promote catalytic *** work not only improves the removal rate of heavy metal ions but also obtains high-performance catalysts,while providing a new approach for the treatment and secondary utilization of heavy metal ion wastewater as well as the preparation of low-cost catalysts.

关键词： Bifunctional electrocatalyst Covalently modified MOF Ethylenediaminetetraacetic dianhydride Heavy metals

Hydroxylated metal–organic-layer nanocages anchoring single atomic cobalt sites for robust photocatalytic CO_(2) reduction

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Nano Research 2024年第4期17卷 2410-2419页

作者： Weiyi Pan Zhihe Wei Yanhui Su Yuebin Lian Zhangyi zheng Huihong Yuan Yongze Qin Xulan Xie Qianqian Bai Zhenyang Jiao Wei hua Jinzhou Chen Wenjun yang Zhao Deng yang Peng Soochow Institute for Energy and Materials Innovations College of EnergySoochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Photoelectric Engineering Changzhou institute of technologyChangzhou 213032China Jiangsu Key Laboratory for Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123China

Assembly of two-dimensional(2D)metal–organic layers(MOLs)based on the hard and soft acid–base theorem represents an exquisite strategy for the construction of photocatalytic platforms in virtue of the highly exposed active sites,much improved mass transport,and greatly elevated ***,nanocages composed of MOLs are produced for the first time through a cosolvent approach utilizing zirconium-based UiO-66-(OH)2 as the structural *** endow the catalytic activity for CO_(2) conversion,single atomic Co^(2+)sites are appended to the Zr-oxo nodes of the MOL cages,demonstrating a remarkable CO yield of 7.74 mmol·g^(-1)·h^(-1) and operational stability of 97.1%product retention after five repeated *** an outstanding photocatalytic performance is mainly attributed to the unique nanocage morphology comprising enormous 2D nanosheets for augmented Co^(2+)exposure and the abundant surface hydroxyl groups for local CO_(2) *** work underlines the tailoring of both metal–organic framework(MOF)morphology and functionality to boost the turnover rate of photocatalytic CO_(2) reduction reaction(CO_(2)RR).

关键词： photocatalytic CO_(2) reduction metal–organic layer nanocage single-atom catalyst co-catalyst