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Science China Chemistry 2024年第9期67卷 3091-3097页

作者： Wei Xiong Tianjun Yue Haiwang Lai Chunyan Lyu Weimin Ren hua lu Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116081China

Polythiourethanes(PTU)and polythioesters(PTE)derived from renewable sources are emerging sustainable polymers for their excellent degradability and ***,P(TU-alt-TE)copolymers have been rare and challenging to ***,we report the efficient synthesis of novel P(TU-alt-TE)copolymers via the alternating copolymerization of N-thiocarboxyanhydrides(NTA)/episufides(ES)and provide mechanistic insight into the alternating chain propagation process via density functional theory(DFT)*** incorporation of ESs into traditional peptide backbone is capable of adjusting the glass transition temperature below thermal decomposition temperature,which confers better thermal processability by regulating the rigidity of the backbone and the hydrogen bond interaction among the polymer *** PTUs with tailored properties are accessible by altering the feeding ratio of NTAs and(bifunctional)***,the thiourethane in the backbone can endow interesting underwater adhesion properties to the *** the broad scope of NTA and ES monomers,this method is expected to provide a promising and general route to a wide range of P(TU-alt-TE)copolymers with diverse properties.

关键词： poly(thiourethane-alt-thioester) alternating ring-opening copolymerization N-thiocarboxyanhydrides episulfides

High myopia as a risk factor in primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 750-753页

作者： Sheng-Ju Chen Peng lu Wen-Fang Zhang Jian-hua lu Department of Ophthalmology the Second Hospital of Lanzhou University

Glaucoma, one of the leading causes of irreversible blindness in the adult population worldwide, is a progressive optic neuropathy. Primary open angle glaucoma (POAG) is the most commonly reported type of glaucoma in population based prevalence studies worldwide. Elevated intraocular pressure is a well-known major risk factor for POAG. In addition, there is growing evidence that other risk factors like age, gender, race, refractive error, heredity and systemic factors may play a role in glaucoma pathogenesis. Many studies found that high myopia has been associated with POAG, however, direct and convincing evidences are still lacking. The aim of this review is to summarize the evidences implicating high myopia as a risk factor in the pathogenesis of POAG.

关键词： high myopia primary open angle glaucoma risk factor

Enantioselective Total Synthesis of(+)-Propolisbenzofuran B

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Chinese Journal of Chemistry 2024年第22期42卷 2833-2839页

作者： Wen-Xiu Xu Li-Han Zhao Yao Zhu Hai-hua lu Department of Chemistry Zhejiang University866 Yuhangtang RoadHangzhouZhejiang 310058China Key Laboratory of Precise Synthesis of Functional Molecules of zhejiang Province Department of Chemistry and Research Center for Industries oftheFutureWestlake University600 Dunyu RoadHangzhouZhejiang 310030China Institute of Natural Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhouZhejiang 310024China

Comprehensive Summary The first catalytic asymmetric total synthesis of(+)-propolisbenzofuran B,enabled by a highly enantioselective rhodium-catalyzed hydrogenation of a tetrasubstituted olefin,was *** noteworthy aspects include the construction of the central hydrodibenzo[b,d]furan core through a sequence of Zn(II)-mediated regioselective benzofuran formation and Dieckmann condensation,as well as C-H oxidations,involving a visible light-induced Fe(III)-catalyzed benzylic C(sp3)-H ***,the absolute configuration was confirmed by X-ray analysis of a carbonate intermediate.

关键词： Propolisbenzofuran B Total synthesis Enantioselective hydrogenation Photocatalysis C-H functionalization Natural products Alkenes Chirality

Tailoring Cationic Helical Polypeptides for Efficient Cytosolic Protein Delivery

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Chemical Research in Chinese Universities 2020年第1期36卷 134-138页

作者： WANG Ruijue SHENG Kai HOU Yingqin SUN Jialing lu hua Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871P.R.China

Protein delivery is of central importance for both diagnostic and therapeutic ***,protein delivery faces challenges including poor endosomal escape and thus limited ***,we report the facile construction and screening of a small library of cationic helical polypeptides for cytosolic protein *** library is based on a random copolymer poly(γ-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}esteryl-L-glutamate)-randompoly(γ-6-chlorohexyl-L-glutamate)[P(EG3-r-ClC6)Glu],which is then modified with various pyridine derivatives and alkyl *** Cytometry,confocal laser scanning microscopy,and viability assay collaboratively identify two leading polymers,showing efficient delivery of enhanced green fluorescent protein(eGFP)and low *** finding is further validated by the cytosolic delivery of RNase A and cytochrome C(Cyt C)to HeLa cells in the viability ***,this work demonstrates that high-throughput screening is an effective and viable approach to the selection of cationic helical polypeptides for the cytosolic delivery of functional proteins.

关键词： Cationic helical polypeptide Protein delivery Cytosolic protein

Regulation of the cellular uptake of nanopartides by the orientation of helical polypeptides

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Nano Research 2019年第4期12卷 889-896页

作者： Chong Zhang Jianhua lu Falin Tian Lindong Li Yingqin Hou Yaoyi Wang Lingdong Sun Xinghua Shi hua lu Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education Peking University Beijing 100871 China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China State Key Laboratory of Rare Earth Materials Chemistry and Applications PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry Peking University Beijing 100871 China

Controlling the cellular interactio n and internal izatio n of polymer-modified nan oparticles (NPs) is of central importa nee to the developme nt of promisi ng nano medici nes. Here, we describe the use of synthetic polypeptides for NP surface coati ng and regulati on of their cellular uptake behaviors by simply switching the conformation and anchoring orientation. Our results show that gold NPs (AuNPs) coated with a helical poly(Y-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl「glutamate)(L-P(EG3Glu)5o) from the C-terminus ((L-C)-AuNPs) exhibit greater zeta potential and more cellular uptake (2.0-5.5 fold higher) than those coated with the same polypeptide but anchored from the N-terminus ((L-N)-AuNPs), or from both the C- and N-terminus at a 1/1 molar ratio ((L-C/L-N)-AuNPs). A similar orientation-regulated cellular internalization pattern is observed in D-P(EG3Glu)50 but not the unstructured DL-P(EG3Glu)5o-rnodified AuNPs, suggesting an important and universal role of the helix-derived macrodipole in cellular uptake. Moreover, this orientation-governed internalization is successfully reproduced in P(EG3Glu)50-coated gold nano rods (AuNRs), and applied to the desig n of doxorubici reloaded polypeptide micelles. Simulation study offers time-resolved in sights regarding the NP-membrane in teracti ons and membrane remodeling. Thus, our study provides a delicate way of regulating the surface chemistry of NPs and the subsequent NP-cell interactions. Moreover, the results highlight the uniqueness of polypeptides in NP surface engineering, and urge a more careful consideration on the polymer orientation effect.

关键词： helix orientation polypeptides cellular uptake gold nanoparticles

Synthesis and optoelectronic properties of a novel molecular semiconductor of dithieno[5,6-b:11,12-b']coronene-2,3,8,9-tetracarboxylic tetraester

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Chinese Chemical Letters 2014年第1期25卷 65-68页

作者： Chun Zhan You-Yu Jiang Ming-Yan Yang lu-hua lu Sheng-Qiang Xiao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology WUT-USG Joint Laboratory of Advanced Optoelectronic Materials and Devices Wuhan University of Technology Center for Chemical and Materials Engineering Wuhan University of Technology

A facile procedure for the synthesis ofdithieno[5,6-b：11,12-b＇]coronene-2,3,8,9-tetracarboxylic tetra（2- ethylhexyl）ester （DTCTI＇E-EH） from readily available perylene-3,4,9,10-tetracaroboxylic dianhydride is described. The electronic properties of DTCTTE-EH were elucidated on the basis of UV-vis spectra, emission spectrum and electrochemical measurement, which demonstrate that DTCTTE is a new class of components for promising semiconducting materials.

关键词： Polycyclic aromatic molecules Coronene tetracarboxylic tetraester Semiconductor Optoelectronic property

A New Sesquiterpene from the Alga Caloglossa Leprieurii

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Chinese Chemical Letters 2002年第10期13卷 953-954页

作者： Xiao hua XU Chang Jian LIN Jian hua lu Guang Min YAO Yan Ming LI Institute of Elemento-Organic Chemistry Nankai UniversityTianjin 300071

A new bromo-sesquiterpene 1, has been isolated from the alga Caloglossa leprieurii collected from the XiSha islands in south china sea. Its structure has been determined on the basis of spectral analysis. and The rela... 详细信息

关键词： Caloglossa leprieuriii hydroclathrol spectral analysis.

Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis

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World Journal of Stem Cells 2023年第9期15卷 908-930页

作者： lu Lv En-Hai Cui Bin Wang Li-Qin Li Feng hua hua-Dong lu Na Chen Wen-Yan Chen Department of Respiratory and Critical Care Medicine Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000Zhejiang ProvinceChina Traditional Chinese Medicine Key Laboratory Cultivation Base of Zhejiang Province for the Development and Clinical Transformation of Immunomodulatory Drugs Huzhou 313000Zhejiang ProvinceChina

BACKGROUND Acute lung injury(ALI)and its final severe stage,acute respiratory distress syndrome,are associated with high morbidity and mortality rates in patients due to the lack of effective specific *** microbiota homeostasis,including that in ALI,is important for human *** suggests that the gut microbiota improves lung injury through the lung-gut *** umbilical cord mesenchymal cells(HUC-MSCs)have attractive prospects for ALI *** study hypothesized that HUC-MSCs improve ALI via the lung-gut *** To explore the effects of HUC-MSCs on lipopolysaccharide(LPS)-induced ALI in mice and the involvement of the lung-gut axis in this *** C57BL/6 mice were randomly divided into four groups(18 rats per group):Sham,sham+HUC-MSCs,LPS,and LPS+*** was induced in mice by intraperitoneal injections of LPS(10 mg/kg).After 6 h,mice were intervened with 0.5 mL phosphate buffered saline(PBS)containing 1×10^(6) HUC-MSCs by intraperitoneal *** the negative control,100 mL 0.9%NaCl and 0.5 mL PBS were *** lavage fluid(BALF)was obtained from anesthetized mice,and their blood,lungs,ileum,and feces were obtained by an aseptic technique following CO_(2) ***’s staining,enzyme-linked immunosorbent assay,hematoxylin-eosin staining,Evans blue dye leakage assay,immunohistochemistry,fluorescence in situ hybridization,western blot,16S rDNA sequencing,and non-targeted metabolomics were used to observe the effect of HUC-MSCs on ALI mice,and the involvement of the lung-gut axis in this process was ***-way analysis of variance with post-hoc Tukey’s test,independent-sample Student’s t-test,Wilcoxon rank-sum test,and Pearson correlation analysis were used for statistical *** HUC-MSCs were observed to improve pulmonary edema and lung and ileal injury,and decrease mononuclear cell and neutrophil counts,protein concentrations in BALF and inflammatory cytokine levels in the se

关键词： Acute lung injury Human umbilical cord mesenchymal cells Lipopolysaccharide Microflora Untargeted metabolomics Toll-like receptor 4/nuclear factor kappa-B signaling pathway

Biochemical responses of freshwater fish Carassius auratus to polycyclic aromatic hydrocarbons and pesticides

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Water Science and Engineering 2012年第2期5卷 145-154页

作者： Yong JI Guang-hua lu Chao WANG Jie ZHANG College of Environment Hohai University Nanjing 210098 P. R. China School of Hydraulic and Ecological Engineering Nanchang Institute of Technology Nanehang 330099 P. R. China

The freshwater fish Carassius auratus was chosen as an experimental subject, and their hepatic biochemical responses to the medium-term exposure of Benzo（k）fluoranthene （BkF） alone and in combination with PCB 118 and dichlorodiphenyltrichloroethane （DDT） were investigated by measuring the reduced glutathione （GSH）, glutathione S-transferase （GST）, and thiobarbituric acid reactive substances （TBARS）, to assess sublethal effects. The hepatic GSH content was significantly inhibited by organic pollutants, alone and in mixtures, while the TBARS content was significantly induced after three days of exposure. Bell-shaped concentration-response charts of GST activities were obtained. Significant dose-response relationships were found for hepatic GSH and TBARS contents of all concentrations and for the GST activity, except at the highest concentration. The GSH content, GST activity, and TBARS content in Carassius auratus were confirmed as useful biomarkers of exposure to organic pollutions.

关键词： biochemical response S-transferase (GST) thiobarbituric acid Carassius auratus glutathione (GSH) glutathione reactive substances ( TBARS)

Controlled fabrication of hierarchically microstructured surfaces via surface wrinkling combined with template replication

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Chinese Chemical Letters 2015年第1期26卷 15-20页

作者： Chuang Tian Hai-Peng Ji Chuan-Yong Zong Cong-hua lu School of Materials Science and Engineering Tianjin University

In this paper,we present a simple method by combining surface wrinkling and template replication to create a series of hierarchical structures on polydimethylsiloxane（PDMS） *** primary stable lined patterns are formed by duplicating commercialized compact disk and digital versatile disk with *** secondary microscale patterns are from surface wrinkling,which is elicited by oxygen plasma（OP） treatment of the prestrained PDMS stamp followed with the prestrain *** systematically varying the OP exposure duration,the prestrain,and the angle（θ） between the primary pattern orientation and the prestrain direction,we obtain highly ordered well-organized composite patterns from different patterning techniques and with different length scales and mechanical stabilities.

关键词： Surface wrinkling Template replication Stress relief Hierarchical structures