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Recyclable polythioesters and polydisulfides with near-equilibrium thermodynamics and dynamic covalent bonds

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Science China Chemistry 2023年第3期66卷 725-738页

作者： Wei Xiong hua lu Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The accumulation of discarded petroleum-based plastics causes serious environmental ***,recyclable polymers with neutrality in thermodynamics,such as polyesters,polycarbonates,and polyolefins,have been developed as promising alternatives to traditional petroleum-based ***,the chemical recycle of these polymers usually requires high energy input and expensive *** covalent bonds,such as thioester and disulfide bonds,have emerged as building blocks for constructing recyclable polymers that can be rapidly degraded/recycled under mild *** this review,we introduce representative studies on recyclable polythioesters and polydisulfides with respect to their synthetic strategies,thermodynamic manipulation,physicochemical properties,and preliminary *** also highlight the important role of kinetic factors played in the design of recyclable ***,major challenges,perspectives,and future opportunities in the synthesis and applications of polythioesters/polydisulfides are discussed.

关键词： polythioesters polydisulfides recyclable near-equilibrium thermodynamics dynamic covalent bond

Site-specific protein-polymer conjugate micelles with dramatically enhanced pharmacology

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Science China Materials 2018年第12期61卷 1627-1628页

作者： hua lu Center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University

Protein drugs are increasingly used in the clinical treatment of various diseases including cancer and infectious diseases because of their specificity and high biological activity[1]. Nevertheless, the efficacy of protein drugs is constrained by their relatively short in vivo circulation half-life [2].As a result,frequent administration at high concentrations is often required,leading to undesirable side effects and poor patient compliance [3].

关键词： PHPMA Site-specific protein-polymer conjugate micelles with dramatically enhanced pharmacology PEG IFN

Legends of p53:untold four-decade stories

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Journal of Molecular Cell Biology 2019年第7期11卷 521-522页

作者： hua lu Department of Biochemistry & Molecular Biology and Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA.

Since its discovery in 1979,p53 has been the most intensively studied molecule in biomedical research and described as the most important tumor suppressor in human *** more we study p53 the less we know about it as depicted by the cover of this *** celebrate the 40th anniversary of p53 discovery,to cheer researchers who have dedicated their entire careers to study p53,and to help readers better understand p53 and its history,this special issue of Journal of Molecular Cell Biology (JMCB) has fortunately collected remarkably interesting and historical papers from a number of hard core p53 researchers in the field of cancer,many of whom are pioneering and world-class scientists.

关键词： discovery intensively scientists

政策干预下农地经营权流转抑制耕地撂荒研究——来自江西丘陵地区的证据

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云南农业大学学报（社会科学版） 2025年第1期19卷 108-115页

作者：周来友卢华江西财经大学应用经济学院江西南昌330013 新余学院经济管理学院江西新余338004

利用江西丘陵地区的调研数据,验证农地经营权流转是否能有效治理耕地撂荒,并引入政府干预变量,观察政府干预情况下农地经营权流转对耕地撂荒影响的异质性影响。研究发现:农地经营权流转能显著促进耕地撂荒,但异质性的分析结果显示政府... 详细信息

利用江西丘陵地区的调研数据,验证农地经营权流转是否能有效治理耕地撂荒,并引入政府干预变量,观察政府干预情况下农地经营权流转对耕地撂荒影响的异质性影响。研究发现:农地经营权流转能显著促进耕地撂荒,但异质性的分析结果显示政府干预能有效缓解这一趋势;进一步的分析发现,随着农户外出务工程度的加深,其农地经营权流转行为会激励耕地撂荒。最后提出应有效发挥政府干预力量的对策建议,具体路径包括政府应通过土地整治、兴修水利等途径完善农业生产基础设施,改善偏远地块的耕种条件,避免其被撂荒的命运。

关键词：农地经营权流转耕地撂荒治理丘陵地区

p53 and MDM2： their Yin-Yang intimacy

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Journal of Molecular Cell Biology 2017年第1期9卷 1-2页

作者： hua lu Department of Biochemistry & Molecular Biology and Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA

The phiLosophy of Yin （阴） and Yang （阳） formed in ancient China describes a subtle, complementary, and sometimes intimate relationship between two opposites. This thousands of years old phil- osophy is, however, perfectly suited to describe the relationship between p53 and MDM2, whose genes evolved hundreds of millions of years ago. p53 and MDM2 are found in both （some） invertebrate and （all） vertebrate organisms, and mutually live with and almost always depend on each other in most multi-cellular organisms, including humans.

关键词： @@

New players critical for breast cancer

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Journal of Molecular Cell Biology 2018年第4期10卷 271-272页

作者： hua lu Department of Biochemistry & Molecular Biology and Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA

Breast cancer （BC） is the most malignant cancer and the second leading cause of deaths in women worldwide. It is typically classified into the following three subtypes： estrogen receptor （ER）/progesterone receptor （PR）-positive （luminal）, human epidermal growth factor receptor 2 （HER2）-amplified, and ER/PR/HER2-triple negative BC （TNBC）. Tremendous progress has been made to understand molecular mechanisms underlying BC development, progression, and metastasis, and to develop molecule-targeted therapies for clinical applications.

关键词：癌症播放器应用程序开发雌激素受体乳世界范围种子类型生长因素

Spectroscopic investigation on chirality transfer in additive-driven self-assembly of block polymers

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Chinese Chemical Letters 2017年第7期28卷 1358-1364页

作者： Li-hua Pang Jing-Min Li Xue-Min lu Qing-hua lu School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Chiral supramolecules prepared by the additive-driven self-assembly of block copolymers provide a facile method to construct helical nanostructures. In this study, we investigated the chiral transfer from chiral tartaric acid to poly（styrene）-b-poly（ethylene oxide） using small-angle X-ray scattering,transmission electron microscopy, circular dichroism, and vibrational circular dichroism. The results showed that the chirality was transferred to both the segments of block copolymer irrespective of the interaction with the chiral additives and formation of helical phase structure. However, the chirality transfer was carried out using different methods： for poly（ethylene oxide） segments, the chirality transfer was carried out via direct hydrogen bond formation; for polystyrene segments, the chirality transfer was carried out via the cooperative motion of block copolymers during the thermal annealing.

关键词： Block polymer Chirality Additive-driven Hydrogen bond Helical structure

Effect of Growth Temperature on Carbon Nanotube Grafting Morphology and Mechanical Behavior of Carbon Fibers and Carbon] Carbon Composites

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Journal of Materials Science & Technology 2017年第1期33卷 65-70页

作者： Lei Feng Ke-Zhi Li Jin-hua lu Le-hua Qi State Key Laboratory of Solidification Processing Carbon/Carbon Composites Research Center Northwestern Polytechnical University Xi'an 710072 China School of Mechatronic Engineering Northwestern Polytechnical University Xi'an 710072 China

High-purity carbon nanotubes （CNTs） with different orientation and lengths were grafted on carbon fibers （CFs） in woven fabrics by using double injection chemical vapor deposition and adjusting the growth temperature. Scanning electron microscopy （SEM）, transmission electron microscopy （TEM） and Raman investigations reveal that the grafted CNTs change from being predominantly aligned and uniform in di- ameter to absolutely disordered and variable in diameter, whilst they show significantly increased crystallinity, as the growth temperature is increased from 730 ~C to 870 ~C. In tensile tests of fiber bundles, much more strength degradation of CFs was observed after the growth process at higher temperature than that at lower temperature. These hybrid preforms produced at different growth temperatures were used to reinforce carbon/carbon （C/C） composites. An increment of 34.4% in out-of-plane compressive strength （OCS） was obtained for the composites containing CNTs grown at 730℃, while the OCS increment exhibits an obvious decrease with increasing the growth temperature. Compared with the higher growth temperature, the lower temperature contributes to the decrease in the strength loss of reinforcing fibers and meanwhile the growth of large extending length of CNTs, which can provide long reinforcement to the pyrocarbon matrix, and thus increase the compressive strength better.

关键词： Carbon nanotubes Carbon fibers Chemical vapor deposition Carbon/carbon composites Mechanical strength

Semisymmetric graphs of order 6p^2 and prime valency

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Science China Mathematics 2012年第12期55卷 2579-2592页

作者： HAN hua lu ZaiPing Center for Combinatorics LPMC- TJKLC Nankai University Tianjin 300071 China

In this paper, we investigate semisymmetric graphs of order 6p2 and of prime valency. First, we give a classification of the quasiprimitive permutation groups of degree dividing 3p2, and then, on the basis of the classification result, we prove that, for primes k and p, a connected graph Γ of order 6p2 and valency k is semisymmetric if and only if k = 3 and either Γ is the Gray graph, or p ≡ 1 (mod 6) and Γ is isomorphic to one known graph.

关键词： semisymmetric graph bi-Cayley graph normal cover quasiprimitive permutation group